Impaired telomere length and telomerase activity in peripheral blood leukocytes and granulosa cells in patients with biochemical primary ovarian insufficiency
Abstract
Study question Are telomere length and telomerase activity associated with biochemical primary ovarian insufficiency (POI)? Summary answer Shortened telomere length and diminished telomerase activity were associated with biochemical POI. What is known already POI is a result of pathological reproductive aging and encompasses occult, biochemical and overt stages. Studies have indicated telomere length as a biomarker for biological aging. Study design, size, duration A total of 120 patients with biochemical POI and 279 control women were recruited by the Center for Reproductive Medicine of Shandong University. Participants/materials, setting, methods Telomere length in peripheral blood leukocytes (LTL) and granulosa cells (GTL) was measured using a modified Quantitative Polymerase Chain Reaction technique. The relative telomerase activity (RTA) in granulosa cells was detected using a modified quantitative-telomeric repeat amplification protocol assay. Main results and the role of chance After adjusting for age, patients with biochemical POI (n = 120) exhibited significantly shorter LTLs (0.75 ± 0.09 vs 1.79 ± 0.12, P Large scale data N/A. Limitations, reasons for caution The cross-sectional nature of this study might have its limit in telomere length as well as telomerase activity along with the progressing decline in ovarian function. Wider implications of the findings These findings suggest that telomere length and telomerase activity may be considered as indicators for progr…
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Patients with premature ovarian insufficiency have shorter telomeres and reduced telomerase activity in leukocytes and granulosa cells than healthy individuals.
“patients with premature ovarian insufficiency have shorter telomeres and reduced telomerase activity in leukocytes and granulosa cells than healthy individuals179”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [179]
Telomere shortening is associated with reduced fertility in several ways.
“Telomere shortening has been associated with reduced fertility in several ways177–180.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [179]
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Telomeres and oocyte maturation rate are not reduced by COVID-19 except in severe cases
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Intraovarian condensed platelet cytokines for infertility and menopause—Mirage or miracle?
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Mechanistic study on the role of multi-pathway autophagy in ovarian aging: literature review
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Telomeres and SIRT1 as Biomarkers of Gamete Oxidative Stress, Fertility, and Potential IVF Outcome
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Genetics of premature ovarian insufficiency
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- Authors
- Xu, X., Chen, X., Zhang, X., Liu, Y., Wang, Z., Wang, P., Du, Y., Qin, Y., & Chen, Z.-J.
- Affiliations
- Shandong University (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Chen, Zi-Jiang
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-11-11
- Volume
- 32
- Issue
- 1
- Pages
- 201-207
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2556684732
- Cited by
- 109
- References
- 30
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 14 · 2023: 18 · 2022: 17 · 2021: 16 · 2020: 14 · 2019: 6 · 2018: 10 · 2017: 1
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Basic Research Program of China (2012CB944700)
- Science research foundation (201402004)
- National Natural Science Foundation of China (31471352, 81270662, 81471509, 81300461, 81522018)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- telomere length, telomerase activity, peripheral blood leukocytes, granulosa cells, biological aging, reproductive aging, premature ovarian failure, women of reproductive age, ovarian reserve, telomere repeat amplification protocol, quantitative polymerase chain reaction
- MeSH terms
- Adult, Cross-Sectional Studies, Female, Granulosa Cells, Humans, Leukocytes, Mononuclear, Telomere, Primary Ovarian Insufficiency, Telomerase
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