Assessment of Human Vitamin C Status

Ascorbate is an outstanding antioxidant in human blood plasma

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The antioxidant role of vitamin C

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Nutritional status in a healthy elderly population: vitamin C

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The distribution of ascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration

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Carnitine

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Biochemical indices of human vitamin C status

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Ascorbic acid in lymphocytes: Cell preparation and liquid-chromatographic assay

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The Effect of Controlled Ascorbic Acid Depletion and Supplementation on Periodontal Health

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Vitamin C status and nutrient interactions in a healthy elderly population.

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Ascorbic acid status: biochemical and clinical considerations

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ESPEN micronutrient guideline

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Update on the Biological Characteristics of the Antioxidant Micronutrients

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Vitamin C Deficiency and Depletion in the United States: The Third National Health and Nutrition Examination Survey, 1988 to 1994

Hampl, J. S., Taylor, C. A., & Johnston, C. S. (2004) · American Journal of Public Health · doi:10.2105/ajph.94.5.870 · Cited by 207

Antioxidants and sperm DNA damage: a clinical perspective

Zini, A., San Gabriel, M., & Baazeem, A. (2009) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-009-9343-5 · Cited by 203

Vitamin C deficiency in cancer patients

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Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials

Lykkesfeldt, J., & Poulsen, H. E. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509993229 · Cited by 191

Authors' Perspective: What is the Optimum Intake of Vitamin C in Humans?

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Micronutrient deficiency in obese subjects undergoing low calorie diet

Damms-Machado, A., Weser, G., & Bischoff, S. C. (2012) · Nutrition Journal · doi:10.1186/1475-2891-11-34 · Cited by 157

Does diabetes mellitus increase the requirement for vitamin C?

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Oro-Facial Gangrene (Noma/Cancrum Oris): Pathogenetic Mechanisms

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Vitamins C and E Inhibit O 2 − Production in the Pig Coronary Artery

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Evaluation of Oxidative Stress and Nitric Oxide Levels in Patients with Oral Cavity Cancer

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Antioxidant therapy in male infertility: fact or fiction?

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Pathogenesis of cancrum oris (noma): confounding interactions of malnutrition with infection.

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Red cell and plasma folate, folate consumption, and the risk of colorectal adenomatous polyps.

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Vitamin C Deficiency in a Population of Young Canadian Adults

Cahill, L. E., Corey, P., & El‐Sohemy, A. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp156 · Cited by 126

Cellular Ascorbate Depletion in Healthy Men

Jacob, R. A., Pianalto, F., & Agee, R. E. (1992) · Journal of Nutrition · doi:10.1093/jn/122.5.1111 · Cited by 104

Low vitamin C values are linked with decreased physical performance and increased oxidative stress: reversal by vitamin C supplementation

Paschalis, V., Theodorou, A. A., Kyparos, A., Dipla, K., Zafeiridis, A., Panayiotou, G., Vrabas, I. S., & Nikolaidis, M. G. (2016) · European Journal of Nutrition · doi:10.1007/s00394-014-0821-x · Cited by 103

Vitamin C Status Correlates with Markers of Metabolic and Cognitive Health in 50-Year-Olds: Findings of the CHALICE Cohort Study

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Oxidative Stress and Male Infertility

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Vitamin C Status of an Outpatient Population

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Nutrition and allergic disease

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Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations

Carr, A. C., Bozonet, S. M., Pullar, J. M., Simcock, J. W., & Vissers, M. C. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.053207 · Cited by 88

The University of Minnesota Cancer Prevention Research Unit vegetable and fruit classification scheme (United States)

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A systematic review of the role of vitamin insufficiencies and supplementation in COPD

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Functional genetic variants of glutathione S-transferase protect against serum ascorbic acid deficiency

Cahill, L. E., Fontaine‐Bisson, B., & El‐Sohemy, A. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28327 · Cited by 74

Enhanced lipid peroxidation and nitric oxide products with deranged antioxidant status in patients with head and neck squamous cell carcinoma

Rasheed, M. H., Beevi, S. S., & Geetha, A. (2006) · Oral Oncology · doi:10.1016/j.oraloncology.2006.02.013 · Cited by 70

