Cited by 351Reproductive Biology and FertilityReproductive Health and TechnologiesAntioxidant Activity and Oxidative Stress

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Oxidative stress and antioxidants: exposure and impact on female fertility

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Ruder, E. H., Hartman, T. J., Blumberg, J., Goldman, M. B.·2008·Human Reproduction Update

DOI 10.1093/humupd/dmn011PMC PMC2772106

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Abstract

BACKGROUND: Reproductive failure is a significant public health concern. Although relatively little is known about factors affecting fertility and early pregnancy loss, a growing body of literature suggests that environmental and lifestyle factors play an important role. There is sufficient evidence to hypothesize that diet, particularly its constituent antioxidants, and oxidative stress (OS) may influence the timing and maintenance of a viable pregnancy. We hypothesize that conditions leading to OS in the female affect time-to-pregnancy and early pregnancy loss. METHODS: We review the epidemiology of female infertility related to antioxidant defenses and oxidation and examine potential sources of OS from the ovarian germ cell through the stages of human pregnancy and pregnancy complications related to infertility. Articles were identified through a search of the PubMed database. RESULTS: Female OS is a likely mediator of conception and threshold levels for OS exist, dependent on anatomic location and stage of preconception. CONCLUSIONS: Prospective pregnancy studies with dietary assessment and collection of biological samples prior to conception with endpoints of time-to-pregnancy and early pregnancy loss are needed.

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The Physiology of Reproduction
Legendre, M., & Jalabert, B. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-2-176_1 · Cited by 7,876
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility
Anway, M. D., Cupp, A. S., Uzumcu, M., & Skinner, M. K. (2005) · Science · doi:10.1126/science.1108190 · Cited by 2,563
Free radicals and tissue damage produced by exercise
Davies, K. J. A., Quintanilha, A. T., Brooks, G. A., & Packer, L. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(82)80124-1 · Cited by 1,739
Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings
Guerin, P. J. (2001) · Human Reproduction Update · doi:10.1093/humupd/7.2.175 · Cited by 1,419
Role of reactive oxygen species in male infertility
Sharma, R. K., & Agarwal, A. K. (1996) · Urology · doi:10.1016/s0090-4295(96)00313-5 · Cited by 987
Oxidative stress in the placenta
Myatt, L., & Cui, X.-L. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0677-x · Cited by 803
Present knowledge in nutrition
Brown, M. L. (1990) · JAMA · doi:10.1001/jama.1954.03690350086043 · Cited by 777
Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.
Schmidt, H. H. H. W., Gagné, G. D., Nakane, M., Pollock, J. S., MILLER, M. F., & Murad, F. (1992) · Journal of Histochemistry & Cytochemistry · doi:10.1177/40.10.1382087 · Cited by 610
Relative Impact of Oxidative Stress on Male Reproductive Function
Sikka, S. C. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013373039 · Cited by 604
The Ovarian Androgen Producing Cells: A Review of Structure/Function Relationships1,2
Erickson, G. F., Magoffin, D. A., Dyer, C. A., & Hofeditz, C. (1985) · Endocrine Reviews · doi:10.1210/edrv-6-3-371 · Cited by 569
The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility
Ebisch, I. M. W., Thomas, C. M. G., Peters, W. H. M., Braat, D. D. M., & Steegers‐Theunissen, R. P. M. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml054 · Cited by 505
Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial
Bedaiwy, M. A. (2002) · Human Reproduction · doi:10.1093/humrep/17.2.426 · Cited by 485
Detection of reactive oxygen species (ROS) and apoptosis in human fragmented embryos
Yang, H. W., Hwang, K. J., Kwon, H. C., Kim, H. S., Choi, K. W., & Oh, K. S. (1998) · Human Reproduction · doi:10.1093/humrep/13.4.998 · Cited by 483
Coordination of nuclear and cytoplasmic oocyte maturation in eutherian mammals
Eppig, J. J. (1996) · Reproduction Fertility and Development · doi:10.1071/rd9960485 · Cited by 467
Reactive Oxygen Species-Induced Oxidative Stress in the Development of Insulin Resistance and Hyperandrogenism in Polycystic Ovary Syndrome
González, F., Rote, N. S., Minium, J., & Kirwan, J. P. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1696 · Cited by 459
Diet and Lifestyle in the Prevention of Ovulatory Disorder Infertility
Chavarro, J. E., Rich-Edwards, J. W., ROSNER, B. A., & Willett, W. C. (2007) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000287293.25465.e1 · Cited by 452
Mechanisms of homocysteine-induced oxidative stress
Tyagi, N., Sedoris, K. C., Steed, M. M., Ovechkin, A. V., Moshal, K. S., & Tyagi, S. C. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00548.2005 · Cited by 435
Biochemistry of the induction and prevention of lipoperoxidative damage in human spermatozoa
Storey, B. (1997) · Molecular Human Reproduction · doi:10.1093/molehr/3.3.203 · Cited by 399
Electron-spin resonance study of mainstream and sidestream cigarette smoke: nature of the free radicals in gas-phase smoke and in cigarette tar.
