Brain‐derived neurotrophic factor as a biomarker for mood disorders: An historical overview and future directions

Hashimoto, Kenji

doi:10.1111/j.1440-1819.2010.02113.x

Cited by 388Treatment of Major DepressionNerve injury and regenerationTryptophan and brain disorders

Brain‐derived neurotrophic factor as a biomarker for mood disorders: An historical overview and future directions

Open access

Hashimoto, Kenji·2010·Psychiatry and Clinical Neurosciences

DOI 10.1111/j.1440-1819.2010.02113.x

Open this paper in CoChat — free account Open PDF

Abstract

Mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BPD), are the most prevalent psychiatric conditions, and are also among the most severe and debilitating. However, the precise neurobiology underlying these disorders is currently unknown. One way to combat these disorders is to discover novel biomarkers for them. The development of such biomarkers will aid both in the diagnosis of mood disorders and in the development of effective psychiatric medications to treat them. A number of preclinical studies have suggested that the brain‐derived neurotrophic factor (BDNF) plays an important role in the pathophysiology of MDD. In 2003, we reported that serum levels of BDNF in antidepressant‐naive patients with MDD were significantly lower than those of patients medicated with antidepressants and normal controls, and that serum BDNF levels were negatively correlated with the severity of depression. Additionally, we found that decreased serum levels of BDNF in antidepressant‐naive patients recovered to normal levels associated with the recovery of depression after treatment with antidepressant medication. This review article will provide an historical overview of the role played by BDNF in the pathophysiology of mood disorders and in the mechanism of action of therapeutic agents. Particular focus will be given to the potential use of BDNF as a biomarker for mood disorders. BDNF is initially synthesized as a precursor protein proBDNF, and then proBDNF is proteolytically cleaved to the mature BDNF. Finally, future perspectives on the use of proBDNF as a novel biomarker for mood disorders will be discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1440-1819.2010.02113.x

Cites

178 of 178 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Other variations in the BDNF gene may be influencing the susceptibility to DD.
“In spite of these reports, other variations in the BDNF gene may be influencing the susceptibility to DD [228].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [228]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Part of this paper’s reference list could not be split into single entries.

Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States: Results From the National Comorbidity Survey
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370 · see citing works
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394 · see citing works
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00035-7 · Cited by 3,888 · see citing works
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848 · see citing works
Bipolar Disorder
Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515 · see citing works
Neurobiology of Depression
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works
Suicide Prevention Strategies: A Systematic Review
Mann, J. J., Apter, A., Bertolote, J., Beautrais, A., Currier, D., Haas, A., Hegerl, U., Lonnqvist, J., Malone, K., Marusic, A., et al. (2005) · JAMA · doi:10.1001/jama.294.16.2064 · Cited by 2,852 · see citing works
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195 · see citing works
Major depressive disorder
Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166 · see citing works
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129 · see citing works
Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109 · see citing works
Hippocampal atrophy in recurrent major depression
Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932 · see citing works
Hippocampal Volume Reduction in Major Depression
Bremner, J. D., Narayan, M., Anderson, E. R., Staib, L. H., Miller, H. L., & Charney, D. S. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.115 · Cited by 1,670 · see citing works
Regulation of Cell Survival by Secreted Proneurotrophins
Lee, R., Kermani, P., Teng, K. K., & Hempstead, B. L. (2001) · Science · doi:10.1126/science.1065057 · Cited by 1,670 · see citing works
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654 · see citing works
Hippocampal volume and depression: a meta-analysis of MRI studies
Videbech, P., & Ravnkilde, B. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.1957 · Cited by 1,590 · see citing works
Assessing antidepressant activity in rodents: recent developments and future needs
Cryan, J. F., Markou, A., & Lucki, I. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02017-5 · Cited by 1,551 · cited 1× · see citing works
“At the present time, therefore, it seems unlikely that heterozygous BDNF mice will provide an effective model of genetic vulnerability to depression, although further detailed studies will be needed to confirm this.(48) The development of a conditional targeting strategy for the BDNF gene will help to discriminate bet…”
Background
Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
Smith, M., Makino, S., Květňanský, R., & Post, R. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01768.1995 · Cited by 1,429 · see citing works
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426 · see citing works
The yin and yang of neurotrophin action
Lu, B., Pang, P. T., & Woo, N. H. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1726 · Cited by 1,356 · see citing works
Transport of brain-derived neurotrophic factor across the blood–brain barrier
Pan, W., Banks, W. A., Fasold, M. B., Bluth, J., & Kastin, A. J. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00141-5 · Cited by 1,354 · see citing works
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
Chen, Z.-Y., Jing, D., Bath, K. G., Ieraci, A., Khan, T., Siao, C.-J., Herrera, D. G., Toth, M., Yang, C., McEwen, B. S., et al. (2006) · Science · doi:10.1126/science.1129663 · Cited by 1,340 · see citing works
Decreased serum brain-derived neurotrophic factor levels in major depressed patients
Karege, F., Perret, G., Bondolfi, G., Schwald, M., Bertschy, G., & Aubry, J.-M. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00005-7 · Cited by 1,232 · see citing works
Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications
Sen, S., Duman, R., & Sanacora, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.005 · Cited by 1,232 · see citing works
New insights into BDNF function in depression and anxiety
Martinowich, K., Manji, H., & Lu, B. (2007) · Nature Neuroscience · doi:10.1038/nn1971 · Cited by 1,221 · see citing works
Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus
Nibuya, M., Nestler, E., & Duman, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02365.1996 · Cited by 1,206 · see citing works
Increased hippocampal bdnf immunoreactivity in subjects treated with antidepressant medication
Chen, B., Dowlatshahi, D., MacQueen, G. M., Wang, J.-F., & Young, L. T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01083-6 · Cited by 1,164 · see citing works
Lower Hippocampal Volume in Patients Suffering From Depression: A Meta-Analysis
Campbell, S., Marriott, M., Nahmias, C., & MacQueen, G. M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.4.598 · Cited by 1,156 · see citing works
Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants
Shimizu, E., Hashimoto, K., Okamura, N., Koike, K., Komatsu, N., Kumakiri, C., Nakazato, M., Watanabe, H., Shinoda, N., Okada, S.-I., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00181-1 · Cited by 1,151 · see citing works
Self-citation
Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity
Pang, P. T., Teng, H. K., Zaitsev, E., Woo, N. T., Sakata, K., Zhen, S., Teng, K. K., Yung, W.-H., Hempstead, B. L., & Lu, B. (2004) · Science · doi:10.1126/science.1100135 · Cited by 1,136 · see citing works
Psychiatric Comorbidities and Schizophrenia
Buckley, P. F., Miller, B. J., Lehrer, D. S., & Castle, D. J. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn135 · Cited by 1,121 · see citing works
Mice lacking brain-derived neurotrophic factor develop with sensory deficits
Ernfors, P., Lee, K.-F., & Jaenisch, R. (1994) · Nature · doi:10.1038/368147a0 · Cited by 1,067 · see citing works
Brain-Derived Neurotrophic Factor val 66 met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance
Hariri, A. R., Goldberg, T. E., Mattay, V. S., Kolachana, B. S., Callicott, J. H., Egan, M. F., & Weinberger, D. R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-17-06690.2003 · Cited by 1,045 · see citing works
Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development
Jones, K. R., Fariñas, I., Backus, C., & Reichardt, L. F. (1994) · Cell · doi:10.1016/0092-8674(94)90377-8 · Cited by 1,041 · see citing works
Neuropsychopharmacology: The Fifth Generation of Progress
Sagduyu, K. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1251-a · Cited by 1,023 · see citing works
ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTRand Sortilin
Teng, H. K., Teng, K. K., Lee, R., Wright, S., Tevar, S., Almeida, R. D., Kermani, P., Torkin, R., Chen, Z.-Y., Lee, F. S., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5123-04.2005 · Cited by 1,013 · see citing works
A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression
Brunoni, A. R., Lopes, M., & Fregni, F. (2008) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009309 · Cited by 972 · see citing works
Brain volume abnormalities in major depressive disorder: A meta‐analysis of magnetic resonance imaging studies
Koolschijn, P. C. M. P., van Haren, N. E. M., Lensvelt‐Mulders, G. J. L. M., Hulshoff Pol, H. E., & Kahn, R. S. (2009) · Human Brain Mapping · doi:10.1002/hbm.20801 · Cited by 902 · see citing works
Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
Sanacora, G., Zarate, C. A., Krystal, J. H., & Manji, H. K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2462 · Cited by 894 · see citing works
Altered Gene Expression of Brain-Derived Neurotrophic Factor and Receptor Tyrosine Kinase B in Postmortem Brain of Suicide Subjects
Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875 · see citing works
Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
Lyons, W. E., Mamounas, L. A., Ricaurte, G. A., Coppola, V., Reid, S. W., Bora, S. H., Wihler, C., Koliatsos, V. E., & Tessarollo, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15239 · Cited by 862 · see citing works
Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)
Siuciak, J. A., Lewis, D. R., Wiegand, S. J., & Lindsay, R. M. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00169-4 · Cited by 841 · see citing works
Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
Rajkowska, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00950-1 · Cited by 822 · see citing works
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
Woo, N. H., Teng, H. K., Siao, C.-J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1510 · Cited by 815 · see citing works
BDNF regulates eating behavior and locomotor activity in mice
Kernie, S. G., Liebl, D. J., & Parada, L. F. (2000) · The EMBO Journal · doi:10.1093/emboj/19.6.1290 · Cited by 806 · see citing works
Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects
Saarelainen, T., Hendolin, P., Lucas, G., Koponen, E., Sairanen, M., MacDonald, E., Agerman, K., Haapasalo, A., Nawa, H., Aloyz, R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00349.2003 · Cited by 800 · see citing works
Postnatal Developmental Profile of Brain-Derived Neurotrophic Factor in Rat Brain and Platelets
Karege, F., Schwald, M., & Cisse, M. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00529-3 · Cited by 799 · see citing works
Conditional Deletion Of Brain-Derived Neurotrophic Factor in the Postnatal Brain Leads to Obesity and Hyperactivity
Rios, M., Fan, G., Fekete, C., Kelly, J., Bates, B., Kuehn, R., Lechan, R. M., & Jaenisch, R. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.10.0706 · Cited by 781 · see citing works
BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?
Lü, Y., Christian, K. M., & Lu, B. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.018 · Cited by 768 · see citing works
The neurotrophin hypothesis for synaptic plasticity
Schinder, A. F. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01672-6 · Cited by 729 · see citing works
Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease
Mattson, M. P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1418.005 · Cited by 640 · see citing works
Neurotrophin signalling in health and disease
Chao, M. V., Rajagopal, R., & Lee, F. S. (2006) · Clinical Science · doi:10.1042/cs20050163 · Cited by 626 · see citing works
Increased Levels of Glutamate in Brains from Patients with Mood Disorders
Hashimoto, K., Sawa, A., & Iyo, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.017 · Cited by 609 · see citing works
Self-citation
Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs
Karege, F., Vaudan, G., Schwald, M., Perroud, N., & La Harpe, R. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.12.020 · Cited by 600 · see citing works
New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function
Greenberg, M. E., Xu, B., Lu, B., & Hempstead, B. L. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3566-09.2009 · Cited by 597 · see citing works
The Brain-Derived Neurotrophic Factor Gene Confers Susceptibility to Bipolar Disorder: Evidence from a Family-Based Association Study
Neves-Pereira, M., Mundo, E., Muglia, P., King, N. A., Macciardi, F. M., & Kennedy, J. L. (2002) · The American Journal of Human Genetics · doi:10.1086/342288 · Cited by 594 · see citing works
Low Brain-Derived Neurotrophic Factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity
Karege, F., Bondolfi, G., Gervasoni, N., Schwald, M., Aubry, J., & Bertschy, G. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.008 · Cited by 594 · see citing works
Biosynthesis and Post-translational Processing of the Precursor to Brain-derived Neurotrophic Factor
Mowla, S. J., Farhadi, H. F., Pareek, S., Atwal, J. K., Morris, S. J., Seidah, N. G., & Murphy, R. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008104200 · Cited by 572 · see citing works
Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus
Sklar, P. B., Gabriel, S., McInnis, M. G., Bennett, P., Lim, Y.-M., Tsan, G., Schaffner, S. F., Kirov, G., Jones, I. R., Owen, M. J., et al. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001058 · Cited by 563 · see citing works
Preclinical models: status of basic research in depression
Nestler, E. J., Gould, E., & Manji, H. K. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01405-1 · Cited by 559 · see citing works
Neurotrophins and depression
Altar, C. A. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01309-7 · Cited by 535 · see citing works
Transcranial Magnetic Stimulation in the Treatment of Depression
Gershon, A. A., Dannon, P. N., & Grunhaus, L. J. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.5.835 · Cited by 532 · see citing works
Critical Role of Brain-Derived Neurotrophic Factor in Mood Disorders
Hashimoto, K., Shimizu, E., & Iyo, M. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.02.003 · Cited by 522 · see citing works
Self-citation
Human and rat brain-derived neurotrophic factor and neurotrophin-3: Gene structures, distributions, and chromosomal localizations
Maisonpierre, P. C., Beau, M. M. L., Espinosa, R., Ip, N. Y., Belluscio, L., de la Monte, S. M., Squinto, S. P., Furth, M. E., & Yancopoulos, G. D. (1991) · Genomics · doi:10.1016/0888-7543(91)90436-i · Cited by 511 · see citing works
Electroconvulsive Therapy for Depression
Lisanby, S. H. (2007) · New England Journal of Medicine · doi:10.1056/nejmct075234 · Cited by 503 · see citing works
Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors
Monteggia, L. M., Luikart, B., Barrot, M., Theobold, D., Malkovska, I., Nef, S., Parada, L. F., & Nestler, E. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.021 · Cited by 502 · see citing works
Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for Difficult-to-Treat depression
Manji, H. K., Quiroz, J. A., Sporn, J., Payne, J. L., Denicoff, K. D., Gray, N. A., Zarate, C. A., & Charney, D. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00117-3 · Cited by 499 · see citing works
Bipolar Disorder
Belmaker, R. H. (2004) · New England Journal of Medicine · doi:10.1056/nejmra035354 · Cited by 473 · see citing works
Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder
Kauer‐Sant’Anna, M., Kapczinski, F. P., Andreazza, A. C., Bond, D. J., Lam, R. W. M., Young, L. T., & Yatham, L. N. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009310 · Cited by 434 · see citing works
Development and natural history of mood disorders
Costello, E. J., Pine, D. S., Hammen, C., March, J. S., Plotsky, P. M., Weissman, M. M., Biederman, J., Goldsmith, H. H., Kaufman, J., Lewinsohn, P. M., et al. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01372-0 · Cited by 430 · see citing works
Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression
Eisch, A. J., Bolaños, C. A., de Wit, J., Simonak, R. D., Pudiak, C. M., Barrot, M., Verhaagen, J., & Nestler, E. J. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.003 · Cited by 420 · see citing works
Exercise, Antidepressant Medications, and Enhanced Brain Derived Neurotrophic Factor Expression
Russo-Neustadt, A. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00059-7 · Cited by 411 · see citing works
Association of the Brain-Derived Neurotrophic Factor Val66Met Polymorphism With Reduced Hippocampal Volumes in Major Depression
Frodl, T., Schüle, C., Schmitt, G., Born, C., Baghai, T., Zill, P., Bottlender, R., Rupprecht, R., Bondy, B., Reiser, M., et al. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.4.410 · Cited by 394 · see citing works
Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes
Cunha, A. B. M., Frey, B. N., Andreazza, A. C., Goi, J. D., Rosa, A. R., Gonçalves, C. A., Santin, A. M. P., & Kapczinski, F. P. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.12.085 · Cited by 391 · see citing works
Glutamate-based antidepressants: 20 years on
Skolnick, P., Popik, P., & Trullás, R. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.09.002 · Cited by 382 · see citing works
Emerging role of glutamate in the pathophysiology of major depressive disorder
Hashimoto, K. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.05.005 · Cited by 381 · see citing works
Self-citation
Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy
Adachi, M., Barrot, M., Autry, A. E., Theobald, D., & Monteggia, L. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.019 · Cited by 380 · see citing works
Increased BDNF Promoter Methylation in the Wernicke Area of Suicide Subjects
Keller, S., Sarchiapone, M., Zarrilli, F., Videtič, A., Ferraro, A., Carli, V., Sacchetti, S., Lembo, F., Angiolillo, A., Jovanovic, N., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.9 · Cited by 379 · see citing works
Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain
Fukumoto, T., Morinobu, S., Okamoto, Y., Kagaya, A., & Yamawaki, S. (2001) · Psychopharmacology · doi:10.1007/s002130100871 · Cited by 377 · see citing works
Effect of treatment on serum brain–derived neurotrophic factor levels in depressed patients
Gonul, A. S., Akdeniz, F., Taneli, F., Donat, O., Eker, Ç., & Vahip, S. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0578-6 · Cited by 375 · see citing works
Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases
Seidah, N. G., Benjannet, S., Pareek, S., Chrétien, M., & Murphy, R. A. (1996) · FEBS Letters · doi:10.1016/0014-5793(95)01520-5 · Cited by 364 · see citing works
Finding the Intracellular Signaling Pathways Affected by Mood Disorder Treatments
Coyle, J. T., & Duman, R. S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00195-8 · Cited by 357 · see citing works
