The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Effects of Light and Food Schedules on Liver and Tumor Molecular Clocks in Mice
Open accessAbstract
BACKGROUND: Disrupted circadian coordination accelerates malignant growth, but the molecular mechanism is unclear. METHODS: Healthy or Glasgow osteosarcoma-bearing mice (n = 162) were synchronized with light and darkness over 2-3 weeks, submitted to an 8-hour advance onset of light every 2 days (chronic jet lag) to disrupt circadian coordination, or submitted to chronic jet lag and meal timing to prevent molecular clock alteration. The expression of molecular clock genes and of the cell cycle genes c-Myc and p53 in liver and tumor was determined with quantitative reverse transcription-polymerase chain reaction at six circadian times over a 24-hour period of light and darkness and analyzed with analysis of variance and cosinor. Tumor weight was measured daily over the course of the experiment. All statistical tests were two-sided. RESULTS: In synchronized mice, mean mRNA levels of clock genes Rev-erbalpha, Per2, and Bmal1 varied by 206-, four-, and 26-fold, respectively, over the 24 hours in healthy mouse liver; by 36-, 35-, and 32-fold in the livers of tumor-bearing mice; and by 9.4-, 5.5-, and sixfold in tumor tissue (P = .046 to <.001). In mice subjected to chronic jet lag, the periodic changes were dampened and the clock gene rhythms were temporally shifted in liver and ablated in tumor, and tumor growth was accelerated. Meal timing reversed the chronic jet lag-induced alterations in Rev-erbalpha and Per2 expression in liver and of all three clock genes in tumor and slowed tumor growth. Tumor growth differed as a function of light and feeding schedules (P = .04). No obvious rhythm was detected for p53 or c-Myc in liver or tumor tissues of synchronized mice. In healthy mice subjected to chronic jet lag, the mean level of p53 expression was cut in half (P = .002), and a 12-fold circadian variation in c-Myc mRNA level (P = .03) was induced in the liver of healthy mice, whereas complex expression patterns were found in the liver and tumor of tumor-bearing mice. CONCLUSIONS: Altered light-dark or feeding schedules modified the expression of molecular clock genes and genes involved in carcinogenesis and tumor progression.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“this protocol has been shown to disrupt the oscillations of the core circadian genes in multiple tissues (Filipski et al., 2005; Lee et al., 2010; Thaiss et al., 2014).”
From Circadian Rhythm Disruption Promotes Lung Tumorigenesis (2016) · cites this paper as Filipski et al., 2005
In the citing paper
“Emerging evidence in several different cellular and in vivo models points to an important role of the core circadian genes in carcinogenesis (Filipski et al., 2005; Fu et al., 2002; Gery et al., 2006; Janich et al., 2011; Kettner et al., 2014; Lee et al., 2010; Puram et al., 2016; Sahar and Sassone-Corsi, 2009; Van Dycke et al., 2015; Wood et al., 2008).”
From Circadian Rhythm Disruption Promotes Lung Tumorigenesis (2016) · cites this paper as Filipski et al., 2005
In the citing paper
“Earlier reports using germline mutations in circadian components have highlighted a role for circadian rhythm disruption in tumor predisposition (Filipski et al., 2005; Fu et al., 2002; Gery et al., 2006; Janich et al., 2011; Kettner et al., 2014; Lee et al., 2010; Sahar and Sassone-Corsi, 2009; Van Dycke et al., 2015; Wood et al., 2008).”
From Circadian Rhythm Disruption Promotes Lung Tumorigenesis (2016) · cites this paper as Filipski et al., 2005
In the citing paper
“This would be in line with other studies in which phase advances induce c-myc expression directly and 3 days after exposure [11, 27”
From Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice (2015) · cites this paper as [11]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394
Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198
Entrainment of the circadian clock in the liver by feeding
Stokkan, K.-A., Yamazaki, S., Tei, H., Sakaki, Y., & Menaker, M. (2001) · Science · doi:10.1126/science.291.5503.490 · Cited by 1,800
Suprachiasmatic nucleus : the mind's clock
Klein, D. C., Moore, R. Y., & Reppert, S. M. (1991) · Cited by 1,715
Methods for cosinor-rhythmometry.
Nelson, W. E., Tong, Y. L., Lee, J. K., & Franz Halberg, A. (1979) · PubMed · Cited by 1,701
Fu, L., Pelicano, H., Liu, J., Huang, P., & Lee, C. C. (2002) · Cell · doi:10.1016/s0092-8674(02)00961-3 · Cited by 1,268
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,223
Rotating night shifts and risk of breast cancer in women participating in the nurses׳ health study
Schernhammer, E. S., Laden, F., Speizer, F. E., Willett, W. C., Hunter, D. J., Kawachi, I., & Colditz, G. A. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.20.1563 · Cited by 1,142
Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo
Matsuo, T., Yamaguchi, S., Mitsui, S., Emi, A., Shimoda, F., & Okamura, H. (2003) · Science · doi:10.1126/science.1086271 · Cited by 1,132
Research works printed but not linked: 6
- Shah, 1984, Cancer Research, 44, 3403
- Bryant, 1998, Methods in molecular biology (Clifton, N.J.), 86, 69
- Nelson, 1979, Chronobiologia, 6, 305
- Tampellini, 1998, Cancer Research, 58, 3896
- Koyanagi, 2003, Cancer Research, 63, 7277
- 1997, American Journal of Physiology -- Legacy Content, 273, R1891
Cited by
Sorted by citations
Gery, S., Komatsu, N., Baldjyan, L., Yu, A., Koo, D., & Koeffler, H. P. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.038 · Cited by 630
“In addition, malignant growth in mice with disruption of circadian coordination has been attributed to abnormal expression of c-Myc (Filipski et al., 2005).”