PRYOR, W. A., Prier, D. G., & CHURCH, D. F. (1983) · Environmental Health Perspectives · doi:10.1289/ehp.8347345 · Cited by 387
Glutathione Concentration during Maturation and after Fertilization in Pig Oocytes: Relevance to the Ability of Oocytes to Form Male Pronucleus1
YOSHIDA, M., Ishigaki, K., Nagai, T., CHIKYU, M., & Pursel, V. G. (1993) · Biology of Reproduction · doi:10.1095/biolreprod49.1.89 · Cited by 373
The importance of having high glutathione (GSH) level after bovine in vitro maturation on embryo development: Effect of β-mercaptoethanol, cysteine and cystine
de Matos, D. G., & Furnus, C. C. (2000) · Theriogenology · doi:10.1016/s0093-691x(99)00278-2 · Cited by 363
The influence of cigarette smoking on circulating concentrations of antioxidant micronutrients
Alberg, A. J. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00386-4 · Cited by 356
Correlates of Markers of Oxidative Status in the General Population
Trevisan, M. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.4.348 · Cited by 351
Body Mass Index and Ovulatory Infertility
Grodstein, F., GOLDMAN, M. B., & Cramer, D. W. (1994) · Epidemiology · doi:10.1097/00001648-199403000-00016 · Cited by 326
Self-citation
USE OF TIME TO PREGNANCY TO STUDY ENVIRONMENTAL EXPOSURES
Baird, D. D., Wilcox, A. J., & Weinberg, C. R. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114417 · Cited by 325
Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease
Fenkçi, V., Fenkçi, S. M., Yılmazer, M., & Serteser, M. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00571-5 · Cited by 306
Characteristics of human mononuclear phagocytes
van Furth, R., Raeburn, J. A., & van Zwet, T. (1979) · Blood · doi:10.1182/blood.v54.2.485.485 · Cited by 303
The role of glutathione in mammalian gametes.
Luberda, Z. (2005) · PubMed · Cited by 297
Oxidative stress and the ovary*1
Behrman, H. R. (2001) · Journal of the Society for Gynecologic Investigation · doi:10.1016/s1071-5576(00)00106-4 · Cited by 293
Ovarian Function in Superoxide Dismutase 1 and 2 Knockout Mice
Matzuk, M. M., Dionne, L., Guo, Q., Kumar, T. R., & Lebovitz, R. M. (1998) · Endocrinology · doi:10.1210/endo.139.9.6289 · Cited by 282
Detection of oxidative DNA damage in human sperm and its association with sperm function and male infertility
Shen, H., & Ong, C. N. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00234-8 · Cited by 267
Hypoxic but not anoxic stabilization of HIF-1α requires mitochondrial reactive oxygen species
Schroedl, C., McClintock, D. S., Budinger, G. R. S., & Chandel, N. S. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00014.2002 · Cited by 266
Effects of age, cigarette smoking, and other factors on fertility: findings in a large prospective study.
Howe, G. R., Westhoff, C. L., Vessey, M. P., & Yeates, D. (1985) · BMJ · doi:10.1136/bmj.290.6483.1697 · Cited by 265
Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus.
Li, S., Washburn, K. A., Moore, R., Uno, T., Teng, C. T., Newbold, R. R., McLachlan, J. A., & Negishi, M. (1997) · PubMed · Cited by 260
Effect of oxidative stress in follicular fluid on the outcome of assisted reproductive procedures
Pasqualotto, E. B., Agarwal, A. K., Sharma, R. K., Izzo, V. M., Pinotti, J. A., Joshi, N., & Rose, B. I. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.11.021 · Cited by 243
Placental isoprostane is significantly increased in preeclampsia
Walsh, S. W. (2000) · The FASEB Journal · doi:10.1096/fj.14.10.1289 · Cited by 234
Does moderate alcohol consumption affect fertility? Follow up study among couples planning first pregnancy
Jensen, T. K., Hjøllund, N. H., Henriksen, T. B., Scheike, T., Kolstad, H. A., Giwercman, A., Ernst, E., Bonde, J. ., Skakkebak, N. E., & Olsen, J. (1998) · BMJ · doi:10.1136/bmj.317.7157.505 · Cited by 229
Antioxidant systems in normal pregnancy and in pregnancy-induced hypertension
Wisdom, S., Wilson, R., McKillop, J. H., & Walker, J. J. (1991) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(91)90018-m · Cited by 228
Effects of glutathione-oxidizing agents on microtubule assembly and microtubule-dependent surface properties of human neutrophils.
Oliver, J. M., Albertini, D. F., & Berlin, R. D. (1976) · The Journal of Cell Biology · doi:10.1083/jcb.71.3.921 · Cited by 219
Antioxidants and reactive oxygen species in follicular fluid of women undergoing IVF: relationship to outcome
Oyawoye, O. A. (2003) · Human Reproduction · doi:10.1093/humrep/deg450 · Cited by 219
Reactive oxygen species level in follicular fluid--embryo quality marker in IVF?
Das, S. (2006) · Human Reproduction · doi:10.1093/humrep/del156 · Cited by 216
Generation and disposal of reactive oxygen metabolites in the lung.
Kinnula, V., Jd, C., & Raivio, K. O. (1995) · PubMed · Cited by 214
Antioxidant Defenses in the Lung
Fridovich, I., & Freeman, B. E. (1986) · Annual Review of Physiology · doi:10.1146/annurev.ph.48.030186.003401 · Cited by 213
The effect of follicular fluid reactive oxygen species on the outcome of in vitro fertilization.
