Cited by 81Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchMemory Processes and Influences

Fear learning induces persistent facilitation of amygdala synaptic transmission

Schroeder, Bradley W., Shinnick‐Gallagher, Patricia·2005·European Journal of Neuroscience

Abstract

In the maintenance phase of fear memory, synaptic transmission is potentiated and the stimulus requirements and signalling mechanisms are altered for long‐term potentiation (LTP) in the cortico‐lateral amygdala (LA) pathway. These findings link amygdala synaptic plasticity to the coding of fear memories. Behavioural experiments suggest that the amygdala serves to store long‐term fear memories. Here we provide electrophysiological evidence showing that synaptic alterations in rats induced by fear conditioning are evident in vitro 10 days after fear conditioning. We show that synaptic transmission was facilitated and that high‐frequency stimulation dependent LTP (HFS–LTP) of the cortico‐lateral amygdala pathway remained attenuated 10 days following fear conditioning. Additionally, we found that the low‐frequency stimulation dependent LTP (LFS–LTP) measured 24 h after fear conditioning was absent 10 days post‐training. The persistent facilitation of synaptic transmission and occlusion of HFS–LTP suggests that, unlike hippocampal coding of contextual fear memory, the cortico‐lateral amygdala synapse is involved in the storage of long‐term fear memories. However, the absence of LFS–LTP 10 days following fear conditioning suggests that amygdala physiology 1 day following fear learning may reflect a dynamic state during memory stabilization that is inactive during the long‐term storage of fear memory. Results from these experiments have significant implications regarding the locus of storage for maladaptive fear memories and the synaptic alterations induced by these memories.

Integrity signals

Registry

Crossref · 10.1111/j.1460-9568.2005.04343.x

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 54 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Schroeder, B. W., & Shinnick‐Gallagher, P.
Affiliations
The University of Texas Medical Branch at Galveston (US)
Corresponding author
Shinnick‐Gallagher, Patricia
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2005-10
Volume
22
Issue
7
Pages
1775-1783
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
OpenAlex
W2033726811
Cited by
81
References
54
Citations by year
2026: 2 · 2025: 1 · 2024: 4 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 8 · 2014: 5 · 2013: 6 · 2012: 3
FWCI
2.15
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5f30mh067458-02)
  • National Institute of Mental Health (F 30 MH067458, MH58327, R01MH058327)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
fear memory, amygdala, synaptic transmission, long-term potentiation, fear conditioning, synaptic plasticity, memory storage, memory stabilization, low-frequency stimulation, high-frequency stimulation, contextual fear
MeSH terms
Amygdala, Analysis of Variance, Animals, Behavior, Animal, Dose-Response Relationship, Radiation, Electric Stimulation, Fear, Learning, Male, Synaptic Transmission, Time Factors, Rats, Sprague-Dawley, Excitatory Postsynaptic Potentials, Rats, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review