Risk Factors for Endometrioid, Mucinous and Serous Benign Ovarian Cysts
Open accessAbstract
Parazzini F (Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy), La Vecchia C, Franceschi S, Negri E and Cecchettil G. Risk factors for endometrioid, mucinous and serous benign ovarian cysts. International Journal of Epidemiology 1989, 18: 108–112. To evaluate the risk factors for serous, mucinous and endometrioid ovarian cysts, data were collected in a case-control study conducted in the greater Milan area based on 202 women with benign cysts (114 endometrioid and 88 serous or mucinous) of the ovary and 1127 controls. Questions were asked about menstrual and reproductive characteristics, marital status, education, history of various diseases, and lifetime use of oral contraceptives and other hormonal treatments. Higher social class, earlier menarche and longer interval between age at first marriage and first birth, a likely indicator of subfertility, were associated with an increased risk of serous, mucinous and endometrioid cysts. Women with endometrioid cyst were characterized by low parity, less frequent irregular or long menses, more frequent oral contraceptive use and low body mass index, while the most relevant risk factor associated with serous and mucinous cysts was greater age at first birth. The present data point out the epidemiological differences between endometrioid and serous or mucinous cysts. Further, they suggest that analyses of risk factors for epithelial ovarian cancer subdivided by various histotypes may be of interest in order to confirm possible heterogeneities in the aetiology of ovarian epithelial neoplasms.
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Early menarche before the age of 11 is associated with the risk of endometriosis.
“epidemiological studies analyzing the cycle of women with endometriosis have shown that the early first cycle (before the age of 11) is associated with the risk of endometriosis [43,44,45,46]”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [44]
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- Authors
- PARAZZINI, F., LA VECCHIA, C., FRANCESCHI, S., NEGRI, E., & CECCHETTI, G.
- Affiliations
- Mario Negri Institute for Pharmacological Research (IT)
- Centro di Riferimento Oncologico (IT)
- University of Milan (IT)
- Venue
- International Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1989
- Volume
- 18
- Issue
- 1
- Pages
- 108-112
- ISSN
- 0300-5771 (ISSN-L)
- 1464-3685
- OpenAlex
- W2131851698
- Cited by
- 58
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2021: 1 · 2019: 1 · 2017: 2 · 2013: 2 · 2012: 3
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- green
- serval.unil.ch
- Licence
- other-oa
- Locations
- International Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, other-oa)
- reroDoc Digital Library (submittedVersion)
- IRIS (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Funders
- Regione Lombardia
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- benign ovarian cysts, endometrioid cysts, serous cyst, mucinous cyst, risk factors, age at first birth, parity, oral contraceptive use, menstrual characteristics, age at menarche, body mass index, ovarian epithelial neoplasms
- MeSH terms
- Adult, Age Factors, Aged, Endometriosis, Epidemiologic Methods, Female, Humans, Marriage, Menarche, Menstruation, Middle Aged, Ovarian Cysts, Ovarian Neoplasms, Parity, Risk Factors, Social Class
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