The DOI matches its Crossref record; 160 of the 161 references it cites were found in a registry or an index.
Oxidative stress and antioxidants: exposure and impact on female fertility
Open accessAbstract
BACKGROUND: Reproductive failure is a significant public health concern. Although relatively little is known about factors affecting fertility and early pregnancy loss, a growing body of literature suggests that environmental and lifestyle factors play an important role. There is sufficient evidence to hypothesize that diet, particularly its constituent antioxidants, and oxidative stress (OS) may influence the timing and maintenance of a viable pregnancy. We hypothesize that conditions leading to OS in the female affect time-to-pregnancy and early pregnancy loss. METHODS: We review the epidemiology of female infertility related to antioxidant defenses and oxidation and examine potential sources of OS from the ovarian germ cell through the stages of human pregnancy and pregnancy complications related to infertility. Articles were identified through a search of the PubMed database. RESULTS: Female OS is a likely mediator of conception and threshold levels for OS exist, dependent on anatomic location and stage of preconception. CONCLUSIONS: Prospective pregnancy studies with dietary assessment and collection of biological samples prior to conception with endpoints of time-to-pregnancy and early pregnancy loss are needed.
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“Human reproduction is a complex but not very efficient process, as less than one -third of fertilized human embryos have a chance of surviving upto a term delivery (Ruder et al., 2008).”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Ruder et al., 2008
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Citations
Cites
The Physiology of Reproduction
Legendre, M., & Jalabert, B. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-2-176_1 · Cited by 7,876
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility
Anway, M. D., Cupp, A. S., Uzumcu, M., & Skinner, M. K. (2005) · Science · doi:10.1126/science.1108190 · Cited by 2,563
Free radicals and tissue damage produced by exercise
Davies, K. J. A., Quintanilha, A. T., Brooks, G. A., & Packer, L. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(82)80124-1 · Cited by 1,739
Guerin, P. J. (2001) · Human Reproduction Update · doi:10.1093/humupd/7.2.175 · Cited by 1,419
Role of reactive oxygen species in male infertility
Sharma, R. K., & Agarwal, A. K. (1996) · Urology · doi:10.1016/s0090-4295(96)00313-5 · Cited by 987
Oxidative stress in the placenta
Myatt, L., & Cui, X.-L. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0677-x · Cited by 803
Present knowledge in nutrition
Brown, M. L. (1990) · JAMA · doi:10.1001/jama.1954.03690350086043 · Cited by 777
Schmidt, H. H. H. W., Gagné, G. D., Nakane, M., Pollock, J. S., MILLER, M. F., & Murad, F. (1992) · Journal of Histochemistry & Cytochemistry · doi:10.1177/40.10.1382087 · Cited by 610
Relative Impact of Oxidative Stress on Male Reproductive Function
Sikka, S. C. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013373039 · Cited by 604
Research works printed but not linked: 4
- Furnus CC, de Matos DG, Moses DF. Cumulus expansion during in vitro maturation of bovine oocytes: relationship with intracellular glutathione level and its role on subsequent embryo development. Mol Reprod Dev 1998;51:76-83.
- Goldman MB, Missmer SA, Barberi RL. Infertility. In Women and Helath, ed. Goldman MB, Hatch MC, San Diego: Academic Press, 2000, pp. 196-214.
- Kodaman PH, Behrman HR. Endocrine-regulated and protein kinase C-dependent generation of superoxide by rat preovulatory follicles. Endocrinology 2001;142:687-693.
- Paszkowski T, Clarke RN. Antioxidative capacity of preimplantation embryo culture medium declines following the incubation of poor quality embryos. Hum Reprod 1996;11:2493-2495.
Cited by
Sorted by citations
Items 301–351 of 351
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Kacem, O., Mustapha, H., Sallem, A., Harzallah, M., Zidi, I., Hachani, F., Chachia, S., Khélifi, A., Saad, A., & Ajina, M. (2015) · Advances in Reproductive Sciences · doi:10.4236/arsci.2015.32003
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Córdova-Izquierdo, A., Jor, S. O., Gustavo, R. L., Campos, V. M. X., Betancourt, P., Denise, S., Mary, S., Rubén, H. C., Mosqueda, J., Liera, G., et al. (2010)
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Gupta, S. K. (2024) · International Research Journal of Pharmacy
Impact of Oxidative Stress on Female Fertility.
Harris, T. (2013) · Digital Commons - East Tennessee State University (East Tennessee State University)
Nutritional counseling impact on assisted reproduction treatment outcomes
Halpern, G., Sardinha, F. A. A., Setti, A. S., Iaconelli, A., & Borges, E. (2013) · JBRA · doi:10.5935/1518-0557.20130001
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Meng, L. (2016) · doi:10.18174/389440
Harissatria, H., & Hendri, J. (2016) · JURNAL PETERNAKAN · doi:10.24014/jupet.v13i1.2384
Inayatilah, F. R. (2017) · Journal of Islamic Pharmacy · doi:10.18860/jip.v2i1.4250
Faruk, E. M., & Morsy, S. A. E.-S. (2015) · The Egyptian Journal of Histology · doi:10.1097/01.ehx.0000475203.36934.2e
Effect of Stress on Histopathology of Male Reproductive System in Rats
Sangishetti, V. P., Dh, N., Bb, N., Bb, G., Shinde, B. B., & Rr, K. (2017) · International Journal of Current Research in Physiology and Pharmacology (IJCRPP) · doi:10.5281/zenodo.2530802
Możliwości przywracania i utrzymania jakości mitochondriów w oocytach ssaków
Gąsior, Ł., & Polański, Z. (2018) · Kosmos · doi:10.36921/kos.2018_2434
Noise stress on female mice impair oocyte developmental potential.