Suicide attempts in bipolar I and bipolar II disorder: a review and meta‐analysis of the evidence
Novick, D. M., Swartz, H. A., & Frank, E. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00786.x · Cited by 357 · see citing works
Differential Sorting of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Hippocampal Neurons
Mowla, S. J., Pareek, S., Farhadi, H. F., Petrecca, K., Fawcett, J. P., Seidah, N. G., Morris, S. J., Sossin, W. S., & Murphy, R. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02069.1999 · Cited by 350 · see citing works
Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay
Radka, S. F., Hoist, P. A., Fritsche, M., & Altar, C. A. (1996) · Brain Research · doi:10.1016/0006-8993(95)01321-0 · Cited by 348 · see citing works
Plasma Protein Biomarkers for Depression and Schizophrenia by Multi Analyte Profiling of Case-Control Collections
Domenici, E., Willé, D. R., Tozzi, F., Prokopenko, I., Miller, S. L., McKeown, A., Brittain, C. F., Rujescu, D., Giegling, I., Turck, C. W., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009166 · Cited by 347 · see citing works
Physical activity–antidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model
Russo-Neustadt, A., Ha, T., Ramirez, R., & Kesslak, J. P. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00364-8 · Cited by 346 · see citing works
Combined Dexamethasone/Corticotropin Releasing Hormone Test Predicts Treatment Response in Major Depression–A Potential Biomarker?
Ising, M., Horstmann, S., Kloiber, S., Lucae, S., Binder, E. B., Kern, N., Künzel, H. E., Pfennig, A., Uhr, M., & Holsboer, F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.039 · Cited by 341 · see citing works
Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: The possibility to explain ethnic mental traits
Shimizu, E., Hashimoto, K., & Iyo, M. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20118 · Cited by 328 · see citing works
Self-citation
Evidence for a Relationship Between Genetic Variants at the Brain-Derived Neurotrophic Factor (BDNF) Locus and Major Depression
Schumacher, J. H., Jamra, R. A., Becker, T., Ohlraun, S., Klopp, N., Binder, E. B., Schulze, T. G., Deschner, M., Schmäl, C., Höfels, S., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.006 · Cited by 305 · see citing works
Human platelets contain brain-derived neurotrophic factor
Yamamoto, H., & Gurney, M. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-11-03469.1990 · Cited by 304 · see citing works
Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain
Altar, C. A., Whitehead, R. E., Chen, R., Wörtwein, G., & Madsen, T. M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00073-8 · Cited by 300 · see citing works
Long-Term Repetitive Transcranial Magnetic Stimulation Increases the Expression of Brain-Derived Neurotrophic Factor and Cholecystokinin mRNA, but not Neuropeptide Tyrosine mRNA in Specific Areas of Rat Brain
Müller, M. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00099-3 · Cited by 292 · see citing works
Role of the brain‐derived neurotrophic factor at glutamatergic synapses
Carvalho, A. L., Caldeira, M. V., Santos, S. D., & Duarte, C. B. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707509 · Cited by 290 · see citing works
Slow Transcranial Magnetic Stimulation, Long-Term Depotentiation, and Brain Hyperexcitability Disorders
Hoffman, R. E., & Çavuş, I. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1093 · Cited by 286 · see citing works
Hippocampal mossy fiber sprouting induced by chronic electroconvulsive seizures
Vaidya, V. A., Siuciak, J. A., Du, F., & Duman, R. S. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00289-9 · Cited by 276 · see citing works
Pro-Region of Neurotrophins
Lu, B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00538-5 · Cited by 267 · see citing works
Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: An essential step for neuroprotection against glutamate excitotoxicity
Hashimoto, R., Takei, N., Shimazu, K., Christ, L. A., Lu, B., & Chuang, D. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00217-4 · Cited by 257 · see citing works
The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression
Hwang, J., Tsai, S., Hong, C., Yang, C.-H., Lirng, J., & Yang, Y.-M. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.013 · Cited by 253 · see citing works
Repeated stress increases catalytic TrkB mRNA in rat hippocampus
Nibuya, M., Takahashi, M., Russell, D., & Duman, R. S. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00335-3 · Cited by 236 · see citing works
Alternative Splicing, Methylation State, and Expression Profile of Tropomyosin-Related Kinase B in the Frontal Cortex of Suicide Completers
Ernst, C., Deleva, V., Deng, X., Sequeira, A., Pomarenski, A., Klempan, T., Ernst, N., Quirion, R., Gratton, A., Szyf, M., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archpsyc.66.1.22 · Cited by 235 · see citing works
Stress increases brain-derived neurotropic factor messenger ribonucleic acid in the hypothalamus and pituitary
Smith, M. A., Makino, S., Kim, S. Y., & Květňanský, R. (1995) · Endocrinology · doi:10.1210/endo.136.9.7649080 · Cited by 226 · see citing works
Decreased Plasma Brain Derived Neurotrophic Factor Levels in Unmedicated Bipolar Patients During Manic Episode
Machado‐Vieira, R., Dietrich, M. O., Leke, R., Cereser, V. H., Zanatto, V. C., Kapczinski, F. P., Souza, D. O., Portela, L. V., & Gentil, V. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.070 · Cited by 223 · see citing works
Association Study of a Brain-Derived Neurotrophic-Factor Genetic Polymorphism and Mood Disorders, Age of Onset and Suicidal Behavior
Hong, C., Huo, S.-J., Yen, F.-C., Tung, C.-L., Pan, G.-M., & Tsai, S. (2003) · Neuropsychobiology · doi:10.1159/000074636 · Cited by 218 · see citing works
Association study of a brain‐derived neurotrophic‐factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response
Tsai, S., Cheng, C., Yu, Y. W., Chen, T., & Hong, C. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20026 · Cited by 213 · see citing works
Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression.
MacQUEEN, G. M., Ramakrishman, K., Croll, S. D., Siuciak, J. A., Yu, G., Young, T., & Fahnestock, M. L. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.5.1145 · Cited by 212 · see citing works
Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women
Aydemir, Ç., Yalcın, E., Aksaray, S., Kısa, C., Yildirim, S. G., Uzbay, T. I., & Göka, E. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.03.025 · Cited by 210 · see citing works
Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments
Piccinni, A., Marazziti, D., Catena, M., Domenici, L., Debbio, A. D., Bianchi, C., Mannari, C., Martini, C., Pozzo, E. D., Schiavi, E., et al. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.05.005 · Cited by 206 · see citing works
Partial Normalization of Serum Brain-Derived Neurotrophic Factor in Remitted Patients after a Major Depressive Episode
Gervasoni, N., Aubry, J., Bondolfi, G., Osiek, C., Schwald, M., Bertschy, G., & Karege, F. (2005) · Neuropsychobiology · doi:10.1159/000085725 · Cited by 204 · see citing works
The NMDA Receptor as a Therapeutic Target in Major Depressive Disorder
Pittenger, C., Sanacora, G., & Krystal, J. H. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780363267 · Cited by 203 · see citing works
Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victims
Pandey, G. N., Ren, X., Rizavi, H. S., Conley, R. R., Roberts, R. C., & Dwivedi, Y. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009000 · Cited by 203 · see citing works
The Relationship Between Panic Disorder and Major Depression: A New Family Study
Weissman, M. M. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820220017003 · Cited by 196 · see citing works
Clinical role of brain-derived neurotropic factor in mood disorders
Hashimoto, K. (2004) · Medical Entomology and Zoology · Cited by 183 · see citing works
Self-citation
Neuroprotective and Neurotrophic Actions of the Mood Stabilizer Lithium: Can It Be Used to Treat Neurodegenerative Diseases?
Chuang, D. (2004) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v16.i12.90 · Cited by 180 · see citing works
Decreased levels of plasma BDNF in first-episode schizophrenia and bipolar disorder patients
Palomino, A., Vallejo‐Illarramendi, A., González-Pinto, A. M., Aldama, A., González‐Gómez, C., Mosquera, F., González-García, G., & Matute, C. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.05.028 · Cited by 180 · see citing works
Electroconvulsive Therapy (ECT) increases serum Brain Derived Neurotrophic Factor (BDNF) in drug resistant depressed patients
