. Plasma levels of soluble CD14 independently predict mortality in HIV infection.

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559

CD4+ Count–Guided Interruption of Antiretroviral Treatment

The Strategies for Management of Antiretroviral Therapy (SMART) Study Group (2006) · New England Journal of Medicine · doi:10.1056/nejmoa062360 · Cited by 2,250

CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract

Brenchley, J. M., Schacker, T. W., Ruff, L. E., Price, D. A., Taylor, J. H., Beilman, G. J., Nguyen, P. L., Khoruts, A., Larson, M. C., Haase, A. T., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040874 · Cited by 1,836

. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection.

Kuller, L. H., Tracy, R., Belloso, W., Wit, S. D., Drummond, F., Lane, H. C., Ledergerber, B., Lundgren, J., Neuhaus, J., Nixon, D., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050203 · Cited by 1,617

Gastrointestinal Tract as a Major Site of CD4 + T Cell Depletion and Viral Replication in SIV Infection

Veazey, R. S., DeMaria, M. A., Chalifoux, L. V., Shvetz, D. E., Pauley, D. R., Knight, H., Rosenzweig, M., Johnson, R. P., Desrosiers, R. C., & Lackner, A. A. (1998) · Science · doi:10.1126/science.280.5362.427 · Cited by 1,404

LPS, TLR4 and infectious disease diversity

Miller, S., Ernst, R. K., & Bader, M. W. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1068 · Cited by 1,059

Shorter Survival in Advanced Human Immunodeficiency Virus Type 1 Infection Is More Closely Associated with T Lymphocyte Activation than with Plasma Virus Burden or Virus Chemokine Coreceptor Usage

Giorgi, J. V., Hultin, L. E., McKeating, J. A., Johnson, T. D., Owens, B. M., Jacobson, L. P., Shih, R., Lewis, J., Wiley, D. J., Phair, J. P., et al. (1999) · The Journal of Infectious Diseases · doi:10.1086/314660 · Cited by 1,032

T Cell Activation Is Associated with Lower CD4+T Cell Gains in Human Immunodeficiency Virus–Infected Patients with Sustained Viral Suppression during Antiretroviral Therapy

Hunt, P. W., Martin, J. N., Sinclair, E., Bredt, B. M., Hagos, E., Lampiris, H. W., & Deeks, S. G. (2003) · The Journal of Infectious Diseases · doi:10.1086/374786 · Cited by 852

Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load

Deeks, S. G., Ramirez, C. M., Liu, L., Guo, H., Gascon, R., Narváez, A. B., Hunt, P. W., Martin, J. N., Kahn, J. S., Levy, J. A., et al. (2004) · Blood · doi:10.1182/blood-2003-09-3333 · Cited by 803

Plasma Levels of Bacterial DNA Correlate with Immune Activation and the Magnitude of Immune Restoration in Persons with Antiretroviral‐Treated HIV Infection

Jiang, W., Lederman, M. M., Hunt, P. W., Sieg, S. F., Haley, K. P., Rodriguez, B. A., LANDAY, A. L., Martin, J. N., Sinclair, E., Asher, A. I., et al. (2009) · The Journal of Infectious Diseases · doi:10.1086/597476 · Cited by 598

Viremic and Virologically Suppressed HIV Infection Increases Age-Related Changes to Monocyte Activation Equivalent to 12 and 4 Years of Aging, Respectively

Angelovich, T. A., Hearps, A. C., Maisa, A., Martin, G. E., Lichtfuss, G. F., Cheng, W., Palmer, C. S., LANDAY, A. L., Crowe, S. M., & Jaworowski, A. (2015) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000559 · Cited by 44

HIV , highly active antiretroviral therapy and the heart: a cellular to epidemiological review

Lambert, C., Sandesara, P. B., Hirsh, B. J., Shaw, L. J., Lewis, W., Quyyumi, A. A., Schinazi, R., Post, W. S., & Sperling, L. S. (2015) · HIV Medicine · doi:10.1111/hiv.12346 · Cited by 44

HIV infection: focus on the innate immune cells

Espíndola, M. S., Soares, L. S., Galvão-Lima, L. J., Zambuzi, F. A., Cacemiro, M. D. C., Brauer, V. S., & Frantz, F. G. (2016) · Immunologic Research · doi:10.1007/s12026-016-8862-2 · Cited by 48

Why the HIV Reservoir Never Runs Dry: Clonal Expansion and the Characteristics of HIV-Infected Cells Challenge Strategies to Cure and Control HIV Infection

Lau, C., Adan, M. A., & Maldarelli, F. M. (2021) · Viruses · doi:10.3390/v13122512 · Cited by 45

