The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The Distribution of HIV DNA and RNA in Cell Subsets Differs in Gut and Blood of HIV-Positive Patients on ART: Implications for Viral Persistence
Open accessAbstract
Even with optimal antiretroviral therapy, human immunodeficiency virus (HIV) persists in plasma, blood cells, and tissues. To develop new therapies, it is essential to know what cell types harbor residual HIV. We measured levels of HIV DNA, RNA, and RNA/DNA ratios in sorted subsets of CD4+ T cells (CCR7+, transitional memory, and effector memory) and non-CD4+ T leukocytes from blood, ileum, and rectum of 8 ART-suppressed HIV-positive subjects. Levels of HIV DNA/million cells in CCR7+ and effector memory cells were higher in the ileum than blood. When normalized by cell frequencies, most HIV DNA and RNA in the blood were found in CCR7+ cells, whereas in both gut sites, most HIV DNA and RNA were found in effector memory cells. HIV DNA and RNA were observed in non-CD4+ T leukocytes at low levels, particularly in gut tissues. Compared to the blood, the ileum had higher levels of HIV DNA and RNA in both CD4+ T cells and non-CD4+ T leukocytes, whereas the rectum had higher HIV DNA levels in both cell types but lower RNA levels in CD4+ T cells. Future studies should determine whether different mechanisms allow HIV to persist in these distinct reservoirs, and the degree to which different therapies can affect each reservoir.
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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BackgroundIdentification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
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Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
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Self-citationQuantification of latent tissue reservoirs and total body viral load in HIV-1 infection
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Cited by
International AIDS Society global scientific strategy: towards an HIV cure 2016
International AIDS Society Towards a Cure Working Group, Deeks, S. G., Lewin, S. R., Ross, A. L., Ananworanich, J., Benkirane, M., Cannon, P., Chomont, N., Douek, D., Lifson, J. D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4108 · Cited by 425
Self-citationKünzli, M., & Masopust, D. (2023) · Nature Immunology · doi:10.1038/s41590-023-01510-4 · Cited by 338
HIV persists throughout deep tissues with repopulation from multiple anatomical sources
Chaillon, A., Gianella, S., Dellicour, S., Rawlings, S. A., Schlub, T. E., De Oliveira, M. F., Ignacio, C., Porrachia, M., Vrancken, B., & Smith, D. M. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134815 · Cited by 250
Ait-Ammar, A., Kula, A., Darcis, G., Verdikt, R., De Wit, S., Gautier, V., Mallon, P. W. G., Marcello, A., Rohr, O., & Van Lint, C. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.03060 · Cited by 163
Vellas, C., Nayrac, M., Collercandy, N., Requena, M., Jeanne, N., Latour, J., Dimeglio, C., Cazabat, M., Barange, K., Alric, L., et al. (2024) · eBioMedicine · doi:10.1016/j.ebiom.2023.104954 · Cited by 17
Metadata
- Authors
- Yukl, S. A., Shergill, A. K., Ho, T., Killian, M., Girling, V., Epling, L., Li, P., Wong, L. K., Crouch, P., Deeks, S. G., Havlir, D. V., McQuaid, K., Sinclair, E., & Wong, J. K.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-07-12
- Volume
- 208
- Issue
- 8
- Pages
- 1212-1220
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2135817676
- Cited by
- 184
- References
- 5
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yukl, S. A., Shergill, A. K., Ho, T., Killian, M., Girling, V., Epling, L., Li, P., Wong, L. K., Crouch, P., Deeks, S. G., Havlir, D. V., McQuaid, K., Sinclair, E., & Wong, J. K. (2013). The Distribution of HIV DNA and RNA in Cell Subsets Differs in Gut and Blood of HIV-Positive Patients on ART: Implications for Viral Persistence. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jit308
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