Attaran, M., Pasqualotto, E., Falcone, T., Goldberg, J. M., Miller, K. F., Agarwal, A., & Sharma, R. K. (2000) · PubMed · Cited by 213
Mammalian oocyte maturation
Thibault, C., Szöllösi, D., & GÉRARD, M. (1987) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19870701 · Cited by 211
Alcohol and caffeine consumption and decreased fertility
Hakim, R. B., Gray, R. H., & Zacur, H. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00257-x · Cited by 205
Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol
Newbold, R. F. (1998) · Carcinogenesis · doi:10.1093/carcin/19.9.1655 · Cited by 204
Selenium dependent glutathione peroxidase activity in human follicular fluid
Paszkowski, T., Traub, A. I., Robinson, S. Y., & McMaster, D. (1995) · Clinica Chimica Acta · doi:10.1016/0009-8981(95)98130-9 · Cited by 203
Antioxidant enzymatic defences in human follicular fluid: characterization and age-dependent changes
Carbone, M. C. (2003) · Molecular Human Reproduction · doi:10.1093/molehr/gag090 · Cited by 202
CAFFEINATED BEVERAGES AND DECREASED FERTILITY
Wilcox, A. J., Weinberg, C. R., & Baird, D. D. (1988) · The Lancet · doi:10.1016/s0140-6736(88)90933-6 · Cited by 201
Elevated serum levels of tumor necrosis factor alpha in normal-weight women with polycystic ovary syndrome
González, F., Thusu, K., Abdel-Rahman, E., Prabhala, A., Tomani, M., & Dandona, P. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90100-2 · Cited by 199
Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol
Newbold, R. R., Hanson, R. B., Jefferson, W. N., Bullock, B. C., Haseman, J., & McLachlan, J. A. (2000) · Carcinogenesis · doi:10.1093/carcin/21.7.1355 · Cited by 197
Effect of glutathione synthesis stimulation during in vitro maturation of ovine oocytes on embryo development and intracellular peroxide content
de Matos, D. G., Gasparrini, B., Pasqualini, S., & Thompson, J. G. (2002) · Theriogenology · doi:10.1016/s0093-691x(02)00643-x · Cited by 193
Oxidative stress and endometriosis
Jackson, L. W., Schisterman, E. F., Dey-Rao, R., Browne, R. W., & Armstrong, D. (2005) · Human Reproduction · doi:10.1093/humrep/dei001 · Cited by 192
Infertility in women and moderate alcohol use.
Grodstein, F., GOLDMAN, M. B., & Cramer, D. W. (1994) · American Journal of Public Health · doi:10.2105/ajph.84.9.1429 · Cited by 187
Self-citation
Physiological aspects and clinical sequelae of energy deficiency and hypoestrogenism in exercising women
Souza, M. J. D., & Williams, N. I. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh033 · Cited by 180
α-Tocopherol Transfer Protein Is Important for the Normal Development of Placental Labyrinthine Trophoblasts in Mice
Jishage, K.-I., Arita, M., Igarashi, K., Iwata, T., Watanabe, M., Ogawa, M., Ueda, O., Kamada, N., Inoue, K., Arai, H., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000676200 · Cited by 180
Body Mass Index and Delayed Conception: A European Multicenter Study on Infertility and Subfecundity
Bolúmar, F., Olsen, J., Rebagliato, M., Sáez-Lloret, I., Bisanti, L., & the European Study Group on Infertility and Subfecundity (2000) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010150 · Cited by 177
Oxidative stress markers in preovulatory follicular fluid in humans
Jóźwik, M. (1999) · Molecular Human Reproduction · doi:10.1093/molehr/5.5.409 · Cited by 177
Impact of oxidative stress in aged mouse oocytes on calcium oscillations at fertilization
Takahashi, T., Takahashi, E., Igarashi, H., Tezuka, N., & Kurachi, H. (2003) · Molecular Reproduction and Development · doi:10.1002/mrd.10341 · Cited by 171
Homocysteine, glutathione and related thiols affect fertility parameters in the (sub)fertile couple
Ebisch, I. M. W., Peters, W. H. M., Thomas, C. M. G., Wetzels, A. M. M., Peer, P. G. M., & Steegers‐Theunissen, R. P. M. (2006) · Human Reproduction · doi:10.1093/humrep/del081 · Cited by 171
Role of Mitochondrial Oxidant Generation in Endothelial Cell Responses to Hypoxia
Pearlstein, D. P., Ali, M. H., Mungai, P. T., Hynes, K. L., Gewertz, B. L., & Schumacker, P. T. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000012262.76205.6a · Cited by 165
Enhancement of Human Monocyte and Peritoneal Macrophage Chemiluminescence Activities in Women With Endometriosis
Zeller, J. M., Henig, I. J., Radwańska, E., & Dmowski, W. P. (1987) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1987.tb00097.x · Cited by 164
Effects of alcohol consumption on female fertility during an 18-year period
Eggert, J., Theobald, H., & Engfeldt, P. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.06.018 · Cited by 160
Uterine peroxidase as a marker for estrogen action.