Microbial Translocation and Cardiometabolic Risk Factors in HIV Infection

Trøseid, M., Manner, I. W., Pedersen, K. K., Haissman, J. M., Kvale, D., & Nielsen, S. D. (2014) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2013.0280 · Cited by 42

Antibiotic and Antiinflammatory Therapy Transiently Reduces Inflammation and Hypercoagulation in Acutely SIV-Infected Pigtailed Macaques

Pandrea, I., Xu, C., Stock, J. L., Frank, D. N., Ma, D., Policicchio, B. B., He, T., Kristoff, J., Cornell, E. S., Haret-Richter, G. S., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005384 · Cited by 43

Impact of HIV infection and smoking on lung immunity and related disorders

Rossouw, T. M., Anderson, R., & Feldman, C. H. (2015) · European Respiratory Journal · doi:10.1183/13993003.00353-2015 · Cited by 43

CCR6− regulatory T cells blunt the restoration of gut Th17 cells along the CCR6–CCL20 axis in treated HIV-1-infected individuals

Loiseau, C., Réquena, M., Mavigner, M., Cazabat, M., Carrère, N., Suc, B., Barange, K., Alric, L., Marchou, B., Massip, P., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.7 · Cited by 44

Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection

Haissman, J. M., Haugaard, A. K., Ostrowski, S. R., Berge, R. K., Hov, J. R., Trøseid, M., & Nielsen, S. D. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-017-2547-x · Cited by 45

An altered cytotoxic program of CD8+ T-cells in HIV-infected patients despite HAART-induced viral suppression

Perdomo-Celis, F., Velilla, P. A., Taborda, N. A., & Rugeles, M. T. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210540 · Cited by 45

Fecal and Circulating Biomarkers for the Non-Invasive Assessment of Intestinal Permeability

Pérez-Díaz-del-Campo, N., Castelnuovo, G., Ribaldone, D. G., & Caviglia, G. P. (2023) · Diagnostics · doi:10.3390/diagnostics13111976 · Cited by 48

Monocytes Expand with Immune Dysregulation and Is Associated with Insulin Resistance in Older Individuals with Chronic HIV

Shikuma, C. M., Chow, D. C., Gangcuangco, L. M. A., Zhang, G., Keating, S. M., Norris, P. J., Seto, T. B., Parikh, N. I., Kallianpur, K. J., Nakamoto, B. K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090330 · Cited by 41

Relationships Between Inflammation, Immune Activation, and Bone Health Among HIV-Infected Adults on Stable Antiretroviral Therapy

Erlandson, K. M., O’Riordan, M. A., Labbato, D. E., & McComsey, G. A. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000005 · Cited by 42

Applications and Limitations of Inflammatory Biomarkers for Studies on Neurocognitive Impairment in HIV Infection

Cassol, E., Misra, V., Morgello, S., & Gabuzda, D. H. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9512-2 · Cited by 44

Elevated Plasma Soluble CD14 and Skewed CD16+ Monocyte Distribution Persist despite Normalisation of Soluble CD163 and CXCL10 by Effective HIV Therapy: A Changing Paradigm for Routine HIV Laboratory Monitoring?

Castley, A. S. L., Berry, C., French, M. A., Fernández, S., Krueger, R. G., & Nolan, D. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115226 · Cited by 42

Geriatric Syndromes in Older Adults Living with HIV and Cognitive Impairment

Hosaka, K. R. J., Greene, M. L., Premeaux, T. A., Javandel, S., Allen, I. E., Ndhlovu, L. C., & Valcour, V. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16034 · Cited by 45

African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity

Raehtz, K. D., Barrenäs, F., Xu, C., Busman‐Sahay, K., Valentine, A., Law, G. L., Ma, D., Policicchio, B. B., Wijewardana, V., Brocca‐Cofano, E., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008333 · Cited by 42

Gastrointestinal Dysfunction and HIV Comorbidities

Sim, J. H., Mukerji, S. S., Russo, S. C., & Lo, J. (2021) · Current HIV/AIDS Reports · doi:10.1007/s11904-020-00537-8 · Cited by 40

Changes in Inflammatory and Atherogenesis Biomarkers With the 2-Drug Regimen Dolutegravir Plus Lamivudine in Antiretroviral Therapy–Experienced, Virologically Suppressed People With HIV-1: A Systematic Literature Review

Llibre, J. M., Cahn, P. E., Lo, J., Barber, T., Mussini, C., van Welzen, B. J., Hernandez, B., Donovan, C., Kisare, M., Sithamparanathan, M., et al. (2022) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofac068 · Cited by 40

