Melatonin as a biomarker of circadian dysregulation

Principles and Practice of Sleep Medicine

Kryger, M. H., Roth, T. G., & Dement, W. C. (2011) · Elsevier eBooks · doi:10.1016/c2009-0-59875-3 · Cited by 5,118 · see citing works

A self-assessment questionnaire to determine morningness- eveningness in human circadian rhythms

Home, J. K. (1976) · Medical Entomology and Zoology · Cited by 4,783 · see citing works

Urinary Creatinine Concentrations in the U.S. Population: Implications for Urinary Biologic Monitoring Measurements

Barr, D. B., Wilder, L. C., Caudill, S. P., Gonzalez, A. J., Needham, L. L., & Pirkle, J. L. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7337 · Cited by 1,923 · see citing works

Light Suppresses Melatonin Secretion in Humans

Lewy, A. J., Wehr, T. A., Goodwin, F. K., Newsome, D. A., & Markey, S. P. (1980) · Science · doi:10.1126/science.7434030 · Cited by 1,913 · see citing works

Stability, precision, and near-24-hour period of the human circadian pacemaker

Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., Ronda, J. M., Silva, E. J., Allan, J. S., Emens, J. S., et al. (1999) · Science · doi:10.1126/science.284.5423.2177 · Cited by 1,705 · see citing works

Melatonin in Humans

Brzezinski, A. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701163360306 · Cited by 1,549 · see citing works

Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression

Zeitzer, J. M., Dijk, D., Kronauer, R. E., Brown, E. N., & Czeisler, C. A. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00695.x · Cited by 1,175 · see citing works

The basic physiology and pathophysiology of melatonin

Claustrat, B., Brun, J., & Chazot, G. (2004) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.08.001 · Cited by 951 · see citing works

Influence of Muscle Mass and Physical Activity on Serum and Urinary Creatinine and Serum Cystatin C

Baxmann, A. C., Ahmed, M. S., Marques, N. A. A. C., Menon, V. B., Pereira, A. B., Kirsztajn, G. M., & Heilberg, I. P. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02870707 · Cited by 796 · see citing works

The Pineal Gland

Wurtman, R. J., & Axelrod, J. (1965) · Scientific American · doi:10.1038/scientificamerican0765-50 · Cited by 774 · see citing works

Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle

Czeisler, C. A., Allan, J. S., Strogatz, S. H., Ronda, J. M., Sánchez, R., Ríos, C. D., Freitag, W. O., Richardson, G. S., & Kronauer, R. E. (1986) · Science · doi:10.1126/science.3726555 · Cited by 770 · see citing works

Antidepressant and Circadian Phase-Shifting Effects of Light

Lewy, A. J., Sack, R. L., Miller, L. S., & Hoban, T. M. (1987) · Science · doi:10.1126/science.3798117 · Cited by 709 · see citing works

Radioimmunoassay of Serum Concentrations of Melatonin in Sheep Exposed to Different Lighting Regimens

Rollag, M. D., & Niswender, G. D. (1976) · Endocrinology · doi:10.1210/endo-98-2-482 · Cited by 643 · see citing works

Dose-response relationships for resetting of human circadian clock by light

Boivin, D. B., Duffy, J. F., Kronauer, R. E., & Czeisler, C. A. (1996) · Nature · doi:10.1038/379540a0 · Cited by 559 · see citing works

Entrainment of the human circadian system by light

Duffy, J. F., & Wright, K. P. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405277983 · Cited by 515 · see citing works

Salivary Melatonin as a Circadian Phase Marker: Validation and Comparison to Plasma Melatonin

Voultsios, A., Kennaway, D. J., & Dawson, D. E. (1997) · Journal of Biological Rhythms · doi:10.1177/074873049701200507 · Cited by 468 · see citing works

Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture.

Hill, S. M., & Blask, D. E. (1988) · PubMed · Cited by 442 · see citing works

Melatonin-Depleted Blood from Premenopausal Women Exposed to Light at Night Stimulates Growth of Human Breast Cancer Xenografts in Nude Rats

Blask, D. E., Brainard, G. C., Dauchy, R. T., Hanifin, J. P., Davidson, L. K., Krause, J. A., Sauer, L. A., Rivera-Bermudez, M. A., Dubocovich, M. L., Jasser, S. A., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1945 · Cited by 431 · see citing works

Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase in human sleep and chronobiological disorders

Pandi-Perumal, S. R., Smits, M. G., Spence, W., Srinivasan, V., Cardinali, D. P., Lowe, A. D., & Kayumov, L. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.06.020 · Cited by 416 · see citing works

The effects of prior light history on the suppression of melatonin by light in humans

Hébert, M., Martin, S. K., Lee, C., & Eastman, C. I. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.01885.x · Cited by 413 · see citing works

The Endogenous Melatonin Profile as a Marker for Circadian Phase Position

Lewy, A. J., Cutler, N. L., & Sack, R. L. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000641 · Cited by 392 · see citing works

