The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings
Open accessAbstract
Oxidative stress is involved in the aetiology of defective embryo development. Reactive oxygen species (ROS) may originate from embryo metabolism and/or embryo surroundings. Embryo metabolism generates ROS via several enzymatic mechanisms. The relative contribution of each source seems different depending on the species, the stage of development, and the culture conditions. Several exogenous factors and culture conditions can enhance the production of ROS by embryos. ROS can alter most types of cellular molecules, and also induce development block and retardation. Multiple mechanisms of embryo protection against ROS exist, and these have complementary actions. External protection, present in follicular and tubal fluids, mainly comprises non-enzymatic antioxidants such as hypotaurine, taurine and ascorbic acid. Internal protection mainly comprises antioxidant enzymes: superoxide dismutase, glutathione peroxidase and gamma-glutamylcysteine synthetase. Transcripts encoding for these enzymes are present in the oocyte, embryo and oviduct. It may be important that these transcripts are stored during oocyte maturation in order to allow the embryo to acquire the aptitude to develop. It is now common to add antioxidant compounds to culture media. Nevertheless, maintaining the pro-oxidant-antioxidant equilibrium in embryos through such supplementation is a complex problem. Further studies are necessary to limit oxidative stress during embryo culture.
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Cites
Mitochondrial damage induced by conditions of oxidative stress
Kowaltowski, A. J., & Vercesi, A. E. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00216-0 · Cited by 866
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Role of oxidative stress in female reproduction
Agarwal, A., Gupta, S., & Sharma, R. K. (2005) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-3-28 · Cited by 1,729
Regulation of lipid peroxidation and ferroptosis in diverse species
Conrad, M., Kagan, V. E., Bayir, H., Pagnussat, G. C., Head, B., Traber, M. G., & Stockwell, B. R. (2018) · Genes & Development · doi:10.1101/gad.314674.118 · Cited by 544
Pathogenic mechanisms in endometriosis-associated infertility
Gupta, S., Goldberg, J. M., Aziz, N., Goldberg, E., Krajcir, N., & Agarwal, A. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.02.093 · Cited by 409
Oxidative stress and peritoneal endometriosis
Van Langendonckt, A., Casanas-Roux, F., & Donnez, J. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02959-x · Cited by 391
Oxidative stress and antioxidants: exposure and impact on female fertility
Ruder, E. H., Hartman, T. J., Blumberg, J., & Goldman, M. B. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn011 · Cited by 351
Oxygen-Regulated Gene Expression in Bovine Blastocysts1
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Current Thinking on the Pathogenesis of Endometriosis
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Observations on intrauterine oxygen tension measured by fibre-optic microsensors
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Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review
Rahman, S., Huang, Y., Zhu, L., Feng, S., Khan, I., Wu, J., Li, Y., & Wang, X. (2018) · Nutrients · doi:10.3390/nu10070834 · Cited by 69
“The exogenous sources are smoking, alcohol, toxins, and radiation, while the endogenous sources are immature sperm, leukocytes, varicoceles, and cryptorchidism, as well as oocytes, embryo, ovary, and the uterine cavity [48].”
BackgroundMukherjee, K., Edgett, B. A., Burrows, H. W., Castro, C., Griffin, J. L., Schwertani, A. G., Gurd, B. J., & Funk, C. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092031 · Cited by 65
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Meuter, A., Rogmann, L.-M., Winterhoff, B. J., Tchkonia, T., Kirkland, J. L., & Morbeck, D. E. (2014) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-014-0299-8 · Cited by 36
Wang, S., Yang, H., Fu, Y., Teng, X., Wang, C., & Xu, W. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7982344 · Cited by 19
Metadata
- Authors
- Guerin, P.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-03-01
- Volume
- 7
- Issue
- 2
- Pages
- 175-189
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2126657029
- Cited by
- 1,418
- References
- 1
- FWCI
- 23.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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