Monocytes in HIV and SIV Infection and Aging: Implications for Inflamm-Aging and Accelerated Aging

Wallis, Z. K., & Williams, K. C. (2022) · Viruses · doi:10.3390/v14020409 · Cited by 41

Circulating Levels of Tissue Factor Microparticle Procoagulant Activity Are Reduced With Antiretroviral Therapy and Are Associated With Persistent Inflammation and Coagulation Activation Among HIV-Positive Patients

Baker, J. V., Hullsiek, K. H., Bradford, R. L., Prosser, R., Tracy, R. P., & Key, N. S. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3182910121 · Cited by 41

Late Antiretroviral Therapy (ART) Initiation Is Associated with Long-Term Persistence of Systemic Inflammation and Metabolic Abnormalities

Ghislain, M., Bastard, J., Meyer, L., Capeau, J., Fellahi, S., Gérard, L., May, T., Simon, A., Vigouroux, C., Goujard, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144317 · Cited by 41

Does systemic inflammation and immune activation contribute to fracture risk in HIV?

McGinty, T., Mirmonsef, P., Mallon, P. W. G., & LANDAY, A. L. (2016) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000275 · Cited by 41

Altered Monocyte and Endothelial Cell Adhesion Molecule Expression Is Linked to Vascular Inflammation in Human Immunodeficiency Virus Infection

Kulkarni, M., Bowman, E., Gabriel, J., Amburgy, T., Mayne, E. S., Zidar, D. A., Maierhofer, C., Turner, A. N., Bazan, J. A., Koletar, S. L., et al. (2016) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofw224 · Cited by 41

Mucosal IgA Responses: Damaged in Established HIV Infection—Yet, Effective Weapon against HIV Transmission

Kulkarni, V., & Ruprecht, R. M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01581 · Cited by 41

A prospective study of serum microbial translocation biomarkers and risk of AIDS-related non-Hodgkin lymphoma

Epeldegui, M., Magpantay, L. I., Guo, Y., Halec, G., Cumberland, W. G., Yen, P. K., Macatangay, B. J. C., Margolick, J. B., Rositch, A. F., Wolinsky, S. M., et al. (2018) · AIDS · doi:10.1097/qad.0000000000001771 · Cited by 41

Dynamic Shifts in the HIV Proviral Landscape During Long Term Combination Antiretroviral Therapy: Implications for Persistence and Control of HIV Infections

Anderson, E. M., Simonetti, F. R., Gorelick, R. J., Hill, S., Gouzoulis, M. A., Bell, J., Rehm, C. A., Pérez, L., Boritz, E., Wu, X., et al. (2020) · Viruses · doi:10.3390/v12020136 · Cited by 41

LPS-Binding Protein and IL-6 Mark Paradoxical Tuberculosis Immune Reconstitution Inflammatory Syndrome in HIV Patients

Goovaerts, O., Jennes, W., Loembé, M. M., Ceulemans, A., Worodria, W. O., Mayanja‐Kizza, H., Colebunders, R., Kestens, L., & the TB-IRIS Study Group (2013) · PLoS ONE · doi:10.1371/journal.pone.0081856 · Cited by 40

High Soluble CD14 Levels at Primary HIV-1 Infection Predict More Rapid Disease Progression

Krastinova, E., Lécuroux, C., Leroy, C., Seng, R., Cabie, A., Rami, A., Venet, A., Meyer, L., & Goujard, C. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv145 · Cited by 40

A prospective study of endothelial activation biomarkers, including plasma angiopoietin-1 and angiopoietin-2, in Kenyan women initiating antiretroviral therapy

Graham, S. M., Rajwans, N., Tapia, K. A., Jaoko, W. G., Estambale, B. B. A., McClelland, R. S., Overbaugh, J. M., & Liles, W. C. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-263 · Cited by 41

Macrophages in Progressive Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections

DiNapoli, S. R., Hirsch, V. M., & Brenchley, J. M. (2016) · Journal of Virology · doi:10.1128/jvi.00672-16 · Cited by 42

During Hepatitis C Virus (HCV) Infection and HCV-HIV Coinfection, an Elevated Plasma Level of Autotaxin Is Associated With Lysophosphatidic Acid and Markers of Immune Activation That Normalize During Interferon-Free HCV Therapy

Kostadinova, L., Shive, C. L., Judge, C. J., Zebrowski, E., Compan, A., Rife, K. M., Hirsch, A., Falck-Ytter, Y. T., Schlatzer, D., Li, X., et al. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw372 · Cited by 40

From Wasting to Obesity: The Contribution of Nutritional Status to Immune Activation in HIV Infection

