Common and diverse features of cocirculating type 2 and 3 recombinant vaccine-derived polioviruses isolated from patients with poliomyelitis and healthy children.

Joffret, Marie-Line; Jégouic, Sophie; Bessaud, Maël; Balanant, Jean; Tran, Coralie; Caro, Valerie; Holmblat, Barbara; Razafindratsimandresy, Richter; Reynes, Jean-Marc; Rakoto-Andrianarivelo, Mala; Delpeyroux, Francis

doi:10.1093/infdis/jis204

Cited by 44Viral Infections and Immunology ResearchVirology and Viral DiseasesEvolution and Genetic Dynamics

Common and diverse features of cocirculating type 2 and 3 recombinant vaccine-derived polioviruses isolated from patients with poliomyelitis and healthy children.

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Joffret, Marie-Line, Jégouic, Sophie, Bessaud, Maël, Balanant, Jean, Tran, Coralie, Caro, Valerie, Holmblat, Barbara, Razafindratsimandresy, Richter +3 more·2012·The Journal of Infectious Diseases

DOI 10.1093/infdis/jis204

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Abstract

BACKGROUND: Five cases of poliomyelitis due to type 2 or 3 recombinant vaccine-derived polioviruses (VDPVs) were reported in the Toliara province of Madagascar in 2005. METHODS: We sequenced the genome of the VDPVs isolated from the patients and from 12 healthy children and characterized phenotypic aspects, including pathogenicity, in mice transgenic for the poliovirus receptor. RESULTS: We identified 6 highly complex mosaic recombinant lineages composed of sequences derived from different vaccine polioviruses and other species C human enteroviruses (HEV-Cs). Most had some recombinant genome features in common and contained nucleotide sequences closely related to certain cocirculating coxsackie A virus isolates. However, they differed in terms of their recombinant characteristics or nucleotide substitutions and phenotypic features. All VDPVs were neurovirulent in mice. CONCLUSIONS: This study confirms the genetic relationship between type 2 and 3 VDPVs, indicating that both types can be involved in a single outbreak of disease. Our results highlight the various ways in which a vaccine-derived poliovirus may become pathogenic in complex viral ecosystems, through frequent recombination events and mutations. Intertypic recombination between cocirculating HEV-Cs (including polioviruses) appears to be a common mechanism of genetic plasticity underlying transverse genetic variability.

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The genomes of the VDPVs from the 2001-2002 and 2005 Madagascar outbreaks belong to several independent, complex mosaic recombinant lineages composed of sequences derived from vaccine polioviruses and other co-circulating species C human enteroviruses.
“The genomes of these VDPVs belong to several independent, complex mosaic recombinant lineages composed of sequences derived from vaccine polioviruses and other co-circulating species C human enteroviruses (human EV-C) (4,5).”
From Reemergence of Recombinant Vaccine–derived Polioviruses in Healthy Children, Madagascar (2013) · cites this paper as [5]
All these results indicated an intense circulation of enterovirus strains and a rapid evolution between PV and HEV-C, involving multiple rounds of intratypic and intertypic recombination in a short period of time and in a restricted geographic area.
“All these results indicated an intense circulation of enterovirus strains and a rapid evolution between PV and HEV-C, involving multiple rounds of intratypic and intertypic recombination in a short period of time and in a restricted geographic area [89,90].”
From Recombination between Poliovirus and Coxsackie A Viruses of Species C: A Model of Viral Genetic Plasticity and Emergence (2011) · cites this paper as [90]
The cVDPV of both types in Madagascar presented PV/HEV-C recombinant genomes, confirming that cVDPVs are associated with the co-circulation of HEV-Cs and with genetic exchanges between both partners.
“The cVDPV of both types presented PV/HEV-C recombinant genomes, confirming that cVDPVs are associated with the co-circulation of HEV-Cs and with genetic exchanges between both partners.”
From Recombination between Poliovirus and Coxsackie A Viruses of Species C: A Model of Viral Genetic Plasticity and Emergence (2011) · cites this paper as [90]
The finding that some recombinant cVDPV genomes have kept only the capsid genomic regions from the genuine OPV strains indicated that all the other parts of the genome can be shared by other HEV-Cs.
“The finding that some recombinant cVDPV genomes have kept only the capsid genomic regions from the genuine OPV strains [54,61,67,89,90] indicated that all the other parts of the genome can be shared by other HEV-Cs.”
From Recombination between Poliovirus and Coxsackie A Viruses of Species C: A Model of Viral Genetic Plasticity and Emergence (2011) · cites this paper as [90]
All recombinant cVDPV genomes described so far had kept at least the entire region encoding the capsid proteins of OPV strains (with more than 1% nt substitutions), and some or all of the rest of the genome, particularly the region encoding non-structural proteins, originates from other HEV-Cs.
“All recombinant cVDPV genomes described so far had kept at least the entire region encoding the capsid proteins of OPV strains (with more than 1% nt substitutions), and some or all of the rest of the genome, particularly the region encoding non-structural proteins, originates from other HEV-Cs [67,83,84,88–90].”
From Recombination between Poliovirus and Coxsackie A Viruses of Species C: A Model of Viral Genetic Plasticity and Emergence (2011) · cites this paper as [90]

