Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review
Open accessAbstract
Sperm cells are highly sensitive to reactive oxygen species (ROS), which are produced during cellular oxidation. In normal cell biology, ROS levels increase with a decreasing antioxidant response, resulting in oxidative stress which threatens sperm biology. Oxidative stress has numerous effects, including increased apoptosis, reduced motion parameters, and reduced sperm integrity. In this regard, green tea polyphenols (GrTPs) have been reported to possess properties that may increase the quality of male and female gametes, mostly via the capability of catechins to reduce ROS production. GrTPs have antioxidant properties that improve major semen parameters, such as sperm concentration, motility, morphology, DNA damage, fertility rate, and gamete quality. These unique properties of green tea catechins could improve reproductive health and represent an important study area. This exploratory review discusses the therapeutic effects of GrTPs against infertility, their possible mechanisms of action, and recommended supportive therapy for improving fertility in humans and in animals.
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Polyphenols may improve fertility through their anti-inflammatory and antioxidant effects.
“According to Rahman et al., polyphenols may therefore improve fertility through their anti-inflammatory and antioxidant effects [88].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [88]
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- Authors
- Rahman, S., Huang, Y., Zhu, L., Feng, S., Khan, I., Wu, J., Li, Y., & Wang, X.
- Affiliations
- Anhui Agricultural University (CN)
- Corresponding author
- Wang, Xichun
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2018-06-27
- Volume
- 10
- Issue
- 7
- Pages
- 834
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6073549
- OpenAlex
- W2810239044
- Cited by
- 69
- References
- 124
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 15 · 2023: 4 · 2022: 12 · 2021: 12 · 2020: 5 · 2019: 9
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- green tea polyphenols, catechins, male infertility, female infertility, oxidative stress, reactive oxygen species, antioxidant activity, semen quality, sperm motility, sperm DNA damage, gamete quality, reproductive health
- MeSH terms
- Animals, Antioxidants, Female, Fertility, Fertility Agents, Female, Fertility Agents, Male, Humans, Infertility, Female, Infertility, Male, Male, Ovum, Pregnancy, Risk Factors, Spermatozoa, Tea, Oxidative Stress, Polyphenols, Reproductive Health
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