Koethe, J. R., Heimburger, D. C., PrayGod, G., & Filteau, S. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw286 · Cited by 40

Coronary Artery Disease in HIV-Infected Patients: Downside of Living Longer

Lacson, J. C. A., Barnes, R. P., & Bahrami, H. (2017) · Current Atherosclerosis Reports · doi:10.1007/s11883-017-0651-4 · Cited by 40

Altered Intestinal Permeability and Fungal Translocation in Ugandan Children With Human Immunodeficiency Virus

Dirajlal‐Fargo, S., Kamari, V. E., Weiner, L. D., Shan, L., Sattar, A., Kulkarni, M., Funderburg, N., Nazzinda, R., Karungi, C. K., Kityo, C. M., et al. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz561 · Cited by 40

Persistence of monocyte activation under treatment in people followed since acute HIV-1 infection relative to participants at high or low risk of HIV infection

Novelli, S., Lécuroux, C., Goujard, C., Reynes, J., Villemant, A., Blum, L., Essat, A., Avettand-Fènoël, V., Launay, O., Molina, J., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.103129 · Cited by 40

Sitagliptin Reduces Inflammation and Chronic Immune Cell Activation in HIV+ Adults With Impaired Glucose Tolerance

Best, C. J., Struthers, H., Laciny, E., Royal, M., Reeds, D. N., & Yarasheski, K. E. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1531 · Cited by 40

Bovine immunoglobulin protein isolates for the nutritional management of enteropathy

Petschow, B. W. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i33.11713 · Cited by 40

Influence of Common Mucosal Co‐Factors on HIV Infection in the Female Genital Tract

Ferreira, V. H., Kafka, J. K., & Kaushic, C. (2014) · American Journal of Reproductive Immunology · doi:10.1111/aji.12221 · Cited by 43

Short Intracellular HIV-1 Transcripts as Biomarkers of Residual Immune Activation in Patients on Antiretroviral Therapy

Ishizaka, A., Sato, H., Nakamura, H., Koga, M., Kikuchi, T., Hosoya, N., Koibuchi, T., Nomoto, A., Kawana‐Tachikawa, A., & Mizutani, T. (2016) · Journal of Virology · doi:10.1128/jvi.03158-15 · Cited by 39

Soluble CD14, CD163, and CD27 biomarkers distinguish ART-suppressed youth living with HIV from healthy controls

Williams, J., Zhang, X., Karki, M., Chi, Y., Wallet, S. M., Rudy, B. J., Nichols, S., Goodenow, M. M., & Sleasman, J. W. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3a0717-294rr · Cited by 39

Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging

Belkina, A. C., Starchenko, A., Drake, K., Proctor, E. A., Pihl, R. M. F., Olson, A., Lauffenburger, D. A., Lin, N., & Snyder-Cappione, J. E. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02783 · Cited by 39

The Role of Statins in the Setting of HIV Infection

Eckard, A. R., & McComsey, G. A. (2015) · Current HIV/AIDS Reports · doi:10.1007/s11904-015-0273-9 · Cited by 38

Dissecting Drivers of Immune Activation in Chronic HIV-1 Infection

Streeck, H., Maestri, A., Habermann, D., Crowell, T. A., Esber, A. L., Son, G., Eller, L. A., Eller, M. A., Parikh, A. P., Horn, P. A., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2022.104182 · Cited by 38

HIV/neuroAIDS biomarkers

Rahimian, P., & He, J. J. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.003 · Cited by 39

Lower Pretreatment Gut Integrity Is Independently Associated With Fat Gain on Antiretroviral Therapy

Kamari, V. E., Moser, C., Hileman, C. O., Currier, J. S., Brown, T. T., Johnston, L., Hunt, P. W., & McComsey, G. A. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy716 · Cited by 38

Diet Quality Is Low and Differs by Sex in People with HIV

Weiss, J. J., Sánchez, L. P., Hubbard, J. L., Lo, J., Grinspoon, S. K., & Fitch, K. V. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy241 · Cited by 38

Gut epithelial impairment, microbial translocation and immune system activation in inflammatory bowel disease–associated spondyloarthritis

Luchetti, M. M., Ciccia, F., Avellini, C., Benfaremo, D., Rizzo, A. G., Spadoni, T., Svegliati, S., Marzioni, D., Santinelli, A., Costantini, A., et al. (2020) · Rheumatology · doi:10.1093/rheumatology/keaa164 · Cited by 39

Macrophage maturation from blood monocytes is altered in people with HIV, and is linked to serum lipid profiles and activation indices: A model for studying atherogenic mechanisms

