The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Muscle Protein Anabolic Resistance to Essential Amino Acids Does Not Occur in Healthy Older Adults Before or After Resistance Exercise Training
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“it is revealing that mTOR-lysosomal colocalization after essential amino acid ingestion is increased after 12 weeks of training in older muscle, which was associated with ~ 20% greater postprandial mixed muscle protein synthetic response [64].”
From Protein Requirements for Master Athletes: Just Older Versions of Their Younger Selves (2021) · cites this paper as [64]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gait speed and survival in older adults.
Studenski, S. (2011) · JAMA · doi:10.1001/jama.2010.1923 · Cited by 4,558
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211
Mixed muscle protein synthesis and breakdown after resistance exercise in humans
Phillips, S. M., Tipton, K. D., Aarsland, A., Wolf, S. E., & Wolfe, R. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e99 · Cited by 1,132
Bar-Peled, L., Chantranupong, L., Cherniack, A. D., Chen, W. W., Ottina, K. A., Grabiner, B. C., Spear, E. D., Carter, S. L., Meyerson, M., & Sabatini, D. M. (2013) · Science · doi:10.1126/science.1232044 · Cited by 1,080
Katsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923
DeSouza, C. A., Shapiro, L. F., Clevenger, C. M., Dinenno, F. A., Monahan, K. D., Tanaka, H., & Seals, D. R. (2000) · Circulation · doi:10.1161/01.cir.102.12.1351 · Cited by 896
Volpi, E., Kobayashi, H., Sheffield-Moore, M., Mittendorfer, B., & Wolfe, R. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.2.250 · Cited by 846
Self-citationCermak, N. M., Res, P. T., de Groot, L. C., Saris, W. H., & van Loon, L. J. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.037556 · Cited by 827
Kumar, V., Selby, A., Rankin, D., Patel, R., Atherton, P., Hildebrandt, W., Williams, J., Smith, K., Seynnes, O., Hiscock, N., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.164483 · Cited by 740
Dreyer, H. C., Fujita, S., Cadenas, J. G., Chinkes, D. L., Volpi, E., & Rasmussen, B. B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.113175 · Cited by 570
Self-citation
Research works printed but not linked: 29
- Newman, 2006, Strength, but not muscle mass, is associated with mortality in the Health, Aging and Body Composition Study cohort, J Gerontol A Biol Sci Med Sci, 61, 72, 10.1093/gerona/61.1.72 · DOI · Paper page
- Cruz-Jentoft, 2010, Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People, Age Ageing, 39, 412, 10.1093/ageing/afq034 · DOI · Paper page
- Volpi, 2001, Basal muscle amino acid kinetics and protein synthesis in healthy young and older men, JAMA, 286, 1206, 10.1001/jama.286.10.1206 · DOI · Paper page
- Markofski, 2015, Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women, Exp Gerontol, 65, 1, 10.1016/j.exger.2015.02.015 · DOI · Paper page
- Fujita, 2009, Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism, Diabetologia, 52, 1889, 10.1007/s00125-009-1430-8 · DOI · Paper page
- Rasmussen, 2006, Insulin resistance of muscle protein metabolism in aging, FASEB J, 20, 768, 10.1096/fj.05-4607fje · DOI · Paper page
- Rérat, 1992, Splanchnic fluxes of amino acids after duodenal infusion of carbohydrate solutions containing free amino acids or oligopeptides in the non-anaesthetized pig, Br J Nutr, 68, 111, 10.1079/BJN19920071 · DOI
- Katsanos, 2005, Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids, Am J Clin Nutr, 82, 1065, 10.1093/ajcn/82.5.1065 · DOI · Paper page
- Symons, 2009, A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects, J Am Diet Assoc, 109, 1582, 10.1016/j.jada.2009.06.369 · DOI · Paper page
- Volpi, 1999, Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction, Am J Physiol, 277, E513
- Shad, 2016, Does the muscle protein synthetic response to exercise and amino acid-based nutrition diminish with advancing age? A systematic review, Am J Physiol Endocrinol Metab, 311, E803, 10.1152/ajpendo.00213.2016 · DOI
- Kiskini, 2013, The muscle protein synthetic response to the combined ingestion of protein and carbohydrate is not impaired in healthy older men, Age (Dordr), 35, 2389, 10.1007/s11357-013-9522-2 · DOI
- Moore, 2015, Protein ingestion to stimulate myofibrillar protein synthesis requires greater relative protein intakes in healthy older versus younger men, J Gerontol A Biol Sci Med Sci, 70, 57, 10.1093/gerona/glu103 · DOI · Paper page