Lyttle, C. R., & DeSombre, E. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3162 · Cited by 158
Opposing Effects of Glutathione Depletion and Follicle-Stimulating Hormone on Reactive Oxygen Species and Apoptosis in Cultured Preovulatory Rat Follicles
Tsai-Turton, M., & Luderer, U. (2005) · Endocrinology · doi:10.1210/en.2005-1281 · Cited by 154
Oxidative stress indices in follicular fluid as measured by the thermochemiluminescence assay correlate with outcome parameters in in vitro fertilization
Wiener‐Megnazi, Z., Vardi, L., Lissak, A., Shnizer, S., Reznick, A. Z., Ishai, D., Lahav‐Baratz, S., Shiloh, H., Koifman, M., & Dirnfeld, M. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.06.013 · Cited by 151
Thapsigargin activates a calcium influx pathway in the unfertilized mouse egg and suppresses repetitive calcium transients in the fertilized egg.
Kline, D., & Kline, J. T. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37088-7 · Cited by 141
Changes in activity of superoxide dismutase in the human endometrium throughout the menstrual cycle and in early pregnancy
Sugino, N., 嶋村, 勝., Takiguchi, S., Tamura, H., Ono, M., Nakata, M., Nakamura, Y., Ogino, K., Uda, T., & Kato, H. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019299 · Cited by 140
Tumor Necrosis Factor-α Stimulates Proliferation of Rat Ovarian Theca-Interstitial Cells1
Spaczyński, R., Arici, A. M., & Dulęba, A. J. (1999) · Biology of Reproduction · doi:10.1095/biolreprod61.4.993 · Cited by 136
Why does hydrosalpinx reduce fertility?: The importance of hydrosalpinx fluid
Strandell, A. (2002) · Human Reproduction · doi:10.1093/humrep/17.5.1141 · Cited by 136
Smoking induces oxidative stress inside the Graafian follicle
Paszkowski, T. (2002) · Human Reproduction · doi:10.1093/humrep/17.4.921 · Cited by 133
Glutathione (GSH) concentrations vary with the cell cycle in maturing hamster oocytes, zygotes, and pre‐implantation stage embryos
Zuelke, K. A., Jeffay, S. C., Zucker, R. M., & Perreault, S. D. (2002) · Molecular Reproduction and Development · doi:10.1002/mrd.10214 · Cited by 133
Developmental exposure to environmental endocrine disruptors: Consequences within the ovary and on female reproductive function
Uzumcu, M., & Zachow, R. J. (2006) · Reproductive Toxicology · doi:10.1016/j.reprotox.2006.10.006 · Cited by 132
Allopurinol and Markers of Muscle Damage Among Participants in the Tour de France
Gómez‐Cabrera, M. C., Pallardó, F. V., Sastre, J., Viña, J., & Garcia-del-Moral, L. (2003) · JAMA · doi:10.1001/jama.289.19.2503-b · Cited by 126
Glutathione Oxidation is Associated with Altered Microtubule Function and Disrupted Fertilization in Mature Hamster Oocytes1
Zuelke, K. A., Jones, D. P., & Perreault, S. D. (1997) · Biology of Reproduction · doi:10.1095/biolreprod57.6.1413 · Cited by 125
Total antioxidant status of peritoneal fluid in infertile women
Polak, G., Kozioł-Montewka, M., Gogacz, M., Błaszkowska, I., & Kotarski, J. (2001) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(00)00352-3 · Cited by 122
Importance portance of reactive oxygen species in the peritoneal fluid of women with endometriosis or idiopathic infertility
Wang, Y., Sharma, R. K., Falcone, T., Goldberg, J. M., & Agarwal, A. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00343-9 · Cited by 118
Oral antioxidants counteract the negative effects of female aging on oocyte quantity and quality in the mouse
Tarín, J. J., Pérez‐Albalá, S., & Cano, A. (2002) · Molecular Reproduction and Development · doi:10.1002/mrd.10041 · Cited by 115
Evidence That Hydrogen Peroxide Blocks Hormone- Sensitive Cholesterol Transport into Mitochondria of Rat Luteal Cells*
Behrman, H. R., & Aten, R. F. (1991) · Endocrinology · doi:10.1210/endo-128-6-2958 · Cited by 114
Regulation of Ovarian Antioxidant Vitamins, Reduced Glutathione, and Lipid Peroxidation by Luteinizing Hormone and Prostaglandin F2α1
Aten, R. F., Duarte, K. M., & Behrman, H. R. (1992) · Biology of Reproduction · doi:10.1095/biolreprod46.3.401 · Cited by 111
Preventive Nutrition. The Comprehensive Guide for Health Professionals
Bendich, A. (1997) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(97)89441-3 · Cited by 108
Relation of Female Infertility to Consumption of Caffeinated Beverages
Grodstein, F., GOLDMAN, M. B., RYAN, L. M., & Cramer, D. W. (1993) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116644 · Cited by 103
Self-citation
Nitric oxide in the endometrium
Cameron, I. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.5.565 · Cited by 103
The presence of antibodies to oxidative modified proteins in serum from polycystic ovary syndrome patients
Palacio, J. R., Iborra, A., Ulčová-Gallová, Z., Badía, R., & Martínez, P. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03061.x · Cited by 103
The Roles of Vitamin A for Cytoplasmic Maturation of Bovine Oocytes
Ikeda, S., KITAGAWA, M., Imai, H., & Yamada, M. (2005) · Journal of Reproduction and Development · doi:10.1262/jrd.51.23 · Cited by 102
Repeated Ovarian Stimulations Induce Oxidative Damage and Mitochondrial DNA Mutations in Mouse Ovaries
Chao, H., LEE, S., Lee, H.-M., Liao, T.-L., Wei, Y., & Kao, S. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1338.016 · Cited by 98
Antioxidants reversibly inhibit the spontaneous resumption of meiosis
Takami, M., Preston, S. L., Toyloy, V. A., & Behrman, H. R. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.4.e684 · Cited by 96