Bowman, E., Cameron, C., Richardson, B., Kulkarni, M., Gabriel, J., Cichon, M. J., Riedl, K. M., Mustafa, Y., Cartwright, M. J., Snyder, B., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008869 · Cited by 41

HIV Infection and the Risk of World Health Organization–Defined Sudden Cardiac Death

Freiberg, M. S., Duncan, M. S., Alcorn, C., Chang, C. H., Kundu, S., Mumpuni, A., Smith, E. K., Loch, S. F., Bedigian, A., Vittinghoff, E., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.021268 · Cited by 38

Integrase Inhibitors Partially Restore Bacterial Translocation, Inflammation and Gut Permeability Induced by HIV Infection: Impact on Gut Microbiota

Villoslada-Blanco, P., Pérez‐Matute, P., Íñiguez, M., Recio‐Fernández, E., Blanco-Navarrete, P., Metola, L., Ibarra, V., Machado‐Alba, J. E., de Toro, M., & Oteo, J. A. (2022) · Infectious Diseases and Therapy · doi:10.1007/s40121-022-00654-4 · Cited by 38

Switch to raltegravir decreases soluble CD14 in virologically suppressed overweight women: the W omen, I ntegrase and F at A ccumulation T rial

Lake, J. E., McComsey, G., Hulgan, T., Wanke, C., Mangili, A., Walmsley, S. L., Stramotas, S., Tracy, R. P., & Currier, J. (2014) · HIV Medicine · doi:10.1111/hiv.12128 · Cited by 40

The Effect of Hepatitis C Virologic Clearance on Cardiovascular Disease Biomarkers in Human Immunodeficiency Virus/Hepatitis C Virus Coinfection

Chew, K. W., Hua, L., Bhattacharya, D., Butt, A. A., Bornfleth, L. D., Chung, R. T., Andersen, J. W., & Currier, J. S. (2014) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofu104 · Cited by 38

Increased Gut Microbial Translocation in HIV-infected Children Persists in Virologic Responders and Virologic Failures After Antiretroviral Therapy

Pilakka‐Kanthikeel, S., Huang, S., Fenton, T., Borkowsky, W., Cunningham, C. K., & Pahwa, S. G. (2012) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e31824da0f5 · Cited by 38

Detection of Microbial Translocation in HIV and SIV Infection Using the Limulus Amebocyte Lysate Assay is Masked by Serum and Plasma

Balagopal, A., Gama, L., Franco, V., Russell, J. N., Quinn, J., Higgins, Y., Smeaton, L. M., Clements, J. E., Thomas, D. L., Gupta, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041258 · Cited by 38

Association of microbial translocation biomarkers with clinical outcome in controllers HIV-infected patients

León, A., Leal, L., Torres, B., Lucero, C., Inciarte, A., Arnedo, M., Plana, M., Vilà, J., Gatell, J. M., & García, F. (2015) · AIDS · doi:10.1097/qad.0000000000000596 · Cited by 37

Loss of a Tyrosine-Dependent Trafficking Motif in the Simian Immunodeficiency Virus Envelope Cytoplasmic Tail Spares Mucosal CD4 Cells but Does Not Prevent Disease Progression

Breed, M. W., Jordan, A. P. O., Aye, P. P., Lichtveld, C. F., Midkiff, C. C., Schiro, F. R., Haggarty, B., Sugimoto, C., Alvarez, X. A., Utay, N. S., et al. (2012) · Journal of Virology · doi:10.1128/jvi.01928-12 · Cited by 36

Gut epithelial barrier dysfunction in human immunodeficiency virus-hepatitis C virus coinfected patients: Influence on innate and acquired immunity

Márquez-Coello, M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i4.1433 · Cited by 40

The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques

Laforge, M., Silvestre, R., Rodrigues, V., Garibal, J., Campillo-Gimenez, L., Mouhamad, S., Monceaux, V., Cumont, M., Rabezanahary, H., Pruvost, A., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95127 · Cited by 41

Lipidome Abnormalities and Cardiovascular Disease Risk in HIV Infection

Bowman, E., & Funderburg, N. (2019) · Current HIV/AIDS Reports · doi:10.1007/s11904-019-00442-9 · Cited by 38

Monocyte Based Correlates of Immune Activation and Viremia in HIV-Infected Long-Term Non-Progressors

Prabhu, V. M., Singh, A. K., Padwal, V., Nagar, V. S., Patil, P., & Patel, V. V. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02849 · Cited by 37

An Inflammatory Story: Antibodies in Tuberculosis Comorbidities

McLean, M. R., Lu, L. L., Kent, S. J., & Chung, A. W. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02846 · Cited by 37

HIV-1 Is Not a Major Driver of Increased Plasma IL-6 Levels in Chronic HIV-1 Disease