BackgroundCircadian Rhythms: Mechanisms and Therapeutic Implications
Levi, F., & Schibler, U. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105208 · Cited by 645
Circadian Rhythm Disruption Promotes Lung Tumorigenesis
Papagiannakopoulos, T., Bauer, M. R., Davidson, S. M., Heimann, M., Subbaraj, L., Bhutkar, A., Bartlebaugh, J., Vander Heiden, M. G., & Jacks, T. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.001 · Cited by 557
“Earlier reports using germline mutations in circadian components have highlighted a role for circadian rhythm disruption in tumor predisposition (Filipski et al., 2005; Fu et al., 2002; Gery et al., 2006; Janich et al., 2011; Kettner et al., 2014; Lee et al., 2010; Sahar and Sassone-Corsi, 2009;…”
InfluentialHaus, E. L., & Smolensky, M. H. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.08.003 · Cited by 499
Circadian Timing in Cancer Treatments
Lévi, F., Okyar, A., Dulong, S., Innominato, P. F., & Clairambault, J. (2010) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.113006.094626 · Cited by 491
Self-citationThe Impact of Sleep and Circadian Disturbance on Hormones and Metabolism
Kim, T., Jeong, J., & Hong, S. (2015) · International Journal of Endocrinology · doi:10.1155/2015/591729 · Cited by 409
“Whenmicewere exposed to chronic jet lag conditions, the expression of various clock genes such as Per2 and BMAL1 in the liver was dampened, the tumor suppressor gene p53 expression was suppressed, and the cell cycle progression gene c-Myc expression was induced [108].”
BackgroundStevens, R. G., Blask, D. E., Brainard, G. C., Hansen, J., Lockley, S. W., Provencio, I., Rea, M. S., & Reinlib, L. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10200 · Cited by 357
“However, other factors are emerging that have this potential and include the timing of meals (Filipski et al. 2005; Mendoza 2007), stress (Funk and Amir 1999), and alcohol (Allen et al.”
Breast cancer and circadian disruption from electric lighting in the modern world
Stevens, R. G., Brainard, G. C., Blask, D. E., Lockley, S. W., & Motta, M. E. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21218 · Cited by 332
“Other notable recent animal experiments also designed to test the idea that circadian disruption from electric light may increase cancer risk have shown that simulated jet lag stimulates cancer growth in mice (85,86); the cell line used was Glasgow osteosarcoma.”
BackgroundHealth Consequences of Circadian Disruption in Humans and Animal Models
Evans, J. A., & Davidson, A. J. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00010-5 · Cited by 291
Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice
Lee, S., Donehower, L. A., Herron, A. J., Moore, D. D., & Fu, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010995 · Cited by 286
“Disruption of circadian rhythm increases spontaneous and carcinogen-induced mammary tumors in rodents [1,2,3,4,5,6].”
BackgroundThe relationship between nutrition and circadian rhythms in mammals
Froy, O. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.03.001 · Cited by 295
“Arrhythmicity induced by SCN lesions [39,40] or chronic jet-lag [41,42] in mice or continuous bright light in rats [143] increases the rate of tumor growth and hastens death.”
BackgroundGiacchetti, S., Bjarnason, G. A., Garufi, C., Genet, D., Iacobelli, S., Tampellini, M., Smaaland, R., Focan, C., Coudert, B. P., Humblet, Y., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.1440 · Cited by 237
Self-citationCell autonomous regulation of herpes and influenza virus infection by the circadian clock
Edgar, R. S., Stangherlin, A., Nagy, A. D., Nicoll, M. P., Efstathiou, S., O'Neill, J. S., & Reddy, A. B. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601895113 · Cited by 229
“Given that global Bmal1 expression is substantially lower in mouse models of circadian desynchronization (23), our work also suggests that shift workers might be more susceptible to viral disease and therefore prime candidates for vaccination against viruses such as influenza.”