Many type 2 VDPV lineages displayed a great part of their 5′NC region derived from non-OPV HEV-Cs.
“In addition, many type 2 VDPV lineages displayed a great part of their 5′NC region derived from non-OPV HEV-Cs.”
From Recombination between Poliovirus and Coxsackie A Viruses of Species C: A Model of Viral Genetic Plasticity and Emergence (2011) · cites this paper as [90]
Recombination sites could be found elsewhere in the P2 or the P3 region.
“Nevertheless, recombination sites could be found elsewhere in the P2 or the P3 region [89,90].”
From Recombination between Poliovirus and Coxsackie A Viruses of Species C: A Model of Viral Genetic Plasticity and Emergence (2011) · cites this paper as [90]
Tous ces virus ont un génome recombinant entre poliovirus et HEV-C, confirmant que l'émergence des souches circulantes de poliovirus dérivées du vaccin et la co-circulation des HEV-C vont de pair à Madagascar.
“Tous ces virus ont un génome recombinant entre PV et HEV-C, confirmant qu'émergence des cPVDV et co-circulation des HEV-C vont de pair à Madagascar [14, 15].”
From Éradication de la poliomyélite et émergence de poliovirus pathogènes dérivés du vaccin: De Madagascar au Cameroun (2013) · cites this paper as [15]
Les souches circulantes de poliovirus dérivées du vaccin de 2005 ont également des régions non structurales apparentées à CVA-17 et CVA-13 ; des séquences de CVA-11 pourraient être impliquées dans la recombinaison de manière ponctuelle.
“Les cPVDV de 2005 ont également des régions non structurales apparentées à ces deux types de CVA ; des séquences de CVA-11 pourraient être impliquées dans la recombinaison de manière ponctuelle [15].”
From Éradication de la poliomyélite et émergence de poliovirus pathogènes dérivés du vaccin: De Madagascar au Cameroun (2013) · cites this paper as [15]
Tous les cPVDV décrits peuvent être neutralisés par les anticorps protecteurs présents chez les individus vaccinés.
“tous les cPVDV décrits peuvent être neutralisés par les anticorps protecteurs présents chez les individus vaccinés”
From Éradication de la poliomyélite et émergence de poliovirus pathogènes dérivés du vaccin: De Madagascar au Cameroun (2013) · cites this paper as [15]
Les épidémies de cPVDV sont arrêtées par des campagnes de vaccination avec le VPO.
“les épidémies de cPVDV sont arrêtées par des campagnes de vaccination avec le VPO [6, 15].”
From Éradication de la poliomyélite et émergence de poliovirus pathogènes dérivés du vaccin: De Madagascar au Cameroun (2013) · cites this paper as [15]
Les génomes des souches circulantes de poliovirus dérivées du vaccin de type 2 de 2005 présentent des extrémités 5' semblables, avec des séquences HEV-C et des sites de recombinaison similaires.
“Les génomes des cPVDV de type 2 de 2005 présentent des extrémités 5' semblables, avec des séquences HEV-C et des sites de recombinaison similaires [15].”
From Éradication de la poliomyélite et émergence de poliovirus pathogènes dérivés du vaccin: De Madagascar au Cameroun (2013) · cites this paper as [15]
Certains génomes de souches circulantes de poliovirus dérivées du vaccin de type 2 et de type 3 ont des extrémités 3' recombinantes analogues présentant des séquences similaires et des sites de recombinaison identiques.
“De plus, certains génomes de cPVDV de type 2 et de type 3 ont des extrémités 3' recombinantes analogues présentant des séquences similaires et des sites de recombinaison identiques.”
From Éradication de la poliomyélite et émergence de poliovirus pathogènes dérivés du vaccin: De Madagascar au Cameroun (2013) · cites this paper as [15]
Les déterminants majeurs de l'atténuation des souches vaccinales Sabin, situés dans la région 5' non codante et affectant l'efficacité de la traduction, ont subi chez les cPVDV des réversions vers le génotype sauvage.
“les déterminants majeurs de l'atténuation des souches vaccinales Sabin, qui se trouvent dans la région 5' non codante et affectent l'efficacité de la traduction, ont subi, chez les cPVDV, des réversions vers le génotype sauvage [13, 15, 20].”
From Éradication de la poliomyélite et émergence de poliovirus pathogènes dérivés du vaccin: De Madagascar au Cameroun (2013) · cites this paper as [15]

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Reemergence of Recombinant Vaccine-Derived
(2016)

Authors: Joffret, M.-L., Jégouic, S., Bessaud, M., Balanant, J., Tran, C., Caro, V., Holmblat, B., Razafindratsimandresy, R., Reynes, J.-M., Rakoto-Andrianarivelo, M., & Delpeyroux, F.
Affiliations: Inserm (FR)
Institut Pasteur (FR)
Institut Pasteur de Madagascar (MG)
ORCID: Joffret, Marie-Line
Bessaud, Maël
Razafindratsimandresy, Richter
Reynes, Jean-Marc
Venue: The Journal of Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2012-03-28
Volume: 205
Issue: 9
Pages: 1363-1373
ISSN: 0022-1899 (ISSN-L)
1537-6613
DOI: 10.1093/infdis/jis204
OpenAlex: W2168311135
Cited by: 44
References: 37
Citations by year: 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 3
FWCI: 3.91
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: other-oa
Locations: The Journal of Infectious Diseases (publishedVersion, other-oa)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: vaccine-derived poliovirus, poliovirus type 2, poliovirus type 3, poliomyelitis, intertypic recombination, Coxsackie A virus, genetic mosaicism, neurovirulence, genome plasticity
MeSH terms: Animals, Child, Disease Outbreaks, Female, Humans, Madagascar, Male, Phenotype, Phylogeny, Poliomyelitis, Protein Conformation, Recombination, Genetic, RNA, Viral, Vaccines, Synthetic, Genome, Viral, Sequence Analysis, DNA, Poliovirus, Poliovirus Vaccines, Enterovirus C, Human, Mice

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Common and diverse features of cocirculating type 2 and 3 recombinant vaccine-derived polioviruses isolated from patients with poliomyelitis and healthy children.

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