Shive, C. L., Biancotto, A., Funderburg, N., Pilch-Cooper, H. A., Valdez, H., Margolis, L. B., Sieg, S. F., McComsey, G. A., Rodriguez, B. A., & Lederman, M. M. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31825ddbbf · Cited by 37

Diagnosis of subclinical atherosclerosis in HIV-infected patients: higher accuracy of the D:A:D risk equation over Framingham and SCORE algorithms

Villar, S. S., Estrada, V., Gómez‐Garré, D., Ávila, M., Fuentes, M. E., San, R. J., Soriano, V., Sánchez-Parra, C., Sainz, T., & Fernández‐Cruz, A. (2012) · European Journal of Preventive Cardiology · doi:10.1177/2047487312452964 · Cited by 37

Inflammation Strikes Again: Frailty and HIV

Fukui, S. M., Piggott, D. A., & Erlandson, K. M. (2018) · Current HIV/AIDS Reports · doi:10.1007/s11904-018-0372-5 · Cited by 39

A Review of Management of Inflammation in the HIV Population

Slim, J., & Saling, C. F. (2016) · BioMed Research International · doi:10.1155/2016/3420638 · Cited by 35

A pilot study of brisk walking in sedentary combination antiretroviral treatment (cART)- treated patients: benefit on soluble and cell inflammatory markers

Bonato, M., Galli, L., Passeri, L., Longo, V., Pavei, G., Bossolasco, S., Bertocchi, C., Cernuschi, M., Balconi, G., Merati, G., et al. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-016-2095-9 · Cited by 38

Anti-Human Immunodeficiency Virus Antibodies in the Cerebrospinal Fluid: Evidence of Early Treatment Impact on Central Nervous System Reservoir?

Burbelo, P. D., Price, R. W., Hagberg, L., Hatano, H., Spudich, S., Deeks, S. G., & Gisslén, M. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix662 · Cited by 36

Incomplete ART adherence is associated with higher inflammation in individuals who achieved virologic suppression in the START study

Castillo‐Mancilla, J., Phillips, A. N., Neaton, J. D., Neuhaus, J., Sharma, S., Baker, J. V., Collins, S., Mannheimer, S., Pett, S. L., Touzeau‐Römer, V., et al. (2019) · Journal of the International AIDS Society · doi:10.1002/jia2.25297 · Cited by 38

Dual therapy combining raltegravir with etravirine maintains a high level of viral suppression over 96 weeks in long-term experienced HIV-infected individuals over 45 years on a PI-based regimen: results from the Phase II ANRS 163 ETRAL study

Katlama, C., Assoumou, L., Valantin, M., Soulié, C., Martínez, E., Béniguel, L., Bouchaud, O., Raffi, F., Molina, J., Fellahi, S., et al. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz224 · Cited by 36

Impact of Acute HIV Infection and Early Antiretroviral Therapy on the Human Gut Microbiome

Sortino, O., Phanuphak, N., Schuetz, A., Ortiz, A. M., Chomchey, N., Belkaid, Y., Davis, J., Mystakelis, H. A., Quiñones, M., Deléage, C., et al. (2019) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofz367 · Cited by 36

Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques

Manuzak, J. A., Zevin, A. S., Cheu, R. K., Richardson, B., Modesitt, J., Hensley‐McBain, T., Miller, C. J., Gustin, A. T., Coronado, E., Gott, T., et al. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0238-1 · Cited by 37

γδ T Cells Are Involved in Acute HIV Infection and Associated with AIDS Progression

Li, Z., Li, W., Li, N., Jiao, Y., Chen, D., Cui, L., Hu, Y., Wu, H., & He, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106064 · Cited by 35

Clinical outcomes and antiretroviral therapy in ‘elite’ controllers: a review of the literature

Crowell, T. A., & Hatano, H. (2015) · Journal of Virus Eradication · doi:10.1016/s2055-6640(20)30488-x · Cited by 35

Efavirenz is associated with higher bone mass in South African children with HIV

Arpadi, S. M., Shiau, S., Strehlau, R., Patel, F., Mbete, N., McMahon, D. J., Kaufman, J. J., Coovadia, A. H., Kuhn, L., & Yin, M. T. (2016) · AIDS · doi:10.1097/qad.0000000000001204 · Cited by 35

Microbial Translocation Associated with an Acute-Phase Response and Elevations in MMP-1, HO-1, and Proinflammatory Cytokines in Strongyloides stercoralis Infection

Rajamanickam, A., Munisankar, S., Bhootra, Y., Dolla, C., Nutman, T. B., & Babu, S. (2016) · Infection and Immunity · doi:10.1128/iai.00772-16 · Cited by 37

