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Cited by 111Microbial infections and disease researchStreptococcal Infections and TreatmentsInfluenza Virus Research Studies

Bacterial adherence to virus-infected cells: a cell culture model of bacterial superinfection.

Sanford, B. A., Shelokov, A., Ramsay, M. A.·1978·Journal of Infectious Diseases
DOI 10.1093/infdis/137.2.176
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Abstract

MDCK cells (a line of stable canine kidney cells) infected with influenza A/NWS/33 virus (a neurotropic variant of the Wilson Smith strain) were tested with 18 selected bacterial species to determine whether mammalian cells become susceptible to bacterial adherence as a result of virus infection. Cell monolayers were washed and examined microscopically for adherence. Bacteria of only two of 18 species were seen to adhere to the infected cells: a group B Streptococcus and Streptococcus sanguis. Control monolayers were negative for adherence. Pretreatment of virus-infected cultures with mouse ascitic fluid containing antibody to influenza A virus completely blocked adherence of the bacteria. Further testing with the strains representative of the five serotypes of group B Streptococcus disclosed that adherence occurred with types Ia, Ic, and II, but not with types Ib and III.

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Crossref · 10.1093/infdis/137.2.176

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  • Exposure of apical receptors like integrins permits adhesion of bacteria such as S. aureus and P. aeruginosa.

    “For example the exposure of apical receptors like integrins permit the adhesion of bacteria such as S. aureus and P. aeruginosa (Sanford et al., 1978; Davison and Sanford, 1981; Bucior et al., 2012; Smith and McCullers, 2014).”

    From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Sanford et al., 1978

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Authors
Sanford, B. A., Shelokov, A., & Ramsay, M. A.
Affiliations
The University of Texas at San Antonio Health Science Center (US)
Venue
Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
1978-02-01
Volume
137
Issue
2
Pages
176-181
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1093/infdis/137.2.176
OpenAlex
W2010644991
Cited by
111
References
16
Citations by year
2023: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 4 · 2014: 5 · 2013: 2 · 2012: 4
FWCI
8.12
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Keywords
bacterial adhesion, superinfection, influenza A virus, Streptococcus agalactiae, Streptococcus sanguinis, viral-bacterial coinfection, antibody inhibition, serotypes, MDCK cells, cell culture model
MeSH terms
Adhesiveness, Cell Transformation, Viral, Cells, Cultured, Hemadsorption, Hemadsorption Inhibition Tests, Influenza A virus, Bacterial Physiological Phenomena

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