BackgroundHadadi, É., Taylor, W. R., Li, X., Aslan, Y., Vilotte, M., Rivière, J., Duvallet, G., Auriau, C., Dulong, S., Raymond‐Letron, I., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16890-6 · Cited by 230
Self-citationAiello, I., Fedele, M. L. M., Román, F. R., Marpegán, L., Caldart, C. S., Chiesa, J. J., Golombek, D. A., Finkielstein, C. V., & Paladino, N. (2020) · Science Advances · doi:10.1126/sciadv.aaz4530 · Cited by 222
The circadian timing system in clinical oncology
Innominato, P. F., Roche, V., Palesh, O. G., Ulusakarya, A., Spiegel, D., & Lévi, F. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.916990 · Cited by 214
Self-citationImplications of circadian clocks for the rhythmic delivery of cancer therapeutics
Lévi, F., Focan, C., Karaboué, A., de la Valette, V., Focan-Henrard, D., Baron, B., Kreutz, F., & Giacchetti, S. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.11.001 · Cited by 199
“In addition, the mRNA expression patterns over the 24 hours appear to be maintained, damped or ablated depending on the type of tumour and/or its developmental stage (Koyanagi et al. 2003; Filipski et al. 2005; You et al. 2005; Iurisci et al. 2006).”
BackgroundChronically Alternating Light Cycles Increase Breast Cancer Risk in Mice
Van Dycke, K. C. G., Rodenburg, W., van Oostrom, C. T. M., van Kerkhof, L. W. M., Pennings, J. L. A., Roenneberg, T., van Steeg, H., & van der Horst, G. T. J. (2015) · Current Biology · doi:10.1016/j.cub.2015.06.012 · Cited by 170
Enhancing circadian clock function in cancer cells inhibits tumor growth
Kießling, S., Beaulieu-Laroche, L., Blum, I. D., Landgraf, D., Welsh, D. K., Storch, K.-F., Labrecque, N., & Cermakian, N. (2017) · BMC Biology · doi:10.1186/s12915-017-0349-7 · Cited by 182
Cryptochrome, Circadian Cycle, Cell Cycle Checkpoints, and Cancer
Gauger, M. A., & Sancar, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1119 · Cited by 185
“Under conditions of jet lag, a rapid change of local time causes the internal clock to not fully synchronize with the local time; this can result in fatigue, irritability, and has been shown to affect fitness and tumor growth in mouse models (Filipski et al., 2005; Filipski et al., 2006).”
BackgroundVisualizing jet lag in the mouse suprachiasmatic nucleus and peripheral circadian timing system
Davidson, A. J., Castanon‐Cervantes, O., Leise, T. L., Molyneux, P. C., & Harrington, M. E. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06534.x · Cited by 171
“Chronic jet lag kills both aged mice (Davidson et al., 2006) and cardiomyopathic hamsters (Penev et al., 1998), accelerates malignant growth in mice (Filipski et al., 2005), and may underlie the disturbing and poorly understood relationship between shift work ª The Authors (2008).”
BackgroundCircadian disrupting exposures and breast cancer risk: a meta-analysis
He, C., Anand, S. T., Ebell, M. H., Vena, J. E., & Robb, S. W. (2015) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-014-0986-x · Cited by 165
Circadian Clock, Cell Division, and Cancer: From Molecules to Organism
Shostak, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040873 · Cited by 169
“Cohorts of tumor-bearing mice, subjected to such treatments, show accelerated tumor growth and increased expression of genes involved in tumorigenesis such as Myc [86,87].”
BackgroundChronotherapy and the molecular clock: Clinical implications in oncology☆
Innominato, P. F., Lévi, F., & Bjarnason, G. A. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.06.002 · Cited by 168
Self-citationPalesh, O. G., Peppone, Innominato, Janelsins, Jeong, M., Sprod, L. K., Savard, J., Rotatori, R. M., Telli, Mustian, et al. (2012) · Nature and Science of Sleep · doi:10.2147/nss.s18895 · Cited by 167
Circadian rhythms – from genes to physiology and disease
Bollinger, T., & Schibler, U. (2014) · Swiss Medical Weekly · doi:10.4414/smw.2014.13984 · Cited by 152
The times they’re a-changing: Effects of circadian desynchronization on physiology and disease
Golombek, D. A., Casiraghi, L. P., Agostino, P. V., Paladino, N., Duhart, J. M., Plano, S. A., & Chiesa, J. J. (2013) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2013.03.007 · Cited by 150
Circadian disruption accelerates liver carcinogenesis in mice
Filipski, E., Subramanian, P., Carrière, J., Guettier, C., Barbason, H., & Lévi, F. (2009) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2009.10.002 · Cited by 146
Self-citationEffect of feeding regimens on circadian rhythms: Implications for agingand longevity
Froy, O., & Miskin, R. (2010) · Aging · doi:10.18632/aging.100116 · Cited by 143
“Also, RF modified the expression of genes involved in carcinogenesis and tumor progression, such as c-myc and p53 [172].”
