Regulation of ribosome biogenesis in skeletal muscle hypertrophy

Figueiredo, Vandré Casagrande; McCarthy, John J.

doi:10.1152/physiol.00034.2018

Cited by 140RNA and protein synthesis mechanismsMuscle Physiology and DisordersMuscle metabolism and nutrition

Regulation of ribosome biogenesis in skeletal muscle hypertrophy

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Figueiredo, Vandré Casagrande, McCarthy, John J.·2019·Physiology

DOI 10.1152/physiol.00034.2018PMC PMC6383632

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Abstract

The ribosome is the enzymatic macromolecular machine responsible for protein synthesis. The rates of protein synthesis are primarily dependent on translational efficiency and capacity. Ribosome biogenesis has emerged as an important regulator of skeletal muscle growth and maintenance by altering the translational capacity of the cell. Here, we provide evidence to support a central role for ribosome biogenesis in skeletal muscle growth during postnatal development and in response to resistance exercise training. Furthermore, we discuss the cellular signaling pathways regulating ribosome biogenesis, discuss how myonuclear accretion affects translational capacity, and explore future areas of investigation within the field.

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Mature mammalian ribosomes are exceptionally stable, with estimated in vivo half-lives spanning several days to over a week, so total RNA accumulation lags behind immediate Pol I activation.
“As mature mammalian ribosomes are exceptionally stable, with estimated in vivo half-lives spanning several days to over a week [25,64], total RNA accumulation lags significantly behind the immediate activation of RNA polymerase I [34].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [25]
The Introduction reports that a single resistance-exercise bout increases 47S pre-rRNA without significantly increasing mature rRNA, while repeated bouts eventually increase mature rRNA and total RNA. It also says early changes suggest Pol I factors are primed for transcription, not that Pol I is immediately activated. The ribosome half-life estimate is attached to other citations in the citing sentence, not to this source. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Following activation, proliferation, and fusion, Pax7+ satellite cells donate new myonuclei to the syncytium, expanding the transcriptional and nucleolar infrastructure available to support continued adaptation.
“Following activation, proliferation, and fusion, Pax7+ satellite cells donate new myonuclei to the syncytium, thereby expanding the transcriptional and nucleolar infrastructure available to support continued adaptation [25,66,67].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [25]
Ribosomes are relatively stable structures, with half-lives that can extend over several days in skeletal muscle.
“Ribosomes are relatively stable structures, with half-lives that can extend over several days in skeletal muscle”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [25]
The Introduction’s Ribophagy section discusses ribosome degradation and turnover but gives no measure of ribosome stability or half-life. Searches for skeletal-muscle ribosome half-life and stability found no passage stating that half-lives extend over several days; the reported 48-hour observation concerns pre-rRNA expression after exercise, not ribosome lifespan. (LLM, conf=0.70)
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The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
The GTEx Consortium, Ardlie, K. G., Deluca, D. S., Segrè, A. V., Sullivan, T. J., Young, T. R., Gelfand, E. T., Trowbridge, C. A., Maller, J. B., Tukiainen, T., et al. (2015) · Science · doi:10.1126/science.1262110 · Cited by 5,062 · see citing works
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,702 · see citing works
SATELLITE CELL OF SKELETAL MUSCLE FIBERS
Mauro, A. (1961) · The Journal of Cell Biology · doi:10.1083/jcb.9.2.493 · Cited by 3,683 · see citing works
The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution
Ban, N., Nissen, P., Hansen, J., Moore, P. B., & Steitz, T. A. (2000) · Science · doi:10.1126/science.289.5481.905 · Cited by 3,327 · see citing works
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
Bodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J. C., Glass, D. J., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1014 · Cited by 2,752 · see citing works
Pax7 Is Required for the Specification of Myogenic Satellite Cells
Seale, P., Sabourin, L. A., Girgis-Gabardo, A., Mansouri, A., Gruß, P., & Rudnicki, M. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00066-0 · Cited by 2,345 · see citing works
The Structural Basis of Ribosome Activity in Peptide Bond Synthesis
Nissen, P., Hansen, J., Ban, N., Moore, P. B., & Steitz, T. A. (2000) · Science · doi:10.1126/science.289.5481.920 · Cited by 2,269 · see citing works
The economics of ribosome biosynthesis in yeast
Warner, J. R. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01460-7 · Cited by 1,933 · see citing works
A unifying model for mTORC1-mediated regulation of mRNA translation
Thoreen, C. C., Chantranupong, L., Keys, H. R., Wang, T., Gray, N. S., & Sabatini, D. M. (2012) · Nature · doi:10.1038/nature11083 · Cited by 1,477 · see citing works
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stabilityPreprint
Sears, R. C., Nuckolls, F., Haura, E. B., Taya, Y., Tamai, K., & Nevins, J. R. (2000) · Genes & Development · doi:10.1101/gad.836800 · Cited by 1,379 · see citing works
Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models
Schiaffino, S., & Mammucari, C. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-4 · Cited by 816 · see citing works
Ribosomal proteins: functions beyond the ribosome
Zhou, X. Y., Liao, W.-J., Liao, J., Liao, P., & Lu, H. (2015) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjv014 · Cited by 740 · see citing works
Specialized ribosomes: a new frontier in gene regulation and organismal biology
Xue, S., & Barna, M. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3359 · Cited by 687 · see citing works
Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle
Wilkinson, S. B., Phillips, S. M., Atherton, P. J., Patel, R., Yarasheski, K. E., Tarnopolsky, M. A., & Rennie, M. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.153916 · Cited by 628 · see citing works
Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth
Drygin, D., Lin, A. H., Bliesath, J., Ho, C., O’Brien, S., Proffitt, C., Omori, M., Haddach, M., Schwaebe, M. K., Siddiqui-Jain, A., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1728 · Cited by 622 · see citing works
Effective fiber hypertrophy in satellite cell-depleted skeletal muscle
McCarthy, J. J., Mula, J., Miyazaki, M., Erfani, R., Garrison, K., Farooqui, A. B., Srikuea, R., Lawson, B. A., Grimes, B., Keller, C., et al. (2011) · Development · doi:10.1242/dev.068858 · Cited by 616 · see citing works
Self-citation
An overview of pre‐ribosomal RNA processing in eukaryotes
Henras, A. K., Plisson‐Chastang, C., O’Donohue, M.-F., Chakraborty, A., & Gleizes, P. (2014) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1269 · Cited by 597 · see citing works
Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases
Mayer, C., & Grummt, I. (2006) · Oncogene · doi:10.1038/sj.onc.1209883 · Cited by 568 · see citing works
Structure of the human 80S ribosome
Khatter, H., Myasnikov, A. G., Natchiar, S. K., & Klaholz, B. P. (2015) · Nature · doi:10.1038/nature14427 · Cited by 546 · see citing works
Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans
Donkin, I., Versteyhe, S., Ingerslev, L. R., Qian, K., Mechta, M., Nordkap, L., Mortensen, B., Appel, E. V. R., Jørgensen, N., Kristiansen, V. B., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.11.004 · Cited by 533 · see citing works
mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding
Delarue, M., Brittingham, G. P., Pfeffer, S., Surovtsev, I. V., Pinglay, S., Kennedy, K. J., Schaffer, M., Gutierrez, J. I., Sang, D., Poterewicz, G., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.042 · Cited by 526 · see citing works
Myosin isoenzyme redistribution in chronic heart overload
Lompré, A., Schwartz, K., d’Albis, A., Lacombe, G., Thiem, N. V., & Bernard Swynghedauw, A. (1979) · Nature · doi:10.1038/282105a0 · Cited by 523 · see citing works
The post-transcriptional steps of eukaryotic ribosome biogenesis
Henras, A. K., Soudet, J., Gérus, M., Lebaron, S., Caizergues‐Ferrer, M., Mougin, A., & Henry, Y. A. L. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8027-0 · Cited by 521 · see citing works
Dynamics of muscle fibre growth during postnatal mouse development