Changes in antioxidant status and cardiovascular risk factors of overweight young men after six weeks supplementation of whey protein isolate and resistance training

Vatani, D. S., & Golzar, F. A. K. (2012) · Appetite · doi:10.1016/j.appet.2012.08.005 · Cited by 64

Vitamin C: optimal dosages, supplementation and use in disease prevention

Pacier, C., & Martirosyan, D. M. (2015) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v5i3.174 · Cited by 75

Role of Marginal Vitamin C Deficiency in Atherogenesis: In Vivo Models and Clinical Studies

Frikke‐Schmidt, H., & Lykkesfeldt, J. (2009) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2009.00420.x · Cited by 57

Bioavailability of vitamin C from kiwifruit in non-smoking males: determination of ‘healthy’ and ‘optimal’ intakes

Carr, A. C., Pullar, J. M., Moran, S., & Vissers, M. C. M. (2012) · Journal of Nutritional Science · doi:10.1017/jns.2012.15 · Cited by 57

Metabolic origin of hypovitaminosis C in acutely hospitalized patients

Evans-Olders, R., Eintracht, S., & Hoffer, L. J. (2010) · Nutrition · doi:10.1016/j.nut.2009.08.015 · Cited by 54

Vitamin C deficiency and secondary hyperparathyroidism in chronic haemodialysis patients

Richter, A. M., Kuhlmann, M. K., Seibert, E., Kotanko, P., Levin, N. W., & Handelman, G. J. (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn084 · Cited by 54

Vitamin C: Is Supplementation Necessary for Optimal Health?

Deruelle, F., & Baron, B. (2008) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2008.0165 · Cited by 54

Haptoglobin genotype modifies the association between dietary vitamin C and serum ascorbic acid deficiency

Cahill, L. E., & El‐Sohemy, A. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29306 · Cited by 53

Does Vitamin C Deficiency Increase Lifestyle-Associated Vascular Disease Progression? Evidence Based on Experimental and Clinical Studies

Tveden‐Nyborg, P., & Lykkesfeldt, J. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5382 · Cited by 52

Vitamin Excess and Deficiency

Diab, L., & Krebs, N. F. (2018) · Pediatrics in Review · doi:10.1542/pir.2016-0068 · Cited by 52

Serum Ascorbic Acid and Cardiovascular Disease Prevalence in U.S. Adults

Simon, J. A., & Hudes, E. S. (1999) · Annals of Epidemiology · doi:10.1016/s1047-2797(99)00008-3 · Cited by 48

Intakes of Vitamin C, Vegetables and Fruits: Which Schoolchildren Are at Risk?

Hampl, J. S., Taylor, C. A., & Johnston, C. S. (1999) · Journal of the American College of Nutrition · doi:10.1080/07315724.1999.10718892 · Cited by 48

Vitamin C Status of a Campus Population: College Students Get a C Minus

Johnston, C. S., Solomon, R. E., & Corte, C. (1998) · Journal of American College Health · doi:10.1080/07448489809600224 · Cited by 44

Supplement use, other dietary and demographic variables, and serum vitamin C in NHANES II.

Dickinson, V., Block, G., & Russek‐Cohen, E. (1994) · Journal of the American College of Nutrition · doi:10.1080/07315724.1994.10718367 · Cited by 44

Micronutrient Depletion in Heart Failure: Common, Clinically Relevant and Treatable

Cvetinovic, N., Loncar, G., Isakovic, A. M., von Haehling, S., Doehner, W., Lainščak, M., & Farkaš, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225627 · Cited by 44

Genetic Variants Shaping Inter-individual Differences in Response to Dietary Intakes—A Narrative Review of the Case of Vitamins

Niforou, A., Konstantinidou, V., & Naska, A. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.558598 · Cited by 41

Vitamin C supplementation modulates gene expression in peripheral blood mononuclear cells specifically upon an inflammatory stimulus: a pilot study in healthy subjects

Canali, R., Natarelli, L., Leoni, G., Azzini, E., Comitato, R., Sancak, O., Barella, L., & Virgili, F. (2014) · Genes & Nutrition · doi:10.1007/s12263-014-0390-x · Cited by 41

Micronutrient concentrations in patients with malignant disease: effect of the inflammatory response

