Dietary protein, endurance exercise, and human skeletal-muscle protein turnover
Abstract
PURPOSE OF REVIEW: Whereas diet and exercise have been shown to influence whole-body protein utilization, little is known about the impact of these factors on skeletal-muscle protein turnover. We highlight the role of dietary protein in modulating skeletal-muscle protein turnover in response to endurance exercise. Effects of endurance exercise on skeletal-muscle protein metabolism are presented and the influence of habitual protein intake on exercise-related protein responses is discussed. RECENT FINDINGS: Skeletal-muscle protein turnover increases in response to endurance exercise training and following a single endurance exercise bout. Nutritional supplementation postexercise favorably affects skeletal-muscle protein synthesis and demonstrates amino acid availability as pivotal to the skeletal-muscle synthetic response following exercise. The level of habitual protein intake influences postexercise skeletal-muscle protein turnover. SUMMARY: Dietary protein and exercise are powerful stimuli affecting protein turnover. Since variation in habitual protein intake influences skeletal-muscle protein turnover postexercise, investigations are needed to determine what role protein intake has in regulating skeletal-muscle protein metabolism. Long-term, well controlled diet and exercise intervention studies are essential for clarification of the relation between protein intake, endurance exercise, and skeletal-muscle protein turnover. Studies designed to characterize this relationship should be attentive to habitual macronutrient and energy intakes.
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Protein intake necessary ranges from 1.2 to 1.6 g/kg per day in the top sport elite athletes.
“Protein intake necessary ranges from 1.2 to 1.6 g/kg per day in the top sport elite athletes [117, 118] so that amino acids are spared for protein synthesis and are not oxidized to assist in meeting energy needs [118].”
From Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes (2016) · cites this paper as [118]
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- Authors
- Rodriguez, N. R., Vislocky, L. M., & Gaine, P. C.
- Affiliations
- University of Connecticut (US)
- Corresponding author
- Rodriguez, Nancy R
- Venue
- Current Opinion in Clinical Nutrition and Metabolic Care
- Published
- 2007-01
- Volume
- 10
- Issue
- 1
- Pages
- 40-45
- ISSN
- 1363-1950 (ISSN-L)
- OpenAlex
- W1968828002
- Cited by
- 61
- References
- 34
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 2 · 2020: 2 · 2019: 1 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 1 · 2013: 5 · 2012: 5
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- dietary protein, endurance exercise, skeletal muscle protein turnover, protein synthesis, amino acid availability, exercise training, muscle protein metabolism
- MeSH terms
- Biological Availability, Dietary Proteins, Humans, Muscle Proteins, Physical Endurance, Muscle, Skeletal
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