The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The p53 C Terminus Controls Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It stabilizes DNA binding, enhances binding to long genomic DNA sequences, and enhances the specificity for different p53 response elements.24-26”
From Mapping Interactions of the Intrinsically Disordered C-Terminal Regions of Tetrameric p53 by Segmental Isotope Labeling and NMR (2022) · cites this paper as [24]
In the citing paper
“It stabilizes DNA binding, enhances binding to long genomic DNA sequences, and enhances the specificity for different p53 response elements.24-26”
From Mapping Interactions of the Intrinsically Disordered C-Terminal Regions of Tetrameric p53 by Segmental Isotope Labeling and NMR (2022) · cites this paper as [24]
In the citing paper
“It stabilizes DNA binding, enhances binding to long genomic DNA sequences, and enhances the specificity for different p53 response elements.24-26”
From Mapping Interactions of the Intrinsically Disordered C-Terminal Regions of Tetrameric p53 by Segmental Isotope Labeling and NMR (2022) · cites this paper as [24]
In the citing paper
“Acetylation of the p53 CTD has been linked to differential gene activation.15,24,31,56”
From Mapping Interactions of the Intrinsically Disordered C-Terminal Regions of Tetrameric p53 by Segmental Isotope Labeling and NMR (2022) · cites this paper as [24]
In the citing paper
“An additional mechanism by which the CTD stabilizes p53 association to its binding sites is the ability of the CTD to induce conformational changes within the DBD following association with DNA (Laptenko et al. 2015).”
From Structural Evolution and Dynamics of the p53 Proteins (2017) · cites this paper as Laptenko et al. 2015
1 more claim about this paper
Create a free account to see every claim other papers make about this one.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163
Self-citationCrystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,551 · cited 3×
“This domain has been subjected to extensive biochemical analysis (Laptenko and Prives, 2006) and its structure has been solved (Cañadillas et al., 2006; Cho et al., 1994; Kitayner et al., 2006; Petty et al., 2011).”
BackgroundMethodTP53 mutations in human cancers: origins, consequences, and clinical use.
Olivier, M., Hollstein, M., & Hainaut, P. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001008 · Cited by 2,199 · cited 1×
“There is a wealth of knowledge about the structure and functions of the conserved central ‘‘core’’ DBD of the p53 protein wherein the vast majority of tumor-derived missense mutations are located (Olivier et al., 2010).”
BackgroundDefinition of a consensus binding site for p53
El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985
DNA damage activates p53 through a phosphorylation–acetylation cascade
Sakaguchi, K., Herrera, J. E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C. W., & Appella, E. (1998) · Genes & Development · doi:10.1101/gad.12.18.2831 · Cited by 1,204
A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome
Wei, C.-L., Wu, Q., Vega, V. B., Chiu, K. P., Ng, P., Zhang, T., Shahab, A., Yong, H. C., Fu, Y., Weng, Z., et al. (2006) · Cell · doi:10.1016/j.cell.2005.10.043 · Cited by 1,141
Feng, L., Lin, T., Uranishi, H., Gu, W., & Xu, Y. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5389-5395.2005 · Cited by 236
Solution structure of p53 core domain: Structural basis for its instability
Cañadillas, J. M. P., Tidow, H., Freund, S. M. V., Rutherford, T. J., Ang, H. C., & Fersht, A. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510941103 · Cited by 174