Human Melatonin Suppression by Light is Intensity Dependent

Mclntyre, I. M., Norman, T. R., Burrows, G. D., & Armstrong, S. M. (1989) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1989.tb00412.x · Cited by 389 · see citing works

Melatonin: From Basic Research to Cancer Treatment Clinics

Vijayalaxmi, V., Thomas, C. R., Reiter, R. J., & Herman, T. S. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.11.004 · Cited by 358 · see citing works

Immunoassay of 6-Hydroxymelatonin Sulfate in Human Plasma and Urine: Abolition of the Urinary 24-Hour Rhythm with Atenolol*

Arendt, J., Bojkowski, C. J., Franey, C. S., WRIGHT, J., & Marks, V. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-6-1166 · Cited by 342 · see citing works

The Durations of Human Melatonin Secretion and Sleep Respond to Changes in Daylength (Photoperiod)

WEHR, T. A. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-6-1276 · Cited by 320 · see citing works

Melatonin inhibition and pinealectomy enhancement of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in the rat.

Tamarkin, L., Cohen, M., Roselle, D., Reichert, C. M., Lippman, M. E., & Chabner, B. A. (1981) · PubMed · Cited by 296 · see citing works

Circadian and sleep-dependent regulation of hormone release in humans.

Czeisler, C. A., & Klerman, E. (1999) · PubMed · Cited by 284 · see citing works

Daily Rhythm in Human Urinary Melatonin

Lynch, H. J., Wurtman, R. J., Moskowitz, M. A., Archer, M. C., & Ho, M. H. (1975) · Science · doi:10.1126/science.1167425 · Cited by 263 · see citing works

Analysis of Melatonin in Human Plasma by Gas Chromatography Negative Chemical Ionization Mass Spectrometry

Lewy, A. J., & Markey, S. P. (1978) · Science · doi:10.1126/science.675255 · Cited by 253 · see citing works

Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells.

Cos, S., Fernández, R., Güezmes, A., & Sánchez‐Barceló, E. J. (1998) · PubMed · Cited by 246 · see citing works

Melatonin and melatonin-progestin combinations alter pituitary-ovarian function in women and can inhibit ovulation

Voordouw, B. C., Euser, R., Verdonk, R. E., Alberda, B. T., de Jong, F. H., Drogendijk, A. C., Fauser, B. C. J. M., & Cohen, M. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.1.1727807 · Cited by 239 · see citing works

Putting Cancer to Sleep at Night: The Neuroendocrine/Circadian Melatonin Signal

Blask, D. E., Dauchy, R. T., & Sauer, L. A. (2005) · Endocrine · doi:10.1385/endo:27:2:179 · Cited by 238 · see citing works

Decreased Nocturnal Plasma Melatonin Peak in Patients with Estrogen Receptor Positive Breast Cancer

Tamarkin, L., Danforth, D. N., Lichter, A., Demoss, E. V., Cohen, M., Chabner, B. A., & Lippman, M. E. (1982) · Science · doi:10.1126/science.7079745 · Cited by 233 · see citing works

Epidemiology of Urinary Melatonin in Women and Its Relation to Other Hormones and Night Work

Schernhammer, E. S., ROSNER, B. A., Willett, W. C., Laden, F., Colditz, G. A., & Hankinson, S. E. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.936.13.6 · Cited by 214 · see citing works

Morningness-Eveningness Questionnaire

Horne, J. A., & Ӧstberg, O. (1976) · PsycTESTS Dataset · doi:10.1037/t02254-000 · Cited by 209 · see citing works

Melatonin secretion in humans assessed by measuring its metabolite, 6-sulfatoxymelatonin.

Bojkowski, C. J., Arendt, J., Shih, M. C., & Markey, S. P. (1987) · Clinical Chemistry · doi:10.1093/clinchem/33.8.1343 · Cited by 207 · see citing works

Melatonin in humans physiological and clinical studies.

Wetterberg, L. (1978) · PubMed · Cited by 203 · see citing works

Melatonin increases p53 and p21WAFl expression in MCF-7 human breast cancer cells in vitro

Mediavilla, M. D., Cos, S., & Sánchez‐Barceló, E. J. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00262-3 · Cited by 190 · see citing works

Epidemiology of Uriniary Melatonin in Women and Its Relation to Other Hormones and Night Work

Stevens, R. G. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-04-0420 · Cited by 184 · see citing works

Urinary Melatonin Levels and Breast Cancer Risk

Schernhammer, E. S., & Hankinson, S. E. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji190 · Cited by 183 · see citing works

THE CORRELATION BETWEEN SERUM AND SALIVARY MELATONIN CONCENTRATIONS AND URINARY 6‐HYDROXYMELATONIN SULPHATE EXCRETION RATES: TWO NON‐INVASIVE TECHNIQUES FOR MONITORING HUMAN CIRCADIAN RHYTHMICITY

Nowak, R., McMillen, I. C., Redman, J. R., et al. (1987) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1987.tb01172.x · Cited by 181 · see citing works

Light-induced melatonin suppression: age-related reduction in response to short wavelength light

