Aerobic exercise training decreases leucine oxidation at rest in healthy adults
Open accessAbstract
Both exercise and dietary protein intake affect whole-body protein turnover (WBPTO). Few studies have investigated the effect of aerobic exercise training on WBPTO [leucine rate of appearance (Ra), oxidation (Ox), and nonoxidative leucine disposal (NOLD)] in untrained individuals consuming a specified level of protein. This study examined the effect of aerobic exercise training on WBPTO in untrained men and women during a controlled diet intervention providing 0.88 g protein/(kg . d). After a 2-wk adaptation to the study diet, 7 subjects [3 men, 4 women; 76.1 +/- 5.8 kg, 164.7 +/- 4.4 cm, 30.7 +/- 4.5% body fat, 39.1 +/- 2.8 VO(2max) (maximal oxygen uptake) mL/(kg . min)] participated in 4 wk of aerobic exercise training (running and walking 4-5 times/wk at 65-85% maximal heart rate). WBPTO (determined via constant infusion of 1-[(13)C] leucine), nitrogen balance, and body composition were determined at baseline and after 4 wk of training. Nitrogen balance (-1.0 +/- 0.7 vs. 0.9 +/- 1.1 g N/24 h, P = 0.03) improved with exercise training, whereas body mass and composition did not change. Leucine Ra did not change, Ox decreased [18 +/- 2 to 15 +/- 2 micromol/(kg . h), P </= 0.001], and NOLD tended to increase [128 +/- 18 to 151 +/- 19 micromol/(kg . h), P = 0.09] in response to training. These data indicate improved protein utilization in response to exercise training in weight-stable subjects. This study emphasizes the importance of dietary control, with specific regard to energy and protein intakes, in the characterization of protein utilization in response to an exercise intervention.
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Endurance training results in a reduction in leucine oxidation.
“It seems paradoxical therefore that endurance training results in a reduction in leucine oxidation [177].”
From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [177]
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- Authors
- Gaine, P. C., Viesselman, C. T., Pikosky, M. A., Martin, W. F., Armstrong, L. E., Pescatello, L. S., & Rodriguez, N. R.
- Affiliations
- University of Connecticut (US)
- Corresponding author
- Rodriguez, Nancy R.
- ORCID
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 135
- Issue
- 5
- Pages
- 1088-1092
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W1961885520
- Cited by
- 26
- References
- 33
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2013: 1 · 2012: 2
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- aerobic exercise training, leucine oxidation, whole-body protein turnover, nitrogen balance, protein intake, protein utilization, untrained individuals, body composition
- MeSH terms
- Adult, Basal Metabolism, Body Weight, Diet, Female, Humans, Leucine, Male, Oxidation-Reduction, Oxygen Consumption, Physical Fitness, Reference Values, Rest, Exercise
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