Neurochemistry of the nucleus accumbens and its relevance to depression and antidepressant action in rodents

Shirayama, Yukihiko; Chaki, Shigeyuki

doi:10.2174/157015906778520773

Cited by 225Neurotransmitter Receptor Influence on BehaviorTreatment of Major DepressionTryptophan and brain disorders

Neurochemistry of the nucleus accumbens and its relevance to depression and antidepressant action in rodents

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Shirayama, Yukihiko, Chaki, Shigeyuki·2006·Current Neuropharmacology

DOI 10.2174/157015906778520773PMC PMC2475798

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Abstract

There is accumulating evidence that the nucleus accumbens (NAc) plays an important role in the pathophysiology of depression. Given that clinical depression is marked by anhedonia (diminished interest or pleasure), dysfunction of the brain reward pathway has been suggested as contributing to the pathophysiology of depression.Since the NAc is the center of reward and learning, it is hypothesized that anhedonia might be produced by hampering the function of the NAc. Indeed, it has been reported that stress, drug exposure and drug withdrawal, all of which produce a depressive-phenotype, alter various functions within the NAc, leading to inhibited dopaminergic activity in the NAc.In this review, we describe various factors as possible candidates within the NAc for the initiation of depressive symptoms. First, we discuss the roles of several neurotransmitters and neuropeptides in the functioning of the NAc, including dopamine, glutamate, gamma-aminobutyric acid (GABA), acetylcholine, serotonin, dynorphin, enkephaline, brain-derived neurotrophic factor (BDNF), cAMP response element-binding protein (CREB), melanin-concentrating hormone (MCH) and cocaine- and amphetamine-regulated transcript (CART). Second, based on previous studies, we propose hypothetical relationships among these substances and the shell and core subregions of the NAc.

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Evidence suggests that dopamine activity is low at times of depression.
“Evidence suggests that dopamine activity is low at such times (Shirayama and Chaki, 2006).”
From A motivation model of sex addiction – Relevance to the controversy over the concept (2022) · cites this paper as Shirayama and Chaki, 2006
The Concluding Remarks report reduced dopaminergic activity in the nucleus accumbens in animal models of depression. This supports the suggested link, but the claim does not retain the paper’s limits to that brain region and primarily rodent evidence. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Restraint stress, the forced swim test, and inescapable shock increase nucleus accumbens dynorphin.
“Restraint stress, the forced swim test, and inescapable shock increases NAc dynorphin (73) and NAc specific infusion of kappa opioid receptor (i.e., the primary target of dynorphin) antagonists has antidepressant effects (74).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [73]