HERLJEVIC, M., MIDDLETON, B., THAPAN, K., & SKENE, D. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2004.12.001 · Cited by 169 · see citing works

Melatonin Inhibition of Reproduction in the Male Hamster: Its Dependency on Time of Day of Administration and on an Intact and Sympathetically Innervated Pineal Gland

Reiter, R. J., Blask, D. E., Johnson, L. Y., Rudeen, P. K., Vaughan, M. K., & Waring, P. J. (2008) · Neuroendocrinology · doi:10.1159/000122616 · Cited by 164 · see citing works

Profile of 24-h Light Exposure and Circadian Phase of Melatonin Secretion in Night Workers

Dumont, M., Benhaberou-Brun, D., & Paquet, J. (2001) · Journal of Biological Rhythms · doi:10.1177/074873001129002178 · Cited by 162 · see citing works

Melatonin reduces prostate cancer cell growth leading to neuroendocrine differentiation via a receptor and PKA independent mechanism

Sainz, R. M., Mayo, J. C., Tan, D., et al. (2004) · The Prostate · doi:10.1002/pros.20155 · Cited by 159 · see citing works

Pineal Melatonin Mediates Photoperiodic Control of Pulsatile Luteinizing Hormone Secretion in the Ewe

Bittman, E. L., Kaynard, A. H., Olster, D. H., et al. (2008) · Neuroendocrinology · doi:10.1159/000124106 · Cited by 151 · see citing works

Prediction of nocturnal plasma melatonin from morning urinary measures

Graham, C. H., Cook, M. R., Kavet, R. I., Sastre, A., & Smith, D. K. (1998) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1998.tb00538.x · Cited by 150 · see citing works

Melatonin and Breast Cancer: A Prospective Study

Travis, R. C., Allen, D. S., Fentiman, I. S., & Key, T. J. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh077 · Cited by 149 · see citing works

Effect of shift work on the night-time secretory patterns of melatonin, prolactin, cortisol and testosterone

Touitou, Y., Motohashi, Y., Reinberg, A., Touitou, C., Bourdeleau, P., Bogdan, A., & Auz�by, A. (1990) · European Journal of Applied Physiology and Occupational Physiology · doi:10.1007/bf00379398 · Cited by 147 · see citing works

Alteration of Internal Circadian Phase Relationships after Morning versus Evening Carbohydrate-Rich Meals in Humans

Kräuchi, K., Cajochen, C., Werth, E., & Wirz‐Justice, A. (2002) · Journal of Biological Rhythms · doi:10.1177/074873040201700409 · Cited by 146 · see citing works

Demonstration of rapid light-induced advances and delays of the human circadian clock using hormonal phase markers

Cauter, E. V., Sturis, J., Byrne, M. M., Blackman, J. D., Leproult, R., Ofek, G., L’Hermite‐Balériaux, M., Refetoff, S., Turek, F. W., & Reeth, O. V. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.6.e953 · Cited by 142 · see citing works

Melatonin, Sleep, and Shift Work Adaptation

Burch, J. B., Yost, M. G., Johnson, W., & Allen, E. (2005) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000177336.21147.9f · Cited by 135 · see citing works

Urinary melatonin levels in human breast cancer patients

Bartsch, C., Bartsch, H., Jain, A., Laumas, K. R., & Wetterberg, L. (1981) · Journal of Neural Transmission · doi:10.1007/bf01256753 · Cited by 133 · see citing works

Reduced salivary cortisol in children with comorbid Attention deficit hyperactivity disorder and oppositional defiant disorder.

Kariyawasam, S. H., Zaw, F. K. M., & Handley, S. L. (2002) · PubMed · Cited by 124 · see citing works

Residential Magnetic Fields, Light-at-Night, and Nocturnal Urinary 6-Sulfatoxymelatonin Concentration in Women

Davis, S. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.7.591 · Cited by 123 · see citing works

Suppression of men's responses to seasonal changes in day length by modern artificial lighting

Wehr, T. A., Giesen, H. A., Moul, D. E., Turner, E. H., & Schwartz, P. J. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.269.1.r173 · Cited by 115 · see citing works

Melatonin and colon carcinogenesis: I. Inhibitory effect of melatonin on development of intestinal tumors induced by 1,2-dimethylhydrazine in rats

Anisimov, V. V. (1997) · Carcinogenesis · doi:10.1093/carcin/18.8.1549 · Cited by 113 · see citing works

Melatonin and steroids in human pre-ovulatory follicular fluid: seasonal variations and granulosa cell steroid production

Yie, S.-M., Brown, G. M., Liu, G.-Y., et al. (1995) · Human Reproduction · doi:10.1093/humrep/10.1.50 · Cited by 107 · see citing works