Menendez, D., Nguyen, T.-A., Freudenberg, J. M., Mathew, V. J., Anderson, C. W., Jothi, R., & Resnick, M. A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt504 · Cited by 154
DNA Binding Cooperativity of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis
Schlereth, K., Beinoraviciute-Kellner, R., Zeitlinger, M. K., Bretz, A. C., Sauer, M., Charles, J. P., Vogiatzi, F., Leich, E., Samans, B., Eilers, M., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.02.037 · Cited by 113
Research works printed but not linked: 57
- An, 2004, Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53, Cell, 117, 735, 10.1016/j.cell.2004.05.009 · DOI · Paper page
- Anderson, 1997, Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation, Mol. Cell. Biol., 17, 6255, 10.1128/MCB.17.11.6255 · DOI
- Ayed, 2001, Latent and active p53 are identical in conformation, Nat. Struct. Biol., 8, 756, 10.1038/nsb0901-756 · DOI
- Barlev, 2001, Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases, Mol. Cell, 8, 1243, 10.1016/S1097-2765(01)00414-2 · DOI · Paper page
- Beno, 2011, Sequence-dependent cooperative binding of p53 to DNA targets and its relationship to the structural properties of the DNA targets, Nucleic Acids Res., 39, 1919, 10.1093/nar/gkq1044 · DOI
- Botcheva, 2011, Distinct p53 genomic binding patterns in normal and cancer-derived human cells, Cell Cycle, 10, 4237, 10.4161/cc.10.24.18383 · DOI
- Chen, 1996, p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells, Genes Dev., 10, 2438, 10.1101/gad.10.19.2438 · DOI · Paper page
- Chuikov, 2004, Regulation of p53 activity through lysine methylation, Nature, 432, 353, 10.1038/nature03117 · DOI · Paper page
- Espinosa, 2001, Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment, Mol. Cell, 8, 57, 10.1016/S1097-2765(01)00283-0 · DOI · Paper page
- Frankel, 1991, Modular structure of transcription factors: implications for gene regulation, Cell, 65, 717, 10.1016/0092-8674(91)90378-C · DOI · Paper page
- Friedler, 2005, Modulation of binding of DNA to the C-terminal domain of p53 by acetylation, Structure, 13, 629, 10.1016/j.str.2005.01.020 · DOI · Paper page
- Frith, 2008, Discovering sequence motifs with arbitrary insertions and deletions, PLoS Comput. Biol., 4, e1000071, 10.1371/journal.pcbi.1000071 · DOI · Paper page
- Funk, 1992, A transcriptionally active DNA-binding site for human p53 protein complexes, Mol. Cell. Biol., 12, 2866
- Gopinath, 2007, Methods developed for SELEX, Anal. Bioanal. Chem., 387, 171, 10.1007/s00216-006-0826-2 · DOI · Paper page
- Gu, 1997, Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain, Cell, 90, 595, 10.1016/S0092-8674(00)80521-8 · DOI · Paper page
- Gu, 2001, Identification of p53 sequence elements that are required for MDM2-mediated nuclear export, Mol. Cell. Biol., 21, 8533, 10.1128/MCB.21.24.8533-8546.2001 · DOI
- Hager, 2009, Transcription dynamics, Mol. Cell, 35, 741, 10.1016/j.molcel.2009.09.005 · DOI · Paper page
- Hamard, 2012, p53 basic C terminus regulates p53 functions through DNA binding modulation of subset of target genes, J. Biol. Chem., 287, 22397, 10.1074/jbc.M111.331298 · DOI · Paper page
- Hamard, 2013, The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo, Genes Dev., 27, 1868, 10.1101/gad.224386.113 · DOI
- Hoh, 2002, The p53MH algorithm and its application in detecting p53-responsive genes, Proc. Natl. Acad. Sci. USA, 99, 8467, 10.1073/pnas.132268899 · DOI · Paper page
- Huggins, 2011, DECOD: fast and accurate discriminative DNA motif finding, Bioinformatics, 27, 2361, 10.1093/bioinformatics/btr412 · DOI
- Hupp, 1994, Allosteric activation of latent p53 tetramers, Curr. Biol., 4, 865, 10.1016/S0960-9822(00)00195-0 · DOI · Paper page