White, R. B., Biérinx, A.-S., Gnocchi, V. F., & Zammit, P. S. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-21 · Cited by 512 · see citing works
The Complexity of Human Ribosome Biogenesis Revealed by Systematic Nucleolar Screening of Pre-rRNA Processing Factors
Tafforeau, L., Zorbas, C., Langhendries, J.-L., Mullineux, S.-T., Stamatopoulou, V., Mullier, R., Wacheul, L., & Lafontaine, D. L. J. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.011 · Cited by 492 · see citing works
Functional Proteomic Analysis of Human Nucleolus
Scherl, A., Couté, Y., Déon, C., Callé, A., Kindbeiter, K., Sanchez, J., Greco, A., Hochstrasser, D. F., & Diaz, J. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-05-0271 · Cited by 480 · see citing works
White Adipose Tissue as Endocrine Organ and Its Role in Obesity
Frigolet, M. E., Torres, N., & Tovar, A. R. (2008) · Archives of Medical Research · doi:10.1016/j.arcmed.2008.09.005 · Cited by 457 · see citing works
eIF4E – from translation to transformation
Mamane, Y., Petroulakis, E., Rong, L., Yoshida, K., Ler, L. W., & Sonenberg, N. (2004) · Oncogene · doi:10.1038/sj.onc.1207549 · Cited by 452 · see citing works
Rapamycin administration in humans blocks the contraction‐induced increase in skeletal muscle protein synthesis
Drummond, M. J., Fry, C. S., Glynn, E. L., Dreyer, H. C., Dhanani, S., Timmerman, K. L., Volpi, E., & Rasmussen, B. B. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.163816 · Cited by 439 · see citing works
The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer
Drygin, D., Rice, W. G., & Grummt, I. (2010) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105844 · Cited by 419 · see citing works
Mechanism of work-induced hypertrophy of skeletal muscle
GOLDBERG, A. L., ETLINGER, J. D., GOLDSPINK, D. F., & JABLECKI, C. (1975) · Medicine and Science in Sports and Exercise · doi:10.1249/00005768-197500730-00016 · Cited by 402 · see citing works
Functions of Ribosomal Proteins in Assembly of Eukaryotic Ribosomes In Vivo
de la Cruz, J., Karbstein, K., & Woolford, J. L. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-033917 · Cited by 387 · see citing works
Cyclin D1: polymorphism, aberrant splicing and cancer risk
Knudsen, K. E., Diehl, J. A., Haiman, C. A., & Knudsen, E. S. (2006) · Oncogene · doi:10.1038/sj.onc.1209371 · Cited by 363 · see citing works
RNA, the first macromolecular catalyst: the ribosome is a ribozyme
Steitz, T. A., & Moore, P. B. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00169-5 · Cited by 319 · see citing works
A housekeeper with power of attorney: the rRNA genes in ribosome biogenesis
Moss, T., Langlois, F., Gagnon-Kugler, T., & Stefanovsky, V. Y. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6278-1 · Cited by 310 · see citing works
Relationship between Protein Synthesis and RNA Content in Skeletal Muscle
Millward, D. J., Garlick, P. J., James, W. P. T., Nnanyelugo, D. O., & RYATT, J. S. (1973) · Nature · doi:10.1038/241204a0 · Cited by 302 · see citing works
The role of skeletal muscle mTOR in the regulation of mechanical load‐induced growth
Goodman, C. A., Frey, J. W., Mabrey, D. M., Jacobs, B. L., Lincoln, H. C., You, J., & Hornberger, T. A. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.218255 · Cited by 297 · see citing works
RNA-polymerase-I-directed rDNA transcription, life and works
Russell, J., & Zomerdijk, J. C. B. M. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.12.008 · Cited by 291 · see citing works
Mitogen-activated protein kinase (MAPK) pathway activation: effects of age and acute exercise on human skeletal muscle
Williamson, D., Gallagher, P. M., Harber, M. P., Hollon, C. J., & Trappe, S. W. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.036673 · Cited by 290 · see citing works
The relationships among IGF-1, DNA content, and protein accumulation during skeletal muscle hypertrophy
Adams, G. R., & Haddad, F. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.6.2509 · Cited by 287 · see citing works
Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E
Rosenwald, I. B., Lazaris-Karatzas, A., Sonenberg, N., & Schmidt, E. V. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7358 · Cited by 287 · see citing works
Satellite cells and myonuclei in young and elderly women and men
Kadi, F., Charifi, N., Denis, C., & Lexell, J. E. (2003) · Muscle & Nerve · doi:10.1002/mus.10510 · Cited by 283 · see citing works
Contribution of satellite cells to IGF‐I induced hypertrophy of skeletal muscle
Barton‐Davis, Shoturma, & Sweeney (1999) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1999.00618.x · Cited by 283 · see citing works
Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program
Chauvin, C., Koka, V., Nouschi, A., Mieulet, V., Hoareau‐Aveilla, C., Dreazen, A., Cagnard, N., Carpentier, W., Kiss, T., Meyuhas, O., et al. (2013) · Oncogene · doi:10.1038/onc.2012.606 · Cited by 279 · see citing works
Phosphorylation of the Eukaryotic Translation Initiation Factor eIF4E Contributes to Its Transformation and mRNA Transport Activities
Topisirovic, I., Ruiz-Gutierrez, M., & Borden, K. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2677 · Cited by 267 · see citing works
In Vitro Model for Stretch-Induced Hypertrophy of Skeletal Muscle
Vandenburgh, H. H., & Kaufman, S. (1979) · Science · doi:10.1126/science.569901 · Cited by 264 · see citing works
Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression
Parks, M. M., Kurylo, C. M., Dass, R. A., Bojmar, L., Lyden, D., Vincent, C. T., & Blanchard, S. C. (2018) · Science Advances · doi:10.1126/sciadv.aao0665 · Cited by 260 · see citing works
ERK-Dependent Phosphorylation of the Transcription Initiation Factor TIF-IA Is Required for RNA Polymerase I Transcription and Cell Growth
Zhao, J., Yuan, X., Frödin, M., & Grummt, I. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00036-4 · Cited by 259 · see citing works
The role of human ribosomal proteins in the maturation of rRNA and ribosome production
Robledo, S. M., Idol, R. A., Crimmins, D. L., Ladenson, J. H., Mason, P. J., & Bessler, M. (2008) · RNA · doi:10.1261/rna.1132008 · Cited by 254 · see citing works
Age effect on transcript levels and synthesis rate of muscle MHC and response to resistance exercise
Balagopal, P., Coenen-Schimke, J. M., Ades, P. A., Adey, D., & Nair, K. S. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e203 · Cited by 248 · see citing works
Resistance exercise-induced increase in muscle mass correlates with p70S6 kinase phosphorylation in human subjects
Terzis, G., Georgiadis, G., Stratakos, G., Vogiatzis, I., Kavouras, S., Manta, P., Mascher, H., & Blomstrand, E. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0564-y · Cited by 242 · see citing works
AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer
Chan, J. C., Hannan, K. M., Riddell, K., Ng, P. Y., Peck, A., Lee, R. S., Hung, S. S. C., Astle, M. V., Bywater, M. J., Wall, M., et al. (2011) · Science Signaling · doi:10.1126/scisignal.2001754 · Cited by 239 · see citing works
Protein Turnover in Skeletal Muscle
Goldberg, A. L. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93116-9 · Cited by 221 · see citing works
Post-exercise cold water immersion attenuates acute anabolic signalling and long-term adaptations in muscle to strength training
Roberts, L. A., Raastad, T., Markworth, J. F., Figueiredo, V. C., Egner, I. M., Shield, A., Cameron‐Smith, D., Coombes, J. S., & Peake, J. M. (2015) · The Journal of Physiology · doi:10.1113/jp270570 · Cited by 218 · see citing works
Self-citation
Time course of changes in markers of myogenesis in overloaded rat skeletal muscles
Adams, G. R., Haddad, F., & Baldwin, K. M. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.5.1705 · Cited by 218 · see citing works
Work-induced growth of skeletal muscle in normal and hypophysectomized rats
Goldberg, A. (1967) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1967.213.5.1193 · Cited by 218 · see citing works
UBF Binding In Vivo Is Not Restricted to Regulatory Sequences within the Vertebrate Ribosomal DNA Repeat
O’Sullivan, A., Sullivan, G. J., & McStay, B. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.2.657-668.2002 · Cited by 215 · see citing works
Translational signaling responses preceding resistance training-mediated myofiber hypertrophy in young and old humans
Mayhew, D. L., Kim, J.-S., Cross, J. M., Ferrando, A. A., & Bamman, M. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91234.2008 · Cited by 215 · see citing works
Ribosome biogenesis: Emerging evidence for a central role in the regulation of skeletal muscle mass
Chaillou, T., Kirby, T. J., & McCarthy, J. J. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24604 · Cited by 211 · see citing works
Self-citation
UBF levels determine the number of active ribosomal RNA genes in mammals