Saliva and serum samples were collected from eight healthy volunteers every two hours during a 26‐hour period. Melatonin concentrations were measured by radioimmunoassay after chloroform extraction using radioiodinated melatonin as a tracer. Five of the subjects had high serum melatonin levels at night (peak levels higher than 75 pg/ml); in three subjects the highest serum melatonin concentration was 20‐40 pg/ml. All subjects had low levels (<10 pg/ml) during the day. The correlations between salivary and serum levels were calculated. The regression line y =0.33×+ 3.7 pg/ml, r= 0.95, P <0.001, was obtained for all detectable value pairs (n= 73). The regression and correlation coefficients were almost equal for the peak values of melatonin and during the rising and descending phases of the secretion patterns. However, no significant correlation was found between low daytime salivary and serum concentrations when calculated separately. In the five high‐secretors the melatonin levels in saliva reflected reliably the changes in serum, but in the three low‐secretors the correlation between salivary and serum melatonin was not significant. The proportion of melatonin found in saliva decreased with increasing serum melatonin levels. Circadian rhythm parameters were estimated by single cosinor analysis. The acrophases did not differ significantly within a subject in the concomitant measurements of serum and salivary melatonin. The measurements of salivary melatonin levels seem valid for studies on melatonin rhythms, but the melatonin concentrations measured in saliva do not always consistently reflect the absolute concentrations in blood.

Laakso, M., Porkka‐Heiskanen, T., Alila, A., et al. (1990) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1990.tb00692.x · Cited by 106 · see citing works

Does melatonin induce apoptosis in MCF‐7 human breast cancer cells in vitro?

Cos, S., Mediavilla, M. D., Fernández, R., González‐Lamuño, D., & Sánchez‐Barceló, E. J. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.1821.x · Cited by 105 · see citing works

Human malignant melanoma cells express high-affinity receptors for melatonin: antiproliferative effects of melatonin and 6-chloromelatonin

Ying, S., Niles, L. P., & Crocker, C. E. (1993) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(93)90084-m · Cited by 103 · see citing works

The oncostatic action of melatonin in an ovarian carcinoma cell line

Petranka, J. G., Baldwin, W. S., Biermann, J., Jayadev, S., Barrett, J. C., & Murphy, E. (1999) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1999.tb00574.x · Cited by 101 · see citing works

Urinary 6-Sulfatoxymelatonin Levels and Risk of Breast Cancer in Postmenopausal Women

Schernhammer, E. S., Berrino, F., Krogh, V., Secreto, G., Micheli, A., Venturelli, E., Sieri, S., Sempos, C. T., Cavalleri, A., Schünemann, H. J., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn171 · Cited by 101 · see citing works

Adaptation of the 6-sulphatoxymelatonin rhythm in shiftworkers on offshore oil installations during a 2-week 12-h night shift

Barnes, R. G., Deacon, S., Forbes, M. J., & Arendt, J. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00965-8 · Cited by 98 · see citing works

Adaptation of the circadian rhythm of 6-sulphatoxymelatonin to a shift schedule of seven nights followed by seven days in offshore oil installation workers

Gibbs, M. A., Hampton, S., Morgan, L., & Arendt, J. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00247-1 · Cited by 95 · see citing works

Morning urinary assessment of nocturnal melatonin secretion in older women

Cook, M. R., Graham, C. H., Kavet, R. I., Stevens, R. G., Davis, S., & Kheifets, L. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.280106.x · Cited by 92 · see citing works

Diurnal preference, sleep habits, circadian sleep propensity and melatonin rhythm in healthy human subjects

Liu, X., Uchiyama, M., Shibui, K., Kim, K., Kudo, Y., Tagaya, H., Suzuki, H., & Okawa, M. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00793-x · Cited by 90 · see citing works

Differential growth inhibitory effect of melatonin on two endometrial cancer cell lines

香西, 洋., Kobayashi, Y., Noda, S., Ishizuka, B., & Saito, K. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.280405.x · Cited by 87 · see citing works

The Dim Light Melatonin Onset, Melatonin Assays and Biological Rhythm Research in Humans

Lewy, A. J. (1999) · Neurosignals · doi:10.1159/000014573 · Cited by 86 · see citing works

Self-report of circadian type reflects the phase of the melatonin rhythm

Gibertini, M., Graham, C. H., & Cook, M. R. (1999) · Biological Psychology · doi:10.1016/s0301-0511(98)00049-0 · Cited by 81 · see citing works

Diurnal Urinary 6‐Sulfatoxymelatonin Levels among Healthy Danish Nurses during Work and Leisure Time

Hansen, Å. M., Garde, A. H., & Hansen, J. (2006) · Chronobiology International · doi:10.1080/07420520601100955 · Cited by 81 · see citing works

Melatonin inhibits dna synthesis in mcf-7 human breast cancer cells in vitro

Cos, S., Fernández, F., & Sánchez‐Barceló, E. J. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00249-4 · Cited by 80 · see citing works

Melatonin and prostate cancer cell proliferation: Interplay with castration, epidermal growth factor, and androgen sensitivity

Siu, S., Lau, K. W., Tam, P. C., & Shiu, S. Y. W. (2002) · The Prostate · doi:10.1002/pros.10098 · Cited by 80 · see citing works

Antiproliferative action of melatonin on human prostate cancer LNCaP cells.

