Ovulation induction: a mini review

Messinis, Ioannis E.

doi:10.1093/humrep/dei128

Cited by 140Ovarian function and disordersReproductive Biology and FertilityReproductive Health and Technologies

Ovulation induction: a mini review

Messinis, Ioannis E.·2005·Human Reproduction

DOI 10.1093/humrep/dei128

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Abstract

Ovulation induction is the method for treating anovulatory infertility. For patients with hypogonadotrophic hypogonadism, the treatment involves administration of both FSH and LH, while HCG is injected for follicle rupture. Pulsatile GnRH has the same effectiveness as gonadotrophins and the advantage of the low multiple pregnancy rate. In polycystic ovary syndrome (PCOS), the first treatment choice is clomiphene citrate. With this drug, in properly selected patients, the cumulative pregnancy rate approaches that of normal women. Low-dose protocols of FSH are the second line of treatment, effective in inducing monofollicular development. Laparoscopic ovarian drilling can be an alternative but not as a first choice treatment in clomiphene-resistant patients. Other treatments, such as pulsatile GnRH and GnRH agonists, are hardly used today in PCOS. However, in obese women with PCOS, weight loss and exercise should be recommended as the first line of therapy. Newer agents including aromatase inhibitors and insulin sensitizers, although promising, need further evaluation.

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There is a large body of observational evidence supporting the use of gonadotrophin therapy in anovulatory women with PCOS.
“Despite a large body of observational evidence supporting the use of gonadotrophin therapy in anovulatory women with PCOS, 232”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [232]
A low-dose 'step-up' protocol is used to reduce the risks of multiple pregnancy and ovarian hyperstimulation syndrome with gonadotrophins.
“A low-dose 'stepup' protocol is used to reduce these risks. 232”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [232]

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Ovulation induction in the treatment of patients with polycystic ovary syndrome
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Ovulation Induction in Anovulatory Patients with Polycystic Ovary Syndrome
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Authors: Messinis, I. E.
Affiliations: University of Thessaly (GR)
Corresponding author: Messinis, Ioannis E.
ORCID: Messinis, Ioannis E.
Venue: Human Reproduction
Publisher: Oxford University Press (OUP)
Published: 2005-07-08
Volume: 20
Issue: 10
Pages: 2688-2697
ISSN: 0268-1161 (ISSN-L)
1460-2350
DOI: 10.1093/humrep/dei128
OpenAlex: W2113821740
Cited by: 140
References: 120
Citations by year: 2026: 1 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 11 · 2014: 8 · 2013: 7 · 2012: 6
FWCI: 1.30
Type: journal article
Language: en
Open access: closed
Locations: Human Reproduction (publishedVersion)
PubMed (publishedVersion)
University of Thessaly Institutional Repository (University of Thessaly) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Keywords: ovulation induction, anovulatory infertility, hypogonadotropic hypogonadism, follicle-stimulating hormone, luteinizing hormone, human chorionic gonadotropin, pulsatile GnRH, clomiphene citrate, polycystic ovary syndrome, low-dose FSH, laparoscopic ovarian drilling, GnRH agonist, obesity, weight loss, aromatase inhibitors, insulin sensitizers
MeSH terms: Body Weight, Clomiphene, Female, Follicle Stimulating Hormone, Chorionic Gonadotropin, Humans, Infertility, Female, Insulin, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Ovary, Ovulation Induction, Laparoscopy, Polycystic Ovary Syndrome, Pregnancy, Pregnancy, Multiple, Recombinant Proteins, Weight Loss, Exercise, Estrogen Receptor Modulators, Aromatase Inhibitors

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Ovulation induction: a mini review

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