The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Oxidative stress and male infertility—a clinical perspective
Open accessAbstract
Oxidative stress occurs when the production of potentially destructive reactive oxygen species (ROS) exceeds the bodies own natural antioxidant defenses, resulting in cellular damage. Oxidative stress is a common pathology seen in approximately half of all infertile men. ROS, defined as including oxygen ions, free radicals and peroxides are generated by sperm and seminal leukocytes within semen and produce infertility by two key mechanisms. First, they damage the sperm membrane, decreasing sperm motility and its ability to fuse with the oocyte. Second, ROS can alter the sperm DNA, resulting in the passage of defective paternal DNA on to the conceptus. This review will provide an overview of oxidative biochemistry related to sperm health and will identify which men are most at risk of oxidative infertility. Finally, the review will outline methods available for diagnosing oxidative stress and the various treatments available.
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Citations
Cites
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“Even men with normozoospermic idiopathic infertility exhibit significantly higher seminal ROS production and lower antioxidant capacity than fertile men (Pasqualotto et al., 2001; Agarwal et al., 2006b), for as yet unknown reasons.”
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“Smoking results in a 48% increase in seminal leukocyte concentrations and a 107% increase in seminal ROS levels (Saleh et al., 2002a).”
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“…be of some clinical relevance since its concentration within both seminal plasma and sperm is elevated in infertile men with excess ROS production, compared with fertile controls or normozoospermic individuals (Sanocka et al., 1997; Nakamura et al., 2002; Tavilani et al., 2005; Hsieh et al., 2006).”
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Cited by
The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis
Robinson, L., Gallos, I. D., Conner, S. J., Rajkhowa, M., Miller, D., Lewis, S., Kirkman-Brown, J., & Coomarasamy, A. (2012) · Human Reproduction · doi:10.1093/humrep/des261 · Cited by 629
On the possible origins of DNA damage in human spermatozoa
Aitken, R. J., & De Iuliis, G. N. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gap059 · Cited by 606
Salas-Huetos, A., Bulló, M., & Salas-Salvadó, J. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx006 · Cited by 491
Zhao, J., Zhang, Q., Wang, Y., & Li, Y. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.06.033 · Cited by 361
Antioxidants for male subfertility
Showell, M. G., Mackenzie-Proctor, R., Brown, J., Yazdani, A., Stankiewicz, M. T., & Hart, R. J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007411.pub3 · Cited by 285
Antioxidants for male subfertility
Smits, R. M., Mackenzie-Proctor, R., Yazdani, A., Stankiewicz, M. T., Jordan, V., & Showell, M. G. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007411.pub4 · Cited by 277
Role of antioxidants in the treatment of male infertility
Kefer, J. C., Agarwal, A., & Sabanegh, E. (2009) · International Journal of Urology · doi:10.1111/j.1442-2042.2009.02280.x · Cited by 273
Oxidative DNA damage impairs global sperm DNA methylation in infertile men
Tunc, O., & Tremellen, K. (2009) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-009-9346-2 · Cited by 248
Self-citationAntioxidants for female subfertility
Showell, M. G., Mackenzie-Proctor, R., Jordan, V., & Hart, R. J. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007807.pub4 · Cited by 119
Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years (2010–2020)
Cirilli, I., Damiani, E., Dludla, P. V., Hargreaves, I., Marcheggiani, F., Millichap, L. E., Orlando, P., Silvestri, S., & Tiano, L. (2021) · Antioxidants · doi:10.3390/antiox10081325 · Cited by 115
Sperm DNA fragmentation and oxidation are independent of malondialdheyde
Zribi, N., Chakroun, N., Elleuch, H., Abdallah, F., Ben Hamida, A., Gargouri, J., Fakhfakh, F., & Keskes, L. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-47 · Cited by 100
Contemporary concepts in the evaluation and management of male infertility
Hwang, K., Walters, R. C., & Lipshultz, L. I. (2011) · Nature Reviews Urology · doi:10.1038/nrurol.2010.230 · Cited by 84
Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review
Rahman, S., Huang, Y., Zhu, L., Feng, S., Khan, I., Wu, J., Li, Y., & Wang, X. (2018) · Nutrients · doi:10.3390/nu10070834 · Cited by 69
“When the production of reactive oxygen species (ROS) exceeds the body’s antioxidant capacity, oxidative stress (OS) occurs [8].”
BackgroundOumaima, A., Tesnim, A., Zohra, H., Amira, S., Ines, Z., Sana, C., Intissar, G., Lobna, E., Ali, J., & Meriem, M. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-1417-4 · Cited by 69
Agarwal, A., Henkel, R., Sharma, R., Tadros, N. N., & Sabanegh, E. (2018) · Andrologia · doi:10.1111/and.12914 · Cited by 44
Prentki Santos, E., López-Costa, S., Chenlo, P., Pugliese, M. N., Curi, S., Ariagno, J., Repetto, H., Sardi, M., Palaoro, L., & Mendeluk, G. (2011) · Andrologia · doi:10.1111/j.1439-0272.2010.01089.x · Cited by 37
Cicek, O. S. Y., Kaya, G., Alyuruk, B., Doger, E., Girisen, T., & Filiz, S. (2021) · International braz j urol · doi:10.1590/s1677-5538.ibju.2019.0751 · Cited by 17
Metadata
- Authors
- Tremellen, K.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-02-14
- Volume
- 14
- Issue
- 3
- Pages
- 243-258
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2140112227
- Cited by
- 1,507
- References
- 4
- FWCI
- 52.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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