Moretti, R. M., Marelli, M. M., Maggi, R., Dondi, D., Motta, M., & Limonta, P. (2000) · Oncology Reports · doi:10.3892/or.7.2.347 · Cited by 78 · see citing works

Radioimmunological Determination of Urinary Melatonin in Humans: Correlation with Plasma Levels and Typical 24-Hour Rhythmicity*

Lang, U., Kornemark, M., Aubert, M. L., & Sizonenko, P. C. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-3-645 · Cited by 76 · see citing works

Growth-inhibitory activity of melatonin on human androgen-independent DU 145 prostate cancer cells

Marelli, M. M., Limonta, P., Maggi, R., Motta, M., & Moretti, R. M. (2000) · The Prostate · doi:10.1002/1097-0045(20001101)45:3 · Cited by 76 · see citing works

Adaptation of the melatonin rhythm in human subjects following nightshift work in Antarctica

Midwinter, M. J., & Arendt, J. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90856-o · Cited by 72 · see citing works

The correlation between human plasma melatonin levels and urinary 6-hydroxymelatonin excretion

Markey, S. P., Higa, S., Shih, M. L., et al. (1985) · Clinica Chimica Acta · doi:10.1016/0009-8981(85)90247-5 · Cited by 72 · see citing works

Melatonin‐induced inhibition of proliferation and G1/S cell cycle transition delay of human choriocarcinoma JAr cells: Possible involvement of MT2 (MEL1B) receptor

Shiu, S. Y. W., Li, L., Xu, J. N., Pang, C. S.-F., Wong, J. T. Y., & Pang, S. F. (1999) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1999.tb00614.x · Cited by 72 · see citing works

Sulphatoxymelatonin excretion in older people: Relationship to plasma melatonin and renal function

Basket, J. J., Cockrem, J. F., & Antunovich, T. A. (1998) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1998.tb00366.x · Cited by 71 · see citing works

Antiproliferative effect of pineal indoles on cultured tumor cell lines

Sze, S. F., Ng, T. B., & Liu, W. K. (1993) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1993.tb00481.x · Cited by 69 · see citing works

Effects of Electric and Magnetic Fields from High-power Lines on Female Urinary Excretion of 6-Sulfatoxymelatonin

Levallois, P. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.7.601 · Cited by 69 · see citing works

Pathologic analysis of advanced adult soft tissue sarcomas, bone sarcomas, and mesotheliomas. The eastern cooperative oncology group (ECOG) experience

Shiraki, M., Enterline, H. T., Brooks, J. J. S., Cooper, N. S., Hirschl, S., Roth, J. A., Rao, U. N. M., Enzinger, F. M., Amato, D. A., & Borden, E. C. (1989) · Cancer · doi:10.1002/1097-0142(19890715)64:2 · Cited by 68 · see citing works

Phase‐shifts in melatonin, 6‐sulphatoxymelatonin and alertness rhythms after treatment with moderately bright light at night

Deacon, S., & Arendt, J. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb03940.x · Cited by 67 · see citing works

Relationship between adenohypophyseal and steroid hormones and variations in serum and urinary melatonin levels during the ovarian cycle, perimenopause and menopause in healthy women

Fernandez, B., Malde, J. L., Montero, A., et al. (1990) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(90)90282-w · Cited by 67 · see citing works

Adapting to phase shifts, I. An experimental model for jet lag and shift work

Deacon, S. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02147-7 · Cited by 64 · see citing works

Creatinine is an appropriate reference for urinary sulphatoxymelatonin of laboratory animals and humans

Klante, G., Brinschwitz, T., Secci, K., Wollnik, F., & Steinlechner, S. (1997) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1997.tb00354.x · Cited by 64 · see citing works

Potential involvement of mt1 receptor and attenuated sex steroid‐induced calcium influx in the direct anti‐proliferative action of melatonin on androgen‐responsive LNCaP human prostate cancer cells

Xi, S. C., Tam, P. C., Brown, G. M., Pang, S. F., & Shiu, S. Y. W. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.d01-64.x · Cited by 63 · see citing works

The validity of the temporal parameters of the daily rhythm of melatonin levels as an indicator of morningness

Griefahn, B. (2002) · Chronobiology International · doi:10.1081/cbi-120004226 · Cited by 61 · see citing works

Melatonin and Colon Carcinogenesis

Anisimov, V. N. (2001) · Springer eBooks · doi:10.1007/978-3-642-59512-7_11 · Cited by 61 · see citing works

Quantification of melatonin in human saliva by liquid chromatography–tandem mass spectrometry using stable isotope dilution

Eriksson, K., Östin, A., & Levin, J. (2003) · Journal of Chromatography B · doi:10.1016/s1570-0232(03)00425-2 · Cited by 59 · see citing works

Shift type and season affect adaptation of the 6-sulphatoxymelatonin rhythm in offshore oil rig workers

Barnes, R. G., Forbes, M. J., & Arendt, J. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00585-0 · Cited by 58 · see citing works

Melatonin, a suppressor of spontaneous murine mammary tumors

Subramanian, A., & Kothari, L. S. (1991) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1991.tb00830.x · Cited by 58 · see citing works

