The DOI matches its Crossref record.
Large-Bowel Carcinogenesis: Fecal Constituents of Populations With Diverse Incidence Rates of Colon Cancer2
Abstract
We studied the quantitative and qualitative aspects of fecal neutral sterols and bile acids and fecal β-glucuronidase activity from populations with various dietary patterns to elucidate the etiologic role of these compounds on colon cancer. The fecal microflora of Americans consuming a mixed Western diet were more able to hydrolyze glucuronide conjugates than were those of American vegetarians and Seventh-Day Adventists, and Japanese and Chinese. The daily fecal excretion of coprostanol, coprostanone, and total neutral sterols was higher in Americans than in other groups. Americans who ate a Westerntype diet excreted high levels of bile acids and more microbially degraded bile acids than did others. Our data showed a strong association between the incidence of colon cancer and the fecal bile acid and neutral sterol excretion.
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Cited by
Bile acids as carcinogens in human gastrointestinal cancers
Bernstein, H., Bernstein, C., Payne, C. M., Dvorakova, K., & Garewal, H. (2005) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2004.08.001 · Cited by 611
Reddy, B. S., & Wynder, E. L. (1977) · Cancer · doi:10.1002/1097-0142(197706)39:6<2533::aid-cncr2820390634>3.0.co;2-x · Cited by 410
Self-citationCarcinogenicity of deoxycholate, a secondary bile acid
Bernstein, C., Holubec, H., Bhattacharyya, A. K., Nguyen, H., Payne, C. M., Zaitlin, B., & Bernstein, H. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0648-7 · Cited by 351
Bile acids as endogenous etiologic agents in gastrointestinal cancer
Bernstein, H., Bernstein, C., Payne, C. M., & Dvorak, K. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.3329 · Cited by 340
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Anticarcinogenic, hypocholesterolemic, and antagonistic activities of Lactobacillus acidophilus
Mitall, B. K., & Garg, S. K. (1995) · Critical Reviews in Microbiology · doi:10.3109/10408419509113540 · Cited by 97
Association between screen-detected gallstone disease and cancer in a cohort study
Shabanzadeh, D. M., Sørensen, L. T., & Jørgensen, T. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.02.013 · Cited by 79
Mathan, V. I., Wiederman, J., Dobkin, J. F., & Lindenbaum, J. (1989) · Gut · doi:10.1136/gut.30.7.971 · Cited by 62
The importance of the ratio of lithocholic to deoxycholic acid in large bowel carcinogenesis
Owen, R. W., Thompson, M. H., Hill, M. J., Wilpart, M., Mainguet, P., & Roberfroid, M. (1987) · Nutrition and Cancer · doi:10.1080/01635588709513913 · Cited by 53
Epithelial cell kinetics in the descending colon of the rat
Rijke, R. P. C., Plaisier, H. M., & Langendoen, N. J. (1979) · Virchows Archiv B Cell Pathology · doi:10.1007/bf02889093 · Cited by 16
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Metadata
- Authors
- Reddy, B. S., & Wynder, E. L.
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1973-06
- Volume
- 50
- Issue
- 6
- Pages
- 1437-1442
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2310561750
- Cited by
- 408
- References
- 0
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- closed
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