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Diagnostic and Statistical Manual of Mental Disorders, 5th Edition
(2013) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9780890425596.893619 · Cited by 4,390 · see citing works
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856 · see citing works
Transcriptional regulation by the phosphorylation-dependent factor CREB
Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587 · see citing works
Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109 · see citing works
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070 · see citing works
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070 · see citing works
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654 · see citing works
Self-citation
Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
Smith, M., Makino, S., Květňanský, R., & Post, R. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01768.1995 · Cited by 1,429 · see citing works
Hypothalamic CART is a new anorectic peptide regulated by leptin
Kristensen, P. L., Judge, M. E., Thim, L., Ribel, U., Christjansen, K. N., Wulff, B. S., Clausen, J. T., Jensen, P. B., Madsen, O. D., Vrang, N., et al. (1998) · Nature · doi:10.1038/29993 · Cited by 1,282 · see citing works
Acute effects of cocaine on human brain activity and emotion
Breiter, H. C., Gollub, R. L., Weisskoff, R. M., Kennedy, D. N., Makris, N., Berke, J. D., Goodman, J. M., Kantor, H. L., Gastfriend, D. R., Riorden, J. P., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80374-8 · Cited by 1,270 · see citing works
Decreased serum brain-derived neurotrophic factor levels in major depressed patients
Karege, F., Perret, G., Bondolfi, G., Schwald, M., Bertschy, G., & Aubry, J.-M. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00005-7 · Cited by 1,232 · see citing works
Striatal interneurones: chemical, physiological and morphological characterization
Kawaguchi, Y., Wilson, C. J., Augood, S. J., & Emson, P. C. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)98374-8 · Cited by 1,197 · see citing works
Chronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · cited 2× · see citing works
“Exposure to chronic stress or withdrawal from long-term ingestion of drugs of abuse causes anhedonia (diminished interest or pleasure), a core symptom of major depressive disorder, in both humans and rodents [5,8,170].”
Background
The melanin‐concentrating hormone system of the rat brain: An immuno‐ and hybridization histochemical characterization
Bittencourt, J. C., Presse, F., Arias, C. M., Peto, C. A., Vaughan, J. M., Nahon, J., Vale, W., & Sawchenko, P. E. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903190204 · Cited by 1,075 · see citing works
Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
Spanagel, R., Herz, A., & Shippenberg, T. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.6.2046 · Cited by 1,005 · see citing works
Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens
Nicola, S. M., Surmeier, D. J., & Malenka, R. C. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.185 · Cited by 931 · see citing works
The nucleus accumbens as a complex of functionally distinct neuronal ensembles: An integration of behavioural, electrophysiological and anatomical data
Pennartz, C. M. A., Groenewegen, H. J., & LOPESDASILVA, F. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90025-6 · Cited by 802 · see citing works
Regulation of cocaine reward by CREB
Carlezon, W. A., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., Duman, R. S., Neve, R. L., & Nestler, E. J. (1998) · Science · doi:10.1126/science.282.5397.2272 · Cited by 767 · see citing works
Endogenous opioid systems and alcohol addiction
Herz, A. (1997) · Psychopharmacology · doi:10.1007/s002130050169 · Cited by 749 · see citing works
Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine
Uzunova, V., Sheline, Y. I., Davis, J. M., Rasmusson, A. M., Uzunov, D. P., Costa, E., & Guidotti, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3239 · Cited by 672 · see citing works
PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine
DOUGLASS, J. O., McKinzie, A. A., & Couceyro, P. R. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-02471.1995 · Cited by 661 · see citing works
Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization
Pierce, R. C., Bell, K., Duffy, P., & Kalivas, P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01550.1996 · Cited by 624 · see citing works
Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments
Krystal, J. H., Sanacora, G., Blumberg, H., Anand, A., Charney, D. S., Marek, G., Epperson, C. N., Goddard, A., & Mason, G. F. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001021 · Cited by 553 · see citing works
Time-Dependent Increases in Brain-Derived Neurotrophic Factor Protein Levels within the Mesolimbic Dopamine System after Withdrawal from Cocaine: Implications for Incubation of Cocaine Craving
Grimm, J. W., Lü, L., Hayashi, T., Hope, B. T., Su, T., & Shaham, Y. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00742.2003 · Cited by 551 · see citing works
The Effects of Opioid Peptides on Dopamine Release in the Nucleus Accumbens: An In Vivo Microdialysis Study
Spanagel, R., Herz, A., & Shippenberg, T. S. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04963.x · Cited by 539 · see citing works
Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats.
Bals-Kubik, R., Ableitner, A., Herz, A., & Shippenberg, T. S. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10296-6 · Cited by 525 · see citing works
Altered Responsiveness to Cocaine and Increased Immobility in the Forced Swim Test Associated with Elevated cAMP Response Element-Binding Protein Expression in Nucleus Accumbens
Pliakas, A. M., Carlson, R. R., Neve, R. L., Konradi, C., Nestler, E. J., & Carlezon, W. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07397.2001 · Cited by 509 · see citing works
Bupropion is a nicotinic antagonist
Slemmer, J. E., Martin, B. R., & Damaj, M. I. (2000) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38905-0 · Cited by 509 · see citing works
CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli
Barrot, M., Olivier, J. D. A., Perrotti, L. I., DiLeone, R. J., Berton, O., Eisch, A. J., Impey, S., Storm, D. R., Neve, R. L., Yin, J. C., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172091899 · Cited by 508 · see citing works
Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist
Borowsky, B., Durkin, M. M., Ogozalek, K. L., Marzabadi, M. R., DeLeon, J., Heurich, R. O., Lichtblau, H., Shaposhnik, Z., Daniewska, I., Blackburn, T. P., et al. (2002) · Nature Medicine · doi:10.1038/nm741 · Cited by 506 · see citing works
Differential control over cocaine-seeking behavior by nucleus accumbens core and shell
Ito, R., Robbins, T. W., & Everitt, B. J. (2004) · Nature Neuroscience · doi:10.1038/nn1217 · Cited by 501 · see citing works
Social defeat stress selectively alters mesocorticolimbic dopamine release: an in vivo microdialysis study
Tidey, J. W., & Miczek, K. A. (1996) · Brain Research · doi:10.1016/0006-8993(96)00159-x · Cited by 496 · see citing works
Effects of Antidepressant Treatment on Neuroactive Steroids in Major Depression
Romeo, E., Ströhle, A., Spalletta, G., di Michele, F., Hermann, B., Holsboer, F., Pasini, A., & Rupprecht, R. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.7.910 · Cited by 463 · see citing works
Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats.
Paulson, P. E., Camp, D. M., & Robinson, T. E. (1991) · Psychopharmacology · doi:10.1007/bf02244248 · Cited by 455 · see citing works
κ Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses
McLaughlin, J. P., Marton-Popovici, M., & Chavkin, C. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05674.2003 · Cited by 432 · see citing works
Glutamate and Depression: Clinical and Preclinical Studies
PAUL, I. A., & SKOLNICK, P. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.016 · Cited by 408 · cited 1× · see citing works
“Dysfunction of excitatory amino acid transmission may play a role in the etiology and pathophysiology of depression [121].”
Background
Selective activation of dopamine transmission in the shell of the nucleus accumbens by stress
Kalivas, P. W., & Duffy, P. (1995) · Brain Research · doi:10.1016/0006-8993(95)00013-g · Cited by 395 · see citing works
Corticolimbic Dopamine Neurotransmission Is Temporally Dissociated from the Cognitive and Locomotor Effects of Phencyclidine
Adams, B. W., & Moghaddam, B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05545.1998 · Cited by 388 · see citing works
Expression of the melanin‐concentrating hormone (MCH) receptor mRNA in the rat brain
Saito, Y., Cheng, M., Leslie, F. M., & Civelli, O. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1191 · Cited by 381 · see citing works
GABA and mood disorders: a brief review and hypothesis
Petty, F. (1995) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00025-i · Cited by 378 · see citing works
Choice selection and reward anticipation: an fMRI study
Ernst, M., Nelson, E. E., McClure, E. B., Monk, C. S., Munson, S., Eshel, N., Zarahn, E., Leibenluft, E., Zametkin, A., Towbin, K., et al. (2004) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.05.011 · Cited by 377 · see citing works
Enhancement of Locomotor Activity and Conditioned Reward to Cocaine by Brain-Derived Neurotrophic Factor
Horger, B. A., Iyasere, C. A., Berhow, M. T., Messer, C. J., Nestler, E. J., & Taylor, J. R. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-04110.1999 · Cited by 375 · see citing works
The Hypothalamic Neuropeptide Melanin-Concentrating Hormone Acts in the Nucleus Accumbens to Modulate Feeding Behavior and Forced-Swim Performance
Georgescu, D., Sears, R. M., Hommel, J. D., Barrot, M., Bolaños, C. A., Marsh, D. J., Bednarek, M. A., Bibb, J. A., Maratos–Flier, E., Nestler, E. J., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1714-04.2005 · Cited by 346 · see citing works
Differential expression of motivational stimulus properties by dopamine in nucleus accumbens shell versus core and prefrontal cortex
Bassareo, V., De Luca, M. A., & Di Chiara, G. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04709.2002 · Cited by 339 · see citing works
Distribution of fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration
Elmquist, J. K., Scammell, T. E., Jacobson, C. D., & Saper, C. B. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960715)371:1 · Cited by 335 · see citing works
Rewarding Actions of Phencyclidine and Related Drugs in Nucleus Accumbens Shell and Frontal Cortex
Carlezon, & Wise, R. A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-09-03112.1996 · Cited by 327 · see citing works
Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration
Weiss, F., Markou, A., Lorang, M. T., & Koob, G. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)91327-b · Cited by 318 · see citing works
Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect
Newton, S. S., Thome, J., Wallace, T. L., Shirayama, Y., Schlesinger, L., Sakai, N., Chen, J., Neve, R., Nestler, E. J., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10883.2002 · Cited by 313 · see citing works
Self-citation
The distribution of the mRNA and protein products of the melanin‐concentrating hormone (MCH) receptor gene, slc‐1, in the central nervous system of the rat
Hervieu, G. J., Cluderay, J. E., Harrison, D. C., Meakin, J., Maycox, P. R., Nasir, S., & Leslie, R. A. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00008.x · Cited by 307 · see citing works
Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant‐like effects
Shirayama, Y., Ishida, H., Iwata, M., Hazama, G., Kawahara, R., & Duman, R. S. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02589.x · Cited by 305 · see citing works
Self-citation
Nicotinic acetylcholine receptors as targets for antidepressants
Shytle, R. D., Silver, A. A., Lukas, R. J., Newman, M. B., Sheehan, D. V., & Sanberg, P. R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001035 · Cited by 279 · see citing works
Examination of the neurochemical substrates mediating the motivational effects of opioids: role of the mesolimbic dopamine system and D-1 vs. D-2 dopamine receptors.
Shippenberg, T. S., Bals-Kubik, R., & Herz, A. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38109-7 · Cited by 275 · see citing works
Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression
Papp, M., & Moryl, E. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90516-9 · Cited by 272 · see citing works