BackgroundErren, T. C., Pape, H. G., Reiter, R. J., & Piekarski, C. (2008) · Naturwissenschaften · doi:10.1007/s00114-007-0335-y · Cited by 133
“suggested that their experimental evidence showing that molecular clocks in tumors could be significantly altered via the disruption of regular photoperiodic synchronization has clinical relevance with regard to cancer risk in individuals exposed to iterative transmeridian flights and prolonged shift work (Filipski et…”
BackgroundInnominato, P. F., Giacchetti, S., Bjarnason, G. A., Focan, C., Garufi, C., Coudert, B. P., Iacobelli, S., Tampellini, M., Durando, X., Mormont, M., et al. (2012) · International Journal of Cancer · doi:10.1002/ijc.27574 · Cited by 129
“Conversely, enhancement of circadian coordination through regular meal timing slowed down experimental cancer growth.(13,14,16,18) The circadian timing system of cancer patients can be evaluated through noninvasive monitoring of the restactivity pattern using a wristwatch actimetry device.”
Self-citationYang, Y., Adebalı, O., Wu, G., Selby, C. P., Chiou, Y., Rashid, N. U., Hu, J., Hogenesch, J. B., & Sancar, A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1804493115 · Cited by 127
Circadian disruption in experimental cancer processes
Filipski, E., & Lévi, F. (2009) · Integrative Cancer Therapies · doi:10.1177/1534735409352085 · Cited by 125
“This partial restoration of the functional molecular clock in jet-lagged mice resulted in reduced growth rate of GOS (Figure 1).(26) The rescue of a defective tumor molecular clock was attempted using seliciclib (aka (R)-Roscovitine, CYC202),(34) a potent inhibitor of cyclin-dependent kinases CDK1, 2, 5, 7, and 9, whi…”
BackgroundInfluentialSelf-citationLight Pollution as a New Risk Factor for Human Breast and Prostate Cancers
Haim, A., & Portnov, B. A. (2013) · Springer eBooks · doi:10.1007/978-94-007-6220-6 · Cited by 133
Metabolic rivalry: circadian homeostasis and tumorigenesis
Kinouchi, K., & Sassone‐Corsi, P. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0291-9 · Cited by 128
Chronotherapeutics: The Relevance of Timing in Cancer Therapy
Lévi, F. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-9004-7 · Cited by 123
Cancer Inhibition through Circadian Reprogramming of Tumor Transcriptome with Meal Timing
Li, X., Delaunay, F., Dulong, S., Claustrat, B., Zampera, S., Fujii, Y., Teboul, M., Beau, J., & Lévi, F. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4235 · Cited by 123
Self-citationBreast cancer among shift workers: results of the WOLF longitudinal cohort study
Knutsson, A., Alfredsson, L. S., Karlsson, B., Åkerstedt, T., Fransson, E. I., Westerholm, P. J. M., & Westerlund, H. (2012) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3323 · Cited by 114
Khan, S., Duan, P., Yao, L., & Hou, H. (2018) · International Journal of Genomics · doi:10.1155/2018/8576890 · Cited by 120
Why does circadian timing of administration matter for immune checkpoint inhibitors’ efficacy?
Karaboué, A., Innominato, P. F., Wreglesworth, N. I., Duchemann, B., Adam, R. A., & Lévi, F. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02704-9 · Cited by 115
“They can be moderated by sex, age, as well as cancer type and stage [49, 118, 119].”
BackgroundSelf-citationIurisci, I., Filipski, E., Reinhardt, J., Bach, S., Gianella-Borradori, A., Iacobelli, S., Meijer, L., & Lévi, F. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2086 · Cited by 105
“In previous studies, we found that the circadian expression pattern of core clock genes Per2, Bmal1, and Rev-erba was severely altered in Glasgow osteosarcoma, a rapidly proliferating tumor transplanted in mice (10, 11 ).”
BackgroundMethodResultInfluentialSelf-citationCircadian rhythms and tumor growth
Greene, M. W. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.01.001 · Cited by 105
Chisholm, R. H., Lorenzi, T., & Clairambault, J. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.06.009 · Cited by 99
“On what informational grounds is such coherence based? Is it synchronisation between cells? Are circadian clocks and the central circadian pacemaker (known to be disrupted in cancer, all the more so as the cancer is more advanced, such enhanced disruption resulting both in poor prognosis and poor response to anticance…”
BackgroundLévi, F., Filipski, E., Iurisci, I., Li, X. M., & Innominato, P. F. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.030 · Cited by 97
Self-citationPPARs and Mitochondrial Metabolism: From NAFLD to HCC
Mello, T., Materozzi, M., & Galli, A. (2016) · PPAR Research · doi:10.1155/2016/7403230 · Cited by 94
Kourtidis, A., Jain, R., Carkner, R. D., Eifert, C., Brosnan, M. J., & Conklin, D. S. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-1550 · Cited by 81
“This altered physiologic program may also implicate NR1D1, a proposed link between the circadian clock and cellular metabolism (29), as a potential mediator of the tumorigenic influences of diet and the “night shift” that have been recently established for breast cancer (40).”
Effects of chronic jet lag on the central and peripheral circadian clocks in CBA/N mice
Iwamoto, A., Kawai, M., Furuse, M., & Yasuo, S. (2013) · Chronobiology International · doi:10.3109/07420528.2013.837478 · Cited by 78
“…of the circadian clock by an irregular light–dark cycle increases the risk of cancer in humans and animals (Conlon et al., 2007; Davidson et al., 2006; Filipski et al., 2004, 2005, 2009; Kubo et al., 2006; Logan et al., 2012; Schernhammer et al., 2001, 2003; Viswanathan & Schernhammer, 2009).”