Bocchio‐Chiavetto, L., Zanardini, R., Bortolomasi, M., Abate, M., Segala, M., Giacopuzzi, M., Riva, M. A., Marchina, E., Pasqualetti, P., Pérez, J., et al. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.04.010 · Cited by 180 · see citing works
Effects of paroxetine or milnacipran on serum brain-derived neurotrophic factor in depressed patients
Yoshimura, R., Mitoma, M., Sugita, A., Hori, H., Okamoto, T., Umene, W., Ueda, N., & Nakamura, J. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.03.001 · Cited by 178 · see citing works
Novel Sequence Variations in the Brain-Derived Neurotrophic Factor Gene and Association With Major Depression and Antidepressant Treatment Response
Licinio, J., Dong, C., & Wong, M. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.38 · Cited by 176 · see citing works
Serum brain-derived neurotrophic factor levels in patients with major depression: Effects of antidepressants
Huang, T., Lee, C., & Liu, Y. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.05.007 · Cited by 174 · see citing works
Expression of hippocampal brain-derived neurotrophic factor and its receptors in Stanley consortium brains
Dunham, J. S., Deakin, J. F. W., Miyajima, F., Payton, A., & Toro, C. T. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.03.008 · Cited by 172 · see citing works
Decreased levels of serum brain‐derived neurotrophic factor in both depressed and euthymic patients with unipolar depression and in euthymic patients with bipolar I and II disorders
Monteleone, P., Serritella, C., Martiadis, V., & Maj, M. (2008) · Bipolar Disorders · doi:10.1111/j.1399-5618.2008.00459.x · Cited by 162 · see citing works
A common thread for pain and memory synapses? Brain-derived neurotrophic factor and trkB receptors
Malcangio, M., & Leßmann, V. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00025-7 · Cited by 154 · see citing works
Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice
Deltheil, T., Guiard, B. P., Cerdan, J., David, D. J., Tanaka, K. F., Repérant, C., Guilloux, J.-P., Coudoré, F., Hen, R., & Gardier, A. M. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.001 · Cited by 153 · see citing works
Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders
Nakazato, M., Hashimoto, K., Shimizu, E., Kumakiri, C., Koizumi, H., Okamura, N., Mitsumori, M., Komatsu, N., & Iyo, M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01746-8 · Cited by 150 · see citing works
Self-citation
Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controls
Shimizu, E., Hashimoto, K., Watanabe, H., Komatsu, N., Okamura, N., Koike, K., 篠田, 直., Nakazato, M., Kumakiri, C., Okada, S.-I., et al. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.08.004 · Cited by 144 · see citing works
Self-citation
Low serum levels of brain-derived neurotrophic factor and epidermal growth factor in patients with chronic schizophrenia
Ikeda, Y., Yahata, N., Ito, I., Nagano, M., Toyota, T., Yoshikawa, T., Okubo, Y., & Suzuki, H. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.01.017 · Cited by 142 · see citing works
Brain‐Derived Neurotrophic Factor Levels in the Nervous System of Wild‐Type and Neurotrophin Gene Mutant Mice
Kolbeck, R., Bartke, I., Eberle, W., & Barde, Y. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0721930.x · Cited by 141 · see citing works
Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder
Nakata, K., Ujike, H., Sakai, A., Uchida, N., Nomura, A., Imamura, T., Katsu, T., Tanaka, Y., Hamamura, T., & Kuroda, S. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01292-2 · Cited by 138 · see citing works
Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilisers
Manji, H. K., Moore, G. J., & Chen, G. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.178.41.s107 · Cited by 138 · see citing works
Molecular basis of lithium action: integration of lithium-responsive signaling and gene expression networks
Lenox, R. H., & Wang, L. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001306 · Cited by 137 · see citing works
Acute exercise ameliorates reduced brain-derived neurotrophic factor in patients with panic disorder
Ströhle, A., Stoy, M., Graetz, B., Scheel, M., Wittmann, A., Gallinat, J., Lang, U. E., Dimeo, F., & Hellweg, R. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.07.013 · Cited by 135 · cited 2× · see citing works
“Moreover, Strohle et al.164 reported that serum BDNF levels in patients with panic disorder were lower than those of healthy control subjects, and that acute exercise significantly increased serum BDNF levels in these patients.”
Background
Future of genetics of mood disorders research
Merikangas, K. R., Chakravarti, A., Moldin, S. O., Araj, H., Blangero, J., Burmeister, M., Crabbe, J. C., Depaulo, J. R., Foulks, E., Freimer, N. B., et al. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01471-3 · Cited by 128 · see citing works
Brain-derived neurotrophic factor ( BDNF) gene: no major impact on antidepressant treatment response
Domschke, K., Lawford, B. R., Laje, G., Berger, K., Young, R. M., Morris, C. P., Deckert, J., Arolt, V., McMahon, F. J., & Baune, B. T. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709000030 · Cited by 122 · see citing works
Association of Polymorphism (Val66Met) of Brain-Derived Neurotrophic Factor with Suicide Attempts in Depressed Patients
Sarchiapone, M., Carli, V., Roy, A., Iacoviello, L., Cuomo, C., Latella, M. C., di Giannantonio, M., Janiri, L., de Gaetano, M., & Janal, M. N. (2008) · Neuropsychobiology · doi:10.1159/000142361 · Cited by 115 · see citing works
Circulating brain-derived neurotrophic factor is decreased in women with anorexia and bulimia nervosa but not in women with binge-eating disorder: relationships to co-morbid depression, psychopathology and hormonal variables
Monteleone, P., Fabrazzo, M., Martiadis, V., Serritella, C., Pannuto, M., & Maj, M. (2004) · Psychological Medicine · doi:10.1017/s0033291704003368 · Cited by 113 · see citing works
Decreased brain-derived neurotrophic factor in medicated and drug-free bipolar patients
Oliveira, G. S., Ceresér, K. M. M., Fernandes, B. S., Kauer‐Sant’Anna, M., Fries, G. R., Stertz, L., de Aguiar, B. W., Pfaffenseller, B., & Kapczinski, F. P. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.04.002 · Cited by 111 · see citing works
Whither proBDNF?
Barker, P. A. (2009) · Nature Neuroscience · doi:10.1038/nn0209-105 · Cited by 110 · see citing works
Increased Plasma Concentration of Brain-Derived Neurotrophic Factor With Electroconvulsive Therapy
Marano, C. M., Phatak, P., Vemulapalli, U. R., Sassan, A., Nalbandyan, M. R., Ramanujam, S., Soekadar, S. R., Demosthenous, M., & Regenold, W. T. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0404 · Cited by 109 · see citing works
Site-Specific Antidepressant Effects of Repeated Subconvulsive Electrical Stimulation: Potential Role of Brain-Derived Neurotrophic Factor
Gersner, R., Tóth, E., Isserles, M., & Zangen, A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.015 · Cited by 107 · see citing works
Biomarkers in psychiatry: drawbacks and potential for misuse
Lakhan, S. E., Vieira, K. F., & Hamlat, E. J. (2010) · International Archives of Medicine · doi:10.1186/1755-7682-3-1 · Cited by 107 · see citing works
State-dependent decrease in levels of brain-derived neurotrophic factor in bipolar disorder: A meta-analytic study
Lin, P. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.09.044 · Cited by 107 · see citing works
Association of Genetic Variants in the Neurotrophic Receptor–Encoding Gene NTRK2 and a Lifetime History of Suicide Attempts in Depressed Patients
Kohli, M. A., Salyakina, D., Pfennig, A., Lucae, S., Horstmann, S., Menke, A., Kloiber, S. M., Hennings, J. M., Bradley, B., Ressler, K. J., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.201 · Cited by 106 · see citing works
Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder
Zou, Y.-F., Ye, D.-Q., Feng, X.-L., Su, H., Pan, F.-M., & Liao, F.-F. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.12.005 · Cited by 104 · see citing works
Serum brain-derived neurotrophic factor (BDNF) levels in patients with panic disorder: As a biological predictor of response to group cognitive behavioral therapy
Kobayashi, K., Shimizu, E., Hashimoto, K., Mitsumori, M., Koike, K., Okamura, N., Koizumi, H., Ohgake, S., Matsuzawa, D., Zhang, L., et al. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.04.010 · Cited by 97 · see citing works
Self-citation
Mapping the differences in the brain concentration of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in an animal model of depression
Angelucci, F., Aloe, L., Jiménez-Vasquez, P. A., & Mathé, A. A. (2000) · Neuroreport · doi:10.1097/00001756-200004270-00044 · Cited by 97 · see citing works