Reciprocal changes in prefrontal and limbic dopamine responsiveness to aversive and rewarding stimuli after chronic mild stress: implications for the psychobiology of depression.
Chiara, G. D., Loddo, P., & Tanda, G. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00236-x · Cited by 266 · see citing works
Antidepressant and anxiolytic‐like effects in mice lacking the group III metabotropic glutamate receptor mGluR7
Cryan, J. F., Kelly, P. H., Neijt, H. C., Sansig, G., Flor, P. J., & van der Putten, H. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02667.x · Cited by 266 · see citing works
MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity
Chaki, S., Yoshikawa, R., Hirota, S., Shimazaki, T., Maeda, M., Kawashima, N., Yoshimizu, T., Yasuhara, A., Sakagami, K., Okuyama, S., et al. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.10.009 · Cited by 254 · see citing works
Self-citation
Perfusate serotonin increases extracellular dopamine in the nucleus accumbens as measured by in vivo microdialysis
Parsons, L. H., & Justice, J. B. (1993) · Brain Research · doi:10.1016/0006-8993(93)90984-u · Cited by 253 · see citing works
Increased cerebrospinal fluid glutamine levels in depressed patients
Levine, J., Panchalingam, K., Rapoport, A., Gershon, S., McClure, R. J., & Pettegrew, J. W. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00284-x · Cited by 240 · cited 1× · see citing works
“In clinical studies, it has been reported that elevated glutamate levels were observed in plasma and cerebrospinal fluid of depressed patients [4,87,98], and the administration of antidepressants has been shown to decrease plasma glutamate levels significantly in patients diagnosed with depression [89].”
Background
The Ventral Tegmental Area Is Required for the Behavioral and Nucleus Accumbens Neuronal Firing Responses to Incentive Cues
Yun, I. A., Wakabayashi, K. T., Fields, H. L., & Nicola, S. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5282-03.2004 · Cited by 238 · see citing works
Role of 5-HT2C receptors in the control of central dopamine function
Matteo, V. D., Blasi, A. D., Giulio, C. D., & Esposito, E. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01688-6 · Cited by 233 · see citing works
Plasma and Platelet Amino Acid Concentrations in Patients Affected by Major Depression and under Fluvoxamine Treatment
Mauri, M. C., Ferrara, A., Boscati, L., Bravin, S., Zamberlan, F., Alecci, M., & INVERNIZZI, G. (1998) · Neuropsychobiology · doi:10.1159/000026491 · Cited by 231 · see citing works
Antidepressant-like actions of an AMPA receptor potentiator (LY392098)
Li, X., Tizzano, J. P., Griffey, K., Clay, M., Lindstrom, T., & Skolnick, P. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00194-5 · Cited by 225 · see citing works
Morphine and Cocaine Exert Common Chronic Actions on Tyrosine Hydroxylase in Dopaminergic Brain Reward Regions
Beitner‐Johnson, D., & Nestler, E. J. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02133.x · Cited by 212 · see citing works
Parallel changes in dopamine D2 receptor binding in limbic forebrain associated with chronic mild stress-induced anhedonia and its reversal by imipramine
Papp, M., Klimek, V., & Willner, P. (1994) · Psychopharmacology · doi:10.1007/bf02245566 · Cited by 202 · see citing works
Baclofen antagonizes nicotine‐, cocaine‐, and morphine‐induced dopamine release in the nucleus accumbens of rat
Fadda, P., Scherma, M., Fresu, A., Collu, M., & Fratta, W. (2003) · Synapse · doi:10.1002/syn.10238 · Cited by 197 · see citing works
Cue-Evoked Firing of Nucleus Accumbens Neurons Encodes Motivational Significance During a Discriminative Stimulus Task
Nicola, S. M., Yun, I. A., Wakabayashi, K. T., & Fields, H. L. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00657.2003 · Cited by 196 · see citing works
Ultrastructure of serotonin‐immunoreactive terminals in the core and shell of the rat nucleus accumbens: Cellular substrates for interactions with catecholamine afferents
Bockstaele, E. J. V., & Pickel, V. M. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903340408 · Cited by 196 · see citing works
Nicotine infused into the nucleus accumbens increases synaptic dopamine as measured by in vivo microdialysis
Mifsud, J.-C., Hernandez, L., & Hoebel, B. G. (1989) · Brain Research · doi:10.1016/0006-8993(89)91518-7 · Cited by 190 · see citing works
Novel allosteric antagonists shed light on mglu5 receptors and CNS disorders
Spooren, W. P. J. M., Gasparini, F., Salt, T. E., & Kuhn, R. R. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01694-1 · Cited by 190 · see citing works
Presynaptic dopamine D1 receptors attenuate excitatory and inhibitory limbic inputs to the shell region of the rat nucleus accumbens studied in vitro
Pennartz, C. M. A., der Weel, M. J. D.-V., Kitai, S. T., & Lopes, F. H. D. S. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.67.5.1325 · Cited by 186 · see citing works
Withdrawal following repeated exposure to d -amphetamine decreases responding for a sucrose solution as measured by a progressive ratio schedule of reinforcement
Barr, A. M., & Phillips, A. G. (1999) · Psychopharmacology · doi:10.1007/s002130050812 · Cited by 185 · see citing works
High Serotonin and 5‐Hydroxyindoleacetic Acid Levels in Limbic Brain Regions in a Rat Model of Depression; Normalization by Chronic Antidepressant Treatment
Zangen, A., Overstreet, D. H., & Yadid, G. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062477.x · Cited by 182 · see citing works
GABA receptors: are cellular differences reflected in function?
Matsumoto, R. R. (1989) · Brain Research Reviews · doi:10.1016/0165-0173(89)90001-5 · Cited by 182 · see citing works
Serum levels of excitatory amino acids, serine, glycine, histidine, threonine, taurine, alanine and arginine in treatment‐resistant depression: modulation by treatment with antidepressants and prediction of clinical responsivity
Maes, M. H. J., Verkerk, R. M., Vandoolaeghe, E., Lin, A., & Scharpé, S. (1998) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1998.tb10004.x · Cited by 179 · see citing works
Repeated electroconvulsive shocks and the brain content of endorphins
Hong, J., Gillin, J. C., Yang, H., et al. (1979) · Brain Research · doi:10.1016/0006-8993(79)90778-9 · Cited by 177 · see citing works
Association between depressive behavior and absence of serotonin-dopamine interaction in the nucleus accumbens
