Cited by 351Reproductive Biology and FertilityReproductive Health and TechnologiesAntioxidant Activity and Oxidative Stress

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Oxidative stress and antioxidants: exposure and impact on female fertility

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Ruder, E. H., Hartman, T. J., Blumberg, J., Goldman, M. B.·2008·Human Reproduction Update

DOI 10.1093/humupd/dmn011PMC PMC2772106

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Abstract

BACKGROUND: Reproductive failure is a significant public health concern. Although relatively little is known about factors affecting fertility and early pregnancy loss, a growing body of literature suggests that environmental and lifestyle factors play an important role. There is sufficient evidence to hypothesize that diet, particularly its constituent antioxidants, and oxidative stress (OS) may influence the timing and maintenance of a viable pregnancy. We hypothesize that conditions leading to OS in the female affect time-to-pregnancy and early pregnancy loss. METHODS: We review the epidemiology of female infertility related to antioxidant defenses and oxidation and examine potential sources of OS from the ovarian germ cell through the stages of human pregnancy and pregnancy complications related to infertility. Articles were identified through a search of the PubMed database. RESULTS: Female OS is a likely mediator of conception and threshold levels for OS exist, dependent on anatomic location and stage of preconception. CONCLUSIONS: Prospective pregnancy studies with dietary assessment and collection of biological samples prior to conception with endpoints of time-to-pregnancy and early pregnancy loss are needed.

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Authors: Ruder, E. H., Hartman, T. J., Blumberg, J., & Goldman, M. B.
Affiliations: Pennsylvania State University (US)
Tufts University (US)
Dartmouth–Hitchcock Medical Center (US)
ORCID: Ruder, E. H.
Hartman, T. J.
Blumberg, J.
Venue: Human Reproduction Update
Publisher: Oxford University Press (OUP)
Published: 2008-04-02
Volume: 14
Issue: 4
Pages: 345-357
ISSN: 1355-4786 (ISSN-L)
1460-2369
DOI: 10.1093/humupd/dmn011
PMC: PMC2772106
OpenAlex: W2100338186
Cited by: 351
References: 161
Citations by year: 2026: 7 · 2025: 20 · 2024: 14 · 2023: 16 · 2022: 19 · 2021: 31 · 2020: 33 · 2019: 21 · 2018: 22 · 2017: 29 · 2016: 26 · 2015: 23 · 2014: 23 · 2013: 17 · 2012: 13
FWCI: 1.75
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Human Reproduction Update (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Agriculture
National Institutes of Health
Agricultural Research Service
National Institute of Child Health and Human Development
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD049762)
Topics: Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: oxidative stress, antioxidants, female infertility, female fertility, time to pregnancy, early pregnancy loss, dietary antioxidants, ovarian germ cells, pregnancy complications, preconception exposure
MeSH terms: Abortion, Spontaneous, Antioxidants, Diet, Female, Fertilization, Humans, Infertility, Female, Oocytes, Ovulation, Embryo Implantation, Pregnancy, Reproduction, Reactive Oxygen Species, Oxidative Stress, Prenatal Nutritional Physiological Phenomena

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Oxidative stress and antioxidants: exposure and impact on female fertility

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