The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Chromosome abnormalities in human embryos
Abstract
The presence of numerical chromosome abnormalities in human embryos was studied using fluorescence in-situ hybridization with four or more chromosome-specific probes. When most cells of an embryo are analysed, this technique allows differentiation to be made between aneuploidy, mosaicism, haploidy and polyploidy. Abnormal types of fertilization, such as unipronucleated, tripronucleated zygotes and zygotes with uneven pronuclei, were studied using this technique. We have found a strong correlation between some types of dysmorphism with chromosomal abnormalities. In addition, the more impaired the development of an embryo, the more chromosomal abnormalities were detected in those embryos. Maternal age and other factors were linked to an increase in chromosome abnormalities (hormonal regimes, temperature changes), but not to intracytoplasmic sperm injection.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors
Kallioniemi, A., Kallioniemi, O.-P., Sudar, D., Rutovitz, D., Gray, J. W., Waldman, F., & Pinkel, D. (1992) · Science · doi:10.1126/science.1359641 · Cited by 3,297
Braude, P., Bolton, V., & Moore, S. (1988) · Nature · doi:10.1038/332459a0 · Cited by 1,463
Munné, S., Alikani, M., Tomkin, G., Grifo, J., & Cohen, J. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57739-5 · Cited by 849
Pickering, S. J., Braude, P. R., Johnson, M. H., Cant, A., & Currie, J. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53644-9 · Cited by 563
Van Blerkom, J., Antczak, M., & Schrader, R. (1997) · Human Reproduction · doi:10.1093/humrep/12.5.1047 · Cited by 526
Munné, S., Lee, A., Rosenwaks, Z., Grifo, J., & Cohen, J. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138001 · Cited by 514
Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy
Hassold, T., & Chiu, D. (1985) · Human Genetics · doi:10.1007/bf00389450 · Cited by 481
Delhanty, J. D. A., Harper, J. C., Ao, A., Handyside, A. H., & Winston, R. M. L. (1997) · Human Genetics · doi:10.1007/s004390050443 · Cited by 389
Lamb, N. E., Freeman, S. B., Savage-Austin, A., Pettay, D., Taft, L., Hersey, J., Gu, Y., Shen, J., Saker, D., May, K. M., et al. (1996) · Nature Genetics · doi:10.1038/ng1296-400 · Cited by 386
Ooplasmic transfer in mature human oocytes
Cohen, J. (1998) · Molecular Human Reproduction · doi:10.1093/molehr/4.3.269 · Cited by 343
Cited by
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
Liang, P., Xu, Y., Zhang, X., Ding, C., Huang, R., Zhang, Z., Lv, J., Xie, X., Chen, Y., Li, Y., et al. (2015) · Protein & Cell · doi:10.1007/s13238-015-0153-5 · Cited by 1,135
Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting
Medicine, A. S. I. R., & ESHRE Special Interest Group Embryology (2011) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2011.02.001 · Cited by 567
Human embryo fragmentation in vitro and its implications for pregnancy and implantation
Alikani, M., Cohen, J., Tomkin, G., Garrisi, G. J., Mack, C., & Scott, R. T. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00092-8 · Cited by 393
Cleavage anomalies in early human embryos and survival after prolonged culture in-vitro
Alikani, M., Calderon, G., Tomkin, G., Garrisi, J., Kokot, M., & Cohen, J. (2000) · Human Reproduction · doi:10.1093/humrep/15.12.2634 · Cited by 305
Chromosome mosaicism in cleavage-stage human embryos: evidence of a maternal age effect
Munné, S., Sandalinas, M., Escudero, T., Márquez, C., & Cohen, J. (2002) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)61810-x · Cited by 278
Metadata
- Authors
- Munne, S.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-11-01
- Volume
- 4
- Issue
- 6
- Pages
- 842-855
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2096581331
- Cited by
- 262
- References
- 34
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Chromosome abnormalities in human embryos. https://app.cochat.ai/papers/10.1093/humupd/4.6.842
- The paper
- Munne, S. (1998). Chromosome abnormalities in human embryos. Human Reproduction Update. https://doi.org/10.1093/humupd/4.6.842
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