Urinary melatonin: a noninvasive method to follow human pineal function as studied in three experimental conditions

Pääkkönen, T., Mäkinen, T., Leppäluoto, J., Vakkuri, O., Rintamäki, H., Palinkas, L. A., & Hassi, J. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00300.x · Cited by 56 · see citing works

Rapid Shift in Sleep Time and Acrophase of Melatonin Secretion in Short Shift Work Schedule

Quera‐Salvá, M. A., Defrance, R., Claustrat, B., de Lattre, J., & Guilleminault, C. (1996) · SLEEP · doi:10.1093/sleep/19.7.539 · Cited by 54 · see citing works

Light intensities required to suppress nocturnal melatonin secretion in albino and pigmented rats

Lynch, H. J., Deng, M., & Wurtman, R. J. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90409-0 · Cited by 53 · see citing works

6‐Sulphatoxymelatonin Production in Breast Cancer Patients

Skene, D. J., Bojkowski, C. J., Currie, J. E., Wright, J., Boulter, P. S., & Arendt, J. (1990) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1990.tb00686.x · Cited by 52 · see citing works

Melatonin administration in tumor-bearing mice (intact and pinealectomized) in relation to stress, zinc, thymulin and IL-2

Mocchegiani, E., Perissin, L., Santarelli, L., Tibaldi, A., Zorzet, S., Rapozzi, V., Giacconi, R., Bulian, D., & Giraldi, T. (1999) · International Journal of Immunopharmacology · doi:10.1016/s0192-0561(98)00067-8 · Cited by 52 · see citing works

Decreases in urine specific gravity and urinary creatinine in elderly women

Moriguchi, J., Ezaki, T., Tsukahara, T., Fukui, Y., Ukai, H., Okamoto, S., Shimbo, S., Sakurai, H., & Ikeda, M. (2005) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-004-0597-z · Cited by 52 · see citing works

Salivary and plasma measures of dim light melatonin onset (DLMO) in patients with rapid cycling bipolar disorder

Leibenluft, E., Feldman‐Naim, S., Turner, E. H., Schwartz, P. J., & Wehr, T. A. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00488-2 · Cited by 51 · see citing works

Nocturnal urinary 6‐sulphatoxymelatonin excretion is decreased in primary breast cancer patients compared to age‐matched controls and shows negative correlation with tumor‐size

Bartsch, C., Bartsch, H., Karenovics, A., Franz, H. B. G., Peiker, G., & Mecke, D. (1997) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1997.tb00335.x · Cited by 51 · see citing works

Rapid Shift in Peak Melatonin Secretion Associated With Improved Performance in Short Shift Work Schedule

Quera‐Salvá, M. A., Guilleminault, C., Claustrat, B., Defrance, R., Gajdos, P., McCann, C. C., & Lattre, J. D. (1997) · SLEEP · doi:10.1093/sleep/20.12.1145 · Cited by 50 · see citing works

Rapid Direct Measurement of Melatonin in Saliva Using an Iodinated Tracer and Solid Phase Second Antibody

English, J., Middleton, B., Arendt, J., & Wirz‐Justice, A. (1993) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456329303000414 · Cited by 49 · see citing works

The Episodic Secretion of Hormones

Crowley, W. F., & Hofler, J. G. (1987) · Medical Entomology and Zoology · Cited by 48 · see citing works

Melatonin's growth-inhibitory effect on hepatoma AH 130 in the rat

Cini, G., Coronnello, M., Mini, E., & Neri, B. (1998) · Cancer Letters · doi:10.1016/s0304-3835(97)00480-1 · Cited by 48 · see citing works

The circadian covariation of fatigue and urinary melatonin.

Åkerstedt, T., Gillberg, M., & Wetterberg, L. (1982) · PubMed · Cited by 48 · see citing works

The Ovarian Life Cycle

Strauss, J. F., & Williams, C. J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4907-4.00008-5 · Cited by 47 · see citing works

Melatonin Rhythms Time Photoperiod-Induced Puberty in the Female Lamb*

Yellon, S. M., & Foster, D. L. (1986) · Endocrinology · doi:10.1210/endo-119-1-44 · Cited by 43 · see citing works

Testosterone treatment alters melatonin concentrations in male patients with gonadotropin-releasing hormone deficiency.

