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Cited by 351Carcinogens and Genotoxicity AssessmentAntioxidant Activity and Oxidative StressDrug Transport and Resistance Mechanisms

Carcinogenicity of deoxycholate, a secondary bile acid

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Bernstein, Carol, Holubec, Hana, Bhattacharyya, Achyut K., Nguyen, Huy, Payne, Claire M., Zaitlin, Beryl, Bernstein, Harris·2011·Archives of Toxicology
DOI 10.1007/s00204-011-0648-7PMC PMC3149672
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Abstract

High dietary fat causes increased bile acid secretion into the gastrointestinal tract and is associated with colon cancer. Since the bile acid deoxycholic acid (DOC) is suggested to be important in colon cancer etiology, this study investigated whether DOC, at a high physiologic level, could be a colon carcinogen. Addition of 0.2% DOC for 8-10 months to the diet of 18 wild-type mice induced colonic tumors in 17 mice, including 10 with cancers. Addition of the antioxidant chlorogenic acid at 0.007% to the DOC-supplemented diet significantly reduced tumor formation. These results indicate that a high fat diet in humans, associated with increased risk of colon cancer, may have its carcinogenic potential mediated through the action of bile acids, and that some dietary anti-oxidants may ameliorate this carcinogenicity.

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  • DCA and LCA are cytotoxic, and DCA is associated with the development of colon cancer.

    “In addition, DCA and LCA are cytotoxic, and DCA is associated with the development of colon cancer (Bernstein et al., 2011).”

    From <i>Akkermansia muciniphila</i> alleviates <scp>high‐fat‐diet</scp> ‐related metabolic‐associated fatty liver disease by modulating gut microbiota and bile acids (2023) · cites this paper as Bernstein et al., 2011

    The Introduction links deoxycholic acid (DOC, also called DCA) to colorectal adenomas, and the Results report colon cancers in DOC-fed mice. The Introduction also says DOC induces apoptosis in colon cells, supporting its cytotoxicity. Although it identifies lithocholic acid (LCA) as a hydrophobic bile acid, our copy does not specifically establish that LCA is cytotoxic. (LLM, conf=0.82)

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Authors
Bernstein, C., Holubec, H., Bhattacharyya, A. K., Nguyen, H., Payne, C. M., Zaitlin, B., & Bernstein, H.
Affiliations
  • University of Arizona (US)
  • University of Calgary (CA)
Corresponding author
Bernstein, Carol
ORCID
Venue
Archives of Toxicology
Publisher
Springer Science and Business Media LLC
Published
2011-01-26
Volume
85
Issue
8
Pages
863-871
ISSN
  • 0340-5761 (ISSN-L)
  • 1432-0738
DOI
10.1007/s00204-011-0648-7
PMC
PMC3149672
OpenAlex
W2023678020
Cited by
351
References
2
Citations by year
2026: 14 · 2025: 15 · 2024: 28 · 2023: 27 · 2022: 41 · 2021: 30 · 2020: 28 · 2019: 20 · 2018: 29 · 2017: 25 · 2016: 20 · 2015: 25 · 2014: 12 · 2013: 16 · 2012: 11
FWCI
5.22
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Archives of Toxicology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Veterans Affairs
  • Office of Research and Development
  • University of Arizona Cancer Center
  • Arizona Biomedical Research Commission
  • National Institutes of Health
  • National Cancer Institute (R01CA119087, 5 RO1 CA119087)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
deoxycholic acid, bile acids, colon cancer, colon carcinogenesis, high-fat diet, dietary fat, chlorogenic acid, antioxidants, cancer prevention
MeSH terms
Animals, Antioxidants, Bile Acids and Salts, Chlorogenic Acid, Colonic Neoplasms, Deoxycholic Acid, Dietary Fats, Male, Risk, Carcinogenicity Tests, Mice

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