Sanij, E., Poortinga, G., Sharkey, K., Hung, S. S. C., Holloway, T. P., Quin, J. E., Robb, E. L., Wong, L. H., Thomas, W. G., Stefanovsky, V. Y., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200805146 · Cited by 210 · see citing works
RNA polymerase III transcription and cancer
White, R. J. (2004) · Oncogene · doi:10.1038/sj.onc.1207547 · Cited by 207 · see citing works
Skeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide‐derived measures of muscle protein synthesis and mechanistic target of rapamycin complex 1 signaling
Brook, M. S., Wilkinson, D. J., Mitchell, W. K., Lund, J. N., Szewczyk, N. J., Greenhaff, P. L., Smith, K., & Atherton, P. J. (2015) · The FASEB Journal · doi:10.1096/fj.15-273755 · Cited by 206 · see citing works
Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans
Brook, M. S., Wilkinson, D. J., Mitchell, W. K., Lund, J. N., Phillips, B. E., Szewczyk, N. J., Greenhaff, P. L., Smith, K., & Atherton, P. J. (2016) · The Journal of Physiology · doi:10.1113/jp272857 · Cited by 204 · see citing works
The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise
Ogasawara, R., Fujita, S., Hornberger, T. A., Kitaoka, Y., Makanae, Y., Nakazato, K., & Ishii, N. (2016) · Scientific Reports · doi:10.1038/srep31142 · Cited by 199 · see citing works
Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes
Gibbons, J. G., Branco, A. T., Godinho, S. A., Yu, S., & Lemos, B. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416878112 · Cited by 198 · see citing works
Basic mechanisms in RNA polymerase i transcription of the ribosomal RNA genes
Goodfellow, S. J., & Zomerdijk, J. C. B. M. (2013) · Subcellular Biochemistry · doi:10.1007/978-94-007-4525-4_10 · Cited by 197 · see citing works
RNA polymerases I and III, non-coding RNAs and cancer
White, R. J. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.003 · Cited by 190 · see citing works
Short-term strength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon: differential effects of specific contraction types
Heinemeier, K. M., Olesen, J. L., Schjerling, P., Haddad, F., Langberg, H., Baldwin, K. M., & Kjær, M. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00866.2006 · Cited by 189 · see citing works
Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo
Kim, S., Li, Q., Dang, C. V., & Lee, L. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200372597 · Cited by 187 · see citing works
hRRN3 is essential in the SL1‐mediated recruitment of RNA Polymerase I to rRNA gene promoters
Miller, G., Panov, K. I., Friedrich, J. K., Trinkle‐Mulcahy, L., Lamond, A. I., & Zomerdijk, J. C. B. M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.6.1373 · Cited by 184 · see citing works
Phosphorylation by G1‐specific cdk–cyclin complexes activates the nucleolar transcription factor UBF
Voit, R., Hoffmann, M., & Grummt, I. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1891 · Cited by 181 · see citing works
The RNA polymerase I transcription machinery
Russell, J., & Zomerdijk, J. C. B. M. (2006) · Biochemical Society Symposia · doi:10.1042/bss0730203 · Cited by 179 · see citing works
Fasted‐state skeletal muscle protein synthesis after resistance exercise is altered with training
Kim, P. L., Staron, R. S., & Phillips, S. M. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.093708 · Cited by 171 · see citing works
Tor Pathway Regulates Rrn3p-dependent Recruitment of Yeast RNA Polymerase I to the Promoter but Does Not Participate in Alteration of the Number of Active Genes
Claypool, J. A., French, S. L., Johzuka, K., Eliason, K., Vũ, L., Dodd, J. A., Beyer, A. L., & Nomura, M. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-08-0594 · Cited by 171 · see citing works
The recruitment of RNA polymerase I on rDNA is mediated by the interaction of the A43 subunit with Rrn3
Peyroche, G., Milkereit, P., Bischler, N., Tschochner, H., Schultz, P., Sentenac, A., Carles, C., & Riva, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.20.5473 · Cited by 169 · see citing works
mTOR function in skeletal muscle hypertrophy: Increased ribosomal RNA via cell cycle regulators
Nader, G. A., McLoughlin, T. J., & Esser, K. A. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00165.2005 · Cited by 166 · see citing works
Ribosomal DNA copy number is coupled with gene expression variation and mitochondrial abundance in humans
Gibbons, J. G., Branco, A. T., Yu, S., & Lemos, B. (2014) · Nature Communications · doi:10.1038/ncomms5850 · Cited by 165 · see citing works
Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics
Haddach, M., Schwaebe, M. K., Michaux, J., Nagasawa, J. Y., O’Brien, S., Whitten, J. P., Pierre, F., Kerdoncuff, P., Darjania, L., Stansfield, R. K., et al. (2012) · ACS Medicinal Chemistry Letters · doi:10.1021/ml300110s · Cited by 165 · see citing works
Ribosome biogenesis may augment resistance training-induced myofiber hypertrophy and is required for myotube growth in vitro
Stec, M. J., Kelly, N. A., Many, G. M., Windham, S. T., Tuggle, S. C., & Bamman, M. M. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00486.2015 · Cited by 161 · see citing works
mTOR binds to the promoters of RNA polymerase I- and III-transcribed genes
Tsang, C. K., Liu, H., & Zheng, X.-F. (2010) · Cell Cycle · doi:10.4161/cc.9.5.10876 · Cited by 157 · see citing works
Differential requirement for satellite cells during overload-induced muscle hypertrophy in growing versus mature mice
Murach, K. A., White, S. H., Wen, Y., Ho, A., Dupont-Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2017) · Skeletal Muscle · doi:10.1186/s13395-017-0132-z · Cited by 156 · see citing works
Ribosomal RNA Depletion for Efficient Use of RNA‐Seq Capacity
O’Neil, D., Glowatz, H., & Schlumpberger, M. (2013) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb0419s103 · Cited by 154 · see citing works
PROTEIN SYNTHESIS DURING WORK-INDUCED GROWTH OF SKELETAL MUSCLE
Goldberg, A. L. (1968) · The Journal of Cell Biology · doi:10.1083/jcb.36.3.653 · Cited by 152 · see citing works
Cardiac hypertrophy: A matter of translation
Hannan, R. D., Jenkins, A., Jenkins, A., & Brandenburger, Y. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03873.x · Cited by 150 · see citing works
Acute resistance exercise activates rapamycin‐sensitive and ‐insensitive mechanisms that control translational activity and capacity in skeletal muscle
West, D. W. D., Baehr, L. M., Marcotte, G. R., Chason, C. M., Tolento, L., Gomes, A. V., Bodine, S. C., & Baar, K. (2015) · The Journal of Physiology · doi:10.1113/jp271365 · Cited by 150 · see citing works
Anabolic and catabolic pathways regulating skeletal muscle mass
McCarthy, J. J., & Esser, K. A. (2010) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32833781b5 · Cited by 148 · see citing works
Self-citation
Regulation of global and specific mRNA translation by the mTOR signaling pathway
Nandagopal, N., & Roux, P. P. (2014) · Translation · doi:10.4161/21690731.2014.983402 · Cited by 144 · see citing works
Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation
Murach, K. A., Fry, C. S., Kirby, T. J., Jackson, J. R., Lee, J. D., White, S. H., Dupont-Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2018) · Physiology · doi:10.1152/physiol.00019.2017 · Cited by 137 · see citing works
Self-citation
Ribosome biogenesis adaptation in resistance training-induced human skeletal muscle hypertrophy
Figueiredo, V. C., Caldow, M. K., Massie, V., Markworth, J. F., Cameron-Smith, D., & Blazevich, A. J. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00050.2015 · Cited by 133 · see citing works
Self-citation
Resistance exercise training modulates acute gene expression during human skeletal muscle hypertrophy
Nader, G. A., von Walden, F., Liu, C., Lindvall, J., Gutmann, L., Pistilli, E. E., & Gordon, P. M. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01366.2013 · Cited by 129 · see citing works
Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription
Voit, R., & Grummt, I. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231071698 · Cited by 125 · see citing works
Decrease in Akt/PKB signalling in human skeletal muscle by resistance exercise
Deldicque, L., Atherton, P. J., Patel, R. S., Theisen, D., Nielens, H., Rennie, M. J., & Francaux, M. (2008) · European Journal of Applied Physiology · doi:10.1007/s00421-008-0786-7 · Cited by 117 · see citing works
S6K1 Is Required for Increasing Skeletal Muscle Force during Hypertrophy
Marabita, M., Baraldo, M., Solagna, F., Ceelen, J., Sartori, R., Nolte, H., Nemazanyy, I., Pyronnet, S., Krüger, M., Pende, M., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.020 · Cited by 116 · see citing works
Human exercise-mediated skeletal muscle hypertrophy is an intrinsic process
West, D. W. D., Burd, N. A., Staples, A. W., & Phillips, S. M. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.05.012 · Cited by 113 · see citing works
