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Cited by 129Hormonal and reproductive studiesMenopause: Health Impacts and TreatmentsAdrenal Hormones and Disorders

Metabolism of DHEA in postmenopausal women following percutaneous administration

Labrie, Fernand, Bélanger, Alain, Bélanger, Patrick, Bérubé, René, Martel, Céline, Cusan, Leonello, Gomez, José, Candas, Bernard +4 more·2007·The Journal of Steroid Biochemistry and Molecular Biology
DOI 10.1016/j.jsbmb.2006.09.034
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Abstract

The marked decline in serum dehydroepiandrosterone (DHEA) with age is believed to play a role in health problems associated with aging, these health issues being potentially preventable or reversible by the exogenous administration of DHEA. In the present study, liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS) and gas chromatrography/mass spectrometry (GC/MS) were used to measure the serum levels of DHEA and 11 of its metabolites in seventy-five 60-65-year-old Caucasian women who received 3g of 0.1%, 0.3%, 1.0% or 2.0% DHEA cream or placebo applied twice daily on the face, upper chest, arms and legs. The serum levels of DHEA increased 574% over control at the 2.0% DHEA dose while the sum of the androgen metabolites androsterone glucuronide (ADT-G), 3alpha-androstenediol-3G (3alpha-diol-3G) and 3alpha-diol-17G increased by only 231%. On the other hand, serum testosterone and dihydrosterone were increased by 192% and 275%, respectively, above basal levels compared to 139% and 158% for estrone and estradiol. Such data show that the transformation of exogenous DHEA in postmenopausal women is preferentially into androgens rather than into estrogens. On the other hand, the present data indicate that serum DHEA measurements following DHEA supplementation in postmenopausal women are an overestimate of the formation of active androgens and estrogens and suggest a decreased efficiency of transformation of DHEA into androgens and estrogens with aging.

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  • The metabolism of DHEA to active androgens reaches saturation with increasing circulating concentrations of DHEA, thereby protecting peripheral tissues from increased intracellular levels of androgens which may result from pathologically increased biosynthesis of androgen precursors in the adrenal.

    “Significantly, the metabolism of DHEA to active androgens reaches saturation with increasing circulating concentrations of DHEA, thereby protecting peripheral tissues from increased intracellular levels of androgens which may result from pathologically increased biosynthesis of androgen precursors in the adrenal (Labrie et al., 2007).”

    From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Labrie et al., 2007

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Authors
Labrie, F., Bélanger, A., Bélanger, P., Bérubé, R., Martel, C., Cusan, L., Gomez, J., Candas, B., Chaussade, V., Castiel, I., Deloche, C., & Leclaire, J.
Affiliations
  • Université Laval (CA)
  • L'Oréal (France) (FR)
Corresponding author
Labrie, Fernand
ORCID
Venue
The Journal of Steroid Biochemistry and Molecular Biology
Publisher
Elsevier BV
Published
2007-02
Volume
103
Issue
2
Pages
178-188
ISSN
0960-0760 (ISSN-L)
DOI
10.1016/j.jsbmb.2006.09.034
OpenAlex
W2058850167
Cited by
129
References
27
Citations by year
2025: 2 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 9 · 2013: 11 · 2012: 8
FWCI
5.66
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
L'Oreal USA
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
dehydroepiandrosterone, DHEA metabolism, postmenopausal women, androgen metabolites, androsterone glucuronide, testosterone, estradiol, estrone, aging, serum steroid levels
MeSH terms
Administration, Cutaneous, Aged, Dehydroepiandrosterone, Dose-Response Relationship, Drug, Female, Humans, Middle Aged, Models, Biological, Placebos, Time Factors, Postmenopause

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