- Moro, 2017, High intensity interval resistance training (HIIRT) in older adults: effects on body composition, strength, anabolic hormones and blood lipids, Exp Gerontol, 98, 91, 10.1016/j.exger.2017.08.015 · DOI
- Glynn, 2010, Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women, J Nutr, 140, 1970, 10.3945/jn.110.127647 · DOI · Paper page
- Fry, 2014, Fibre type-specific satellite cell response to aerobic training in sedentary adults, J Physiol, 592, 2625, 10.1113/jphysiol.2014.271288 · DOI
- Reidy, 2016, Role of ingested amino acids and protein in the promotion of resistance exercise-induced muscle protein anabolism, J Nutr, 146, 155, 10.3945/jn.114.203208 · DOI · Paper page
- Drummond, 2008, Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging, J Appl Physiol (1985), 104, 1452, 10.1152/japplphysiol.00021.2008 · DOI · Paper page
- Pennings, 2011, Exercising before protein intake allows for greater use of dietary protein-derived amino acids for de novo muscle protein synthesis in both young and elderly men, Am J Clin Nutr, 93, 322, 10.3945/ajcn.2010.29649 · DOI · Paper page
- Kumar, 2012, Muscle protein synthetic responses to exercise: effects of age, volume, and intensity, J Gerontol A Biol Sci Med Sci, 67, 1170, 10.1093/gerona/gls141 · DOI
- Reidy, 2017, Post-absorptive muscle protein turnover affects resistance training hypertrophy, Eur J Appl Physiol, 117, 853, 10.1007/s00421-017-3566-4 · DOI
- Brook, 2016, The metabolic and temporal basis of muscle hypertrophy in response to resistance exercise, Eur J Sport Sci, 16, 633, 10.1080/17461391.2015.1073362 · DOI
- Damas, 2016, Susceptibility to exercise-induced muscle damage: a cluster analysis with a large sample, Int J Sports Med, 37, 633, 10.1055/s-0042-100281 · DOI
- Dickinson, 2014, Leucine-enriched amino acid ingestion after resistance exercise prolongs myofibrillar protein synthesis and amino acid transporter expression in older men, J Nutr, 144, 1694, 10.3945/jn.114.198671 · DOI
- Timmerman, 2010, Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling, J Clin Endocrinol Metab, 95, 3848, 10.1210/jc.2009-2696 · DOI · Paper page
- Phillips, 2015, The effects of resistance exercise training on macro- and micro-circulatory responses to feeding and skeletal muscle protein anabolism in older men, J Physiol, 593, 2721, 10.1113/JP270343 · DOI
- Bar-Peled, 2012, SnapShot: mTORC1 signaling at the lysosomal surface, Cell, 151, 10.1016/j.cell.2012.11.038 · DOI
- Dow, 2017, Regular aerobic exercise reduces endothelin-1-mediated vasoconstrictor tone in overweight and obese adults, Exp Physiol, 102, 1133, 10.1113/EP086454 · DOI
- Geirsdottir, 2012, Effect of 12-week resistance exercise program on body composition, muscle strength, physical function, and glucose metabolism in healthy, insulin-resistant, and diabetic elderly Icelanders, J Gerontol A Biol Sci Med Sci, 67, 1259, 10.1093/gerona/gls096 · DOI
Cited by
Egan, B., & Sharples, A. P. (2023) · Physiological Reviews · doi:10.1152/physrev.00054.2021 · Cited by 278
Regulation of ribosome biogenesis in skeletal muscle hypertrophy
Figueiredo, V. C., & McCarthy, J. J. (2019) · Physiology · doi:10.1152/physiol.00034.2018 · Cited by 140
Moro, T., Brightwell, C. R., Phalen, D. E., McKenna, C. F., Lane, S. J., Porter, C., Volpi, E., Rasmussen, B. B., & Fry, C. S. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110723 · Cited by 85
Self-citationThomas, E., Gentile, A., Lakicevic, N., Moro, T., Bellafiore, M., Paoli, A., Drid, P., Palma, A., & Bianco, A. (2021) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-01853-8 · Cited by 34
Self-citationProtein Requirements for Master Athletes: Just Older Versions of Their Younger Selves
Moore, D. R. (2021) · Sports Medicine · doi:10.1007/s40279-021-01510-0 · Cited by 33
Diet and exercise in frailty and sarcopenia. Molecular aspects
Millan-Domingo, F., Garcia-Dominguez, E., Gambini, J., Olaso-Gonzalez, G., Viña, J., & Gomez-Cabrera, M. C. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101322 · Cited by 31
Metadata
- Authors
- Moro, T., Brightwell, C. R., Deer, R. R., Graber, T. G., Galvan, E., Fry, C. S., Volpi, E., & Rasmussen, B. B.
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 148
- Issue
- 6
- Pages
- 900-909
- ISSN
- 0022-3166
- Cited by
- 63
- References
- 27
- Language
- en
- Update notices
- erratum (2018-10-01)
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1693 d)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.