Phosphatidylinositol 3-Kinase and mTOR Signaling Pathways Regulate RNA Polymerase I Transcription in Response to IGF-1 and Nutrients
James, M., & Zomerdijk, J. C. B. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307735200 · Cited by 113 · see citing works
Inventory of High-Abundance mRNAs in Skeletal Muscle of Normal MenPreprint
Welle, S. L., Bhatt, K. S., & Thornton, C. A. (1999) · Genome Research · doi:10.1101/gr.9.5.506 · Cited by 112 · see citing works
Biomarkers associated with low, moderate, and high vastus lateralis muscle hypertrophy following 12 weeks of resistance training
Mobley, C. B., Haun, C. T., Roberson, P. A., Mumford, P. W., Kephart, W. C., Romero, M. A., Osburn, S. C., Vann, C. G., Young, K. C., Beck, D. T., et al. (2018) · PLOS ONE · doi:10.1371/journal.pone.0195203 · Cited by 112 · see citing works
Resistance exercise induced mTORC1 signaling is not impaired by subsequent endurance exercise in human skeletal muscle
Apró, W., Wang, L., Pontén, M., Blomstrand, E., & Sahlin, K. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00091.2013 · Cited by 109 · see citing works
Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growthPreprint
Blattner, C., Jennebach, S., Herzog, F., Mayer, A., Cheung, A. C. M., Witte, G., Lorenzen, K., Hopfner, K., Heck, A. J. R., Aebersold, R. H., et al. (2011) · Genes & Development · doi:10.1101/gad.17363311 · Cited by 109 · see citing works
Satellite cell proliferation and differentiation during postnatal growth of porcine skeletal muscle
Mesires, N. T., & Doumit, M. E. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00341.2001 · Cited by 105 · see citing works
Protein metabolism in rat gastrocnemius muscle after stimulated chronic concentric exercise
Wong, T., & Booth, F. W. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.69.5.1709 · Cited by 104 · see citing works
Impact of resistance exercise on ribosome biogenesis is acutely regulated by post-exercise recovery strategies
Figueiredo, V. C., Roberts, L. A., Markworth, J. F., Barnett, M. P. G., Coombes, J. S., Raastad, T., Peake, J. M., & Cameron-Smith, D. (2016) · Physiological Reports · doi:10.14814/phy2.12670 · Cited by 104 · see citing works
Self-citation
Mechanical loading induces the expression of a Pol I regulon at the onset of skeletal muscle hypertrophy
von Walden, F., Figueiredo, V. C., Farrants, A. Ö., & Nader, G. A. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00460.2011 · Cited by 100 · see citing works
Self-citation
Time course of gene expression during mouse skeletal muscle hypertrophy
Chaillou, T., Lee, J. D., England, J. H., Esser, K. A., & McCarthy, J. J. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00611.2013 · Cited by 97 · see citing works
Self-citation
Multiple interactions between RNA polymerase I, TIF‐IA and TAFI subunits regulate preinitiation complex assembly at the ribosomal gene promoter
Yuan, X., Zhao, J., Zentgraf, H., Hoffmann‐Rohrer, U., & Grummt, I. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf212 · Cited by 96 · see citing works
DNA looping in the RNA polymerase I enhancesome is the result of non-cooperative in-phase bending by two UBF molecules
Stefanovsky, V. Y. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.15.3241 · Cited by 96 · see citing works
Regulation of rDNA transcription in response to growth factors, nutrients and energy
Kusnadi, E. P., Hannan, K. M., Hicks, R. J., Hannan, R. D., Pearson, R. B., & Kang, J. (2014) · Gene · doi:10.1016/j.gene.2014.11.010 · Cited by 95 · see citing works
A novel TBP‐associated factor of SL1 functions in RNA polymerase I transcription
Gorski, J. J., Pathak, S., Panov, K. I., Kasciukovic, T., Panova, T., Russell, J., & Zomerdijk, J. C. B. M. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601601 · Cited by 95 · see citing works
MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL
Landon, A. L., Muniandy, P. A., Shetty, A. C., Lehrmann, E., Volpon, L., Houng, S., Zhang, Y., Dai, B., Peroutka, R. J., Mazan-Mamczarz, K., et al. (2014) · Nature Communications · doi:10.1038/ncomms6413 · Cited by 93 · see citing works
Blunted hypertrophic response in aged skeletal muscle is associated with decreased ribosome biogenesis
Kirby, T. J., Lee, J. D., England, J. H., Chaillou, T., Esser, K. A., & McCarthy, J. J. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00296.2015 · Cited by 89 · see citing works
Self-citation
The influence of activity on muscle size and protein turnover.
Goldspink, D. F. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp011668 · Cited by 87 · see citing works
Myonuclear transcription is responsive to mechanical load and DNA content but uncoupled from cell size during hypertrophy
Kirby, T. J., Patel, R. M., McClintock, T. S., Dupont‐Versteegden, E. E., Peterson, C. A., & McCarthy, J. J. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-08-0585 · Cited by 86 · see citing works
Self-citation
Simultaneous sequencing of coding and noncoding RNA reveals a human transcriptome dominated by a small number of highly expressed noncoding genes
Boivin, V., Deschamps-Francoeur, G., Couture, S., Nottingham, R. M., Bouchard-Bourelle, P., Lambowitz, A. M., Scott, M. S., & Abou-Elela, S. (2018) · RNA · doi:10.1261/rna.064493.117 · Cited by 86 · see citing works
The Roles of RNA in the Synthesis of ProteinPreprint
Moore, P. B., & Steitz, T. A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003780 · Cited by 85 · see citing works
Human tumor suppressor p14ARF negatively regulates rRNA transcription and inhibits UBF1 transcription factor phosphorylation
Ayrault, O., Andrique, L., Fauvin, D., Eymin, B., Gazzéri, S., & Seité, P. (2006) · Oncogene · doi:10.1038/sj.onc.1209743 · Cited by 84 · see citing works
Function of the Growth-Regulated Transcription Initiation Factor TIF-IA in Initiation Complex Formation at the Murine Ribosomal Gene Promoter
Schnapp, A., Schnapp, G., Erny, B., & Grummt, I. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.11.6723 · Cited by 82 · see citing works
Ribosome biogenesis is necessary for skeletal muscle hypertrophy
Wen, Y., Alimov, A. P., & McCarthy, J. J. (2016) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000082 · Cited by 82 · see citing works
Self-citation
The effects of age and resistance loading on skeletal muscle ribosome biogenesis
Stec, M. J., Mayhew, D. L., & Bamman, M. M. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00489.2015 · Cited by 80 · see citing works
Enhanced Protein Synthesis in a Cell-Free System from Hypertrophied Skeletal Muscle
Hamosh, M., Lesch, M., Baron, J., & Kaufman, S. (1967) · Science · doi:10.1126/science.157.3791.935 · Cited by 75 · see citing works
Cellular Events in Renal Hypertrophy
Fine, L. G., & Norman, J. T. (1989) · Annual Review of Physiology · doi:10.1146/annurev.ph.51.030189.000315 · Cited by 74 · see citing works
mTOR signaling regulates myotube hypertrophy by modulating protein synthesis, rDNA transcription, and chromatin remodeling
von Walden, F., Liu, C., Aurigemma, N., & Nader, G. A. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00144.2016 · Cited by 70 · see citing works
Enhanced skeletal muscle ribosome biogenesis, yet attenuated mTORC1 and ribosome biogenesis-related signalling, following short-term concurrent versus single-mode resistance training
Fyfe, J. J., Bishop, D. J., Bartlett, J. D., Hanson, E. D., Anderson, M. J., Garnham, A. P., & Stepto, N. K. (2018) · Scientific Reports · doi:10.1038/s41598-017-18887-6 · Cited by 69 · see citing works
Pre‐ and postnatal growth and protein turnover in four muscles of the rat
Kelly, F. J., Lewis, S. E. M., Anderson, P., & Goldspink, D. F. (1984) · Muscle & Nerve · doi:10.1002/mus.880070309 · Cited by 67 · see citing works
Changes in myonuclear domain size do not precede muscle hypertrophy during prolonged resistance‐type exercise training
Snijders, T., Smeets, J. S. J., van Kranenburg, J. M. X., Kies, A. K., van Loon, L. J. C., & Verdijk, L. B. (2015) · Acta Physiologica · doi:10.1111/apha.12609 · Cited by 67 · see citing works
A Step Subsequent to Preinitiation Complex Assembly at the Ribosomal RNA Gene Promoter Is Rate Limiting for Human RNA Polymerase I-Dependent Transcription
Panov, K. I., Friedrich, J. K., & Zomerdijk, J. C. B. M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.8.2641-2649.2001 · Cited by 66 · see citing works
Correlation between Ribosome Biogenesis and the Magnitude of Hypertrophy in Overloaded Skeletal Muscle
Nakada, S., Ogasawara, R., Kawada, S., Maekawa, T., & Ishii, N. (2016) · PLOS ONE · doi:10.1371/journal.pone.0147284 · Cited by 64 · see citing works
Muscle Protein Anabolic Resistance to Essential Amino Acids Does Not Occur in Healthy Older Adults Before or After Resistance Exercise Training.