DNA damage, DNA susceptibility to oxidation and glutathione level in women with polycystic ovary syndrome
̇ncer, Y. D., Akçay, T., Yesim, T. E., Saygılı, E. İ., & Gündoğdu, S. (2005) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510500375263 · Cited by 95
Evidence for Oxidatively Modified Lipid-Protein Complexes in Endometrium and Endometriosis
Murphy, A. A., Palinski, W., Rankin, S. M., Morales, A. J., & Parthasarathy, S. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00087-9 · Cited by 94
The effects of hydrogen peroxide on steroidogenesis in mouse Leydig tumor cells
Stocco, D. M., Wells, J. O., & Clark, B. J. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243310 · Cited by 94
Manganese Acts Centrally to Stimulate Luteinizing Hormone Secretion: A Potential Influence on Female Pubertal Development
Pine, M. D., Lee, B., Dearth, R. K., Hiney, J. K., & Dees, W. L. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi134 · Cited by 93
Antioxidant defence in recurrent abortion
Vural, P., Akgül, C., Yıldırım, A., & Canbaz, M. (2000) · Clinica Chimica Acta · doi:10.1016/s0009-8981(99)00255-7 · Cited by 91
Transferrin in the developing ovarian follicle: evidence for de-novo expression by granulosa cells
Briggs, D. A. (1999) · Molecular Human Reproduction · doi:10.1093/molehr/5.12.1107 · Cited by 84
Moderate alcohol consumption and waiting time to pregnancy
Juhl, M., Andersen, A. N., Grønbæk, M., & Olsen, J. (2001) · Human Reproduction · doi:10.1093/humrep/16.12.2705 · Cited by 82
Recall of Diet during a Past Pregnancy
Bunin, G. R., Gyllstrom, M. E., Brown, J. E., Kahn, E. B., & Kushi, L. H. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.12.1136 · Cited by 79
Oxygen free radicals and pelvic adhesion formation: I. Blocking oxygen free radical toxicity to prevent adhesion formation in an endometriosis model.
PORTZ, D. M., Elkins, T. E., White, R., Warren, J. S., Adadevoh, S. W. K., & Randolph, J. F. (1991) · PubMed · Cited by 78
The Role of Oxygen Radical-mediated Signaling Pathways in Endometrial Function
Sugino, N. (2007) · Placenta · doi:10.1016/j.placenta.2006.12.002 · Cited by 76
Follicular fluid concentrations of adrenomedullin, vascular endothelial growth factor and nitric oxide in IVF cycles: relationship to ovarian response
Manau, D., Balasch, J., Jiménez, W., Fábregues, F., Cı́vico, S., Casamitjana, R., Creus, M. T., & Vanrell, J. A. (2000) · Human Reproduction · doi:10.1093/humrep/15.6.1295 · Cited by 75
Total antioxidant status and nitric oxide do not increase in peritoneal fluids from women with endometriosis
Ho, H., Wu, M., Chen, S., Chao, K., Chen, C., & Yang, Y. (1997) · Human Reproduction · doi:10.1093/humrep/12.12.2810 · Cited by 73
Higher Rate of Multiple Births after Periconceptional Vitamin Supplementation
Czeizel, A. E., Métneki, J., & Dudás, I. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406093302314 · Cited by 72
Inhibition of protein synthesis and hormone-sensitive steroidogenesis in response to hydrogen peroxide in rat luteal cells
Musicki, B., Aten, R. F., & Behrman, H. R. (1994) · Endocrinology · doi:10.1210/en.134.2.588 · Cited by 72
Identification and measurement of collagen in the bovine corpus luteum and its relationship with ascorbic acid and tissue development
Luck, M., & Zhao, Y. (1993) · Reproduction · doi:10.1530/jrf.0.0990647 · Cited by 70
Increased telomere size in sperm cells of mammals with long terminal (TTAGGG)n arrays
Kozik, A., Bradbury, E. M., & Zalensky, A. O. (1998) · Molecular Reproduction and Development · doi:10.1002/(sici)1098-2795(199809)51:1 · Cited by 69
The associations between smoking, physical activity, dietary habits and plasma homocysteine levels in cardiovascular disease-free people: the ‘ATTICA’ study
Chrysohoou, C. A., Panagiotakos, D. B., Pitsavos, C. E., Zeimbekis, A., Zampelas, A., Papademetriou, L., Masoura, C., & Stefanadis, C. (2004) · Vascular Medicine · doi:10.1191/1358863x04vm542oa · Cited by 66
Oxidative Stress during the Interaction of Gametes1
Miesel, R., Drzejczak, P. J. Ę., & Kurpisz, M. K. (1993) · Biology of Reproduction · doi:10.1095/biolreprod49.5.918 · Cited by 66
Antioxidants may protect against infertility
Tarín, J. J., Brines, J., & Cano, A. (1998) · Human Reproduction · doi:10.1093/humrep/13.6.1415 · Cited by 65
Relationship between oxidative stress and embryotoxicity of hydrosalpingeal fluid
Bedaiwy, M. A., Goldberg, J. M., Falcone, T., Singh, M., Nelson, D. R., Azab, H., Wang, X., & Sharma, R. K. (2002) · Human Reproduction · doi:10.1093/humrep/17.3.601 · Cited by 65
Proliferation of ovarian theca-interstitial cells is modulated by antioxidants and oxidative stress
Dulęba, A. J. (2004) · Human Reproduction · doi:10.1093/humrep/deh299 · Cited by 63
Physical Activity, Nutrition, and Reproduction
Cumming, D. C., Wheeler, G. D., & Harber, V. J. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb30388.x · Cited by 63
Fertilization and early embryology: Antioxidative capacity of preimplantation embryo culture medium declines following the incubation of poor quality embryos
Paszkowski, T., & Clarke, R. N. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019146 · Cited by 60
Endocrine-Regulated and Protein Kinase C-Dependent Generation of Superoxide by Rat Preovulatory Follicles**This work was supported by NIH Grant HD-35663.
