The DOI matches its Crossref record; 160 of the 161 references it cites were found in a registry or an index.
Oxidative stress and antioxidants: exposure and impact on female fertility
Open accessAbstract
BACKGROUND: Reproductive failure is a significant public health concern. Although relatively little is known about factors affecting fertility and early pregnancy loss, a growing body of literature suggests that environmental and lifestyle factors play an important role. There is sufficient evidence to hypothesize that diet, particularly its constituent antioxidants, and oxidative stress (OS) may influence the timing and maintenance of a viable pregnancy. We hypothesize that conditions leading to OS in the female affect time-to-pregnancy and early pregnancy loss. METHODS: We review the epidemiology of female infertility related to antioxidant defenses and oxidation and examine potential sources of OS from the ovarian germ cell through the stages of human pregnancy and pregnancy complications related to infertility. Articles were identified through a search of the PubMed database. RESULTS: Female OS is a likely mediator of conception and threshold levels for OS exist, dependent on anatomic location and stage of preconception. CONCLUSIONS: Prospective pregnancy studies with dietary assessment and collection of biological samples prior to conception with endpoints of time-to-pregnancy and early pregnancy loss are needed.
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“Human reproduction is a complex but not very efficient process, as less than one -third of fertilized human embryos have a chance of surviving upto a term delivery (Ruder et al., 2008).”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Ruder et al., 2008
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Qiao, J., & Feng, H. L. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmq032 · Cited by 479
Diet and Lifestyle in the Prevention of Ovulatory Disorder Infertility
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Metadata
- Authors
- Ruder, E. H., Hartman, T. J., Blumberg, J., & Goldman, M. B.
- Affiliations
- Pennsylvania State University (US)
- Tufts University (US)
- Dartmouth–Hitchcock Medical Center (US)
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-04-02
- Volume
- 14
- Issue
- 4
- Pages
- 345-357
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- PMC
- PMC2772106
- OpenAlex
- W2100338186
- Cited by
- 351
- References
- 161
- Citations by year
- 2026: 7 · 2025: 20 · 2024: 14 · 2023: 16 · 2022: 19 · 2021: 31 · 2020: 33 · 2019: 21 · 2018: 22 · 2017: 29 · 2016: 26 · 2015: 23 · 2014: 23 · 2013: 17 · 2012: 13
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Agriculture
- National Institutes of Health
- Agricultural Research Service
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD049762)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- oxidative stress, antioxidants, female infertility, female fertility, time to pregnancy, early pregnancy loss, dietary antioxidants, ovarian germ cells, pregnancy complications, preconception exposure
- MeSH terms
- Abortion, Spontaneous, Antioxidants, Diet, Female, Fertilization, Humans, Infertility, Female, Oocytes, Ovulation, Embryo Implantation, Pregnancy, Reproduction, Reactive Oxygen Species, Oxidative Stress, Prenatal Nutritional Physiological Phenomena
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