Moro, T., Brightwell, C. R., Deer, R., Graber, T. G., Galvan, E., Fry, C., Volpi, E., & Rasmussen, B. (2018) · Journal of NutriLife · doi:10.1093/jn/nxy064 · Cited by 58 · see citing works
Synthesis of Protein, Ribonucleic Acid, and Ribosomes by Individual Bacterial Cells in Balanced Growth
Ecker, R. E., & Kokaisl, G. (1969) · Journal of Bacteriology · doi:10.1128/jb.98.3.1219-1226.1969 · Cited by 57 · see citing works
ERK Modulates DNA Bending and Enhancesome Structure by Phosphorylating HMG1-Boxes 1 and 2 of the RNA Polymerase I Transcription Factor UBF
Stefanovsky, V. Y., Langlois, F., Bazett‐Jones, D. P., Pelletier, G., & Moss, T. (2006) · Biochemistry · doi:10.1021/bi051782h · Cited by 56 · see citing works
Ibuprofen treatment blunts early translational signaling responses in human skeletal muscle following resistance exercise
Markworth, J. F., Vella, L. D., Figueiredo, V. C., & Cameron‐Smith, D. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01299.2013 · Cited by 55 · see citing works
Self-citation
Post-absorptive muscle protein turnover affects resistance training hypertrophy
Reidy, P., Borack, M. S., Markofski, M., Dickinson, J., Fry, C., Deer, R., Volpi, E., & Rasmussen, B. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3566-4 · Cited by 49 · see citing works
Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease
Diesch, J., Hannan, R. D., & Sanij, E. (2014) · Cell & Bioscience · doi:10.1186/2045-3701-4-43 · Cited by 48 · see citing works
In vitro Activity of Ribosomes and RNA Content of Skeletal Muscle in Young Rats Fed Adequate or Low Protein ,
Young, V. R., & Alexis, S. D. (1968) · Journal of Nutrition · doi:10.1093/jn/96.2.255 · Cited by 40 · see citing works
DNA Binding by the Ribosomal DNA Transcription Factor Rrn3 Is Essential for Ribosomal DNA Transcription
Stepanchick, A. N., Zhi, H., Cavanaugh, A. H., Rothblum, K. N., Schneider, D. A., & Rothblum, L. I. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.444265 · Cited by 40 · see citing works
Regulation of myofibrillar protein turnover during maturation in normal and undernourished rat pups
Fiorotto, M. L., Davis, T. A., & Reeds, P. J. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.4.r845 · Cited by 39 · see citing works
Function of the Growth-Regulated Transcription Initiation Factor TIF-IA in Initiation Complex Formation at the Murine Ribosomal Gene Promoter
Schnapp, A., Schnapp, G., Erny, B., et al. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.11.6723-6732.1993 · Cited by 38 · see citing works
Ribosome abundance regulates the recovery of skeletal muscle protein mass upon recuperation from postnatal undernutrition in mice
Fiorotto, M. L., Davis, T. A., Sosa, H. A., Villegas‐Montoya, C., Estrada, I. J., & Fleischmann, R. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.279067 · Cited by 32 · see citing works
Enhanced RNA polymerase activity in skeletal muscle undergoing hypertrophy
Sobel, B. E., & Kaufman, S. (1970) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(70)90464-9 · Cited by 32 · see citing works
High-power resistance exercise induces MAPK phosphorylation in weightlifting trained men
Galpin, A. J., Fry, A. C., Chiu, L. Z. F., Thomason, D. B., & Schilling, B. K. (2012) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h11-131 · Cited by 31 · see citing works
Loss of REDD1 augments the rate of the overload-induced increase in muscle mass
Gordon, B. S., Liu, C., Steiner, J. L., Nader, G. A., Jefferson, L. S., & Kimball, S. R. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00159.2016 · Cited by 27 · see citing works
Not all the number of skeletal muscle fibers is determined prenatally
Li, M., Zhou, X., Chen, Y., Nie, Y., Huang, H., Chen, H., & Mo, D. (2015) · BMC Developmental Biology · doi:10.1186/s12861-015-0091-8 · Cited by 26 · see citing works
Genetic and Molecular Mechanisms of Cell Size Control
Montagne, J. (2000) · Molecular Cell Biology Research Communications · doi:10.1006/mcbr.2001.0284 · Cited by 25 · see citing works
SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner
Lee, D., An, J., Park, Y.-U., Liaw, H., Woodgate, R., Park, J. H., & Myung, K. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701978114 · Cited by 25 · see citing works
Comparative Analysis of Muscle Hypertrophy Models Reveals Divergent Gene Transcription Profiles and Points to Translational Regulation of Muscle Growth through Increased mTOR Signaling
Pereira, M. G., Dyar, K. A., Nogara, L., Solagna, F., Marabita, M., Baraldo, M., Chemello, F., Germinario, E., Romanello, V., Nolte, H., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00968 · Cited by 23 · see citing works
AKT signalling is required for ribosomal RNA synthesis and progression of E μ‐Myc B ‐cell lymphoma in vivo
Devlin, J. R., Hannan, K. M., Ng, P. Y., Bywater, M. J., Shortt, J., Cullinane, C. M., McArthur, G. A., Johnstone, R. W., Hannan, R. D., & Pearson, R. B. (2013) · FEBS Journal · doi:10.1111/febs.12135 · Cited by 21 · see citing works
Mammalian Rrn3 is required for the formation of a transcription competent preinitiation complex containing RNA polymerase I.
Cavanaugh, A. H., Evans, A., & Rothblum, L. I. (2008) · PubMed · Cited by 21 · see citing works
Ribosomal chromatin organizationThis paper is one of a selection of papers published in this Special Issue, entitled 27th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.
Huang, S., Rothblum, L. I., & Chen, D. (2006) · Biochemistry and Cell Biology · doi:10.1139/o06-089 · Cited by 18 · see citing works
A dynamic ribosomal biogenesis response is not required for IGF‐1–mediated hypertrophy of human primary myotubes
Crossland, H., Timmons, J. A., & Atherton, P. J. (2017) · The FASEB Journal · doi:10.1096/fj.201700329r · Cited by 10 · see citing works
High dose of whey protein after resistance exercise promotes 45 S preribosomal RNA synthesis in older men
Figueiredo, V. C., Zeng, N., D’Souza, R. F., Markworth, J. F., Gatta, P. A. D., Petersen, A. C., Barnett, M. P. G., & Cameron‐Smith, D. (2017) · Nutrition · doi:10.1016/j.nut.2017.11.018 · Cited by 7 · see citing works
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Molecular Responses to Acute Exercise and Their Relevance for Adaptations in Skeletal Muscle to Exercise Training
Egan, B., & Sharples, A. P. (2023) · Physiological Reviews · doi:10.1152/physrev.00054.2021 · Cited by 278 · see citing works
Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions
Roberts, M. D., McCarthy, J. J., Hornberger, T. A., Phillips, S. M., Mackey, A. L., Nader, G. A., Boppart, M. D., Kavazis, A. N., Reidy, P. T., Ogasawara, R., et al. (2023) · Physiological Reviews · doi:10.1152/physrev.00039.2022 · Cited by 214 · see citing works
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Molecular Mechanisms of Skeletal Muscle Hypertrophy
Schiaffino, S., Reggiani, C., Akimoto, T., & Blaauw, B. (2020) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-200568 · Cited by 169 · see citing works
Regulation of Myostatin on the Growth and Development of Skeletal Muscle
Chen, M., Zhao, Y.-P., Zhao, Y., Deng, S., & Yu, K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.785712 · Cited by 153 · see citing works
Exercise Induces Tissue-Specific Adaptations to Enhance Cardiometabolic Health
Ashcroft, S. P., Stocks, B., Egan, B., & Zierath, J. R. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.008 · Cited by 149 · see citing works
Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains
Cramer, A., Prasad, V., Eftestøl, E., Song, T., Hansson, K., Dugdale, H. F., Sadayappan, S., Ochala, J., Gundersen, K., & Millay, D. P. (2020) · Nature Communications · doi:10.1038/s41467-020-20058-7 · Cited by 109 · see citing works
Benefits of higher resistance-training volume are related to ribosome biogenesis
Hammarström, D., Øfsteng, S., Koll, L., Hanestadhaugen, M., Hollan, I., Apró, W., Whist, J. E., Blomstrand, E., Rønnestad, B. R., & Ellefsen, S. (2020) · The Journal of Physiology · doi:10.1113/jp278455 · Cited by 99 · see citing works
Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease
Chiara, L. D., Conte, C., Semeraro, R., Díaz-Bulnes, P., Angelotti, M. L., Mazzinghi, B., Molli, A., Antonelli, G., Landini, S., Melica, M. E., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33110-5 · Cited by 79 · see citing works
Nucleus Type-Specific DNA Methylomics Reveals Epigenetic “Memory” of Prior Adaptation in Skeletal Muscle
Wen, Y., Dungan, C. M., Mobley, C. B., Valentino, T. R., von Walden, F., & Murach, K. A. (2021) · Function · doi:10.1093/function/zqab038 · Cited by 77 · see citing works
Skeletal Muscle Recovery from Disuse Atrophy: Protein Turnover Signaling and Strategies for Accelerating Muscle Regrowth
Mirzoev, T. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217940 · Cited by 65 · see citing works
Pathophysiological mechanisms explaining poor clinical outcome of older cancer patients with low skeletal muscle mass
Looijaard, S. M. L. M., Hekkert, M. L. T. L., Wüst, R. C. I., Otten, R. H. J., Meskers, C. G. M., & Maier, A. B. (2020) · Acta Physiologica · doi:10.1111/apha.13516 · Cited by 65 · see citing works
