Consumption of prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis has minor effects on selected immune parameters in polypectomised and colon cancer patients
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Probiotics (PRO) modulate immunity in humans, while the effect of prebiotics (PRE) and synbiotics (SYN) on the human immune system are not well studied yet. The objective of this study was to investigate whether daily intake of a SYN modulates immune functions. In a randomised double-blind, placebo-controlled trial, thirty-four colon cancer patients who had undergone ‘curative resection’ and forty polypectomised patients participated. Subjects of the SYN group daily received encapsulated bacteria (1 × 10 10 colony-forming units of Lactobacillus rhamnosus GG (LGG) and 1 × 10 10 colony-forming units of Bifidobacterium lactis Bb12 (Bb12)) and 10 g of inulin enriched with oligofructose. Controls received encapsulated maltodextrin and 10 g of maltodextrin. Prior to intervention (T1), and 6 (T2) and 12 weeks after the start of the intervention (T3), phagocytic and respiratory burst activity of neutrophils and monocytes, lytic activity of natural killer cells and production of interleukin (IL)-2, IL-10 and IL-12, as well as tumour necrosis factor-α and interferon-γ (IFN-γ) by activated peripheral blood mononuclear cells (PBMC) were measured. In faeces, the concentrations of transforming growth factor-β1 and prostaglandin E 2 were measured. IL-2 secretion by activated PBMC from the polyp group increased significantly between T1 or T2 and T3 ( P < 0·05). In the cancer group, SYN treatment resulted in an increased capacity of PBMC to produce IFN-γ at T3 ( P < 0·05). Other immunity-related parameters were not affected by SYN treatment, neither in the cancer nor in the polyp group. In conclusion, supplementation with this SYN has minor stimulatory effects on the systemic immune system of the two study groups. Further studies in humans should aim to focus on the gut-associated immune system.
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Administration of B. animalis subsp. lactis BB-12 together with Lactobacillus rhamnosus GG and inulin improved immune functions in resected colorectal cancer patients.
“In this sense, administration of B. animalis subsp. lactis BB-12 together with Lactobacillus rhamnosus GG and inulin improved the immune functions in resected CRC patients (126).”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [126]
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- Authors
- Roller, M., Clune, Y., Collins, K., Rechkemmer, G., & Watzl, B.
- Affiliations
- University College Cork (IE)
- Technical University of Munich (DE)
- Corresponding author
- Watzl, Bernhard
- ORCID
- Watzl, Bernhard
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2007-03-09
- Volume
- 97
- Issue
- 4
- Pages
- 676-684
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2151982384
- Cited by
- 125
- References
- 54
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 9 · 2023: 12 · 2022: 5 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 5 · 2013: 8 · 2012: 4
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- OpenAgrar (submittedVersion)
- Funders
- Universiteit Hasselt
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- synbiotics, prebiotics, inulin, fructooligosaccharides, probiotics, Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. lactis BB-12, colon cancer, polypectomy, immune function, cytokines, interferon-gamma, interleukin-2, natural killer cells, neutrophils, monocytes, peripheral blood mononuclear cells, TGF-β1, prostaglandin E2
- MeSH terms
- Aged, Bifidobacterium, Cells, Cultured, Colonic Neoplasms, Colonic Polyps, Cytotoxicity, Immunologic, Double-Blind Method, Female, Humans, Inulin, Killer Cells, Natural, Male, Middle Aged, Oligosaccharides, Phagocytosis, Cytokines, Respiratory Burst, Probiotics, Lacticaseibacillus rhamnosus
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