The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Rat Models of Type 1 Diabetes: Genetics, Environment, and Autoimmunity
Open accessAbstract
For many years, the vast amount of data gathered from analysis of nonobese diabetic (NOD) and congenic NOD mice has eclipsed interest in the rat for the study of type 1 diabetes. The study of rat models has continued, however, and recently there has been a reanimation of interest for several reasons. First, genetic analysis of the rat has accelerated. Ian4L1, cblb, and Iddm4 are now known to play major roles in rat autoimmunity. Second, rats are amenable to study the interactions of genetics and environment that may be critical for disease expression in humans. Environmental perturbants that predictably enhance the expression of rat autoimmune diabetes include viral infection, toll-like receptor ligation, and depletion of regulatory T cell populations. Finally, data generated in the rat have correctly predicted the outcome of several human diabetes prevention trials, notably the failure of nicotinamide and low dose parenteral and oral insulin therapies.
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Cites
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
THE NOD MOUSE: A Model of Immune Dysregulation
Anderson, M. S., & Bluestone, J. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115643 · Cited by 1,113
Effects of insulin in relatives of patients with type 1 diabetes mellitus
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012350 · Cited by 836
Effects of Oral Insulin in Relatives of Patients With Type 1 Diabetes
The Diabetes Prevention Trial-Type 1 Study Group (2005) · Diabetes Care · doi:10.2337/diacare.28.5.1068 · Cited by 668
The NOD mouse model of type 1 diabetes: As good as it gets?
Atkinson, M. A., & Leiter, E. H. (1999) · Nature Medicine · doi:10.1038/9442 · Cited by 588
Redondo, M. J., Yu, L., Hawa, M., Mackenzie, T., Pyke, D. A., Eisenbarth, G. S., & Leslie, R. D. G. (2001) · Diabetologia · doi:10.1007/s001250051626 · Cited by 322
Cited by
Katsarou, A., Gudbjörnsdottir, S., Rawshani, A., Dabelea, D., Bonifacio, E., Anderson, B. J., Jacobsen, L. M., Schatz, D. A., & Lernmark, Å. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.16 · Cited by 1,475
The use of animal models in diabetes research
King, A. J. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01911.x · Cited by 1,303
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
Nakayama, M., Abiru, N., Moriyama, H., Babaya, N., Liu, E., Miao, D., Yu, L., Wegmann, D. R., Hutton, J. C., Elliott, J. F., et al. (2005) · Nature · doi:10.1038/nature03523 · Cited by 758
Interactions Between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes
Musso, G., Gambino, R., & Cassader, M. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-012510-175505 · Cited by 598
A Comprehensive Review of Interventions in the NOD Mouse and Implications for Translation
Shoda, L. K. M., Young, D. L., Ramanujan, S., Whiting, C. C., Atkinson, M. A., Bluestone, J. A., Eisenbarth, G. S., Mathis, D., Rossini, A. A., Campbell, S. E., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.08.002 · Cited by 317
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Metadata
- Authors
- Mordes, J. P., Bortell, R., Blankenhorn, E. P., Rossini, A. A., & Greiner, D. L.
- Venue
- ILAR Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-01-01
- Volume
- 45
- Issue
- 3
- Pages
- 278-291
- ISSN
- 1084-2020 (ISSN-L)
- OpenAlex
- W2104491684
- Cited by
- 218
- References
- 6
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mordes, J. P., Bortell, R., Blankenhorn, E. P., Rossini, A. A., & Greiner, D. L. (2004). Rat Models of Type 1 Diabetes: Genetics, Environment, and Autoimmunity. ILAR Journal. https://doi.org/10.1093/ilar.45.3.278
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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