Genetic and epigenetic regulation of skeletal muscle ribosome biogenesis with exercise
Figueiredo, V. C., Wen, Y., Alkner, B., Fernandez‐Gonzalo, R., Norrbom, J., Vechetti, I. J., Valentino, T., Mobley, C. B., Zentner, G. E., Peterson, C. A., et al. (2021) · The Journal of Physiology · doi:10.1113/jp281244 · Cited by 64 · see citing works
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Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
Murach, K. A., Liu, Z., Jude, B., Figueiredo, V. C., Wen, Y., Khadgi, S., Lim, S., da Silva, F. M., Greene, N. P., Lanner, J. T., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102515 · Cited by 60 · see citing works
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Skeletal Muscle Ribosome and Mitochondrial Biogenesis in Response to Different Exercise Training Modalities
Mesquita, P. H. C., Vann, C. G., Phillips, S. M., McKendry, J., Young, K. C., Kavazis, A. N., & Roberts, M. D. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.725866 · Cited by 62 · see citing works
The Role of GSK-3β in the Regulation of Protein Turnover, Myosin Phenotype, and Oxidative Capacity in Skeletal Muscle under Disuse Conditions
Mirzoev, T. M., Sharlo, K. A., & Shenkman, B. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105081 · Cited by 60 · see citing works
State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions
Lavin, K. M., Coen, P. M., Baptista, L. C. P., Bell, M. B., Drummer, D. J., Harper, S. A., Lixandrão, M. E., McAdam, J. S., O’Bryan, S. M., Ramos, S. V., et al. (2022) · Comprehensive physiology · doi:10.1002/cphy.c200033 · Cited by 74 · see citing works
Revisiting the roles of protein synthesis during skeletal muscle hypertrophy induced by exercise
Figueiredo, V. C. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00162.2019 · Cited by 58 · see citing works
Self-citation
Ribosome biogenesis and degradation regulate translational capacity during muscle disuse and reloading
Figueiredo, V. C., D’Souza, R. F., Pelt, D. W. V., Lawrence, M. M., Zeng, N., Markworth, J. F., Poppitt, S. D., Miller, B. F., Mitchell, C. J., McCarthy, J. J., et al. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12636 · Cited by 57 · see citing works
Self-citation
Ribosome biogenesis in skeletal muscle: coordination of transcription and translation
von Walden, F. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00963.2018 · Cited by 57 · see citing works
The myonuclear DNA methylome in response to an acute hypertrophic stimulus
von Walden, F., Rea, M., Mobley, C. B., Fondufe‐Mittendorf, Y. N., McCarthy, J. J., Peterson, C. A., & Murach, K. A. (2020) · Epigenetics · doi:10.1080/15592294.2020.1755581 · Cited by 53 · see citing works
Self-citation
Resistance Exercise, Aging, Disuse, and Muscle Protein Metabolism
McKendry, J., Stokes, T., Mcleod, J. C., & Phillips, S. M. (2021) · Comprehensive physiology · doi:10.1002/cphy.c200029 · Cited by 71 · see citing works
Six Weeks of Low-Load Blood Flow Restricted and High-Load Resistance Exercise Training Produce Similar Increases in Cumulative Myofibrillar Protein Synthesis and Ribosomal Biogenesis in Healthy Males
Sieljacks, P., Wang, J., Groennebaek, T., Rindom, E., Jakobsgaard, J. E., Herskind, J., Gravholt, A., Møller, A. B., Musci, R. V., de Paoli, F. V., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00649 · Cited by 50 · see citing works
Massage as a mechanotherapy promotes skeletal muscle protein and ribosomal turnover but does not mitigate muscle atrophy during disuse in adult rats
Lawrence, M. M., Pelt, D. W. V., Confides, A. L., Hunt, E. R., Hettinger, Z. R., Laurin, J. L., Reid, J. J., Peelor, F. F., Butterfield, T. A., Dupont‐Versteegden, E. E., et al. (2020) · Acta Physiologica · doi:10.1111/apha.13460 · Cited by 46 · see citing works
Does a Hypertrophying Muscle Fibre Reprogramme its Metabolism Similar to a Cancer Cell?
Wackerhage, H., Vechetti, I. J., Baumert, P., Gehlert, S., Becker, L., Jaspers, R. T., & de Angelis, M. H. (2022) · Sports Medicine · doi:10.1007/s40279-022-01676-1 · Cited by 46 · see citing works
Improvements in skeletal muscle fiber size with resistance training are age-dependent in older adults: a systematic review and meta-analysis
Straight, C. R., Fedewa, M. V., Toth, M. J., & Miller, M. S. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00170.2020 · Cited by 46 · see citing works
First discovered, long out of sight, finally visible: ribosomal DNA
Hall, A. N., Morton, E. A., & Queitsch, C. (2022) · Trends in Genetics · doi:10.1016/j.tig.2022.02.005 · Cited by 43 · see citing works
Exercise Training in Obese Rats Does Not Induce Browning at Thermoneutrality and Induces a Muscle-Like Signature in Brown Adipose Tissue
Aldiss, P., Lewis, J. E., Lupini, I., Bloor, I. D., Chavoshinejad, R., Boocock, D. J., Miles, A. K., Ebling, F. J. P., Budge, H., & Symonds, M. E. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00097 · Cited by 41 · see citing works
c-Myc overexpression increases ribosome biogenesis and protein synthesis independent of mTORC1 activation in mouse skeletal muscle
Mori, T., Ato, S., Knudsen, J. R., Henriquez-Olguin, C., Li, Z., Wakabayashi, K., Suginohara, T., Higashida, K., Tamura, Y., Nakazato, K., et al. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00164.2021 · Cited by 40 · see citing works
Skeletal muscle fibers count on nuclear numbers for growth
Prasad, V., & Millay, D. P. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.04.015 · Cited by 39 · see citing works
Mechanosensitive pathways controlling translation regulatory processes in skeletal muscle and implications for adaptation
Kirby, T. J. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01031.2018 · Cited by 37 · see citing works
Molecular Regulation of Skeletal Muscle Growth and Organelle Biosynthesis: Practical Recommendations for Exercise Training
Solsona, R., Pavlin, L., Bernardi, H., & Sanchez, A. M. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052741 · Cited by 39 · see citing works
Interactions between Growth of Muscle and Stature: Mechanisms Involved and Their Nutritional Sensitivity to Dietary Protein: The Protein-Stat Revisited
Millward, D. J. (2021) · Nutrients · doi:10.3390/nu13030729 · Cited by 42 · see citing works
Dietary Selenium Promotes Somatic Growth of Rainbow Trout (Oncorhynchus mykiss) by Accelerating the Hypertrophic Growth of White Muscle
Wang, L., Zhang, D., Li, S., Wang, L., Yin, J., Xu, Z., & Zhang, X. (2020) · Biological Trace Element Research · doi:10.1007/s12011-020-02282-w · Cited by 33 · see citing works
Ribosome accumulation during early phase resistance training in humans
Hammarström, D., Øfsteng, S. J., Jacobsen, N. B., Flobergseter, K. B., Rønnestad, B. R., & Ellefsen, S. (2022) · Acta Physiologica · doi:10.1111/apha.13806 · Cited by 32 · see citing works
Massage as a Mechanotherapy for Skeletal Muscle
Pelt, D. W. V., Lawrence, M. M., Miller, B. F., Butterfield, T. A., & Dupont‐Versteegden, E. E. (2021) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000244 · Cited by 31 · see citing works
Resistance Exercise, Aging, Disuse, and Muscle Protein Metabolism
McKendry, J., Stokes, T., Mcleod, J. C., & Phillips, S. M. (2021) · Comprehensive physiology · doi:10.1002/j.2040-4603.2021.tb00179.x · Cited by 28 · see citing works
The Degree of Aminoacidemia after Dairy Protein Ingestion Does Not Modulate the Postexercise Anabolic Response in Young Men: A Randomized Controlled Trial
Chan, A., D’Souza, R. F., Beals, J. W., Zeng, N., Prodhan, U. K., Fanning, A. C., Poppitt, S. D., Li, Z. A., Burd, N. A., Cameron‐Smith, D., et al. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz099 · Cited by 27 · see citing works
Extracellular vesicles and high‐density lipoproteins: Exercise and oestrogen‐responsive small RNA carriers
Karvinen, S. M., Korhonen, T.-M. K., Sievänen, T., Karppinen, J. E., Juppi, H., Jakoaho, V., Kujala, U. M., Laukkanen, J. A., Lehti, M., & Laakkonen, E. K. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12308 · Cited by 25 · see citing works
Effect of dietary selenium on postprandial protein deposition in the muscle of juvenile rainbow trout (Oncorhynchus mykiss)
Wang, L., Wang, L., Zhang, D., Li, S., Yin, J., Xu, Z., & Zhang, X. (2020) · British Journal Of Nutrition · doi:10.1017/s000711452000313x · Cited by 22 · see citing works
What are the potential mechanisms of fatigue-induced skeletal muscle hypertrophy with low-load resistance exercise training?
Flewwelling, L. D., Hannaian, S. J., Cao, V., Chaillou, T., Churchward‐Venne, T. A., & Cheng, A. J. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00266.2024 · Cited by 21 · see citing works
Targeting skeletal muscle mitochondrial health in obesity
Pileggi, C. A., Hooks, B. G., McPherson, R., Dent, R. R. M., & Harper, M.-E. (2022) · Clinical Science · doi:10.1042/cs20210506 · Cited by 21 · see citing works
From skeletal muscle damage and regeneration to the hypertrophy induced by exercise: what is the role of different macrophage subsets?
