Brief report: sluggish cognitive tempo among pediatric survivors of acute lymphoblastic leukemia
Abstract
OBJECTIVE: The purpose of the present study was to assess sluggish cognitive tempo (SCT) behavioral symptoms among pediatric survivors of acute lymphoblastic leukemia (ALL) and to determine the relationship of these behaviors with cognitive late effects. METHODS: ALL survivors (n = 80) and a sibling control group (n = 19) were administered intelligence (IQ) testing, achievement testing and SCT behavioral items. Group differences (patients vs. siblings) were examined on the SCT behaviors and partial correlations were conducted to explore the relationship of the SCT behaviors with IQ and achievement, while controlling for age at treatment and time since treatment. RESULTS: ALL survivors exhibited significantly more SCT symptoms than the sibling control group and increased SCT symptoms were associated with lower IQ and achievement scores. CONCLUSIONS: ALL survivors are vulnerable to SCT symptoms and these behaviors are associated with cognitive late effects. SCT symptoms may represent a behavioral component of cognitive late effects.
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Working memory was uniquely associated with SCT, while findings for processing speed, inhibition, and IQ were mixed or weak.
“Studies investigating neuropsychological measures found working memory to be uniquely associated with SCT and reported mixed findings or weak associations for processing speed, inhibition, and IQ.65,66”
From Report of a Work Group on Sluggish Cognitive Tempo: Key Research Directions and a Consensus Change in Terminology to Cognitive Disengagement Syndrome (2023) · cites this paper as [66]
The Associations of SCT with Intelligence and Academic Achievement section reports a modest but statistically significant association between higher SCT scores and lower estimated IQ in pediatric ALL survivors (r = −.302, p = .007). The paper does not test whether working memory is uniquely associated with SCT or report SCT associations for inhibition or processing speed; the Discussion raises reduced processing speed only as a possibility. Page numbers are unavailable in our copy. (LLM, conf=0.85)
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- Authors
- Reeves, C. B., Palmer, S., Gross, A. M., Simonian, S. J., Taylor, L., Willingham, E., & Mulhern, R. K.
- Affiliations
- Medical University of South Carolina (US)
- Venue
- Journal of Pediatric Psychology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04-09
- Volume
- 32
- Issue
- 9
- Pages
- 1050-1054
- ISSN
- 0146-8693 (ISSN-L)
- 1465-735X
- OpenAlex
- W2160353462
- Semantic Scholar
- 7cc64e53e29693e575da9f8965f0a4c183737be6
- Cited by
- 66
- References
- 21
- Citations by year
- 2025: 1 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 8 · 2014: 5 · 2013: 6 · 2012: 3
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Psychology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- sluggish cognitive tempo, acute lymphoblastic leukemia, childhood cancer survivors, intelligence quotient, academic performance, behavioral symptoms, siblings as controls
- MeSH terms
- Adolescent, Child, Cognition Disorders, Female, Humans, Male, Neuropsychological Tests, Severity of Illness Index, Survival Rate, Precursor Cell Lymphoblastic Leukemia-Lymphoma
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