Targeting Cannabinoid Receptor 2 on Peripheral Leukocytes to Attenuate Inflammatory Mechanisms Implicated in HIV-Associated Neurocognitive Disorder

Rizzo, M. D., Henriquez, J. E., Blevins, L. K., Bach, A. P., Crawford, R. B., & Kaminski, N. E. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-020-09918-7 · Cited by 35

Increased Microbial Translocation in ≤180 Days Old Perinatally Human Immunodeficiency Virus-positive Infants as Compared With Human Immunodeficiency Virus-exposed Uninfected Infants of Similar Age

Papasavvas, E., Azzoni, L., Foulkes, A. S., Violari, A., Cotton, M. F., Pistilli, M., Reynolds, G., Yin, X., Glencross, D. K., Stevens, W. S., et al. (2011) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e31821d141e · Cited by 35

Prospective Analysis of Lipid Composition Changes with Antiretroviral Therapy and Immune Activation in Persons Living with HIV

Belury, M. A., Bowman, E., Gabriel, J., Snyder, B., Kulkarni, M., Palettas, M. S., Mo, X. M., Lake, J. E., Zidar, D. A., Sieg, S. F., et al. (2017) · Pathogens and Immunity · doi:10.20411/pai.v2i3.218 · Cited by 35

Kinetics of Microbial Translocation Markers in Patients on Efavirenz or Lopinavir/r Based Antiretroviral Therapy

Vesterbacka, J., Nowak, P., Barqasho, B., Abdurahman, S., Nyström, J., Nilsson, S., Funaoka, H., Kanda, T., Andersson, L., Gisslén, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055038 · Cited by 36

Circulating Biomarkers of Immune Activation Distinguish Viral Suppression from Nonsuppression in HAART-Treated Patients with Advanced HIV-1 Subtype C Infection

Malherbe, G. P., Steel, H. C., Cassol, S. A., de Oliveira, T., Seebregts, C. J., Anderson, R., Cassol, E., & Rossouw, T. M. (2014) · Mediators of Inflammation · doi:10.1155/2014/198413 · Cited by 38

Reduced CD14 expression on classical monocytes and vascular endothelial adhesion markers independently associate with carotid artery intima media thickness in chronically HIV-1 infected adults on virologically suppressive anti-retroviral therapy

Barbour, J. D., Jalbert, E., Chow, D. C., Gangcuangco, L. M. A., Norris, P. J., Keating, S. M., Heitman, J. W., Nagamine, L. S., Seto, T. B., Ndhlovu, L. C., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.10.021 · Cited by 35

Hospitalizations among HIV controllers and persons with medically controlled HIV in the U.S. Military HIV Natural History Study

Crowell, T. A., Ganesan, A., Berry, S. A., Deiss, R., Agan, B. K., & Okulicz, J. F. (2016) · Journal of the International AIDS Society · doi:10.7448/ias.19.1.20524 · Cited by 34

Human Immunodeficiency Virus 1 and Type I Interferons—Where Sex Makes a Difference

Ziegler, S. M., & Altfeld, M. A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01224 · Cited by 34

Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells

Mudd, J. C., Busman‐Sahay, K., DiNapoli, S. R., Lai, S. Y., Sheik, V., Lisco, A., Deléage, C., Richardson, B., Palesch, D., Paiardini, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05528-3 · Cited by 34

A Low Frequency of IL-17-Producing CD8+ T-Cells Is Associated With Persistent Immune Activation in People Living With HIV Despite HAART-Induced Viral Suppression

Perdomo-Celis, F., Feria, M. G., Taborda, N. A., & Rugeles, M. T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02502 · Cited by 34

Inflammatory and cardiovascular diseases biomarkers in chronic hepatitis C virus infection: A review

Babiker, A., Hassan, M. S., Muhammed, S., Taylor, G. H., Poonia, B., Shah, A. S. V., & Bagchi, S. (2019) · Clinical Cardiology · doi:10.1002/clc.23299 · Cited by 33

Mechanisms of systemic low-grade inflammation in HIV patients on long-term suppressive antiretroviral therapy: the inflammasome hypothesis

Guerville, F., Vialemaringe, M., Cognet, C., Duffau, P., Lazaro, E., Cazanave, C., Bonnet, F., Leleux, O., Rossignol, R., Pinson, B., et al. (2023) · AIDS · doi:10.1097/qad.0000000000003546 · Cited by 36

Bone Health in HIV-Infected Children, Adolescents and Young Adults: A Systematic Review