Mayland, C. R., Allen, K. R., Degg, T. J., & Bennet, M. (2004) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/000456304322880032 · Cited by 41

Hyperphenylalaninaemia in children with falciparum malaria

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Marginal Ascorbate Status (Hypovitaminosis C) Results in an Attenuated Response to Vitamin C Supplementation

Carr, A. C., Pullar, J. M., Bozonet, S. M., & Vissers, M. C. M. (2016) · Nutrients · doi:10.3390/nu8060341 · Cited by 40

Modification of a disposable pencil graphite electrode with multiwalled carbon nanotubes: application to electrochemical determination of diclofenac sodium in some pharmaceutical and biological samples

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Reference Values for α-Tocopherol and β-Carotene in the Whitehall II Study

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Determination of plasma and leukocyte vitamin C concentrations in a randomized, double-blind, placebo-controlled trial with Ester-C(®)

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Scurvy—Characteristic Features and Forensic Issues

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Effect of vitamin C supplementation on lipoprotein cholesterol, apolipoprotein, and triglyceride concentrations

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Genetic Determinants of Dietary Antioxidant Status

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People with Marginal Vitamin C Status are at High Risk of Developing Vitamin C Deficiency

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Lens Cadmium, Lead, and Serum Vitamins C, E, and Beta Carotene in Cataractous Smoking Patients

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Vitamin C deficiency in Australian hospitalised patients: an observational study

Sharma, Y., Miller, M., Shahi, R., Doyle, A., Horwood, C., Hakendorf, P. H., & Thompson, C. H. (2018) · Internal Medicine Journal · doi:10.1111/imj.14030 · Cited by 27

Bleeding tendency and ascorbic acid requirements: systematic review and meta-analysis of clinical trials

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Liposomal delivery enhances absorption of vitamin C into plasma and leukocytes: A double-blind, placebo-controlled, randomized trial

Purpura, M., Jäger, R., Godavarthi, A., Bhaskarachar, D., & Tinsley, G. M. (2024) · European Journal of Nutrition · doi:10.1007/s00394-024-03487-8 · Cited by 24

Evidence of a Positive Link between Consumption and Supplementation of Ascorbic Acid and Bone Mineral Density

Rondanelli, M., Peroni, G., Fossari, F., Vecchio, V., Faliva, M. A., Naso, M., Perna, S., Paolo, E. D., Riva, A., Petrangolini, G., et al. (2021) · Nutrients · doi:10.3390/nu13031012 · Cited by 24

Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients

Sotomayor, C. G., Eisenga, M. F., Neto, A. W. G., Özyilmaz, A., Gans, R. O. B., de Jong, W. H. A., Zelle, D. M., Berger, S. P., Gaillard, S., Navis, G. J., et al. (2017) · Nutrients · doi:10.3390/nu9060568 · Cited by 24

Symposium 1 Newer aspects of micronutrients in chronic disease

Thurnham, D. I. (1994) · Proceedings of The Nutrition Society · doi:10.1079/pns19940065 · Cited by 23

Effects of erythorbic acid on vitamin C metabolism in young women

Sauberlich, H., Tamura, T., Craig, C., Freeberg, L., & Liu, T. (1996) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.3.336 · Cited by 22

Scurvy: old disease, new lessons

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Ascorbic acid, glycation, glycohemoglobin and aging

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Endocrine disruptors in food contact materials; is there a health threat?

Ćwiek-Ludwicka, K., & Ludwicki, J. K. (2014) · PubMed · Cited by 20

Effect of Vitamin C on Plasma Lipids

Howard, P. A., & Meyers, D. G. (1995) · Annals of Pharmacotherapy · doi:10.1177/106002809502901112 · Cited by 20

Vitamin C metabolites, independent of smoking status, significantly enhance leukocyte, but not plasma ascorbate concentrations

Moyad, M. A., Combs, M. A., Vrablic, A. S., Velasquez, J., Turner, B., & Bernal, S. (2008) · Advances in Therapy · doi:10.1007/s12325-008-0106-y · Cited by 15

Lifestyle, Inflammation, and Vascular Calcification in Kidney Transplant Recipients: Perspectives on Long-Term Outcomes