BackgroundResultInfluentialLight pollution, reproductive function and cancer risk.
Stiborová, M., Martínek, V., Schmeiser, H. H., & Frei, E. (2006) · PubMed · Cited by 77
Altinok, A., Lévi, F., & Goldbeter, A. (2008) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2008.10.024 · Cited by 77
Implications of circadian clocks for the rhythmic delivery of cancer therapeutics
Lévi, F., Altinok, A., Clairambault, J., & Goldbeter, A. (2008) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2008.0114 · Cited by 77
“In addition, the mRNA expression patterns over the 24 hours appear to be maintained, damped or ablated depending on the type of tumour and/or its developmental stage (Koyanagi et al. 2003; Filipski et al. 2005; You et al. 2005; Iurisci et al. 2006).”
BackgroundImmunoregulatory role of melatonin in cancer
Moradkhani, F., Moloudizargari, M., Fallah, M., Asghari, N., Khoei, H. H., & Asghari, M. H. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29036 · Cited by 79
“In vivo dysregulated circadian rhythm modifies clock genes including Rev‐ erb alpha, Per2, and Bmal1 and alters P53 and c‐MYC at messenger RNA (mRNA) level finally triggering tumorigenesis (Filipski et al., 2005; Filipski, Li, & Levi, 2006).”
BackgroundCancer Chronotherapeutics: Experimental, Theoretical, and Clinical Aspects
Ortiz‐Tudela, E., Mteyrek, A., Ballesta, A., Innominato, P. F., & Lévi, F. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_11 · Cited by 74
Self-citationClock gene Per2 as a controller of liver carcinogenesis
Mteyrek, A., Filipski, E., Guettier, C., Okyar, A., & Lévi, F. (2016) · Oncotarget · doi:10.18632/oncotarget.11037 · Cited by 73
“Such desynchronization of molecular clocks could further alter xenobiotic metabolism and detoxification, and favor carcinogenic processes, and even more so in clockdefective Per2m/m mice [39, 40].”
Self-citationOral mucositis in morning vs. evening irradiated patients: A randomised prospective study
Goyal, M. K., Shukla, P., Gupta, D., Bisht, S. S., Dhawan, A., Gupta, S., Pant, M. C., & Verma, N. S. (2009) · International Journal of Radiation Biology · doi:10.1080/09553000902883802 · Cited by 71
“6 35 31 17 5 30 25 25 9 0.120 7 29 36 18 5 19 36 25 9 0.041 In t J R ad ia t B io l D ow nl oa de d fr om in fo rm ah ea lth ca re .c om b y U ni ve rs ity o f C on ne ct ic ut o n 10 /3 0/ 14 Fo r pe rs on al u se o nl y. Mormont and Lévi 2003, Filipski et al. 2005).”
InfluentialKubo, T., Oyama, I., Nakamura, T., Kunimoto, M., Kadowaki, K., Otomo, H., Fujino, Y., Fujimoto, N., Matsumoto, T., & Matsuda, S. (2011) · International Journal of Urology · doi:10.1111/j.1442-2042.2010.02714.x · Cited by 70
The interrelations among feeding, circadian rhythms and ageing
Froy, O., & Miskin, R. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.03.002 · Cited by 74
An association between clock genes and clock‐controlled cell cycle genes in murine colorectal tumors
Soták, M., Polidarová, L., Ergang, P., Sumová, A., & Pácha, J. (2012) · International Journal of Cancer · doi:10.1002/ijc.27760 · Cited by 66
“To date, only few reports described the clock gene expression patterns over the 24 hr in mouse tumors and showed that daily expression of clock genes remains mostly coordinated but damped in amplitude.(21,30,31) Similar trend of damping and disruption of clock gene and clock-controlled gene expression was found also i…”
BackgroundHuisman, S. A., Oklejewicz, M., Ahmadi, A. R., Tamanini, F., IJzermans, J. N. M., van der Horst, G. T. J., & de Bruin, R. W. F. (2014) · International Journal of Cancer · doi:10.1002/ijc.29089 · Cited by 65
“In osteosarcoma-bearing mice, circadian amplitudes were also dampened in the tumor compared to liver tissue.(32) Although Per2 did not oscillate in the tumor according to the cosinor analyses, there was a significant difference in expression level in time.”
ResultMatsunaga, N., Ogino, T., Hara, Y., Tanaka, T., Koyanagi, S., & Ohdo, S. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-4034 · Cited by 64
Search for the feeding-entrainable circadian oscillator: a complex proposition
Davidson, A. J. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00073.2006 · Cited by 64
Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
Wang, Y., Narasimamurthy, R., Qu, M., Shi, N., Guo, H.-D., Xue, Y., & Barker, N. (2024) · Nature Cancer · doi:10.1038/s43018-024-00759-4 · Cited by 62
Tabony, A. M., Yoshida, T., Galvez, S., Higashi, Y., Sukhanov, S., Chandrasekar, B., Mitch, W. E., & Delafontaine, P. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.174839 · Cited by 61
Tumor Growth Rate Determines the Timing of Optimal Chronomodulated Treatment Schedules
Bernard, S., Bernard, B., Lévi, F., & Herzel, H. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000712 · Cited by 60
“In tumors, the response is perturbed and advanced-stage cancer cells can escape or even disrupt circadian control [12,13].”