Arpadi, S. M. (2014) · Journal of AIDS & Clinical Research · doi:10.4172/2155-6113.1000374 · Cited by 34

Monitoring cellular immune markers in HIV infection

Sauce, D., Elbim, C., & Appay, V. (2013) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32835d08a9 · Cited by 36

Immune activation and neuroinflammation in alcohol use and HIV infection: evidence for shared mechanisms

Monnig, M. A. (2016) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2016.1211667 · Cited by 35

HIV-associated gut microbial alterations are dependent on host and geographic context

Rocafort, M., Gootenberg, D. B., Luévano, J. M., Paer, J. M., Hayward, M. R., Bramante, J. T., Ghebremichael, M. S., Xu, J., Rogers, Z. H., Munoz, A. R., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44566-4 · Cited by 33

Determinants of Progression to AIDS and Death Following HIV Diagnosis: A Retrospective Cohort Study in Wuhan, China

Jiang, H., Xie, N., Cao, B., Tan, L., Fan, Y., Zhang, F., Yao, Z., Liu, L., & Nie, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083078 · Cited by 33

Differential alterations of the CD4 and CD8 T cell subsets in HIV-infected patients on highly active antiretroviral therapy with low CD4 T cell restoration

Méndez‐Lagares, G., García‐Pergañeda, A., Pozo‐Balado, M. D. M., Genebat, M., Ruíz-Mateos, E., García, M., Muñoz‐Fernández, M. Á., Pacheco, Y. M., & Leal, M. (2012) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr594 · Cited by 33

Interleukin-37 Expression Is Increased in Chronic HIV-1-Infected Individuals and Is Associated with Inflammation and the Size of the Total Viral Reservoir

Højen, J. F., Rasmussen, T. A., Andersen, K. L. D., Winckelmann, A. A., Laursen, R. R., Gunst, J. D., Møller, H. J., Fujita, M., Østergaard, L. J., Søgaard, O. S., et al. (2015) · Molecular Medicine · doi:10.2119/molmed.2015.00031 · Cited by 33

Is low‐level HIV ‐1 viraemia associated with elevated levels of markers of immune activation, coagulation and cardiovascular disease?

Elvstam, O., Medstrand, P., Jansson, M., Isberg, P.-E., Gisslén, M., & Björkman, P. (2019) · HIV Medicine · doi:10.1111/hiv.12756 · Cited by 33

Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infections

Saini, P., Adeniji, O. S., & Abdel‐Mohsen, M. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104354 · Cited by 32

Elite control of HIV: is this the right model for a functional cure?

Cockerham, L. R., & Hatano, H. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2014.11.003 · Cited by 32

Using the Pathogenic and Nonpathogenic Nonhuman Primate Model for Studying Non-AIDS Comorbidities

Pandrea, I., LANDAY, A. L., Wilson, C. C., Stock, J. L., Tracy, R. P., & Apetrei, C. (2015) · Current HIV/AIDS Reports · doi:10.1007/s11904-014-0245-5 · Cited by 32

Distinct gut microbiota profile in antiretroviral therapy-treated perinatally HIV-infected patients associated with cardiac and inflammatory biomarkers

Sessa, L., Reddel, S., Manno, E. C., Quagliariello, A., Cotugno, N., CHIERICO, F. D., Amodio, D., Capponi, C., Leone, F., Bernardi, S., et al. (2019) · AIDS · doi:10.1097/qad.0000000000002131 · Cited by 32

Predict Mortality in

(2016)

High Soluble CD14 Levels at Primary HIV-1 Infection Predict More Rapid Disease Progression

Krastinova, E., Lécuroux, C., Leroy, C., Seng, R., Cabie, A., Rami, A., Venet, A., Meyer, L., & Goujard, C. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv145 · Cited by 40

Elevated Levels of Serum-Soluble CD14 in Human Immunodeficiency Virus Type 1 (HIV-1) Infection: Correlation to Disease Progression and Clinical Events

Lien, E., Aukrust, P., Sundan, A., Müller, F., Frøland, S. S., & Espevik, T. (1998) · Blood · doi:10.1182/blood.v92.6.2084 · Cited by 172

Association of Plasma Soluble Vascular Cell Adhesion Molecule-1 and sCD14 With Mortality in HIV-1–Infected West African Adults With High CD4 Counts

Affi, R., Gabillard, D., Dunyach‐Remy, C., Ntakpe, J.-B., Moh, R., Badjé, A., Kouamé, G. M., Karcher, S., Carrou, J. L., Danel, C., et al. (2020) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002533 · Cited by 11

Study of the plasma levels of soluble CD14 in HIV infected patients

Maes, N. (2012) · Document Server@UHasselt (UHasselt)