Zangen, A., Nakash, R., Overstreet, D. H., & Yadid, G. (2001) · Psychopharmacology · doi:10.1007/s002130100746 · Cited by 177 · see citing works
Cholinergic mechanisms in depression
Dilsaver, S. C. (1986) · Brain Research Reviews · doi:10.1016/0165-0173(86)90016-0 · Cited by 174 · see citing works
Fluoxetine Combined with a Serotonin-1A Receptor Antagonist Reversed Reward Deficits Observed during Nicotine and Amphetamine Withdrawal in Rats
Harrison, A. A. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00237-2 · Cited by 167 · see citing works
Implication of brain-derived neurotrophic factor in the release of dopamine and dopamine-related behaviors induced by methamphetamine
Narita, M., Aoki, K., Takagi, M., Yajima, Y., & Suzuki, T. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00099-x · Cited by 164 · see citing works
Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression
Overstreet, D. H., Puciłowski, O., Rezvani, A. H., & Janowsky, D. S. (1995) · Psychopharmacology · doi:10.1007/bf02245589 · Cited by 161 · see citing works
Selected executive skills in adolescents with recent first episode major depression
Kyte, Z. A., Goodyer, I. M., & Sahakian, B. J. (2005) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00400.x · Cited by 160 · see citing works
Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine
Hikida, T., Kitabatake, Y., Pastan, I. H., & Nakanishi, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0631749100 · Cited by 157 · see citing works
Clinical Studies Implementing Glutamate Neurotransmission in Mood Disorders
Sanacora, G., Rothman, D. L., Mason, G. F., & Krystal, J. H. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.018 · Cited by 157 · see citing works
A ‘crash’ course on psychostimulant withdrawal as a model of depression
Barr, A. M., Markou, A., & Phillips, A. G. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02086-2 · Cited by 156 · see citing works
Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments
Lammers, C.-H., Díaz, J., Jc, S., & Sokoloff, P. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000754 · Cited by 155 · see citing works
Selective breeding for increased cholinergic function: Development of a new animal model of depression
Overstreet, D. H. (1986) · Biological Psychiatry · doi:10.1016/0006-3223(86)90007-7 · Cited by 152 · see citing works
Serotonin-3 receptor and ethanol-stimulated dopamine release in the nucleus accumbens
Campbell, A. D., & McBride, W. J. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00050-7 · Cited by 149 · see citing works
Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice
Morishima, Y., Miyakawa, T., Furuyashiki, T., Tanaka, Y., Mizuma, H., & Nakanishi, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500914102 · Cited by 148 · see citing works
Transcranial magnetic stimulation induces increases in extracellular levels of dopamine and glutamate in the nucleus accumbens
Zangen, A., & Hyodo, K. (2002) · NeuroReport · doi:10.1097/00001756-200212200-00005 · Cited by 145 · see citing works
Reversal of stress-induced anhedonia by the dopamine receptor agonist, pramipexole
Willner, P., Lappas, S., Cheeta, S., & Muscat, R. (1994) · Psychopharmacology · doi:10.1007/bf02245568 · Cited by 142 · see citing works
The Regulation of Dopamine Transmission by Metabotropic Glutamate Receptors
Hu, G., Duffy, P., Swanson, C. J., Ghasemzadeh, M. B., & Kalivas, P. W. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38151-0 · Cited by 140 · see citing works
Antidepressantlike effects of chronic nicotine on learned helplessness paradigm in rats
Semba, J., Mataki, C., Yamada, S., Nankai, M., & Toru, M. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00477-0 · Cited by 140 · see citing works
Projection neurons of the nucleus accumbens: an intracellular labeling study
Chang, H. T., & Kitai, S. T. (1985) · Brain Research · doi:10.1016/0006-8993(85)90894-7 · Cited by 138 · see citing works
Long‐term behavioral and neurochemical effects of chronic stress exposure in rats
Mangiavacchi, S., Masi, F., Scheggi, S., Leggio, B., De Montis, M. G., & Gambarana, C. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00665.x · Cited by 137 · see citing works
Antidepressants Noncompetitively Inhibit Nicotinic Acetylcholine Receptor Function
Fryer, J. D., & Lukas, R. J. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0721117.x · Cited by 137 · see citing works
Hippocampal inputs to identified neurons in an in vitro slice preparation of the rat nucleus accumbens: evidence for feed-forward inhibition
Pennartz, C. M. A., & Kitai, S. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-09-02838.1991 · Cited by 137 · see citing works
GABA Transmission in the Nucleus Accumbens Is Altered after Withdrawal from Repeated Cocaine
Xi, Z., Ramamoorthy, S., Shen, H., LAKE, R. W., Samuvel, D. J., & Kalivas, P. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03498.2003 · Cited by 136 · see citing works
Limbic dopaminergic adaptation to a stressful stimulus in a rat model of depression
Yadid, G., Overstreet, D. H., & Zangen, A. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03248-0 · Cited by 135 · see citing works
Anxiolytic- and Antidepressant-Like Profile of ATC0065 and ATC0175: Nonpeptidic and Orally Active Melanin-Concentrating Hormone Receptor 1 Antagonists
Chaki, S., Funakoshi, T., Hirota-Okuno, S., Nishiguchi, M., Shimazaki, T., Iijima, M., Grottick, A. J., Kanuma, K., Omodera, K., Sekiguchi, Y., et al. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.081711 · Cited by 132 · see citing works
Self-citation
A Chronic Stress that Impairs Reactivity in Rats Also Decreases Dopaminergic Transmission in the Nucleus Accumbens: A Microdialysis Study
Gambarana, C., Masi, F., Tagliamonte, A., Scheggi, S., Ghiglieri, O., & Montis, M. G. D. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722039.x · Cited by 131 · see citing works
A distinct neurochemical profile in WKY rats at baseline and in response to acute stress: implications for animal models of anxiety and depression
Garza, R. D. L., & Mahoney, J. J. (2004) · Brain Research · doi:10.1016/j.brainres.2004.06.052 · Cited by 131 · see citing works
Neurobiology of Depression