BackgroundBouchahda, M., Adam, R. A., Giacchetti, S., Castaing, D., Brézault, C., Hauteville, D., Innominato, P. F., Focan, C., Machover, D., & Lévi, F. (2009) · Cancer · doi:10.1002/cncr.24549 · Cited by 58
Self-citationCircadian disruption enhances HSF1 signaling and tumorigenesis in Kras -driven lung cancer
Pariollaud, M., Ibrahim, L. H., Irizarry, E., Mello, R. M., Chan, A. B., Altman, B. J., Shaw, R. J., Bollong, M. J., Wiseman, R. L., & Lamia, K. A. (2022) · Science Advances · doi:10.1126/sciadv.abo1123 · Cited by 57
Sleep and Health Consequences of Shift Work in Women
Chung, S. A., Wolf, T. K., & Shapiro, C. M. (2009) · Journal of Women s Health · doi:10.1089/jwh.2007.0742 · Cited by 64
“…with chronic experimental jet lag due to downregulation of two clock genes, per2 and reverb-a , which would normally inhibit tumor growth, 114,115 and abnormal circadian expression of period genes in a patient with non-24-hour circadian rhythm sleep disorder was found to normalize with…”
Mechanisms That Enhance Sustainability of p53 Pulses
Kim, J. K., & Jackson, T. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065242 · Cited by 53
“proposed, such as c-myc [71,72].”
Vasu, V. T., Cross, C. E., & Gohil, K. (2009) · Integrative Cancer Therapies · doi:10.1177/1534735409352027 · Cited by 52
“suppressor” gene regulating cell proliferation.(28) Preitner et al(5) showed in Nr1d1 null mice that the expression of SCN and liver Nr1d1 is negatively regulated by Per and Cry proteins”
BackgroundChen, Z. (2012) · Oncology Reports · doi:10.3892/or.2012.1688 · Cited by 52
“This result is consistent with previous reports as circadian disruption has shown the same effect on Glasgow osteosarcoma (GOS) or pancreatic adenocarcinoma (PO3) (9,10).”
Circadian genesPer1andPer2increase radiosensitivity of gliomain vivo
Zhanfeng, N., Li, Y., Fei, Z., Hao, S., Guangxing, L., & Hechun, X. (2015) · Oncotarget · doi:10.18632/oncotarget.3179 · Cited by 50
“Abnormal expression of c-Myc has been suggested as the cause of malignant growth in mice with disrupted circadian coordination [28].”
Changes of physiological functions induced by shift work
Herichová, I. (2013) · Endocrine Regulations · doi:10.4149/endo_2013_03_159 · Cited by 51
Health risks associated with genetic alterations in internal clock system by external factors
Khan, S., Nabi, G., Yao, L., Siddique, R., Sajjad, W., Kumar, S., Duan, P., & Hou, H. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.23744 · Cited by 58
“The disrupted circadian clock through bright light increases the risks of breast cancer [6,73].”
BackgroundScully, C. G., Karaboué, A., Liu, W., Meyer, J., Innominato, P. F., Chon, K. H., Gorbach, A. M., & Lévi, F. (2010) · Interface Focus · doi:10.1098/rsfs.2010.0012 · Cited by 48
Self-citationSynchronisation and control of proliferation in cycling cell population models with age structure
Billy, F., Clairambault, J., Fercoq, O., Gaubertt, S., Lepoutre, T., Ouillon, T., & Saito, S. (2012) · Mathematics and Computers in Simulation · doi:10.1016/j.matcom.2012.03.005 · Cited by 45
Disruption of central and peripheral circadian clocks in police officers working at night
Koshy, A., Cuesta, M., Boudreau, P., Cermakian, N., & Boivin, D. B. (2019) · The FASEB Journal · doi:10.1096/fj.201801889r · Cited by 46
“The rhythms of clock gene expression in the liver of these mice were significantly dampened when compared with mice that were exposed to standard lighting conditions (45).”
BackgroundInnominato, P. F., Giacchetti, S., Moreau, T., Smaaland, R., Focan, C., Bjarnason, G. A., Garufi, C., Iacobelli, S., Tampellini, M., Tumolo, S., et al. (2011) · Chronobiology International · doi:10.3109/07420528.2011.597532 · Cited by 48
“This circadian disruption interferes with the beneficial control exerted by the circadian timing system on tumor progression, and can concurrently hamper both treatment tolerability and anticancer efficacy (Filipski et al., 2002, 2004, 2005; Lévi et al., 2010).”