Efficacy of electroconvulsive therapy is associated with changing blood levels of homovanillic acid and brain-derived neurotrophic factor (BDNF) in refractory depressed patients: A pilot study
Okamoto, T., Yoshimura, R., Ikenouchi, A., Hori, H., Umene‐Nakano, W., Inoue, Y., Ueda, N., & Nakamura, J. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.02.009 · Cited by 96 · see citing works
Manic-depression genes and the new millennium: poised for discovery
Baron, M. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000998 · Cited by 95 · see citing works
Cognitive function and serum levels of brain‐derived neurotrophic factor in patients with bipolar disorder
Dias, V. V., Brissos, S., Frey, B. N., Andreazza, A. C., Cardoso, C., & Kapczinski, F. P. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00733.x · Cited by 92 · see citing works
Serum brain-derived neurotrophic factor (BDNF) is not associated with response to electroconvulsive therapy (ECT): A pilot study in drug resistant depressed patients
Fernandes, B. S., Gama, C. S., Massuda, R., Torres, M., Camargo, D., Kunz, M., Belmonte-de-Abreu, P. S., Kapczinski, F. P., Fleck, M. P. D. A., & Lobato, M. I. R. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.02.032 · Cited by 90 · see citing works
Management of Psychiatric Comorbidity in Anorexia Nervosa and Bulimia Nervosa
Woodside, B., & Staab, R. (2006) · CNS Drugs · doi:10.2165/00023210-200620080-00004 · Cited by 88 · see citing works
BDNF variant linked to anxiety‐related behaviors
Hashimoto, K. (2007) · BioEssays · doi:10.1002/bies.20534 · Cited by 88 · see citing works
Self-citation
The Val66Met polymorphism of the brain‐derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients
Iga, J., Ueno, S., Yamauchi, K., Numata, S., Tayoshi‐Shibuya, S., Kinouchi, S., Nakataki, M., Song, H., Hokoishi, K., Tanabe, H., et al. (2007) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30520 · Cited by 87 · see citing works
Neuroimaging genetics: New perspectives in research on major depression?
Frodl, T., Möller, H. ‐., & Meisenzahl, E. (2008) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2008.01225.x · Cited by 87 · see citing works
L INKAGE A NALYSIS IN P SYCHIATRIC D ISORDERS : The Emerging Picture
Sklar, P. B. (2002) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.3.022502.103141 · Cited by 87 · see citing works
Spatiotemporal selective effects on brain-derived neurotrophic factor andtrkB messenger RNA in rat hippocampus by electroconvulsive shock
Lindefors, N., Brodin, E., & METSIS, M. L. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00550-o · Cited by 83 · see citing works
Developing novel treatments for mood disorders: accelerating discovery
Tamminga, C. A., Nemeroff, C. B., Blakely, R., Brady, L. S., Carter, C. S., Davis, K. L., Dingledine, R. J., Gorman, J. M., Grigoriadis, D. E., Henderson, D. C., et al. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01470-1 · Cited by 80 · see citing works
Activation of Extracellular Signal‐Regulated Kinase (ERK) and Akt by Human Serotonin 5‐HT 1B Receptors in Transfected BE(2)‐C Neuroblastoma Cells Is Inhibited by RGS4
Lione, A. M., Errico, M., Lin, S. L., & Cowen, D. S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750934.x · Cited by 77 · see citing works
Role of BDNF Val66Met functional polymorphism in Alzheimer's disease-related depression
Borroni, B., Archetti, S., Costanzi, C., Grassi, M., FERRARI, M. M. H., Radeghieri, A., Caimi, L., Caltagirone, C., Luca, M. D., & Padovani, A. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.11.023 · Cited by 67 · see citing works
Association between brain‐derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene
Vincze, I., Perroud, N. A., Burési, C., Baud, P., Bellivier, F., Étain, B., Fournier, C., Karege, F., Matthey, M., Preisig, M., et al. (2008) · Bipolar Disorders · doi:10.1111/j.1399-5618.2008.00603.x · Cited by 66 · see citing works
Role of brain-derived neurotrophic factor in eating disorders: Recent findings and its pathophysiological implications
Hashimoto, K., Koizumi, H., Nakazato, M., Shimizu, E., & Iyo, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.01.007 · Cited by 65 · see citing works
Self-citation
Low serum BDNF and food intake regulation: A possible new explanation of the pathophysiology of eating disorders
Saitô, S., Watanabe, K., Hashimoto, E., & Saito, T. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.12.009 · Cited by 64 · see citing works
Identification of pro- and mature brain-derived neurotrophic factor in human saliva
Mandel, A. L., Özdener, M. H., & Utermohlen, V. (2009) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2009.04.005 · Cited by 63 · see citing works
Serum brain-derived neurotrophic factor level in dysthymia: A comparative study with major depressive disorder
Aydemır, Ö., Deveci, A., Taşkın, O., Taneli, F., & Esen-Danacı, A. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.02.013 · Cited by 62 · see citing works
The Level of Serum Brain-Derived Neurotrophic Factor Is Associated With the Therapeutic Efficacy of Modified Electroconvulsive Therapy in Chinese Patients With Depression
Hu, Y., Yu, X., Yang, F., Si, T., Wang, W., Tan, Y., Zhou, D., Wang, H., & Chen, D. (2010) · Journal of Ect · doi:10.1097/yct.0b013e3181c18bbf · Cited by 60 · see citing works
Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Affective Disorders
Schlaepfer, T., Kosel, M., & Nemeroff, C. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300038 · Cited by 59 · see citing works
Neurotrophic factors in serum following ECT: A pilot study
Grønli, O., Stensland, G. Ø., Wynn, R., & Olstad, R. (2009) · The World Journal of Biological Psychiatry · doi:10.3109/15622970701586323 · Cited by 55 · see citing works
Effect of risperidone on plasma catecholamine metabolites and brain‐derived neurotrophic factor in patients with bipolar disorders
Yoshimura, R., Nakano, Y., Hori, H., Ikenouchi, A., Ueda, N., & Nakamura, J. (2006) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.804 · Cited by 51 · see citing works
Plasma BDNF and tPA are associated with late‐onset geriatric depression
Shi, Y., You, J., Yuan, Y., Zhang, X., Li, H., & Hou, G. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02074.x · Cited by 45 · see citing works
Changes in Brain-Derived Neurotrophic Factor Following Treatment with Mifepristone in Bipolar Disorder and Schizophrenia
Mackin, P., Gallagher, P., Watson, S., Young, A. H., & Ferrier, I. N. (2007) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670701213211 · Cited by 45 · see citing works
A three‐year follow‐up study of the psychosocial predictors of delayed and unresolved post‐traumatic stress disorder in Taiwan Chi‐Chi earthquake survivors
Su, C., Tsai, K., Chou, F. H., Ho, W., Liu, R., & Lin, W. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02087.x · Cited by 42 · see citing works
Toward molecular diagnostics of mood disorders in psychiatry
Avissar, S., & Schreiber, G. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02351-1 · Cited by 42 · see citing works
The mood stabilizer lamotrigine produces antidepressant behavioral effects in rats: role of brain-derived neurotrophic factor
Li, N., He, X., Qi, X., Zhang, Y., & He, S. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881109359102 · Cited by 37 · see citing works
Dietary restriction changes behaviours in brain‐derived neurotrophic factor heterozygous mice: role of serotonergic system
Koizumi, H., Hashimoto, K., & Iyo, M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05094.x · Cited by 37 · see citing works
Self-citation
Serum brain‐derived neurotrophic factor levels in conversion disorder: Comparative study with depression
Deveci, A., Aydemır, Ö., Taşkın, O., Taneli, F., & Esen-Danacı, A. (2007) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2007.01710.x · Cited by 29 · see citing works
Acute prefrontal cortex transcranial magnetic stimulation in healthy volunteers: No effects on brain-derived neurotrophic factor (BDNF) concentrations in serum
Lang, U. E., Hellweg, R., Gallinat, J., & Bajbouj, M. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.08.008 · Cited by 29 · see citing works
BDNF Val66Met polymorphism and protein levels in Amniotic Fluid
Cattaneo, A., Bocchio‐Chiavetto, L., Zanardini, R., et al. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-16 · Cited by 19 · see citing works
Managing bipolar disorders in children and adolescents
Taylor, E. A. (2009) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.117 · Cited by 14 · see citing works
P.3.a.017 Decreased serum pro BDNF/BDNF ratio in patients with schizophrenia
Carlino, D., Leone, E., Tongiorgi, E., et al. (2008) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(08)70570-4 · Cited by 1 · see citing works

