Cohort Profile: LifeLines, a three-generation cohort study and biobank.
Abstract
The LifeLines Cohort Study is a large population-based cohort study and biobank that was established as a resource for research on complex interactions between environmental, phenotypic and genomic factors in the development of chronic diseases and healthy ageing. Between 2006 and 2013, inhabitants of the northern part of The Netherlands and their families were invited to participate, thereby contributing to a three-generation design. Participants visited one of the LifeLines research sites for a physical examination, including lung function, ECG and cognition tests, and completed extensive questionnaires. Baseline data were collected for 167 729 participants, aged from 6 months to 93 years. Follow-up visits are scheduled every 5 years, and in between participants receive follow-up questionnaires. Linkage is being established with medical registries and environmental data. LifeLines contains information on biochemistry, medical history, psychosocial characteristics, lifestyle and more. Genomic data are available including genome-wide genetic data of 15 638 participants. Fasting blood and 24-h urine samples are processed on the day of collection and stored at -80 °C in a fully automated storage facility. The aim of LifeLines is to be a resource for the national and international scientific community. Requests for data and biomaterials can be submitted to the LifeLines Research Office [LLscience@umcg.nl].
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Both the original Lifelines Cohort Study and the add-on study are largely representative of the general population in the Northern part of the Netherlands.
“Both the original Lifelines Cohort Study and our add-on study are largely representative of the general population in the Northern part of the Netherlands”
From The decreasing prevalence of ADHD across the adult lifespan confirmed (2022) · cites this paper as [12]
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- Authors
- Scholtens, S., Smidt, N., Swertz, M. A., Bakker, S. J., Dotinga, A., Vonk, J. M., van Dijk, F., van Zon, S. K., Wijmenga, C., Wolffenbuttel, B. H., & Stolk, R. P.
- Affiliations
- Lifelines (NL)
- University Medical Center Groningen (NL)
- Corresponding author
- Scholtens, Salome
- ORCID
- Venue
- International Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-12-14
- Volume
- 44
- Issue
- 4
- Pages
- 1172-1180
- ISSN
- 0300-5771 (ISSN-L)
- 1464-3685
- OpenAlex
- W2103516623
- Cited by
- 847
- References
- 6
- Citations by year
- 2026: 63 · 2025: 79 · 2024: 104 · 2023: 98 · 2022: 114 · 2021: 95 · 2020: 99 · 2019: 53 · 2018: 43 · 2017: 47 · 2016: 29 · 2015: 20 · 2014: 1 · 2013: 1
- FWCI
- 21.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- Lifelines cohort, biobanks, chronic disease, healthy aging, environmental exposure, genetic factors, biomaterials, population-based cohort, socio-psychological factors, lifestyle, medical registries
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Child, Child, Preschool, Chronic Disease, Environment, Female, Humans, Infant, Life Style, Male, Middle Aged, Netherlands, Surveys and Questionnaires, Registries, Research Design, Cohort Studies, Biological Specimen Banks, Young Adult
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