Yousaf, M., Kundi, H., & Qamar, A. (2019) · The Professional Medical Journal · doi:10.29309/tpmj/2019.26.06.3603
Abdel-Khalek, A. E., Ashmawy, T., & Abdel-Rafaa, L. (2013) · Journal of Animal and Poultry Production · doi:10.21608/jappmu.2013.71532
Verma, S. (2020) · Fertility Science and Research · doi:10.4103/2394-4285.288706
OXIDATIVE STRESS: A CAUSE OF INFERTILITY IN WOMEN
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Alcohol Use Disorder and Parental Alcohol Use Disorder as Predictors of Reproductive Timing
Blake, A. J., Smyth, H. L., Sternberg, A., Waddell, J. T., & Chassin, L. (2020) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2020.81.575
Environmental Pollution and Health Consequences
Rössner, P., & Šrám, R. J. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0679-6_17
The Free Radical Theory of Ageing: Does it apply to Antarctic and Temperate Sea Urchins?
Beaumont, T. F. B. (2011) · Otago University Research Archive (University of Otago)
(2009) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e32832c972c
Öhm, V. (2018) · MDPI eBooks · doi:10.3390/books978-3-03842-906-7
Hechtman, L. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-2333-5.00179-6
Non-Specific Medical Treatment Methods in Female Infertility
Kaplanoğlu, D. K., & Tok, A. (2022) · Düzce Tıp Fakültesi Dergisi · doi:10.18678/dtfd.1191606
The Association between Female Infertility and Catalase Enzyme in Karbala Province of Iraq
Razzak, M. A. A., & Ahmed, M. N. (2022) · International Journal of Drug Delivery Technology · doi:10.25258/ijddt.12.3.35
Prashad, S. V., Prajapati, K., Moharir, G., Ojeh, N. O., Sinha, S., Kumar, S., Haque, M., & Bharatha, A. (2023) · Cureus · doi:10.7759/cureus.40381
Ramadhani, A., Dwiningsih, S. R., & Herawati, L. (2023) · Indonesian Midwifery and Health Sciences Journal · doi:10.20473/imhsj.v7i2.2023.100-109
Altaee, M. F., Abdulmalek, H. W., & Al-Ahmed, H. I. (2022) · journal of the college of basic education · doi:10.35950/cbej.v19i79.7410
Impact of Age on some Oxidant and Antioxidants Marker During Menstrual Cycles
Hasan, N. K. A., & Khalifa, A. A. (2024) · Mağallaẗ ʻulūm al-rāfidayn · doi:10.33899/rjs.2024.184534
Aksin, Ş., & Yılmaz, M. (2025) · Medicine · doi:10.1097/md.0000000000041641
Akhtar, M. F., Ali, S. M., Hassan, F., & Changfa, W. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1633945 · Cited by 2
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Wu, Q., Xiao, C., Ouyang, B., Simal‐Gándara, J., Qi, Y., & Chen, Z. (2025) · eFood · doi:10.1002/efd2.70091
Yang, Z., Hellwich, E., Rafiq, N. M., Joselin, A. P., Im, D. S., Kaushik, G., Singh, Y., Mulac‐Jeričević, B., Jiang, H., González-Menéndez, I., et al. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01344-w
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Jovandarić, M. Z. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33931-8.00002-5
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Nguyen, L. T. K., Tran, D. N., Nahar, S., Kim, T. K., Jeong, J.-W., & Yoo, J. (2026) · The FASEB Journal · doi:10.1096/fj.202600629r
Faghfouri, A. H., Gholami, S., Mokari‐Yamchi, A., Karimi, N., & Vazifekhah, S. (2026) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-026-09056-7
Žaja, I. Ž., Djuricic, D., Kowalczyk, A., Strelec, S., Ružić, A., Vugrovečki, A. S., Poljičak-Milas, N., Samardžija, M., Bačić, G., Mačešić, N., et al. (2026) · Agriculture · doi:10.3390/agriculture16151646
Zhang, Z., Wang, D., Lin, Q., Guo, P., & Wang, Z. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1914362
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Metadata
- Authors
- Ruder, E. H., Hartman, T. J., Blumberg, J., & Goldman, M. B.
- Affiliations
- Pennsylvania State University (US)
- Tufts University (US)
- Dartmouth–Hitchcock Medical Center (US)
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-04-02
- Volume
- 14
- Issue
- 4
- Pages
- 345-357
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- PMC
- PMC2772106
- OpenAlex
- W2100338186
- Cited by
- 351
- References
- 161
- Citations by year
- 2026: 7 · 2025: 20 · 2024: 14 · 2023: 16 · 2022: 19 · 2021: 31 · 2020: 33 · 2019: 21 · 2018: 22 · 2017: 29 · 2016: 26 · 2015: 23 · 2014: 23 · 2013: 17 · 2012: 13
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Agriculture
- National Institutes of Health
- Agricultural Research Service
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD049762)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- oxidative stress, antioxidants, female infertility, female fertility, time to pregnancy, early pregnancy loss, dietary antioxidants, ovarian germ cells, pregnancy complications, preconception exposure
- MeSH terms
- Abortion, Spontaneous, Antioxidants, Diet, Female, Fertilization, Humans, Infertility, Female, Oocytes, Ovulation, Embryo Implantation, Pregnancy, Reproduction, Reactive Oxygen Species, Oxidative Stress, Prenatal Nutritional Physiological Phenomena
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