Cited by 324Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Fear Conditioning Occludes LTP-Induced Presynaptic Enhancement of Synaptic Transmission in the Cortical Pathway to the Lateral Amygdala

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Tsvetkov, Evgeny, Carlezon, William A., Benes, Francine M., Kandel, Eric R., Bolshakov, Vadim Y.·2002·Neuron

Abstract

Auditory information critical for fear conditioning, a model of emotional learning, is conveyed to the lateral nucleus of the amygdala via two routes: directly from the medial geniculate nucleus and indirectly from the auditory cortex. Here we show in the cortico-amygdala pathway that learned fear occludes electrically induced long-term potentiation (LTP). Quantal analysis of the expression of LTP in this pathway reveals a significant presynaptic component reflected in an increase in probability of transmitter release. Conditioned fear also is accompanied by the enhancement in transmitter release at this cortico-amygdala synapse. These results indicate that the synaptic projections from the auditory cortex to the lateral amygdala are modified during the acquisition and expression of fear to auditory stimulation, thus further strengthening the proposed link between LTP in the auditory pathways to the amygdala and learned fear.

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Crossref · 10.1016/s0896-6273(02)00645-1

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Authors
Tsvetkov, E., Carlezon, W. A., Benes, F. M., Kandel, E. R., & Bolshakov, V. Y.
Affiliations
  • Harvard University (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Bolshakov, Vadim Y.
Venue
Neuron
Publisher
Elsevier BV
Published
2002-04
Volume
34
Issue
2
Pages
289-300
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2040002918
Cited by
321
References
51
Citations by year
2026: 2 · 2025: 10 · 2024: 9 · 2023: 4 · 2022: 2 · 2021: 7 · 2020: 10 · 2019: 10 · 2018: 11 · 2017: 16 · 2016: 7 · 2015: 19 · 2014: 21 · 2013: 22 · 2012: 10
FWCI
8.19
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (R01DA012736, DA12736)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
fear conditioning, long-term potentiation, lateral amygdala, auditory cortex, medial geniculate body, synaptic transmission, emotional learning, auditory fear
MeSH terms
Amygdala, Animals, Cerebral Cortex, Conditioning, Psychological, Electrophysiology, Fear, Neural Pathways, Synaptic Transmission, Synapses, Rats, Sprague-Dawley, Presynaptic Terminals, Long-Term Potentiation, Rats, In Vitro Techniques

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