Minari, A. L. A., & dos Santos, R. V. T. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00038.2021 · Cited by 20 · see citing works
The Role of IL-6 Released During Exercise to Insulin Sensitivity and Muscle Hypertrophy
Lima, V. L. D. M., Madureira, Á. N. D. M., & de Oliveira, J. R. S. (2022) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557522666220309161245 · Cited by 20 · see citing works
Repeated and Interrupted Resistance Exercise Induces the Desensitization and Re-Sensitization of mTOR-Related Signaling in Human Skeletal Muscle Fibers
Jacko, D., Schaaf, K., Masur, L., Windoffer, H., Aussieker, T., Schiffer, T., Zacher, J., Bloch, W., & Gehlert, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105431 · Cited by 20 · see citing works
State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions
Lavin, K. M., Coen, P. M., Baptista, L. C. P., Bell, M. B., Drummer, D. J., Harper, S. A., Lixandrão, M. E., McAdam, J. S., O’Bryan, S. M., Ramos, S. V., et al. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00211.x · Cited by 20 · see citing works
RNA-binding proteins: The next step in translating skeletal muscle adaptations?
Pelt, D. W. V., Hettinger, Z. R., & Vanderklish, P. W. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00076.2019 · Cited by 19 · see citing works
Muscle hypertrophy is correlated with load progression delta, climb volume, and total load volume in rodents undergoing different ladder-based resistance training protocols
Neto, W. K., Silva, W. D. A., de Oliveira, T. V. A., Boas, A. E. D. S. V., Ciena, A. P., Anaruma, C. A., Gorzi, A., Caperuto, É. C., & Gama, E. F. (2022) · Tissue and Cell · doi:10.1016/j.tice.2021.101725 · Cited by 19 · see citing works
Early accentuated muscle hypertrophy is strongly associated with myonuclear accretion
Lundberg, T. R., Martínez-Aranda, L. M., Sanz, G., Hansson, B., von Walden, F., Tesch, P. A., & Fernandez‐Gonzalo, R. (2020) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00061.2020 · Cited by 19 · see citing works
Skeletal muscle–targeted delivery of Fgf6 protects mice from diet-induced obesity and insulin resistance
Xu, B., Liu, C., Zhang, H., Zhang, R., Tang, M., Huang, Y., Li, J., Xu, L., Hu, C., & Jia, W. (2021) · JCI Insight · doi:10.1172/jci.insight.149969 · Cited by 19 · see citing works
Scaling of nuclear numbers and their spatial arrangement in skeletal muscle cell size regulation
Hansson, K., & Eftestøl, E. (2023) · Molecular Biology of the Cell · doi:10.1091/mbc.e22-09-0424 · Cited by 17 · see citing works
Review: Understanding fish muscle biology in the indeterminate growth species pacu (Piaractus mesopotamicus)
Perez, E. S., Duran, B. O. D. S., Zanella, B. T. T., & Dal‐Pai‐Silva, M. (2023) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2023.111502 · Cited by 17 · see citing works
Muscle from aged rats is resistant to mechanotherapy during atrophy and reloading
Lawrence, M. M., Pelt, D. W. V., Confides, A. L., Hettinger, Z. R., Hunt, E. R., Reid, J. J., Laurin, J. L., Peelor, F. F., Butterfield, T. A., Miller, B. F., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00215-y · Cited by 17 · see citing works
Targeting cancer via ribosome biogenesis: the cachexia perspective
Figueiredo, V., & McCarthy, J. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03888-6 · Cited by 15 · see citing works
Self-citation
High Responders to Hypertrophic Strength Training Also Tend to Lose More Muscle Mass and Strength During Detraining Than Low Responders
Räntilä, A., Ahtiainen, J. P., Avela, J., Restuccia, J., Kidgell, D. J., & Häkkinen, K. (2021) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000004044 · Cited by 18 · see citing works
Repeated bouts of resistance exercise in rats alter mechanistic target of rapamycin complex 1 activity and ribosomal capacity but not muscle protein synthesis
Kotani, T., Takegaki, J., Tamura, Y., Kouzaki, K., Nakazato, K., & Ishii, N. (2021) · Experimental Physiology · doi:10.1113/ep089699 · Cited by 16 · see citing works
Positional Context of Myonuclear Transcription During Injury-Induced Muscle Regeneration
Buckley, K. H., Nestor‐Kalinoski, A. L., & Pizza, F. X. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.845504 · Cited by 16 · see citing works
Transcriptome Analysis of Differentially Expressed mRNA Related to Pigeon Muscle Development
Ding, H., Lin, Y., Zhang, T., Chen, L., Zhang, G., Wang, J., Xie, K., & Dai, G. (2021) · Animals · doi:10.3390/ani11082311 · Cited by 15 · see citing works
Inhibition of mTORC1 differentially affects ribosome biogenesis in rat soleus muscle at the early and later stages of hindlimb unloading.
Rozhkov, S., Sharlo, K., Shenkman, B., & Mirzoev, T. (2022) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2022.109411 · Cited by 9 · see citing works
Genome-Wide Association (GWAS) Applied to Carcass and Meat Traits of Nellore Cattle
Reis, H. B. D., Carvalho, M. E., Espigolan, R., Poleti, M., Ambrizi, D. R., Berton, M. P., Ferraz, J. B. S., Mattos, E. C., & Eler, J. P. (2023) · Metabolites · doi:10.3390/metabo14010006 · Cited by 15 · see citing works
More than just a garbage can: emerging roles of the lysosome as an anabolic organelle in skeletal muscle
Sawan, S. A., Mazzulla, M., Moore, D. R., & Hodson, N. W. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00241.2020 · Cited by 15 · see citing works
Going nuclear: Molecular adaptations to exercise mediated by myonuclei
Koopmans, P. J., Zwetsloot, K. A., & Murach, K. A. (2022) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2022.11.005 · Cited by 15 · see citing works
Intensity-dependent cardiopulmonary response during and after strength training
Lässing, J., Maudrich, T., Kenville, R., Uyar, Z., Bischoff, C., Fikenzer, S., Busse, M. W., & Falz, R. (2023) · Scientific Reports · doi:10.1038/s41598-023-33873-x · Cited by 15 · see citing works
Post-natal muscle growth and protein turnover: a narrative review of current understanding
Millward, D. J. (2023) · Nutrition Research Reviews · doi:10.1017/s0954422423000124 · Cited by 14 · see citing works
The Plateau in Muscle Growth with Resistance Training: An Exploration of Possible Mechanisms
Kataoka, R., Hammert, W. B., Yamada, Y., Song, J. S., Seffrin, A., Kang, A., Spitz, R. W., Wong, V. H. Y., & Loenneke, J. P. (2023) · Sports Medicine · doi:10.1007/s40279-023-01932-y · Cited by 16 · see citing works
Throwing cold water on muscle growth: A systematic review with meta‐analysis of the effects of postexercise cold water immersion on resistance training‐induced hypertrophy
Piñero, A., Burke, R., Augustin, F., Mohan, A. E., Dejesus, K., Sapuppo, M., Weisenthal, M., Coleman, M., Androulakis‐Korakakis, P., Grgić, J., et al. (2024) · European Journal of Sport Science · doi:10.1002/ejsc.12074 · Cited by 14 · see citing works
Mild hypothermia affects the morphology and impairs glutamine-induced anabolic response in human primary myotubes
Rantala, R., & Chaillou, T. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00008.2019 · Cited by 14 · see citing works
Mining of chicken muscle growth genes and the function of important candidate gene RPL3L in muscle development
Lin, S., Xian, M., Ren, T., Mo, G., Zhang, L., & Zhang, X. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1033075 · Cited by 14 · see citing works
Consecutive bouts of electrical stimulation-induced contractions alter ribosome biogenesis in rat skeletal muscle
Kotani, T., Takegaki, J., Takagi, R., Nakazato, K., & Ishii, N. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00665.2018 · Cited by 14 · see citing works
Phosphorylation of eukaryotic initiation factor 4E is dispensable for skeletal muscle hypertrophy
Figueiredo, V. C., Englund, D. A., Vechetti, I. J., Alimov, A. P., Peterson, C. A., & McCarthy, J. J. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00380.2019 · Cited by 13 · see citing works
Self-citation
Skeletal muscle signaling responses to resistance exercise of the elbow extensors are not compromised by a preceding bout of aerobic exercise
Hansson, B., Olsen, L. A., Nicoll, J. X., von Walden, F., Melin, M., Strömberg, A., Rullman, E., Gustafsson, T. P., Fry, A. C., Fernandez‐Gonzalo, R., et al. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00022.2019 · Cited by 13 · see citing works
Exercise does not induce browning of WAT at thermoneutrality and induces an oxidative, myogenic signature in BATPreprint
Aldiss, P., Lewis, J. E., Lupini, I., Boocock, D. J., Miles, A. K., Ebling, F. J. P., Budge, H., & Symonds, M. E. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/649061 · Cited by 13 · see citing works
A history of omics discoveries reveals the correlates and mechanisms of loading-induced hypertrophy in adult skeletal muscle. 2024 CaMPS young investigator award invited review
Chambers, T. L., & Murach, K. A. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00968.2024 · Cited by 11 · see citing works
Engineering Extracellular Vesicles Mimetics for Targeted Chemotherapy of Drug-Resistant Ovary Cancer
Liu, X., Liu, G., Mao, Y., Luo, J., Cao, Y., Tan, W., Li, W., Yu, H., Jia, X., & Li, H. (2023) · Nanomedicine · doi:10.2217/nnm-2023-0289 · Cited by 11 · see citing works
Reduced Physical Activity Alters the Leucine-Stimulated Translatome in Aged Skeletal Muscle
Mahmassani, Z. S., McKenzie, A. I., Petrocelli, J. J., de Hart, N. M. M. P., Fix, D. K., Kelly, J. J., Baird, L. M., Howard, M. T., & Drummond, M. J. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab077 · Cited by 11 · see citing works
Does the blunted stimulation of skeletal muscle protein synthesis by aging in response to mechanical load result from impaired ribosome biogenesis?