Flagged first, then by citations

Research works printed but not linked: 4

Reichardt LF. Neurotrophin-regulated signaling path- ways. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2006; 361: 1545-1564.
U.S.A. 1999; 96: 15239-15244.
Hariri AR, Goldberg TE, Mattay VS et al. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and pre- dicts memory performance. J. Neurosci. 2003; 23: 6690- 6694.
Sklar P. Linkage analysis in psychiatric disorders: The emerging picture. Annu. Rev. Genomics Hum. Genet. 2003; 3: 371-413.

Sorted by citations

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects
Yang, C., Shirayama, Y., Zhang, J.-C., Ren, Q., Yao, W., Ma, M., Dong, C., & Hashimoto, K. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.136 · Cited by 605 · see citing works
Self-citation
The neurobiology of suicide
van Heeringen, K., & Mann, J. J. (2014) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)70220-2 · Cited by 550 · see citing works
Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets
Zhang, J.-C., Yao, W., & Hashimoto, K. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160119094646 · Cited by 538 · see citing works
Self-citation
Overview of the Genetics of Major Depressive Disorder
Lohoff, F. W. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0150-6 · Cited by 498 · see citing works
Depression and cardiac disease: epidemiology, mechanisms, and diagnosis.
Huffman, J. C., Celano, C. M., Beach, S. R., Motiwala, S. R., & Januzzi, J. L. (2013) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2013/695925 · Cited by 445 · see citing works
DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression
Fuchikami, M., Morinobu, S., Segawa, M., Okamoto, Y., Yamawaki, S., Ozaki, N., Inoue, T., Kusumi, I., Koyama, T., Tsuchiyama, K., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023881 · Cited by 378 · see citing works
Rapid‐acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective
Hashimoto, K. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12902 · Cited by 335 · see citing works
Self-citation
The neurodevelopmental origins of suicidal behavior
Turecki, G., Ernst, C., Jollant, F., Labonté, B., & Mechawar, N. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.008 · Cited by 299 · see citing works
Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation
Zhang, J.-C., Wu, J., Fujita, Y., Yao, W., Ren, Q., Yang, C., Li, S.-X., Shirayama, Y., & Hashimoto, K. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu077 · Cited by 289 · see citing works
Self-citation
Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor
Wei, Y., Chang, L., & Hashimoto, K. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01121-1 · Cited by 248 · see citing works
Self-citation
BDNF promoter methylation and suicidal behavior in depressive patients
Kang, H.-J., Kim, J.-M., Lee, J.-Y., Kim, S.-Y., Bae, K.-Y., Kim, S.-W., Shin, I.-S., Kim, H.-R., Shin, M.-G., & Yoon, J.-S. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.08.001 · Cited by 218 · see citing works
Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites
Yang, C., Yang, J., Luo, A., & Hashimoto, K. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0624-1 · Cited by 190 · see citing works
Self-citation
Assessment of a Multi-Assay, Serum-Based Biological Diagnostic Test for Major Depressive Disorder: A Pilot and Replication Study
Papakostas, G. I., Shelton, R. C., Kinrys, G., Henry, M. E., Bakow, B. R., Lipkin, S. H., Pi, B., Thurmond, L., & Bilello, J. A. (2013) · Molecular Psychiatry · doi:10.1038/mp.2011.166 · Cited by 180 · see citing works
Acute administration of ketamine in rats increases hippocampal BDNF and mTOR levels during forced swimming test
Yang, C., Hu, Y.-M., Zhou, Z.-Q., Zhang, G.-F., & Yang, J.-J. (2013) · Upsala Journal of Medical Sciences · doi:10.3109/03009734.2012.724118 · Cited by 173 · see citing works
Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat
Zhang, C., Zhang, Y.-P., Li, Y.-Y., Liu, B.-P., Wang, H.-Y., Li, K.-W., Zhao, S., & Song, C. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.07.001 · Cited by 172 · see citing works
Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice
Yao, W., Zhang, J.-C., Ishima, T., Dong, C., Yang, C., Ren, Q., Ma, M., Han, M., Wu, J., Suganuma, H., et al. (2016) · Scientific Reports · doi:10.1038/srep30659 · Cited by 154 · see citing works
Self-citation
Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist
Shirayama, Y., Yang, C., Zhang, J.-C., Ren, Q., Yao, W., & Hashimoto, K. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.09.002 · Cited by 137 · see citing works
Self-citation
An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients with Schizophrenia
Shiina, A., Kanahara, N., Sasaki, T., Oda, Y., Hashimoto, T., Hasegawa, T., Yoshida, T., Iyo, M., & Hashimoto, K. (2015) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2015.13.1.62 · Cited by 107 · see citing works
Self-citation
Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandem
Popova, N. K., & Naumenko, V. S. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1572747 · Cited by 105 · see citing works
Plasma levels of mature brain-derived neurotrophic factor (BDNF) and matrix metalloproteinase-9 (MMP-9) in treatment-resistant schizophrenia treated with clozapine.
Yamamori, H., Hashimoto, R., Ishima, T., Kishi, F., Yasuda, Y., Ohi, K., Fujimoto, M., Umeda-Yano, S., Ito, A., Hashimoto, K., et al. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.09.059 · Cited by 101 · see citing works
Self-citation
Retracted: Regional Differences in Brain-Derived Neurotrophic Factor Levels and Dendritic Spine Density Confer Resilience to Inescapable Stress
Yang, C., Shirayama, Y., Zhang, J.-C., Ren, Q., & Hashimoto, K. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu121 · Cited by 103 · see citing works
Self-citation
Retracted
A narrative literature review of depression following traumatic brain injury: prevalence, impact, and management challenges
Juengst, S. B., Kumar, R. G., & Wagner, A. K. (2017) · Psychology Research and Behavior Management · doi:10.2147/prbm.s113264 · Cited by 102 · see citing works
Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches
Balmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103 · see citing works
“In spite of these reports, other variations in the BDNF gene may be influencing the susceptibility to DD [228].”
Result
Essential Role of Keap1-Nrf2 Signaling in Mood Disorders: Overview and Future Perspective
Hashimoto, K. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01182 · Cited by 98 · see citing works
Multiplex quantitative assays indicate a need for reevaluating reported small-molecule TrkB agonists
Boltaev, U., Meyer, Y., Tolibzoda, F., Jacques, T., Gassaway, M., Xu, Q., Wagner, F., Zhang, Y.-L., Palmer, M., Holson, E., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aal1670 · Cited by 94 · see citing works
Brain-Derived Neurotrophic Factor Serum Levels and Genotype: Association with Depression during Interferon-α Treatment
Lotrich, F. E., Albusaysi, S., & Ferrell, R. E. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.263 · Cited by 92 · see citing works
TrkB inhibition as a therapeutic target for CNS-related disorders
Boulle, F., Kenis, G., Cazorla, M., Hamon, M., Steinbusch, H. W. M., Lanfumey, L., & van den Hove, D. L. A. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.06.002 · Cited by 80 · see citing works
Alterations in BDNF (brain derived neurotrophic factor) and GDNF (glial cell line-derived neurotrophic factor) serum levels in bipolar disorder: The role of lithium
Tunca, Z., Ozerdem, A., Ceylan, D., Yalçın, Y., Can, G., Resmi, H., Akan, P., Ergör, G., Aydemir, Ö., Cengisiz, C., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.05.012 · Cited by 77 · see citing works
The brain‐derived neurotrophic‐factor ( BDNF ) val66met polymorphism is associated with geriatric depression: A meta‐analysis
Pei, Y., Smith, A. K., Wang, Y., Pan, Y., Yang, J., Chen, Q., Pan, W., Bao, F., Zhao, L., Tie, C., et al. (2012) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32062 · Cited by 67 · see citing works
Can tai chi and Qigong postures shape our mood? Toward an embodied cognition framework for mind-body research
Osypiuk, K., Thompson, E., & Wayne, P. M. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00174 · Cited by 61 · see citing works
BDNF polymorphism predicts the rate of decline in skilled task performance and hippocampal volume in healthy individuals
Sanchez, M. M., Das, D., Taylor, J. L., Noda, A., Yesavage, J. A., & Salehi, A. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.47 · Cited by 45 · see citing works
Aligning physiology with psychology: Translational neuroscience in neuropsychiatric drug discovery
McArthur, R. A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.004 · Cited by 42 · see citing works
Attenuation of mania-like behavior in Na+,K+-ATPase α3 mutant mice by prospective therapies for bipolar disorder: Melatonin and exercise
Kirshenbaum, G. S., Burgess, C. R., Déry, N., Fahnestock, M., Peever, J. H., & Roder, J. C. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.12.011 · Cited by 33 · see citing works
PGC-1α–FNDC5–BDNF signaling pathway in skeletal muscle confers resilience to stress in mice subjected to chronic social defeat
Zhan, G., Huang, N., Li, S., Hua, D., Zhang, J., Fang, X., Yang, N., Luo, A., & Yang, C. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5041-2 · Cited by 32 · see citing works
Brain-derived neurotrophic factor as a suicide factor in mental disorders
Grah, M., Mihanovic, M., Ruljancic, N., Restek-Petrovic, B., Molnar, S., & Jelavic, S. (2014) · Acta Neuropsychiatrica · doi:10.1017/neu.2014.27 · Cited by 29 · see citing works
Brain-derived neurotrophic factor serum levels in genetically isolated populations: gender-specific association with anxiety disorder subtypes but not with anxiety levels or Val66Met polymorphism
Carlino, D., Francavilla, R., Baj, G., Kulak, K., d’Adamo, P., Ulivi, S., Cappellani, S., Gasparini, P., & Tongiorgi, E. (2015) · PeerJ · doi:10.7717/peerj.1252 · Cited by 23 · see citing works