Kim, Y. K. (2003) · Journal of the Korean Medical Association · doi:10.5124/jkma.2003.46.9.783 · Cited by 128 · see citing works
CART peptide-immunoreactive neurones in the nucleus accumbens in monkeys: Ultrastructural analysis, colocalization studies, and synaptic interactions with dopaminergic afferents
Smith, Y., Kieval, J. Z., Couceyro, P. R., & Kuhar, M. J. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990517)407:4 · Cited by 122 · see citing works
Opposite responses of mesolimbic dopamine system to controllable and uncontrollable aversive experiences
Cabib, S., & Puglisi‐Allegra, S. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-03333.1994 · Cited by 120 · see citing works
GABAergic modulation of learned helplessness
Petty, F., & Sherman, A. D. (1981) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(81)90210-0 · Cited by 117 · see citing works
Effect of antidepressant drugs on dopamine D 1 and D 2 receptor expression and dopamine release in the nucleus accumbens of the rat
Ainsworth, K., Smith, S. E., Zetterström, T., Pei, Q., Franklin, M., & Sharp, T. (1998) · Psychopharmacology · doi:10.1007/s002130050791 · Cited by 111 · see citing works
Intra-Accumbal Injection of CART (Cocaine-Amphetamine Regulated Transcript) Peptide Reduces Cocaine-Induced Locomotor Activity
Jaworski, J. N., Kozel, M. A., Philpot, K. B., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.052332 · Cited by 111 · see citing works
Localization of glial cell line-derived neurotrophic factor receptor alpha and c-ret mRNA in rat central nervous system
Glazner, G. W., Mu, X., & Springer, J. E. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980202)391:1 · Cited by 110 · see citing works
Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment
Dremencov, E., Newman, M. E., Kinor, N., Blatman‐Jan, G., Schindler, C. J., Overstreet, D. H., & Yadid, G. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.09.013 · Cited by 105 · see citing works
Mesolimbic dopamine super-sensitivity in melanin-concentrating hormone-1 receptor-deficient mice
Smith, D. G., Tzavara, E. T., Shaw, J., Luecke, S., Wade, M., Davis, R., Salhoff, C., Nomikos, G. G., & Gehlert, D. R. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4079-04.2005 · Cited by 103 · see citing works
Changes in dopamine receptor mRNA expression following chronic mild stress and chronic antidepressant treatment
Dziedzicka‐Wasylewska, M., Willner, P., & Papp, M. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199711000-00017 · Cited by 101 · see citing works
increased dopamine and serotonin metabolism in rat nucleus accumbens produced by intracranial self-stimulation of medial forebrain bundle as measured by in vivo microdialysis
Nakahara, D., Ozaki, N., Miura, Y., Miura, H., & Nagatsu, T. (1989) · Brain Research · doi:10.1016/0006-8993(89)91234-1 · Cited by 99 · see citing works
Extracellular acetylcholine is increased in the nucleus accumbens following the presentation of an aversively conditioned taste stimulus
Mark, G. P., Weinberg, J. B., Rada, P. V., & Hoebel, B. G. (1995) · Brain Research · doi:10.1016/0006-8993(95)00401-b · Cited by 97 · see citing works
Excitatory amino acid receptors within nucleus accumbens subregions differentially mediate spatial learning in the rat
Maldonado-Irizarry, C. S., & Kelley, A. E. (1995) · Behavioural Pharmacology · doi:10.1097/00008877-199508000-00013 · Cited by 91 · see citing works
Kappa Opioid Receptor Inhibition of Glutamatergic Transmission in the Nucleus Accumbens Shell
Hjelmstad, G. O., & Fields, H. L. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.3.1153 · Cited by 90 · see citing works
Antidepressant-like effects of the subtype-selective nicotinic acetylcholine receptor agonist, SIB-1508Y, in the learned helplessness rat model of depression
Ferguson, S. M., Brodkin, J. D., Kenneth Lloyd, G., & Menzaghi, F. (2000) · Psychopharmacology · doi:10.1007/s002130000531 · Cited by 85 · see citing works
Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place
Tran, A. H., Tamura, R., Uwano, T., Kobayashi, T., Katsuki, M., & Ono, T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409726102 · Cited by 83 · see citing works
Endogenous enkephalins, not endorphins, modulate basal hedonic state in mice
Skoubis, P. D., Lam, H. A., Shoblock, J. R., Narayanan, S., & Maidment, N. T. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03956.x · Cited by 82 · see citing works
Antidepressant-Like Effect of D2/3 Receptor-, but not D4 Receptor-Activation in the Rat Forced Swim Test
Basso, A. M., Gallagher, K. B., Bratcher, N. A., Brioni, J. D., Moreland, R. B., Hsieh, G. C., Drescher, K. U., Fox, G. B., Decker, M. W., & Rueter, L. E. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300677 · Cited by 79 · see citing works
Blunting of reactivity of dopamine transmission to palatable food: a biochemical marker of anhedonia in the CMS model?
Chiara, G. D., & Tanda, G. (1997) · Psychopharmacology · doi:10.1007/s002130050465 · Cited by 78 · see citing works
Activation of 5-HT2A/2C receptors within the nucleus accumbens increases local dopaminergic transmission
Yan, Q. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00208-7 · Cited by 77 · see citing works
Depletion of mesolimbic dopamine during behavioral despair: Partial reversal by chronic imipramine
Rossetti, Z. L., Lai, M., Hmaidan, Y., & Gessa, G. L. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90257-i · Cited by 76 · see citing works
Involvement of GABA and cholinergic receptors in the nucleus accumbens on feedback control of somatodendritic dopamine release in the ventral tegmental area
Rahman, S., & McBride, W. J. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00739.x · Cited by 75 · see citing works
Nicotine and nicotinic receptor antagonists potentiate the antidepressant‐like effects of imipramine and citalopram
Popik, P., Kozela, E., & Krawczyk, M. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705359 · Cited by 74 · see citing works
GABAergic dysfunction in mood disorders
Brambilla, P., Perez, J., Barale, F., Schettini, G., & Soares, J. C. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001395 · Cited by 73 · see citing works
Chronic antidepressant treatment increases enkephalin levels in n. accumbens and striatum of the rat
