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The Transactivation Domains of the p53 Protein
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“Phosphorylation of TAD has been shown to serve as a switch to rapidly turn p53 function on and off but also as a mechanism for a graded p53 response.276,277”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [277]
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Citations
Cites
Mdm2 promotes the rapid degradation of p53
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Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312 · cited 2×
“…protein, an E3 ubiquitin ligase that inhibits p53mediated transactivation both by binding and concealing the p53 TAD and by targeting p53 for ubiquitin-mediated proteolysis (Momand et al. 1992; Oliner et al. 1992; Chen et al. 1993a; Haupt et al. 1997; Honda et al. 1997; Kubbutat et al. 1997).”
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Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., & Pavletich, N. P. (1996) · Science · doi:10.1126/science.274.5289.948 · Cited by 2,206
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
Honda, R., Tanaka, H., & Yasuda, H. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01480-4 · Cited by 1,951
Amplification of a gene encoding a p53-associated protein in human sarcomas
Oliner, J. D., Kinzler, K. W., Meltzer, P. S., George, D. L., & Vogelstein, B. (1992) · Nature · doi:10.1038/358080a0 · Cited by 1,949
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
de Oca Luna, R. M., Wagner, D. S., & Lozano, G. (1995) · Nature · doi:10.1038/378203a0 · Cited by 1,420 · cited 1×
“5–11.5, respectively, because of inappropriate p53-driven apoptosis or cell-cycle arrest in embryos (Jones et al. 1995; Montes de Oca Luna et al. 1995; de Rozieres et al. 2000; Parant et al. 2001; Finch et al. 2002; Migliorini et al. 2002).”
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Cited by
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer
Mello, S. S., Valente, L. J., Raj, N., Seoane, J. A., Flowers, B. M., McClendon, J., Bieging-Rolett, K. T., Lee, J., Ivanochko, D., Kozak, M. M., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.09.007 · Cited by 179
Self-citationLarge-scale mapping and mutagenesis of human transcriptional effector domains
DelRosso, N., Tycko, J., Suzuki, P., Andrews, C., Aradhana, Mukund, A., Liongson, I., Ludwig, C., Spees, K., Fordyce, P., et al. (2023) · Nature · doi:10.1038/s41586-023-05906-y · Cited by 130
Targeting Therapies for the p53 Protein in Cancer Treatments
Levine, A. J. (2019) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055455 · Cited by 84
Structural Evolution and Dynamics of the p53 Proteins
Chillemi, G., Kehrloesser, S., Bernassola, F., Desideri, A., Dötsch, V., Levine, A. J., & Melino, G. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a028308 · Cited by 65
Metadata
- Authors
- Raj, N., & Attardi, L. D.
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2016-11-18
- Volume
- 7
- Issue
- 1
- Pages
- a026047
- ISSN
- 2157-1422
- Cited by
- 168
- References
- 18
- Language
- en
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