BackgroundSelf-citationCircadian clock synchrony and chronotherapy opportunities in cancer treatment
Damato, A. R., & Herzog, E. D. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.07.017 · Cited by 45
Clark, J. W., Fixaris, M. C., Belanger, G. V., & Rosenwasser, A. M. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00476.x · Cited by 45
“Experimental LD phase shifts mimic the abrupt changes in illumination schedule associated with transmeridian travel or shift work schedules, and result in transient circadian desynchrony at the behavioral level (Aschoff et al., 1975), as well as in the expression of specific clock genes within distinct subnuclei of th…”
BackgroundInfluentialOptimization of irinotecan chronotherapy with P-glycoprotein inhibition
Filipski, E., Berland, E., Öztürk, N., Guettier, C., van der Horst, G. T. J., Lévi, F., & Okyar, A. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.12.018 · Cited by 41
Self-citationSix-hour time-restricted feeding inhibits lung cancer progression and reshapes circadian metabolism
Shi, D., Fang, G., Chen, Q., Li, J., Ruan, X. Z., & Lian, X. (2023) · BMC Medicine · doi:10.1186/s12916-023-03131-y · Cited by 42
“TRF slows down osteosarcoma progression and reprogrammed rhythmic components in activity [18], as well as reverses the jet lag-driven alterations in clock genes expression [21].”
BackgroundCircadian rhythm and tumour growth
Clairambault, J., Michel, P., & Benoît Perthame, B. (2005) · Comptes Rendus Mathématique · doi:10.1016/j.crma.2005.10.029 · Cited by 40
Gholam, D., Giacchetti, S., Brézault, C., Bouchahda, M., Hauteville, D., Adam, R. A., Ducot, B., Ghémard, O., Kustlinger, F., Jasmin, C., et al. (2006) · The Oncologist · doi:10.1634/theoncologist.11-10-1072 · Cited by 40
Preclinical relevance of dosing time for the therapeutic index of gemcitabine–cisplatin
Li, X. M., Tanaka, K., Sun, J., Filipski, E., Kayitalire, L., Focan, C., & Lévi, F. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602564 · Cited by 39
“The overall survival estimate of GOS-bearing mice was prolonged from a median of 13 days in controls to 37 days in mice given gemcitabine alone or 42 days in those receiving gemcitabine–CDDP, irrespective of dosing time and interval between both drugs (log rank Po0.”
BackgroundInfluentialSelf-citationKatamune, C., Koyanagi, S., Shiromizu, S., Matsunaga, N., Shimba, S., Shibata, S., & Ohdo, S. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.706481 · Cited by 38
“These epidemiological findings are also supported by animal studies in which repetitive changes in the light-dark cycle facilitate the growth of implanted tumors (8, 9).”
BackgroundClairambault, J. (2009) · Mathematical Modelling of Natural Phenomena · doi:10.1051/mmnp/20094302 · Cited by 38
“To support this hypothesis, one can note that transgenic mice lacking an essential gene of the clock, Per2, are more prone to develop cancers [98, 99], secondly that disrupted circadian rhythms result in faster tumour growth in tumour-bearing mice [84, 85], and thirdly that tumour-bearing patients who show low amplitu…”
BackgroundCritical cholangiocarcinogenesis control by cryptochrome clock genes
Mteyrek, A., Filipski, E., Guettier, C., Oklejewicz, M., van der Horst, G. T. J., Okyar, A., & Lévi, F. (2017) · International Journal of Cancer · doi:10.1002/ijc.30663 · Cited by 37
“They are robustly expressed and rhythmic in the mouse liver.(16,25) Thus, the combined inactivation of Cry1 and Cry2 in mice suppressed rest-activity, core body temperature and corticosterone secretion following constant darkness exposure.”
BackgroundSelf-citationThoracic surface temperature rhythms as circadian biomarkers for cancer chronotherapy
Roche, V., Ali Mohammad-djafari, A., Innominato, P. F., Karaboué, A., Gorbach, A. M., & Lévi, F. (2014) · Chronobiology International · doi:10.3109/07420528.2013.864301 · Cited by 35
“In contrast, CTS re-enforcement with meal timing, a potent synchronizer of peripheral clocks, nearly halves experimental tumor growth (Filipski et al., 2005; Li et al., 2010; Wu et al., 2004).”
BackgroundSelf-citationInhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease
Matsunaga, N., Ikeda, E., Kakimoto, K., Watanabe, M., Shindo, N., Tsuruta, A., Ikeyama, H., Hamamura, K., Higashi, K., Yamashita, T., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.10.008 · Cited by 36
“Molecular dissection of the circadian biological clock has revealed links between genetic mutations and/or alteration of clock genes and diseases, including cancer, metabolic syndrome, and diabetes, in humans and animal models (Filipski et al., 2005; Ohdo et al., 2011).”