Chaillou, T., & Montiel-Rojas, D. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1171850 · Cited by 10 · see citing works
The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice
Koopmans, P. J., Jones, R. G., Cabrera, A. R., Morena, F., Greene, N. P., McCarthy, J. J., Ismaeel, A., Wen, Y., & Murach, K. A. (2026) · Advanced Science · doi:10.1002/advs.202521633 · Cited by 10 · see citing works
Self-citation
Elevated muscle mass accompanied by transcriptional and nuclear alterations several months following cessation of resistance‐type training in rats
Rader, E. P., & Baker, B. A. (2022) · Physiological Reports · doi:10.14814/phy2.15476 · Cited by 9 · see citing works
Increased biological relevance of transcriptome analyses in human skeletal muscle using a model-specific pipeline
Khan, Y., Hammarström, D., Rønnestad, B. R., Ellefsen, S., & Ahmad, R. (2020) · BMC Bioinformatics · doi:10.1186/s12859-020-03866-y · Cited by 9 · see citing works
The Role of Glycogen Synthase Kinase-3 in the Regulation of Ribosome Biogenesis in Rat Soleus Muscle under Disuse Conditions
Rozhkov, S. V., Sharlo, K. A., Shenkman, B. S., & Mirzoev, T. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052751 · Cited by 9 · see citing works
Limited effect of over-the-counter doses of ibuprofen on mechanisms regulating muscle hypertrophy during resistance training in young adults
Lilja, M. R., Moberg, M., Apró, W., Martínez-Aranda, L. M., Rundqvist, H., Langlet, B. S., Gustafsson, T. P., & Lundberg, T. R. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00698.2022 · Cited by 9 · see citing works
Small-RNA Sequencing Reveals Altered Skeletal Muscle microRNAs and snoRNAs Signatures in Weanling Male Offspring from Mouse Dams Fed a Low Protein Diet during Lactation
Kanakis, I., Alameddine, M., Folkes, L., Moxon, S., Myrtziou, I., Ozanne, S. E., Peffers, M. J., Goljanek‐Whysall, K., & Vasilaki, A. (2021) · Cells · doi:10.3390/cells10051166 · Cited by 9 · see citing works
Assessing Human Ribosomal DNA Variation and Its Association With Phenotypic Outcomes
Rodríguez-Algarra, F., Whittaker, E., del Castillo, S., & Rakyan, V. K. (2025) · BioEssays · doi:10.1002/bies.202400232 · Cited by 8 · see citing works
Muscle Cathepsin B Treatment Improves Behavioral and Neurogenic Deficits in a Mouse Model of Alzheimer's Disease
Pinto, A., Haytural, H., Loss, C. M., Álvarez, C., Ertas, A., Curtis, O., Williams, A. R., Murphy, G., Salleng, K. J., Gografe, S., et al. (2025) · Aging Cell · doi:10.1111/acel.70242 · Cited by 8 · see citing works
Identification of Novel Genes Associated with Fish Skeletal Muscle Adaptation during Fasting and Refeeding Based on a Meta-Analysis
Perez, E. S., Cury, S. S., Zanella, B. T. T., Carvalho, R. F., Duran, B. O. D. S., & Dal‐Pai‐Silva, M. (2022) · Genes · doi:10.3390/genes13122378 · Cited by 8 · see citing works
Metformin Pre-Treatment as a Means of Mitigating Disuse-Induced Rat Soleus Muscle Wasting
Mirzoev, T. M., Paramonova, I. I., Rozhkov, S. V., Kalashnikova, E. P., Belova, S. P., Tyganov, S. A., Vilchinskaya, N. A., & Shenkman, B. S. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45040201 · Cited by 7 · see citing works
The effect of blood flow restricted exercise on measures of health and physical fitness across all populations: An umbrella review and meta-meta-analysis
Oborn, C., Nelson, M. J., Davison, K., Murray, J., Green, K., Shahid, J., & Bennett, H. (2025) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2025.02.011 · Cited by 7 · see citing works
Down-regulation of human-specific lncRNA TMEM9B-AS1 in skeletal muscle of people with type 2 diabetes affects ribosomal biogenesis
Sen, I., Smith, J. A. B., Caria, E., Orlov, I. A., Savikj, M., Brady, A. J., Lian, K., Ellefsen, S., Zierath, J. R., & Krook, A. (2025) · Science Advances · doi:10.1126/sciadv.ads4371 · Cited by 7 · see citing works
Nucleolar FRG2 lncRNAs inhibit rRNA transcription and cytoplasmic translation, linking FSHD to dysregulation of muscle-specific protein synthesis
Salsi, V., Losi, F., Fosso, B., Ferrarini, M., Pini, S., Manfredi, M., Vattemi, G. N. A., Mongini, T., Maggi, L., Pesole, G., et al. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf643 · Cited by 7 · see citing works
Molecular signatures underlying heterogenous hypertrophy responsiveness to resistance training in older men and women: a within-subject design
Lixandrão, M. E., Bamman, M. M., Lavin, K. M., Longobardi, I., Telles, G. D., VECHIN, F. C., Damas, F., Drummer, D. J., McAdam, J. S., Costa, L. A. R., et al. (2025) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00052.2025 · Cited by 6 · see citing works
miRNA ‐1 regulation is necessary for mechanical overload‐induced muscle hypertrophy in male mice
Fei, S., Rule, B. D., Godwin, J. S., Mobley, C. B., Roberts, M. D., von Walden, F., & Vechetti, I. J. (2025) · Physiological Reports · doi:10.14814/phy2.70166 · Cited by 7 · see citing works
Response of Resistance Exercise-Induced Muscle Protein Synthesis and Skeletal Muscle Hypertrophy Are Not Enhanced After Disuse Muscle Atrophy in Rat
Ato, S., Kido, K., Sase, K., & Fujita, S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00469 · Cited by 7 · see citing works
Acute hypoxia attenuates resistance exercise-induced ribosome signaling but does not impact satellite cell pool expansion in human skeletal muscle
Horwath, O., Nordström, F., von Walden, F., Apró, W., & Moberg, M. (2023) · The FASEB Journal · doi:10.1096/fj.202202065rr · Cited by 6 · see citing works
Discriminative feature of cells characterizes cell populations of interest by a small subset of genes
Fujii, T., Maehara, K., Fujita, M., & Ohkawa, Y. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009579 · Cited by 6 · see citing works
Normalization of gene expression data revisited: the three viewpoints of the transcriptome in human skeletal muscle undergoing load-induced hypertrophy and why they matter
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The Role of Ribosome Biogenesis in Skeletal Muscle Hypertrophy
Figueiredo, V. C., & McCarthy, J. J. (2017) · Springer eBooks · doi:10.1007/978-981-10-3292-9_6 · Cited by 3 · see citing works
Self-citation
Regulation of Ribosome Biogenesis During Skeletal Muscle Hypertrophy
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Ribosome Biogenesis and Skeletal Muscle in Health and Disease
Figueiredo, V. C. (2016) · ResearchSpace (University of Auckland)
Self-citation
Regulation of ribosome biogenesis during skeletal muscle growth.
Nader, G. A. (2025) · Figshare
Ribosome biogenesis: Emerging evidence for a central role in the regulation of skeletal muscle mass
Chaillou, T., Kirby, T. J., & McCarthy, J. J. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24604 · Cited by 211 · see citing works
Self-citation

Authors: Figueiredo, V. C., & McCarthy, J. J.
Affiliations: University of Kentucky (US)
Corresponding author: McCarthy, John J.
ORCID: Figueiredo, Vandré Casagrande
McCarthy, John J.
Venue: Physiology
Publisher: American Physiological Society
Published: 2019-01-01
Volume: 34
Issue: 1
Pages: 30-42
ISSN: 0886-1714 (ISSN-L)
1548-9213
1548-9221
DOI: 10.1152/physiol.00034.2018
PMC: PMC6383632
OpenAlex: W2903863947
Cited by: 140
References: 148
Citations by year: 2026: 11 · 2025: 16 · 2024: 14 · 2023: 16 · 2022: 26 · 2021: 27 · 2020: 17 · 2019: 12 · 2018: 1
FWCI: 1.40
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Physiology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: HHS | NIH | National Institute on Aging (U.S. National Institute on Aging) (AG049806-03)
HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (AR060701-07)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords: ribosome biogenesis, skeletal muscle hypertrophy, muscle growth, postnatal development, resistance training, translational capacity, myonuclear accretion, cellular signaling pathways, protein synthesis
MeSH terms: Animals, Humans, Hypertrophy, Ribosomes, Protein Biosynthesis, Signal Transduction, Muscle, Skeletal, Muscle Development, Resistance Training

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Regulation of ribosome biogenesis in skeletal muscle hypertrophy

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