Cited by 69Tea Polyphenols and EffectsSperm and Testicular FunctionPhytochemicals and Antioxidant Activities

Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review

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Rahman, Sajid, Huang, Yingying, Zhu, Lei, Feng, Shibin, Khan, Ibrar, Wu, Jinjie, Li, Yu, Wang, Xichun·2018·Nutrients

Abstract

Sperm cells are highly sensitive to reactive oxygen species (ROS), which are produced during cellular oxidation. In normal cell biology, ROS levels increase with a decreasing antioxidant response, resulting in oxidative stress which threatens sperm biology. Oxidative stress has numerous effects, including increased apoptosis, reduced motion parameters, and reduced sperm integrity. In this regard, green tea polyphenols (GrTPs) have been reported to possess properties that may increase the quality of male and female gametes, mostly via the capability of catechins to reduce ROS production. GrTPs have antioxidant properties that improve major semen parameters, such as sperm concentration, motility, morphology, DNA damage, fertility rate, and gamete quality. These unique properties of green tea catechins could improve reproductive health and represent an important study area. This exploratory review discusses the therapeutic effects of GrTPs against infertility, their possible mechanisms of action, and recommended supportive therapy for improving fertility in humans and in animals.

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Authors
Rahman, S., Huang, Y., Zhu, L., Feng, S., Khan, I., Wu, J., Li, Y., & Wang, X.
Affiliations
Anhui Agricultural University (CN)
Corresponding author
Wang, Xichun
Venue
Nutrients
Publisher
MDPI AG
Published
2018-06-27
Volume
10
Issue
7
Pages
834
ISSN
2072-6643 (ISSN-L)
OpenAlex
W2810239044
Cited by
69
References
124
Citations by year
2026: 4 · 2025: 8 · 2024: 15 · 2023: 4 · 2022: 12 · 2021: 12 · 2020: 5 · 2019: 9
FWCI
0.96
Type
journal article
Language
en
Open access
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
green tea polyphenols, catechins, male infertility, female infertility, oxidative stress, reactive oxygen species, antioxidant activity, semen quality, sperm motility, sperm DNA damage, gamete quality, reproductive health
MeSH terms
Animals, Antioxidants, Female, Fertility, Fertility Agents, Female, Fertility Agents, Male, Humans, Infertility, Female, Infertility, Male, Male, Ovum, Pregnancy, Risk Factors, Spermatozoa, Tea, Oxidative Stress, Polyphenols, Reproductive Health

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