BackgroundLIVER CIRCADIAN CLOCK, A PHARMACOLOGIC TARGET OF CYCLIN-DEPENDENT KINASE INHIBITOR SELICICLIB
Iurisci, I., Filipski, E., Sallam, H., Harper, F., Guettier, C., Maire, I., Hassan, M., Iacobelli, S., & Lévi, F. (2009) · Chronobiology International · doi:10.1080/07420520903209942 · Cited by 35
Self-citationSex and Dosing-Time Dependencies in Irinotecan-Induced Circadian Disruption
Ahowesso, C., Li, X., Zampera, S., Maison-Peteri, B., Dulong, S., Beau, J., Hossard, V., Filipski, E., Delaunay, F., Claustrat, B., et al. (2011) · Chronobiology International · doi:10.3109/07420528.2011.569043 · Cited by 33
“(Filipski et al., 2002, 2005, 2009; Fu et al., 2002; Lee et al., 2010).”
Self-citationDaily timed meals dissociate circadian rhythms in hepatoma and healthy host liver
Davidson, A. J., Straume, M., Block, G. D., & Menaker, M. (2005) · International Journal of Cancer · doi:10.1002/ijc.21591 · Cited by 32
“Circadian rhythms in liver function and circadian clock gene expression synchronize to food-restriction schedules,(22,23) and mice on daytime restricted feeding exhibit slower tumor development than mice fed at night or ad libitum.(19,24) Therefore, it is important to understand the biological mechanism(s) that underl…”
BackgroundBae, S.-A., & Androulakis, I. P. (2017) · Gene Regulation and Systems Biology · doi:10.1177/1177625017702393 · Cited by 31
Circadian disruption: from mouse models to molecular mechanisms and cancer therapeutic targets
Wang, Y., Guo, H.-D., & He, F. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10072-0 · Cited by 34
Towards the integration of spatially and temporally resolved murine gene expression databases
Sunkin, S. M. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.02.006 · Cited by 31
Emerging evidence for the interrelationship of xenobiotic exposure and circadian rhythms: a review
Lim, F.-L., Currie, R. A., Orphanides, G., & Moggs, J. G. (2006) · Xenobiotica · doi:10.1080/00498250600861819 · Cited by 31
“Intriguingly, there is also evidence for accelerated tumour growth in mice that lack the SCN clock (Filipski et al. 2003) and in mice made chronically ‘jet-lagged’ under laboratory conditions (Filipski et al. 2004, Filipski et al. 2005).”
BackgroundJensen, L. D., Oliva, D., Andersson, B., & Lewin, F. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10010-6 · Cited by 32
Khan, S., Liu, Y., Siddique, R., Nabi, G., Xue, M., & Hou, H. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.35520 · Cited by 31
“Although the preclinical data support this link; however, the precise molecular mechanisms underlying the relationship between cancer initiation/progression and clock disruption is yet to be understood (7,17,18).”
BackgroundInfluentialCircadian rhythm disruption: health consequences
Sharma, A., Tiwari, S., & Singaravel, M. (2015) · Biological Rhythm Research · doi:10.1080/09291016.2015.1103942 · Cited by 28
“In another study, the expression of per2, bmal1, and rev-erbα in the liver showed lower amplitudes and small phase shift when compared to controls (Filipski et al. 2004, 2005; Herichova 2013).”
BackgroundBMAL1 regulates Propionibacterium acnes -induced skin inflammation via REV-ERBα in mice
Li, F., Lin, L., He, Y., Sun, G., Dong, D., & Wu, B. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.71719 · Cited by 28
“Jet-lagged humans and animals show disrupted expression of clock genes [24,25].”
BackgroundCircadian rhythm and cell population growth
Clairambault, J., Gaubert, S., & Lepoutre, T. (2010) · Mathematical and Computer Modelling · doi:10.1016/j.mcm.2010.05.034 · Cited by 28
Metadata
- Authors
- Filipski, E., Innominato, P. F., Wu, M., Li, X.-M., Iacobelli, S., Xian, L.-J., & Levi, F.
- Affiliations
- Inserm (FR)
- Corresponding author
- Filipski, E.
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-04-05
- Volume
- 97
- Issue
- 7
- Pages
- 507-517
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2128032039
- Cited by
- 200
- References
- 48
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 10 · 2019: 6 · 2018: 10 · 2017: 9 · 2016: 14 · 2015: 9 · 2014: 13 · 2013: 12 · 2012: 12
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JNCI Journal of the National Cancer Institute (publishedVersion)
- PubMed (publishedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (other-oa)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- circadian rhythm, jet lag, light-dark cycle, meal timing, feeding schedule, clock genes, NR1D1, Per2, Bmal1, osteosarcoma, liver, tumor growth, p53, c-Myc, carcinogenesis, tumor progression, molecular clock
- MeSH terms
- Analysis of Variance, Animals, Circadian Rhythm, DNA-Binding Proteins, Food, Light, Liver, Male, Nuclear Proteins, RNA, Messenger, Transcription Factors, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, Proto-Oncogene Proteins c-myc, Receptors, Cytoplasmic and Nuclear, Cell Cycle Proteins, Reverse Transcriptase Polymerase Chain Reaction, Mice, Period Circadian Proteins, Nuclear Receptor Subfamily 1, Group D, Member 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