Neurotrophic factors in brain development
Ringstedt, T. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511711848.008 · Cited by 1 · see citing works
Neurotrophic Factors and Their Receptors in Axonal Regeneration and Functional Recovery After Peripheral Nerve Injury
Boyd, J. G., & Gordon, T. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:3:277 · Cited by 515 · see citing works
Evaluation of brain-derived neurotrophic factor in diabetic rats
Etemad, A., Sheikhzadeh, F., & Ahmadiasl, N. (2014) · Neurological Research · doi:10.1179/1743132814y.0000000428 · Cited by 15 · see citing works
The neurotrophic hypothesis: where does it stand?
Davies, A. M. (1996) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1996.0033 · Cited by 151 · see citing works
Role of neurotrophins in inflammation of the gut.
Reinshagen, M., von Boyen, G., Adler, G., et al. (2002) · PubMed · Cited by 16 · see citing works

Authors: Hashimoto, K.
Affiliations: Chiba University (JP)
Corresponding author: Hashimoto, Kenji
ORCID: Hashimoto, Kenji
Venue: Psychiatry and Clinical Neurosciences
Publisher: Wiley
Published: 2010-07-23
Volume: 64
Issue: 4
Pages: 341-357
ISSN: 1323-1316 (ISSN-L)
1440-1819
DOI: 10.1111/j.1440-1819.2010.02113.x
OpenAlex: W1659530875
Cited by: 388
References: 178
Citations by year: 2026: 8 · 2025: 11 · 2024: 15 · 2023: 15 · 2022: 21 · 2021: 25 · 2020: 22 · 2019: 19 · 2018: 21 · 2017: 27 · 2016: 37 · 2015: 38 · 2014: 31 · 2013: 34 · 2012: 33
FWCI: 3.47
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Psychiatry and Clinical Neurosciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: brain-derived neurotrophic factor, mood disorders, major depressive disorder, bipolar disorder, serum BDNF, biomarkers, antidepressant response, depression severity, proBDNF
MeSH terms: Animals, Bipolar Disorder, Major Depressive Disorder, Humans, Polymorphism, Genetic, Protein Precursors, Biomarkers, Brain-Derived Neurotrophic Factor, Mood Disorders, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Brain‐derived neurotrophic factor as a biomarker for mood disorders: An historical overview and future directions

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks