The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Stress, distress and outcome of assisted reproductive technology (ART): a meta-analysis
Open accessAbstract
BACKGROUND: A number of studies have investigated the relationship between psychological factors such as stress and distress (measured as anxiety and depression) and outcomes of assisted reproductive technology (ART). The results, however, are inconsistent, and the strength of any associations remains to be clarified. We conducted a systematic review and meta-analysis of the results of studies reporting on the associations between stress, anxiety, and depression and ART outcomes. METHODS: Prospective studies reporting data on associations between stress or distress in female patients and ART outcome were identified and evaluated by two independent researchers according to an a priori developed codebook. Authors were contacted in cases of insufficient data reporting. Stress was defined as perceived stress, work-related stress, minor life events or major life events, and distress was defined as anxiety or depression. RESULTS: A total of 31 prospective studies were included. Small, statistically significant, pooled effect sizes were found for stress [ESr, effect size correlation) = -0.08; P = 0.02, 95% confidence interval (CI): -0.15, -0.01], trait anxiety (ESr = -0.14; P = 0.02, 95% CI: -0.25, -0.03) and state anxiety (ESr = -0.10, P = 0.03, 95% CI: -0.19, -0.01), indicating negative associations with clinical pregnancy rates. A non-significant trend (Esr = -0.11, P = 0.06) was found for an association between depression and clinical pregnancy. For serum pregnancy tests and live birth rates, associations between trait anxiety or state anxiety were not significant. The fail safe number did not exceed the suggested criterion in any analyses, between-study heterogeneity was considerable and the mean age, mean duration of infertility and percentage of first time ART attenders in the study samples were found to moderate several of the associations. CONCLUSIONS: Small but significant associations were found between stress and distress and reduced pregnancy chances with ART. However, there were a limited number of studies and considerable between-study heterogeneity. Taken together, the influence of stress and distress on ART outcome may appear somewhat limited.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. (1989) · Technometrics · doi:10.1080/00401706.1989.10488618 · Cited by 99,167
Statistical power analysis for the behavioral sciences
(1990) · Computers, Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,269
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164
(1970) · Cited by 24,983
von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., Vandenbroucke, J. P., & Initiative, F. T. S. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040296 · Cited by 23,020
Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2009) · doi:10.1002/9780470743386 · Cited by 14,225
Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2021) · doi:10.1002/9781119558378 · Cited by 9,799
Vandenbroucke, J. P., von Elm, E., Altman, D. G., Gøtzsche, P. C., Mulrow, C. D., Pocock, S. J., Poole, C., Schlesselman, J. J., Egger, M., & Initiative, F. T. S. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040297 · Cited by 8,613
Moher, D., Cook, D. J., Eastwood, S., Olkin, I., Rennie, D., & Stroup, D. F. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04149-5 · Cited by 4,826
(1988) · Cited by 4,111
Vandenbroucke, J. P., Elm, E. V., Altman, D. G., Gøtzsche, P. C., Mulrow, C. D., Pocock, S. J., Poole, C., Schlesselman, J. J., Egger, M., & initiative, F. T. S. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-8-200710160-00010-w1 · Cited by 3,543
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689
The Hazards of Scoring the Quality of Clinical Trials for Meta-analysis
Jüni, P. (1999) · JAMA · doi:10.1001/jama.282.11.1054 · Cited by 1,981
The social psychology of health
(1989) · Choice Reviews Online · doi:10.5860/choice.26-5686 · Cited by 1,788
Moher, D., Jadad, A. R., Nichol, G., Penman, M., Tugwell, P., & Walsh, S. (1995) · Controlled Clinical Trials · doi:10.1016/0197-2456(94)00031-w · Cited by 1,308
(1995) · Cited by 1,270
Zegers-Hochschild, F., Adamson, G. D., de Mouzon, J., Ishihara, O., Mansour, R., Nygren, K., Sullivan, E., van der Poel, S., & WHO, O. B. O. I. A. (2009) · Human Reproduction · doi:10.1093/humrep/dep343 · Cited by 1,043
Espinosa, J. C. (2004) · Cited by 939
Kunz, R., & Oxman, A. D. (1998) · BMJ · doi:10.1136/bmj.317.7167.1185 · Cited by 770 · cited 1×
“The use of assigning a quality score to each study and using this score to weight the results in meta-analysis is highly debated (Detsky et al., 1992; Kunz and Oxman, 1998; Juni et al., 1999; Greenland and O’Rourke, 2001), and we therefore chose not to use such a scoring procedure.”
MethodStrategies for Measuring Stress in Studies of Psychiatric and Physical Disorders
Cohen, S., Kessler, R. C., & Gordon, L. U. (1995) · Measuring Stress · doi:10.1093/oso/9780195086416.003.0001 · Cited by 764
Measuring stress: A guide for health and social scientists
Deary, I. J. (1996) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(96)00066-9 · Cited by 754
The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996.
Swan, S. H., Elkin, E. P., & Fenster, L. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108961 · Cited by 742
Neurosis and the Social Environment
Henderson, S., Byrne, D. G., & Duncan‐Jones, P. (1982) · Cited by 741
The power of statistical tests for moderators in meta-analysis
Hedges, L. V., & Pigott, T. D. (2004) · Psychological Methods · doi:10.1037/1082-989x.9.4.426 · Cited by 672
Women’s emotional adjustment to IVF: a systematic review of 25 years of research
Verhaak, C. M., Smeenk, J. M. J., Evers, A. W. M., Kremer, J. A. M., Kraaimaat, F. W., & Braat, D. D. M. (2007) · Human Reproduction Update · doi:10.1093/humupd/dml040 · Cited by 671
The Social Psychology of Health.
Gold, D. T., Spacapan, S., & Oskamp, S. (1990) · Contemporary Sociology · doi:10.2307/2073512 · Cited by 640
Incorporating variations in the quality of individual randomized trials into meta-analysis
Detsky, A. S., Naylor, C. D., O'Rourke, K., McGeer, A. J., & L'Abbé, K. A. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90085-2 · Cited by 640
Neurosis and the social environment
Bebbington, P. (1982) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(82)90026-5 · Cited by 638
Amygdala Responses to Emotionally Valenced Stimuli in Older and Younger Adults
Mather, M., Canli, T., English, T., Whitfield, S., Wais, P., Ochsner, K., John, D. E. G., & Carstensen, L. L. (2004) · Psychological Science · doi:10.1111/j.0956-7976.2004.00662.x · Cited by 554
Levenson, R. W., Carstensen, L. L., & Gottman, J. M. (1994) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.67.1.56 · Cited by 443
A review of psychosocial interventions in infertility
Boivin, J. (2003) · Social Science & Medicine · doi:10.1016/s0277-9536(03)00138-2 · Cited by 380
requivalent: A simple effect size indicator.
Rosenthal, R., & Rubin, D. B. (2003) · Psychological Methods · doi:10.1037/1082-989x.8.4.492 · Cited by 380
Klonoff-Cohen, H., Chu, E., Natarajan, L., & Sieber, W. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02008-8 · Cited by 370
Greenland, S. (2001) · Biostatistics · doi:10.1093/biostatistics/2.4.463 · Cited by 359 · cited 1×
“The use of assigning a quality score to each study and using this score to weight the results in meta-analysis is highly debated (Detsky et al., 1992; Kunz and Oxman, 1998; Juni et al., 1999; Greenland and O’Rourke, 2001), and we therefore chose not to use such a scoring procedure.”
MethodVerhaak, C. M., Smeenk, J. M. J., van Minnen, A., Kremer, J. A. M., & Kraaimaat, F. W. (2005) · Human Reproduction · doi:10.1093/humrep/dei015 · Cited by 348
Skakkebæk, N. E., Jørgensen, N., Main, K. M., Meyts, E. R., Leffers, H., Andersson, A., Juul, A., Carlsen, E., Mortensen, G. K., Jensen, T. K., et al. (2006) · International Journal of Andrology · doi:10.1111/j.1365-2605.2005.00573.x · Cited by 312
Women's experience of IVF: a follow-up study
Hammarberg, K. (2001) · Human Reproduction · doi:10.1093/humrep/16.2.374 · Cited by 303
A prospective, longitudinal study of emotions and relationships in in- vitro fertilization treatment
Slade, P., Emery, J., & Lieberman, B. A. (1997) · Human Reproduction · doi:10.1093/humrep/12.1.183 · Cited by 251
Stress level across stages of in vitro fertilization in subsequently pregnant and nonpregnant women
Boivin, J., & Takefman, J. E. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57858-3 · Cited by 235
Psychological functioning across stages of treatment for infertility
Berg, B. J., & Wilson, J. F. (1991) · Journal of Behavioral Medicine · doi:10.1007/bf00844765 · Cited by 233
The effect of anxiety and depression on the outcome of in-vitro fertilization
Smeenk, J. M. J. (2001) · Human Reproduction · doi:10.1093/humrep/16.7.1420 · Cited by 230
Infertility-related stress in men and women predicts treatment outcome 1 year later
Boivin, J., & Schmidt, L. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.12.039 · Cited by 213
CSEMICZKY, G., LANDGREN, B., & COLLINS, A. (2000) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.2000.079002113.x · Cited by 202
Coping Style and Depression Level Influence Outcome in In Vitro Fertilization
Demyttenaere, K., Bonte, L., Gheldof, M., Vervaeke, M., Meuleman, C., Vanderschuerem, D., & D’Hooghe, T. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00089-2 · Cited by 200
Ebbesen, S. M. S., Zachariae, R., Mehlsen, M. Y., Thomsen, D., Hojgaard, A., Ottosen, L., Petersen, T., & Ingerslev, H. J. (2009) · Human Reproduction · doi:10.1093/humrep/dep185 · Cited by 185
Self-citationFemale and male lifestyle habits and IVF: what is known and unknown
Klonoff-Cohen, H. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmh059 · Cited by 173 · cited 6×
“…past two decades suggest that psychological stress and feelings of distress may reduce the chances of obtaining a viable pregnancy with IVF treatment (Demyttenaere et al., 1992, 1994; Thiering et al., 1993; Csemiczky et al., 2000; Kee et al., 2000; Smeenk et al., 2001, 2005; Klonoff-Cohen, 2005).”
BackgroundInfluentialDifferential efficacy of group and individual/couple psychotherapy with infertile patients
de Liz, T. M., & Strauss, B. (2005) · Human Reproduction · doi:10.1093/humrep/deh743 · Cited by 168
Uchino, B. N., Birmingham, W. C., & Berg, C. A. (2010) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbp127 · Cited by 160
Beaurepaire, J., Jones, M., Thiering, P., Saunders, D. M., & Tennant, C. C. (1994) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(94)90118-x · Cited by 158
Does psychological stress affect the outcome of in vitro fertilization?
Anderheim, L., Holter, H., Bergh, C., & Möller, A. (2005) · Human Reproduction · doi:10.1093/humrep/dei219 · Cited by 153
Stress and outcome success in IVF: the role of self-reports and endocrine variables
Smeenk, J. M. J., Verhaak, C. M., Vingerhoets, A. J. J. M., Sweep, F. C. G. J., Merkus, J. M. W. M., Willemsen, S., van Minnen, A., Straatman, H., & Braat, D. D. M. (2005) · Human Reproduction · doi:10.1093/humrep/deh739 · Cited by 151
Thiering, P., Beaurepaire, J., Jones, M., Saunders, D. M., & Tennant, C. (1993) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(93)90004-y · Cited by 142
A Study on Psychological Strain in IVF Patients
SEOK KEE, B., JUNG, B. J., & LEE, S. H. (2000) · Journal of Assisted Reproduction and Genetics · doi:10.1023/a:1009417302758 · Cited by 141 · cited 2×
“…past two decades suggest that psychological stress and feelings of distress may reduce the chances of obtaining a viable pregnancy with IVF treatment (Demyttenaere et al., 1992, 1994; Thiering et al., 1993; Csemiczky et al., 2000; Kee et al., 2000; Smeenk et al., 2001, 2005; Klonoff-Cohen, 2005).”
BackgroundVerhaak, C. M., Smeenk, J. M. J., Eugster, A., van Minnen, A., Kremer, J. A. M., & Kraaimaat, F. W. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)01931-8 · Cited by 134
Facchinetti, F., Volpe, A., Matteo, M. L., Genazzani, A. R., & Artini, G. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81916-4 · Cited by 125
Psychological and hormonal changes in the course of in vitro fertilization
Merari, D., Feldberg, D., Elizur, A., Goldman, J., & Modan, B. (1992) · Journal of Assisted Reproduction and Genetics · doi:10.1007/bf01203757 · Cited by 118
Boivin, J., Andersson, L., Skoog-Svanberg, A., Hjelmstedt, A., Collins, A., & Bergh, T. (1998) · Human Reproduction · doi:10.1093/humrep/13.11.3262 · Cited by 118
Stress and stress-related hormones during in-vitro fertilization treatment
Harlow, C. R., Fahy, U., Talbot, W. M., Wardle, P. G., & Hull, M. G. R. (1996) · Human Reproduction · doi:10.1093/humrep/11.2.274 · Cited by 114
Lancastle, D., & Boivin, J. (2005) · Health Psychology · doi:10.1037/0278-6133.24.2.171 · Cited by 114
Bloom, F. E., Nelson, C. A., & Lazerson, A. (1985) · Medical Entomology and Zoology · Cited by 103
Demyttenaere, K., Nijs, P., Evers‐Kiebooms, G., & Koninckx, P. R. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90024-2 · Cited by 103
Stress and anxiety do not result in pregnancy wastage
Milad, M. P., Klock, S. C., Moses, S., & Chatterton, R. (1998) · Human Reproduction · doi:10.1093/humrep/13.8.2296 · Cited by 99
Lintsen, A. M. E., Verhaak, C. M., Eijkemans, M. J. C., Smeenk, J. M. J., & Braat, D. D. M. (2009) · Human Reproduction · doi:10.1093/humrep/den491 · Cited by 87
Gallinelli, A., Roncaglia, R., Matteo, M. L., Ciaccio, I., Volpe, A., & Facchinetti, F. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)01826-x · Cited by 86
The concerns during assisted reproductive technologies (CART) scale and pregnancy outcomes
Klonoff-Cohen, H. S., & Natarajan, L. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.08.050 · Cited by 86
Psychosocial stress and treatment outcome following assisted reproductive technology
Sanders, K. A., & BRUCE, N. W. (1999) · Human Reproduction · doi:10.1093/humrep/14.6.1656 · Cited by 86
de Klerk, C., Hunfeld, J. A. M., Heijnen, E., Eijkemans, M. J. C., Fauser, B. C. J. M., Passchier, J., & Macklon, N. (2007) · Human Reproduction · doi:10.1093/humrep/dem357 · Cited by 71
Psychosocial aspects ofin vitrofertilization
Visser, A. P., Haan, G., Haan, G., & Wouters, I. (1994) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.3109/01674829409025627 · Cited by 64
Emotional Reactions and Attitudes Prior to In Vitro Fertilization: An Inter-Spouse Study
Merari, D., Chetrit, A., & Modan, B. (2002) · Psychology and Health · doi:10.1080/08870440290025821 · Cited by 46
Emotionally expressive coping reduces pregnancy rates in patients undergoing in vitro fertilization
Panagopoulou, E. P., Vedhara, K., Gaintarzti, C., & Tarlatzis, B. C. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.02.096 · Cited by 46
Stoléru, S., Cornet, D., Vaugeois, P., Fermanian, J., Magnin, F., Zérah, S., & Spira, A. (1997) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.3109/01674829709080688 · Cited by 41
The Effect of Women???s Occupational Psychologic Stress on Outcome of Fertility Treatments
Barzilai-Pesach, V., Sheiner, E. K., Sheiner, E., Potashnik, G., & Shoham‐Vardi, I. (2006) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000183099.47127.e9 · Cited by 40
Demyttenaere, K., Nijs, P., Evers‐Kiebooms, G., & Koninckx, P. R. (1994) · Gynecological Endocrinology · doi:10.3109/09513599409023626 · Cited by 40
Effect of Stress on Pregnancy Outcome among Women Undergoing Assisted Reproduction Procedures
Lovely, L. P., Meyer, W. R., Ekstrom, R. D., & Golden, R. N. (2003) · Southern Medical Journal · doi:10.1097/01.smj.0000054567.79881.e9 · Cited by 38
Karlıdere, T., Bozkurt, A., Özmenler, K. N., Özşahin, A., Küçük, T., & Yetkin, S. (2008) · PubMed · Cited by 36
Psychological state and psychological strain in relation to infertility
Edelmann, R. J., & Connolly, K. (1998) · Journal of Community & Applied Social Psychology · doi:10.1002/(sici)1099-1298(199807/08)8:4<289::aid-casp491>3.0.co;2-w · Cited by 29
Effect of anxiety and depression on ART outcome
Sohrabvand, F., Abedinia, N., Pirjani, R., & Jafarabadi, M. N. (2008) · Bioline International (Bioline International) · Cited by 10
Cited by
Frederiksen, Y., Farver-Vestergaard, I., Skovgård, N. G., Ingerslev, H. J., & Zachariae, R. (2015) · BMJ Open · doi:10.1136/bmjopen-2014-006592 · Cited by 380
“C: 27 (27) RCT Brief coping intervention Other Individual 14 2 IS: CIQ − 4 (8)”
BackgroundSelf-citationPeterson, B. D., Sejbaek, C. S., Pirritano, M., & Schmidt, L. (2014) · Human Reproduction · doi:10.1093/humrep/det412 · Cited by 156
Holley, S. R., Pasch, L. A., Bleil, M. E., Gregorich, S., Katz, P. K., & Adler, N. E. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.02.018 · Cited by 110
Infertility and Perinatal Loss: When the Bough Breaks
Bhat, A., & Byatt, N. (2016) · Current Psychiatry Reports · doi:10.1007/s11920-016-0663-8 · Cited by 106
Rao, M., Zeng, Z., & Tang, L. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0328-z · Cited by 74
Metadata
- Authors
- Matthiesen, S. M. S., Frederiksen, Y., Ingerslev, H. J., & Zachariae, R.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-08-01
- Volume
- 26
- Issue
- 10
- Pages
- 2763-2776
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2168389362
- Cited by
- 284
- References
- 77
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
