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Gain-of-function mutant p53: history and speculation
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“Multiple studies, using either cellular models expressing specific p53 variants or mouse models, suggest an oncogenic GOF for specific p53 variants via the activation of specific pathways associated with metastasis, metabolic reprogramming, or cell differentiation [53].”
From The TP53 tumor suppressor gene: From molecular biology to clinical investigations (2025) · cites this paper as [53]
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Cited by
The TP53 tumor suppressor gene: From molecular biology to clinical investigations
Baliakas, P., & Soussi, T. (2025) · Journal of Internal Medicine · doi:10.1111/joim.20106 · Cited by 50
Small-molecule correctors and stabilizers to target p53
Fallatah, M. M. J., Law, F. V., Chow, W. A., & Kaiser, P. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.02.007 · Cited by 44
Vodicka, P., Andera, L., Opattova, A., & Vodickova, L. (2021) · Cancers · doi:10.3390/cancers13030479 · Cited by 39
Menendez, D., Anand, J. R., Murphy, C. C., Bell, W. J., Fu, J., Slepushkina, N., Buehler, E., Martin, S. E., Lal-Nag, M., Nitiss, J. L., et al. (2022) · Oncotarget · doi:10.18632/oncotarget.28195 · Cited by 22
Metadata
- Authors
- Bargonetti, J., & Prives, C.
- Affiliations
- Department of Biological Sciences Hunter College and The Graduate Center, City University of New York, New York, NY 10021, USA
- Department of Biological Sciences, Columbia University, New York, NY 10027, USA
- Venue
- Journal of Molecular Cell Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-07
- Volume
- 11
- Issue
- 7
- Pages
- 605-609
- ISSN
- 1759-4685
- Cited by
- 88
- References
- 4
- Language
- en
- Funders
- Breast Cancer Research Foundation (BCRF-18-011)
- National Institutes of Health-National Cancer Institute (CA87497)
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