Kodaman, P. H., & Behrman, H. R. (2001) · Endocrinology · doi:10.1210/endo.142.2.7961 · Cited by 60
Inhibition by oestradiol of oxidative stress-induced apoptosis in pig ovarian tissues
Murdoch, W. J. (1998) · Reproduction · doi:10.1530/jrf.0.1140127 · Cited by 60
The Pioneer History of Vitamin E
Evans, H. M. (1962) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60725-6 · Cited by 58
NADPH-diaphorase-positive nerves and the role of nitric oxide in CGRP relaxation of uterine contraction
Shew, R. L., Papka, R. E., McNeill, D. L., & Yee, J. A. (1993) · Peptides · doi:10.1016/0196-9781(93)90157-c · Cited by 57
Endometriosis and infertility: a review.
Allaire, C. (2006) · PubMed · Cited by 56
Ethanol inhibits L-arginine uptake and enhances NO formation in human placenta
Acevedo, C. G., Carrasco, G. A., Burotto, M., Rojas, S., & Bravo, I. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01070-0 · Cited by 52
Endometriosis and infertility: the role of exogenous lipid peroxides in the peritoneal fluid
Arumugam, K., & Dip, Y. C. Y. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57320-8 · Cited by 51
Induction of superoxide dismutase by decidualization in human endometrial stromal cells
Sugino, N. (2000) · Molecular Human Reproduction · doi:10.1093/molehr/6.2.178 · Cited by 50
CAFFEINATED BEVERAGES AND DECREASED FERTILITY
Christianson, R. E., Oechsli, F. W., & Berg, B. V. D. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91745-5 · Cited by 49
Effects of Aging on Ovarian Fecundity in Terms of the Incidence of Apoptotic Granulosa Cells
Sadraie, S. H., Saito, H., Kaneko-Tarui, T., Saito, T., & Hiroi, M. (2000) · Journal of Assisted Reproduction and Genetics · doi:10.1023/a:1009422323306 · Cited by 49
FSH induced stimulation of catalase activity in goat granulosa cells in vitro
Behl, R., & Pandey, R. (2002) · Animal Reproduction Science · doi:10.1016/s0378-4320(02)00006-4 · Cited by 48
Influence of Cigarette Smoking on Vitamin E, Vitamin A, β-Carotene and Lycopene Concentrations in Human Pre-Ovulatory Follicular Fluid
Tiboni, G. M., Bucciarelli, T., Giampietro, F., Sulpizio, M., & Ilio, C. D. (2004) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200401700319 · Cited by 46
Estrogenic and antioxidant effects of a phytoestrogen daidzein on ovarian germ cells in embryonic chickens
Liu, H., Zhang, C., & Zeng, W. (2005) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2005.11.002 · Cited by 45
Nutrient and Food Group Intake by Tobacco Use Status: The 1987 National Health Interview Survey
Subar, A. F., & Harlan, L. C. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb39193.x · Cited by 45
Ovarian vitamin E accumulation: evidence for a role of lipoproteins
Aten, R. F., Kolodecik, T. R., & Behrman, H. R. (1994) · Endocrinology · doi:10.1210/en.135.2.533 · Cited by 45
Semen treatment with progesterone and/or acetyl-L-carnitine does not improve sperm motility or membrane damage after cryopreservation-thawing
Duru, N. K., Morshedi, M., Schuffner, A. G., & Oehninger, S. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01494-1 · Cited by 43
Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women
Hartman, T. J., Baer, D. J., Graham, L., Stone, W. L., Gunter, E. W., Parker, C. E., Albert, P. S., Dorgan, J. F., Clevidence, B. A., Campbell, W. S., et al. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602051 · Cited by 42
Self-citation
Regulation of Vascular Endothelial Growth Factor Synthesis and Release by Human Luteal Cellsin Vitro
Tropea, A., Miceli, F., Minici, F., Tiberi, F., Orlando, M., Gangalè, M. F., Romani, F., Catino, S., Mancuso, S., Navarra, P., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2457 · Cited by 42
Manganese stimulates luteinizing hormone releasing hormone secretion in prepubertal female rats: hypothalamic site and mechanism of action
Lee, B., Hiney, J. K., Pine, M. D., Srivastava, V. K., & Dees, W. L. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.123083 · Cited by 41
The apoptotic profile of human cumulus cells changes with patient age and after exposure to sperm but not in relation to oocyte maturity
Moffatt, O., Drury, S. L., Tomlinson, M., Afnan, M., & Sakkas, D. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02951-5 · Cited by 40
Relationship of age at menarche and subsequent fertility
Komura, H., Miyake, A., Chen, C.-F., Tanizawa, O., & Yoshikawa, H. (1992) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(92)90099-k · Cited by 39
Effect of menstrual cycle phase on the concentration of individual carotenoids in lipoproteins of premenopausal women: a controlled dietary study