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Vitamin C Nutriture and Risk of Atherosclerotic Heart Disease

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Alleviation of oxidative and nitrosative stress following curative resection in patient with oral cavity cancer

Rasheed, M. H., Beevi, S. S., Rajaraman, R., & Bose, S. J. C. (2007) · Journal of Surgical Oncology · doi:10.1002/jso.20818 · Cited by 14

Relevance of Non-ceruloplasmin Copper to Oxidative Stress in Patients with Hepatocellular Carcinoma

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Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults

Calder, P. C., Kreider, R. B., & McKay, D. L. (2025) · Nutrients · doi:10.3390/nu17020279 · Cited by 16

Micronutrient status in children aged 6–59 months with severe wasting and/or nutritional edema: implications for nutritional rehabilitation formulations

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Methods for assessment of vitamin C

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[Preoperative nutritional status and surgical risk. Identification of promissory biochemical markers].

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A study on the concentrations of serum zinc, non-ceruloplasmin copper, reactive oxygen and nitrogen species in children with Wilson's disease

Geetha, A., Jeyachristy, S. A., Selvamathy, S. M. K. N., Ilavarasi, S., & Surendran, R. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.05.005 · Cited by 10

Biochemical Assessment of Vitamins and Trace Metals

Jacob, R. A., & MILNE, D. B. (1993) · Clinics in Laboratory Medicine · doi:10.1016/s0272-2712(18)30444-x · Cited by 9

Vitamin C Transporters in the Retina

Ganapathy, V., Ananth, S., Smith, S. B., & Martin, P. M. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-375-2_23 · Cited by 8

Influence of daily diet on ascorbic acid supply to students.

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A biochemical research focused on the association of the levels of oxidative stress and nitric oxide with premalignant disorders and oral squamous cell carcinoma

Sachdev, R., Garg, K., Mehrotra, V., Shwetam, S., Saxena, S., & Srivastava, A. (2022) · National Journal of Maxillofacial Surgery · doi:10.4103/njms.njms_160_20 · Cited by 6

Effect of smoking on acute phase reactants, stress hormone responses and vitamin C in pulmonary tuberculosis

Opolot, J. O., Theron, A. J., MacPhail, P., Feldman, C. H., & Anderson, R. (2017) · African Health Sciences · doi:10.4314/ahs.v17i2.7 · Cited by 6

Vitamin C Bioequivalence from Gummy and Caplet Sources in Healthy Adults: A Randomized-Controlled Trial

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Plasma Total Ascorbic Acid and Serum 25-Hydroxy-Vitamin-D Status in Patients with Venous Leg Ulcers: A Case–Control Study

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Aspectos Farmacológicos relevantes de las Vitaminas Antioxidantes (E, A y C)

Torres, M., Márquez, M., de Naranjo, R. S., de Yépez, C. R., de García, M. L., Muñoz, M. C. M., & Gómez, M. (2002) · Cited by 5

Effects of Drug Addiction on Antioxidant Vitamins and Nitric Oxide Levels

Sh, S., Hassan, S., El-Aziz, S. E. A., Ghanem, A., Awad, M., & Ali, A. R. (2011) · Cited by 4

Vitamin C Status in Hospitalized Adults According to Subjective Global Assessment Method

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Effects of functional variants of vitamin C transporter genes on apolipoprotein E E4-associated risk of cognitive decline: The Nakajima study

Hayashi, K., Noguchi‐Shinohara, M., Sato, T. K., Hosomichi, K., Kannon, T., Abe, C., Domoto, C., Yuki-Nozaki, S., Mori, A., Horimoto, M., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0259663 · Cited by 4

Transporters and receptors in the posterior segment of the eye

Patel, A., Gokulgandhi, M. R., Khurana, V., & Mitra, A. K. (2013) · Elsevier eBooks · doi:10.1533/9781908818317.169 · Cited by 4

Antioxidants and Sperm DNA Damage

Zini, A. S., & Gabriel, M. S. (2011) · Springer eBooks · doi:10.1007/978-1-4419-6857-9_30 · Cited by 4

Vitamin C

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Studies on Ascorbic acid content of some wild edible fruits from Ahmednagar District, Maharashtra (India).

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Scurvy: a rare cause of haemarthrosis

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