Luboshitzky, R., Lavi, S., Thuma, I., et al. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.2.8636302 · Cited by 40 · see citing works

A novel mechanism for the melatonin inhibition of testosterone secretion by rat Leydig cells: reduction of GnRH-induced increase in cytosolic Ca2+

VALENTI, S., Thellung, S., Florio, T., et al. (1999) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0230299 · Cited by 40 · see citing works

Melatonin supersensitivity to dim light in seasonal affective disorder

McIntyre, I. M., Norman, T. R., Burrows, G., et al. (1990) · The Lancet · doi:10.1016/0140-6736(90)90732-k · Cited by 39 · see citing works

The effect of gender on the melatonin suppression by light: a dose response relationship

Nathan, P. J., Wyndham, E. L., Burrows, G. D., & Norman, T. R. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050022 · Cited by 38 · see citing works

Inhibition of Dunning Tumor Growth by Melatonin

Philo, R., & Berkowitz, A. S. (1988) · The Journal of Urology · doi:10.1016/s0022-5347(17)42795-9 · Cited by 38 · see citing works

Direct determination of endogenous melatonin in human saliva by column‐switching semi‐microcolumn liquid chromatography/mass spectrometry with on‐line analyte enrichment

Motoyama, A., Kanda, T., & Namba, R. (2004) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1473 · Cited by 35 · see citing works

Effects of melatonin on N-nitroso-N-methylurea-induced carcinogenesis in rats and mutagenesis in vitro (Ames test and COMET assay)

Musatov, S. A., Anisimov, V. N., André, V., Vigreux, C., Godard, T., & Sichel, F. (1999) · Cancer Letters · doi:10.1016/s0304-3835(98)00365-6 · Cited by 33 · see citing works

Melatonin synthesis: A possible indicator of intolerance to shiftwork

Griefahn, B., Künemund, C., Golka, K., Thier, R., & Degen, G. H. (2002) · American Journal of Industrial Medicine · doi:10.1002/ajim.10122 · Cited by 31 · see citing works

The validity and feasibility of saliva melatonin assessment in the elderly

Gooneratne, N. S., Metlay, J. P., Guo, W., et al. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.02945.x · Cited by 31 · see citing works

Reproducibility over 5 years of measurements of 6-sulphatoxymelatonin in urine samples from postmenopausal women.

Travis, R. C., Allen, N. E., Peeters, P. H. M., van Noord, P. A. H., & Key, T. J. (2003) · PubMed · Cited by 30 · see citing works

Abnormal melatonin secretion in hypogonadal men: the effect of testosterone treatment

Luboshitzky, R., Wagner, O., Lavi, S., et al. (1997) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1997.2881089.x · Cited by 29 · see citing works

Does Melatonin Alter Pituitary Responsiveness to Gonadotropin-Releasing Hormone in the Ewe?

Robinson, J. E., Kaynard, A. H., & Karsch, F. J. (2008) · Neuroendocrinology · doi:10.1159/000124593 · Cited by 29 · see citing works

Determination of melatonin in saliva using automated solid‐phase extraction, high‐performance liquid chromatography and fluorescence detection

Römsing, S., Bökman, F., & Bergqvist, Y. (2006) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510600548777 · Cited by 28 · see citing works

Re: Melatonin and Breast Cancer: A Prospective Study

Hrushesky, W. J. M., & Blask, D. E. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh175 · Cited by 27 · see citing works

Melatonin and the ovulatory luteinizing hormone surge

Zimmermann, R. C., Schröder, S., Baars, S., et al. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53817-5 · Cited by 23 · see citing works

Melatonin: data consistent with a role in controlling ovarian function

Penny, R., Stanczyk, F. Z., & Goebelsmann, U. (1987) · Journal of Endocrinological Investigation · doi:10.1007/bf03348179 · Cited by 22 · see citing works

Melatonin Participates in the Control of Testosterone Secretion from Rat Testis

VALENTI, S., & Giusti, M. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04228.x · Cited by 20 · see citing works

Differential regulation by melatonin of cell growth and androgen receptor binding to the androgen response element in prostate cancer cells.

Rimler, A., Lupowitz, Z., & Zisapel, N. (2002) · PubMed · Cited by 19 · see citing works

Melatonin concentration before and during testosterone replacement in primary hypogonadic men

Rajmil, O., Puig‐Domingo, M., Tortosa, F. S., et al. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1370048 · Cited by 17 · see citing works

Plasma Melatonin Concentration before and during Testosterone Replacement in Klinefelter’s Syndrome: Relation to Hepatic Indolamine Metabolism and Sympathoadrenal Activity

Çağlayan, S., Özata, M., Özışık, G., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7225 · Cited by 15 · see citing works

Inhibitory effects of melatonin on testosterone but not on androstenedione production during winter in the vespertilionid bat, Scotophilus heathi

Singh, K., & Krishna, A. (1995) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1995.tb00181.x · Cited by 15 · see citing works

Changes in the Concentration of Urinary 6-sulphatoxymelatonin during a Week of Simulated Night Work

Roach, G. D., Lamond, N., Dorrian, J., Burgess, H. J., Holmes, A. L., Fletcher, A., McCULLOCH, K., & Dawson, D. E. (2005) · Industrial Health · doi:10.2486/indhealth.43.193 · Cited by 13 · see citing works

Longitudinal urinary creatinine excretion values among preadolescents and adolescents

Martin, M. D., Woods, J. S., Leroux, B. G., et al. (2007) · Translational research · doi:10.1016/j.trsl.2007.10.001 · Cited by 13 · see citing works

The Pineal Gland and the Menstrual Cycle

Sandyk, R. (1992) · International Journal of Neuroscience · doi:10.3109/00207459208987195 · Cited by 13 · see citing works

Nocturnal melatonin profiles before and one year after beginning shift‐work

Madokoro, S., Nakagawa, H., Misaki, K., et al. (1997) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.1997.tb02360.x · Cited by 8 · see citing works

A week of simulated night work delays salivary melatonin onset.