- Hupp, 1992, Regulation of the specific DNA binding function of p53, Cell, 71, 875, 10.1016/0092-8674(92)90562-Q · DOI · Paper page
- Ito, 2001, p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2, EMBO J., 20, 1331, 10.1093/emboj/20.6.1331 · DOI · Paper page
- Jayaraman, 1995, Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus, Cell, 81, 1021, 10.1016/S0092-8674(05)80007-8 · DOI · Paper page
- Joerger, 2008, Structural biology of the tumor suppressor p53, Annu. Rev. Biochem., 77, 557, 10.1146/annurev.biochem.77.060806.091238 · DOI · Paper page
- Kim, 2012, p53 requires an intact C-terminal domain for DNA binding and transactivation, J. Mol. Biol., 415, 843, 10.1016/j.jmb.2011.12.001 · DOI · Paper page
- Kitayner, 2006, Structural basis of DNA recognition by p53 tetramers, Mol. Cell, 22, 741, 10.1016/j.molcel.2006.05.015 · DOI · Paper page
- Krummel, 2005, The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation, Proc. Natl. Acad. Sci. USA, 102, 10188, 10.1073/pnas.0503068102 · DOI · Paper page
- Laptenko, 2006, Transcriptional regulation by p53: one protein, many possibilities, Cell Death Differ., 13, 951, 10.1038/sj.cdd.4401916 · DOI · Paper page
- Laptenko, 2003, Transcript cleavage factors GreA and GreB act as transient catalytic components of RNA polymerase, EMBO J., 22, 6322, 10.1093/emboj/cdg610 · DOI · Paper page
- Laptenko, 2011, p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation, Proc. Natl. Acad. Sci. USA, 108, 10385, 10.1073/pnas.1105680108 · DOI
- Larson, 2011, What do expression dynamics tell us about the mechanism of transcription?, Curr. Opin. Genet. Dev., 21, 591, 10.1016/j.gde.2011.07.010 · DOI
- Lee, 2000, Local structural elements in the mostly unstructured transcriptional activation domain of human p53, J. Biol. Chem., 275, 29426, 10.1074/jbc.M003107200 · DOI · Paper page
- Li, 2002, Acetylation of p53 inhibits its ubiquitination by Mdm2, J. Biol. Chem., 277, 50607, 10.1074/jbc.C200578200 · DOI · Paper page
- Lohrum, 2001, C-terminal ubiquitination of p53 contributes to nuclear export, Mol. Cell. Biol., 21, 8521, 10.1128/MCB.21.24.8521-8532.2001 · DOI · Paper page
- Luo, 2004, Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo, Proc. Natl. Acad. Sci. USA, 101, 2259, 10.1073/pnas.0308762101 · DOI · Paper page
- McKinney, 2004, p53 linear diffusion along DNA requires its C terminus, Mol. Cell, 16, 413, 10.1016/j.molcel.2004.09.032 · DOI · Paper page
- Mujtaba, 2004, Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation, Mol. Cell, 13, 251, 10.1016/S1097-2765(03)00528-8 · DOI · Paper page
- Nagaich, 1997, DNA bending is essential for the site-specific recognition of DNA response elements by the DNA binding domain of the tumor suppressor protein p53, J. Biol. Chem., 272, 14842, 10.1074/jbc.272.23.14842 · DOI
- Nakamura, 2000, Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination, Mol. Cell. Biol., 20, 9391, 10.1128/MCB.20.24.9391-9398.2000 · DOI
- Nie, 2007, Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination, J. Biol. Chem., 282, 14616, 10.1074/jbc.M610515200 · DOI
- Nikulenkov, 2012, Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis, Cell Death Differ., 19, 1992, 10.1038/cdd.2012.89 · DOI · Paper page
- Okorokov, 2006, The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity, EMBO J., 25, 5191, 10.1038/sj.emboj.7601382 · DOI · Paper page
- Petty, 2011, An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity, EMBO J., 30, 2167, 10.1038/emboj.2011.127 · DOI · Paper page
- Piluso, 2005, Purification of acetyl-p53 using p300 co-infection and the baculovirus expression system, Protein Expr. Purif., 40, 370, 10.1016/j.pep.2004.12.015 · DOI
- Poyurovsky, 2010, The C terminus of p53 binds the N-terminal domain of MDM2, Nat. Struct. Mol. Biol., 17, 982, 10.1038/nsmb.1872 · DOI
- Rodriguez, 2000, Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation, Mol. Cell. Biol., 20, 8458, 10.1128/MCB.20.22.8458-8467.2000 · DOI · Paper page
- Rustandi, 2000, Structure of the negative regulatory domain of p53 bound to S100B(betabeta), Nat. Struct. Biol., 7, 570, 10.1038/76797 · DOI
- Simeonova, 2013, Mutant mice lacking the p53 C-terminal domain model telomere syndromes, Cell Rep., 3, 2046, 10.1016/j.celrep.2013.05.028 · DOI
- Spolar, 1994, Coupling of local folding to site-specific binding of proteins to DNA, Science, 263, 777, 10.1126/science.8303294 · DOI · Paper page
- Stommel, 1999, A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking, EMBO J., 18, 1660, 10.1093/emboj/18.6.1660 · DOI · Paper page
- Tafvizi, 2011, A single-molecule characterization of p53 search on DNA, Proc. Natl. Acad. Sci. USA, 108, 563, 10.1073/pnas.1016020107 · DOI · Paper page
- Temiakov, 2003, Probing the organization of transcription complexes using photoreactive 4-thio-substituted analogs of uracil and thymidine, Methods Enzymol., 371, 133, 10.1016/S0076-6879(03)71009-X · doi:10.1016/s0076-6879(03)71009-x
- Tidow, 2007, Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex, Proc. Natl. Acad. Sci. USA, 104, 12324, 10.1073/pnas.0705069104 · DOI · Paper page
- Trauger, 2001, Footprinting methods for analysis of pyrrole-imidazole polyamide/DNA complexes, Methods Enzymol., 340, 450, 10.1016/S0076-6879(01)40436-8 · DOI
- Wu, 2014, Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response, Mol. Cell, 53, 63, 10.1016/j.molcel.2013.10.031 · DOI
Cited by
The multiple mechanisms that regulate p53 activity and cell fate
Hafner, A., Bulyk, M. L., Jambhekar, A., & Lahav, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0110-x · Cited by 1,129
Therapeutics targeting p53-MDM2 interaction to induce cancer cell death
Koo, N., Sharma, A. K., & Narayan, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095005 · Cited by 153
A Nuclear Phosphoinositide Kinase Complex Regulates P53
Choi, S., Chen, M., Cryns, V. L., & Anderson, R. A. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0297-2 · Cited by 106
Structural Evolution and Dynamics of the p53 Proteins
Chillemi, G., Kehrloesser, S., Bernassola, F., Desideri, A., Dötsch, V., Levine, A. J., & Melino, G. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a028308 · Cited by 65
Krois, A. S., Park, S., Martinez-Yamout, M. A., Dyson, H. J., & Wright, P. E. (2022) · Biochemistry · doi:10.1021/acs.biochem.2c00528 · Cited by 14
Metadata
- Authors
- Laptenko, O., Shiff, I., Freed-Pastor, W., Zupnick, A., Mattia, M., Freulich, E., Shamir, I., Kadouri, N., Kahan, T., Manfredi, J., Simon, I., & Prives, C.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 57
- Issue
- 6
- Pages
- 1034-1046
- ISSN
- 1097-2765
- Cited by
- 119
- References
- 11
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 384 d)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The p53 C Terminus Controls Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain. https://app.cochat.ai/papers/10.1016/j.molcel.2015.02.015
- The paper
- Laptenko, O., Shiff, I., Freed-Pastor, W., Zupnick, A., Mattia, M., Freulich, E., Shamir, I., Kadouri, N., Kahan, T., Manfredi, J., Simon, I., & Prives, C. (2015). The p53 C Terminus Controls Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain. Molecular Cell. https://doi.org/10.1016/j.molcel.2015.02.015
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.