Forman, M., Johnson, E., Lanza, E., Graubard, B., Beecher, G. R., & Muesing, R. A. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.1.81 · Cited by 39
Serum Lipoperoxides in Induced and Spontaneous Abortions
Sane, A. S., Chokshi, S. A., Mishra, V. V., Barad, D., Shah, V., & Nagpal, S. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000293145 · Cited by 38
The effect of preconceptional multivitamin supplementation on the menstrual cycle
Dud�s, I., Rockenbauer, M., & Czeizel, A. E. (1995) · Archives of Gynecology and Obstetrics · doi:10.1007/bf01314639 · Cited by 37
Adverse effects on sperm movement characteristics in women with minimal and mild endometriosis
Curtis, P., Lindsay, P., Jackson, A. E., & Shaw, R. W. (1993) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1993.tb15215.x · Cited by 37
Aging and nutrition.
Mayer, J. (1974) · PubMed · Cited by 36
Eicosatetraynoic and eicosatriynoic acids, lipoxygenase inhibitors, block meiosis via antioxidant action
Takami, M., Preston, S. L., & Behrman, H. R. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.4.c646 · Cited by 35
Effect of reduced oxygen tension on reactive oxygen species production and activity of antioxidant enzymes in swine granulosa cells
Basini, G., Grasselli, F., Bianco, F., Tirelli, M., & Tamanini, C. (2004) · BioFactors · doi:10.1002/biof.5520200201 · Cited by 35
Ascorbic acid stimulates gonadotropin release by autocrine action by means of NO
Karanth, S., Yu, W. H., Walczewska, A., Mastronardi, C. A., & McCann, S. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191369398 · Cited by 31
Effects of energy deprivation on sex hormone patterns in healthy menstruating women
Kurzer, M. S., & Calloway, D. H. (1986) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1986.251.4.e483 · Cited by 30
The physiology of the ovary: Maturation of ovarian granulosa cells and a novel role for antioxidants in the corpus luteum
Rodgers, R. J., Lavranos, T. C., Rodgers, H. F., Young, F. M., & Vella, C. A. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00054-4 · Cited by 30
Effects of maternal ageing and dietary antioxidant supplementation on ovulation, fertilisation and embryo development in vitro in the mouse
Tarín, J. J., Ten, J., Vendrell, F. J., Oliveira, M. N. M. D., & Cano, A. (1998) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19980502 · Cited by 29
Lipid peroxidation in the peritoneal fluid of infertile women with peritoneal endometriosis
do Amaral, V. F., Bydlowski, S. P., Peranovich, T. C., Navarro, P. A., Subbiah, M. T. R., & Ferriani, R. A. (2004) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2004.07.020 · Cited by 29
DECIDUAL ALKALINE PHOSPHATASE ACTIVITY IN THE PREGNANT AND PSEUDOPREGNANT RAT
Manning, J. P., Steinetz, B. G., & Giannina, T. (1969) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1969.tb46416.x · Cited by 29
Fish consumption and time to pregnancy in Japanese women
Arakawa, C., Yoshinaga, J., Okamura, K., Nakai, K., & Satoh, H. (2006) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2006.02.004 · Cited by 25
Reproductive aging results in a reconfigured ovarian antioxidant defense profile in rats
Yeh, J., Bowman, M. J., Browne, R. W., & Chen, N. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.02.054 · Cited by 25
Vitamin E-deficiency induced changes in ovary and uterus
Das, P., & Chowdhury, M. (1999) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006954032164 · Cited by 25
Lessons from Experimental Disruptions of the Menstrual Cycle in Humans and Monkeys
Williams, N. I. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000084528.13358.67 · Cited by 22
Nutritional Prevention of DNA Damage to Sperm and Consequent Risk Reduction in Birth Defects and Cancer in Offspring
Woodall, A., & Ames, B. N. (1997) · Humana Press eBooks · doi:10.1007/978-1-4757-6242-6_20 · Cited by 19
Effects of Smoking on the Levels of Antioxidant Beta Carotene, Alpha Tocopherol and Retinol in Human Ovarian Follicular Fluid
Palan, P. R., Cohen, B. L., Barad, D. H., & Romney, S. L. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000292374 · Cited by 18
Lecithin-cholesterol acyltransferase activity during maturation of human preovulatory follicles with different concentrations of ascorbate, α-tocopherol and nitrotyrosine
Cigliano, L., Balestrieri, M., Spagnuolo, M. S., Dale, B., & Abrescia, P. (2002) · Reproduction Fertility and Development · doi:10.1071/rd01044 · Cited by 18
Critical fatness hypothesis
Frisch, R. E. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e231 · Cited by 18