de Felipe, M. C., de Ceballos, M. L., Gil, C., & Fuentes, J. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90247-x · Cited by 67 · see citing works
Glutamate release in the nucleus accumbens is involved in behavioral depression during the Porsolt swim test
Rada, P. V., Moreno, S. A., Tucci, S. A., Gonzalez, L. E., Harrison, T., Chau, D. T., Hoebel, B. G., & Hernandez, L. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00162-3 · Cited by 67 · see citing works
Nucleus accumbens muscarinic receptors in the control of behavioral depression: antidepressant-like effects of local M1 antagonist in the Porsolt swim test
Chau, D. T., Rada, P. V., Kosloff, R. A., Taylor, J. L., & Hoebel, B. G. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00133-6 · Cited by 66 · see citing works
Multiple Behavioral Effects of Cocaine- and Amphetamine-Regulated Transcript (CART) Peptides in Mice: CART 42–89 and CART 49–89 Differ in Potency and Activity
Bannon, A. W., Seda, J., Carmouché, M., Francis, J. M., Jarosinski, M. A., & DOUGLASS, J. O. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29225-9 · Cited by 65 · see citing works
Apathy is Associated With Volume of the Nucleus Accumbens in Patients Infected With HIV
Paul, R. H., Brickman, A. M., NAVIA, B. A., et al. (2005) · Journal of Neuropsychiatry · doi:10.1176/jnp.17.2.167 · Cited by 61 · see citing works
Dopamine Excites Nucleus Accumbens Neurons through the Differential Modulation of Glutamate and GABA Release
Hjelmstad, G. O. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3280-04.2004 · Cited by 59 · see citing works
Melanin‐Concentrating Hormone Receptor Mutations and Human Obesity: Functional Analysis
Gibson, W. T., Pissios, P., Trombly, D. J., et al. (2004) · Obesity Research · doi:10.1038/oby.2004.89 · Cited by 58 · see citing works
Nicotinic acetylcholine receptor antagonist effect of fluoxetine in rat hippocampal slices
Hennings, E. C. P., Kiss, J. P., & Vizi, E. S. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00343-0 · Cited by 55 · see citing works
Selective modifications in the nucleus accumbens of dopamine synaptic transmission in rats exposed to chronic stress
Scheggi, S., Leggio, B., Masi, F., Grappi, S., Gambarana, C., Nanni, G., Rauggi, R., & Montis, M. G. D. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01193.x · Cited by 53 · see citing works
Stressor-induced alterations in serotonergic activity in an animal model of depression
Connor, T. J., Song, C., Leonard, B. E., Anisman, H., & Merali, Z. (1999) · Neuroreport · doi:10.1097/00001756-199902250-00015 · Cited by 48 · see citing works
Review of placebo-controlled trials with bupropion.
Zung, W. W. K. (1983) · PubMed · Cited by 47 · see citing works
Brain Region Specific Alterations in the Protein and mRNA Levels of Protein Kinase A Subunits in the Post-Mortem Brain of Teenage Suicide Victims
Pandey, G. N., Dwivedi, Y., Ren, X., Rizavi, H. S., Mondal, A. C., Shukla, P. K., & Conley, R. R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300765 · Cited by 45 · see citing works
On the role of endogenous GABA in the forced swimming test in rats
Borsini, F., Mancinelli, A., D'Aranno, V., Evangelista, S., & Meli, A. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90156-6 · Cited by 43 · see citing works
The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals
Fusa, K., Takahashi, I., Watanabe, S., et al. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.016 · Cited by 39 · see citing works
Antidepressant-like actions of intra-accumbens infusions of allopregnanolone in ovariectomized Wistar rats
Molina-Hernández, M., Téllez-Alcántara, N. P., García, J. P., Lopez, J. I. O., & Jaramillo, M. T. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.11.017 · Cited by 37 · see citing works
Repeated cocaine treatment alters tyrosine hydroxylase in the rat nucleus accumbens
Todtenkopf, M. S., Leon, K. R. D., & Stellar, J. R. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00277-x · Cited by 35 · see citing works
Differential effects of melanin concentrating hormone on the central dopaminergic neurons induced by the cocaine‐ and amphetamine‐regulated transcript peptide
Yang, S.-C., & Shieh, K. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02896.x · Cited by 27 · see citing works
Differential effects of chronic imipramine and fluoxetine on basal and amphetamine-induced extracellular dopamine levels in rat nucleus accumbens
Ichikawa, J., Kuroki, T., & Meltzer, H. Y. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00247-7 · Cited by 26 · see citing works
GABAA and GABAB receptors in the nucleus accumbens shell differentially modulate dopamine and acetylcholine receptor-mediated turning behaviour
Akiyama, G., Ikeda, H., Matsuzaki, S., et al. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.02.007 · Cited by 25 · see citing works
Brain-derived neurotrophic factor in the ventral midbrain–nucleus accumbens pathway: a role in depression
Eisch, A. J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00869-2 · Cited by 25 · see citing works
Chronic dietary treatment with antidepressants decrease brain Met-enkephalin-like immunoreactivity in the rat
Kurumaji, A., Mitsushio, H., & Takashima, M. (1988) · Psychopharmacology · doi:10.1007/bf00176843 · Cited by 21 · see citing works
Adaptation of monoaminergic responses to phencyclidine in nucleus accumbens and prefrontal cortex following repeated treatment with fluoxetine or imipramine
Garza, R. D. L., Jentsch, J. D., Verrico, C. D., & Roth, R. H. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03772-1 · Cited by 18 · see citing works
Involvement of NMDA and AMPA/KA receptors in the nucleus accumbens core in instrumental learning guided by reward‐predictive cues
Giertler, C., Bohn, I., & Hauber, W. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03983.x · Cited by 15 · see citing works
Effect of chronic mild stress and prolonged treatment with imipramine on the levels of endogenous Met-enkephalin in the rat dopaminergic mesolimbic system.
Dziedzicka‐Wasylewska, M., & Papp, M. (1997) · PubMed · Cited by 13 · see citing works
Antidepressant modulation of isolation and restraint stress effects on brain chemistry and morphology
McEwen, B. S., Angulo, J. A., Gould, E., Mendelson, S. D., & Watanabe, Y. (1993) · European Psychiatry · doi:10.1017/s092493380000537x · Cited by 8 · see citing works

