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Cited by 49Veterinary Medicine and SurgeryRegulation of Appetite and ObesityPharmacology and Obesity Treatment

Obesity in the dog: role of the adrenal steroid dehydroepiandrosterone (DHEA).

MacEwen, E.Gregory, Kurzman, Ilene D.·1991·The Journal of Nutrition
DOI 10.1093/jn/121.suppl_11.s51
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Abstract

It is estimated that 25-50% of pet dogs are overweight. In rodents and humans the adrenal steroid dehydroepiandrosterone (DHEA) has been associated with loss of body weight and reduction in total body fat content. We have shown that administration of DHEA results in weight loss in spontaneously obese dogs. DHEA also lowered serum cholesterol, in particular, the low density lipoprotein component of the plasma cholesterol. We hypothesize that treatment of obese dogs with DHEA in combination with a low energy, high fiber diet will result in greater weight loss when compared with dogs on the same diet, without DHEA. In the current study, spontaneously obese dogs were fed a uniform low energy, high fiber diet and then randomized to receive DHEA or placebo. Preliminary results show that the mean total body weight lost for dogs receiving DHEA was 3.59 kg compared with 2.38 kg for dogs receiving placebo (P greater than 0.05). The percent excess body weight (above ideal body weight) lost for the DHEA group was 65.7 versus 31.4 for the placebo group (P less than 0.02). The percent excess body weight lost per month on the study for the DHEA group was 15 versus 8.2 for the placebo group (P = 0.069). Although these results are preliminary, they indicate that DHEA combined with a low energy, high fiber diet enhances the loss of excess body weight compared with diet modification alone.

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Crossref · 10.1093/jn/121.suppl_11.s51

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  • The 70-95% reduction in formation of DHEA and DHEA-S by the adrenals during aging results in a dramatic reduction in formation of androgens and estrogens in peripheral target tissues, which could be involved in pathogenesis of age-related diseases such as insulin resistance and obesity.

    “The 70 -95% reduction in the formation of DHEA and DHEA-S by the adrenals during aging results in a dramatic reduction in the formation of androgens and estrogens in peripheral target tissues, which could well be involved in the pathogenesis of age-related diseases such as insulin resistance (307, 308) and obesity (309 -311).”

    From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [310]

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Authors
MacEwen, E. G., & Kurzman, I. D.
Affiliations
University of Wisconsin–Madison (US)
Corresponding author
MacEwen, E.Gregory
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
1991-11
Volume
121
Issue
11 Suppl
Pages
S51-S55
ISSN
0022-3166 (ISSN-L)
DOI
10.1093/jn/121.suppl_11.s51
OpenAlex
W1555837365
Cited by
49
References
31
Citations by year
2023: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2012: 3
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Veterinary › Small Animals › Veterinary Medicine and Surgery
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
Keywords
canine obesity, dehydroepiandrosterone, weight loss, serum cholesterol, low-density lipoprotein, overweight, adrenal steroids, dogs
MeSH terms
Animals, Cholesterol, Dehydroepiandrosterone, Dog Diseases, Dogs, Obesity, Weight Loss

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