α-Tocopherol Concentrations in Plasma but not in Lipoproteins Fluctuate during the Menstrual Cycle in Healthy Premenopausal Women
Lanza, E., Forman, M. R., Johnson, E. J., Muesing, R. A., Graubard, B. I., & Beecher, G. R. (1998) · Journal of Nutrition · doi:10.1093/jn/128.7.1150 · Cited by 11
Natural Control of Fertility
Witschi, E. (1968) · Fertility and Sterility · doi:10.1016/s0015-0282(16)36540-2 · Cited by 11
Oxidation of gonadotrophin (PMSG) by oxygen free radicals alters its structure and hormonal activity
Ortega‐Camarillo, C., Guzmán‐Grenfell, A. M., & Hicks, A. J. J. (1999) · Molecular Reproduction and Development · doi:10.1002/(sici)1098-2795(199903)52:3 · Cited by 10
Selected Topics in the Epidemiology of Reproductive Outcomes
Gray, R. H., & Becker, S. (2000) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a018027 · Cited by 7
Effects of Metal Ions on Plasma Membrane Mg2+‐ATPase in Rat Uterus and Ovaries
Milošević, M. S., Petrović, S., Demajo, M., & Horvat, A. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1342.061 · Cited by 5
Vitamin E: hype or hope.
Ma, G. (1996) · PubMed · Cited by 3

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Furnus CC, de Matos DG, Moses DF. Cumulus expansion during in vitro maturation of bovine oocytes: relationship with intracellular glutathione level and its role on subsequent embryo development. Mol Reprod Dev 1998;51:76-83.
Goldman MB, Missmer SA, Barberi RL. Infertility. In Women and Helath, ed. Goldman MB, Hatch MC, San Diego: Academic Press, 2000, pp. 196-214.
Kodaman PH, Behrman HR. Endocrine-regulated and protein kinase C-dependent generation of superoxide by rat preovulatory follicles. Endocrinology 2001;142:687-693.
Paszkowski T, Clarke RN. Antioxidative capacity of preimplantation embryo culture medium declines following the incubation of poor quality embryos. Hum Reprod 1996;11:2493-2495.

Sorted by citations

Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence
Qiao, J., & Feng, H. L. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmq032 · Cited by 479
Diet and Lifestyle in the Prevention of Ovulatory Disorder Infertility
Chavarro, J. E., Rich-Edwards, J. W., ROSNER, B. A., & Willett, W. C. (2007) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000287293.25465.e1 · Cited by 452
Decidualization of the human endometrium
Okada, H., Tsuzuki, T., & Murata, H. (2018) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12088 · Cited by 407
Impact of stress on oocyte quality and reproductive outcome
Prasad, S., Tiwari, M., Pandey, A. N., Shrivastav, T. G., & Chaube, S. K. (2016) · Journal of Biomedical Science · doi:10.1186/s12929-016-0253-4 · Cited by 384
Does air pollution play a role in infertility? a systematic review.
Carré, J., Gatimel, N., Moreau, J., Parinaud, J., & Léandri, R. (2017) · Environmental Health · doi:10.1186/s12940-017-0291-8 · Cited by 379

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Authors: Ruder, E. H., Hartman, T. J., Blumberg, J., & Goldman, M. B.
Affiliations: Pennsylvania State University (US)
Tufts University (US)
Dartmouth–Hitchcock Medical Center (US)
ORCID: Ruder, E. H.
Hartman, T. J.
Blumberg, J.
Venue: Human Reproduction Update
Publisher: Oxford University Press (OUP)
Published: 2008-04-02
Volume: 14
Issue: 4
Pages: 345-357
ISSN: 1355-4786 (ISSN-L)
1460-2369
DOI: 10.1093/humupd/dmn011
PMC: PMC2772106
OpenAlex: W2100338186
Cited by: 351
References: 161
Citations by year: 2026: 7 · 2025: 20 · 2024: 14 · 2023: 16 · 2022: 19 · 2021: 31 · 2020: 33 · 2019: 21 · 2018: 22 · 2017: 29 · 2016: 26 · 2015: 23 · 2014: 23 · 2013: 17 · 2012: 13
FWCI: 1.75
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Human Reproduction Update (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Agriculture
National Institutes of Health
Agricultural Research Service
National Institute of Child Health and Human Development
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD049762)
Topics: Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: oxidative stress, antioxidants, female infertility, female fertility, time to pregnancy, early pregnancy loss, dietary antioxidants, ovarian germ cells, pregnancy complications, preconception exposure
MeSH terms: Abortion, Spontaneous, Antioxidants, Diet, Female, Fertilization, Humans, Infertility, Female, Oocytes, Ovulation, Embryo Implantation, Pregnancy, Reproduction, Reactive Oxygen Species, Oxidative Stress, Prenatal Nutritional Physiological Phenomena

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Oxidative stress and antioxidants: exposure and impact on female fertility

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