Flagged first, then by citations

Research works printed but not linked: 3

American Psychiatric Association. (1994) Diagnostic and Statisti- cal Manual of Mental Disorders, 4 th Edition. Washington DC, American Psychiatric Press.
Garattini, S. (1997) Pharmacology of amineptine, an antidepressant agent acting on the dopaminergic system: a review. Int. Clin. Psy- chopharmacol., 12 (Suppl 3), S15-S19.
Kelley, A.E., Smith-Roe, S.L., Holahan, M.R. (1997) Response- reinforcement learning is dependent on N-methyl-D-aspartate recep- tor activation in the nucleus accumbens core. Proc. Natl. Acad. Sci. USA, 94, 12174-12179.

Sorted by citations

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Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation
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Self-citation
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“Evidence suggests that dopamine activity is low at such times (Shirayama and Chaki, 2006).”
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Authors: Shirayama, Y., & Chaki, S.
Affiliations: Tottori University (JP)
Chiba University (JP)
ORCID: Shirayama, Yukihiko
Chaki, Shigeyuki
Venue: Current Neuropharmacology
Publisher: Bentham Science Publishers Ltd.
Published: 2006-10-01
Volume: 4
Issue: 4
Pages: 277-291
ISSN: 1570-159X (ISSN-L)
DOI: 10.2174/157015906778520773
PMC: PMC2475798
OpenAlex: W2076866333
Cited by: 225
References: 150
Citations by year: 2026: 4 · 2025: 9 · 2024: 8 · 2023: 8 · 2022: 9 · 2021: 16 · 2020: 13 · 2019: 17 · 2018: 16 · 2017: 15 · 2016: 19 · 2015: 13 · 2014: 11 · 2013: 16 · 2012: 12
FWCI: 1.27
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Current Neuropharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: nucleus accumbens, depression, antidepressant action, anhedonia, brain reward system, dopamine, glutamate, GABA, acetylcholine, serotonin, dynorphin, enkephalin, brain-derived neurotrophic factor, CREB, melanin-concentrating hormone, cocaine- and amphetamine-regulated transcript, stress, drug withdrawal, neurotransmitters, neuropeptides

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Neurochemistry of the nucleus accumbens and its relevance to depression and antidepressant action in rodents

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