Roach, G. D., Burgess, H. J., Lamond, N., Dorrian, J., Holmes, A. L., Fletcher, A., McCulloch, K. M., & Dawson, D. E. (2001) · PubMed · Cited by 7 · see citing works

Plasma Melatonin Concentration before and during Testosterone Replacement in Klinefelter's Syndrome: Relation to Hepatic Indolamine Metabolism and Sympathoadrenal Activity

Çağlayan, S. B. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.2.738 · Cited by 7 · see citing works

Sexually Dimorphic Effects of Melatonin on Prolactin Cell Function in Male and Female Syrian Hamsters

Blask, D. E. (1989) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1989.tb00446.x · Cited by 4 · see citing works

Nuclear exclusion of the androgen receptor by melatonin in prostate cancer cells

Rimler, A., Lupowitz, Z., Bartsch, G. H., et al. (2002) · European Urology Supplements · doi:10.1016/s1569-9056(02)80194-4 · Cited by 1 · see citing works

Untitled work

Prabhala (1991) · doi:10.1002/1097-0142(19910315)67:6

Considerations of circadian impact for defining ‘shift work’ in cancer studies: IARC Working Group Report

Stevens, R. G., Hansen, J., Costa, G., Haus, E., Kauppinen, T., Aronson, K. J., Castaño-Vinyals, G., Davis, S., Frings-Dresen, M. H. W., Fritschi, L., et al. (2011) · Occupational and Environmental Medicine · doi:10.1136/oem.2009.053512 · Cited by 421 · see citing works

Health consequences of electric lighting practices in the modern world: A report on the National Toxicology Program's workshop on shift work at night, artificial light at night, and circadian disruption

Lunn, R. M., Blask, D. E., Coogan, A. N., Figueiro, M. G., Gorman, M. R., Hall, J. E., Hansen, J., Nelson, R. J., Panda, S., Smolensky, M. H., et al. (2017) · Science of The Total Environment · doi:10.1016/j.scitotenv.2017.07.056 · Cited by 402 · see citing works

Disruption of Circadian Rhythms Accelerates Development of Diabetes through Pancreatic Beta-Cell Loss and Dysfunction

Gale, J. E., Cox, H. I., Qian, J., Block, G. D., Colwell, C. S., & Matveyenko, A. V. (2011) · Journal of Biological Rhythms · doi:10.1177/0748730411416341 · Cited by 247 · see citing works

Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health

Almoosawi, S., Vingeliene, S., Gachon, F., Voortman, T., Palla, L., Johnston, J. D., Van Dam, R. M., Darimont, C., & Karagounis, L. G. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy070 · Cited by 247 · see citing works

Shift work and cancer – considerations on rationale, mechanisms, and epidemiology

Costa, G., Haus, E., & Stevens, R. (2010) · Scandinavian Journal of Work, Environment &amp; Health · doi:10.5271/sjweh.2899 · Cited by 241 · see citing works

Case–control study of shift-work and breast cancer risk in Danish nurses: Impact of shift systems

Hansen, J., & Stevens, R. G. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2011.07.005 · Cited by 226 · see citing works

Nested case-control study of night shift work and breast cancer risk among women in the Danish military

Hansen, J., & Lassen, C. F. (2012) · Occupational and Environmental Medicine · doi:10.1136/oemed-2011-100240 · Cited by 214 · see citing works

Oxidative DNA damage during sleep periods among nightshift workers

Bhatti, P., Mirick, D. K., Randolph, T. W., Gong, J., Buchanan, D. T., Zhang, J. (., & Davis, S. (2016) · Occupational and Environmental Medicine · doi:10.1136/oemed-2016-103629 · Cited by 28 · see citing works

Effect of Amputating the Tail on the Circadian Rhythm of Serum Melatonin Level in Mice

Yang, Y. (2011) · Zhongguo Yike Daxue xuebao

Desynchronization of oral temperature, pulse and performance circadian rhythms in shift working Indian nurses.

Pati, A. K., & Saini, S. K. (1991) · PubMed · Cited by 8 · see citing works

How to reduce circadian misalignment in rotating shift workers

Eastman, C. I. (2016) · ChronoPhysiology and Therapy · doi:10.2147/cpt.s111424 · Cited by 28 · see citing works

Effects of circadian misalignment on cognition in chronic shift workers

Chellappa, S. L., Morris, C. J., & Scheer, F. A. J. L. (2019) · Scientific Reports · doi:10.1038/s41598-018-36762-w · Cited by 139 · see citing works

Saliva Supernatant miR-21: a Novel Potential Biomarker for Esophageal Cancer Detection

Xie, Z., Chen, G., Zhang, X., Li, D., Huang, J. J., & Li, Z. (2012) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2012.13.12.6145 · Cited by 37 · see citing works