The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Oxidative stress and male infertility—a clinical perspective
Open accessAbstract
Oxidative stress occurs when the production of potentially destructive reactive oxygen species (ROS) exceeds the bodies own natural antioxidant defenses, resulting in cellular damage. Oxidative stress is a common pathology seen in approximately half of all infertile men. ROS, defined as including oxygen ions, free radicals and peroxides are generated by sperm and seminal leukocytes within semen and produce infertility by two key mechanisms. First, they damage the sperm membrane, decreasing sperm motility and its ability to fuse with the oocyte. Second, ROS can alter the sperm DNA, resulting in the passage of defective paternal DNA on to the conceptus. This review will provide an overview of oxidative biochemistry related to sperm health and will identify which men are most at risk of oxidative infertility. Finally, the review will outline methods available for diagnosing oxidative stress and the various treatments available.
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Cites
A Ca2+-activated NADPH Oxidase in Testis, Spleen, and Lymph Nodes
Bánfi, B., Molnár, G., Maturana, A., Steger, K., Hegedûs, B., Demaurex, N., & Krause, K.-H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103034200 · Cited by 622
Relationship between oxidative stress, varicocele and infertility: A meta-analysis
Agarwal, A., Prabakaran, S., & Allamaneni, S. S. (2006) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)61190-x · Cited by 261 · cited 4×
“Even men with normozoospermic idiopathic infertility exhibit significantly higher seminal ROS production and lower antioxidant capacity than fertile men (Pasqualotto et al., 2001; Agarwal et al., 2006b), for as yet unknown reasons.”
BackgroundInfluentialSaleh, R. A., Agarwal, A., Kandirali, E., Sharma, R. K., Thomas, A. J., Nada, E. A., Evenson, D. P., & Alvarez, J. G. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)04237-1 · Cited by 259 · cited 3×
“Smoking results in a 48% increase in seminal leukocyte concentrations and a 107% increase in seminal ROS levels (Saleh et al., 2002a).”
BackgroundMethodHsieh, Y.-Y., Chang, C.-C., & Lin, C.-S. (2006) · International Journal of Biological Sciences · doi:10.7150/ijbs.2.23 · Cited by 167 · cited 2×
“…be of some clinical relevance since its concentration within both seminal plasma and sperm is elevated in infertile men with excess ROS production, compared with fertile controls or normozoospermic individuals (Sanocka et al., 1997; Nakamura et al., 2002; Tavilani et al., 2005; Hsieh et al., 2006).”
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Cited by
The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis
Robinson, L., Gallos, I. D., Conner, S. J., Rajkhowa, M., Miller, D., Lewis, S., Kirkman-Brown, J., & Coomarasamy, A. (2012) · Human Reproduction · doi:10.1093/humrep/des261 · Cited by 629
On the possible origins of DNA damage in human spermatozoa
Aitken, R. J., & De Iuliis, G. N. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gap059 · Cited by 606
Salas-Huetos, A., Bulló, M., & Salas-Salvadó, J. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx006 · Cited by 491
Zhao, J., Zhang, Q., Wang, Y., & Li, Y. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.06.033 · Cited by 361
Antioxidants for male subfertility
Showell, M. G., Mackenzie-Proctor, R., Brown, J., Yazdani, A., Stankiewicz, M. T., & Hart, R. J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007411.pub3 · Cited by 285
Metadata
- Authors
- Tremellen, K.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-02-14
- Volume
- 14
- Issue
- 3
- Pages
- 243-258
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2140112227
- Cited by
- 1,507
- References
- 4
- FWCI
- 52.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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