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Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions
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“However, single-cell analyses have revealed that, despite the low overall level of mtDNA mutations, the mutational load of individual aging cells becomes significant and may attain a state of homoplasmy in which a mutant genome dominates the normal one (Khrapko et al., 1999).”
From The Hallmarks of Aging (2013) · cites this paper as Khrapko et al., 1999
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Cites
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Cellular senescence and tumor suppressor gene p16
Rayess, H., Wang, M. B., & Srivatsan, E. S. (2012) · International Journal of Cancer · doi:10.1002/ijc.27316 · Cited by 825
Autophagy and aging: The importance of maintaining "clean" cells
Cuervo, A. M., Bergamini, E., Brunk, U. T., Dröge, W., Ffrench, M., & Terman, A. (2005) · Autophagy · doi:10.4161/auto.1.3.2017 · Cited by 792
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Terman, A., Kurz, T., Navratil, M., Arriaga, E. A., & Brunk, U. T. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2598 · Cited by 490
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Somatic mutations and aging: a re-evaluation
Vijg, J. (2000) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(99)00202-x · Cited by 243
Self-citationCao, Z. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.21.4502 · Cited by 170
Hütter, E., Skovbro, M., Lener, B., Prats, C., Rabøl, R., Dela, F., & Jansen‐Dürr, P. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00282.x · Cited by 149
Zhang, D. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00695-8 · Cited by 115
Mosaic deficiency in mitochondrial oxidative metabolism promotes cardiac arrhythmia during aging
Baris, O. R., Ederer, S., Neuhaus, J. F. G., von Kleist-Retzow, J.-C., Wunderlich, C. M., Pal, M., Wunderlich, F. T., Peeva, V., Zsurka, G., Kunz, W. S., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.04.005 · Cited by 87
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The aging myocardium: roles of mitochondrial damage and lysosomal degradation
Terman, A., & Brunk, U. T. (2005) · Heart, Lung and Circulation · doi:10.1016/j.hlc.2004.12.023 · Cited by 80
Do mtDNA deletions drive premature aging in mtDNA mutator mice?
Kraytsberg, Y., Simon, D. K., Turnbull, D. M., & Khrapko, K. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00484.x · Cited by 42
Self-citation
Metadata
- Authors
- Khrapko, K., Bodyak, N., Thilly, W. G., van Orsouw, N. J., Zhang, X., Coller, H. A., Perls, T. T., Upton, M., Vijg, J., & Wei, J. Y.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01-01
- Volume
- 27
- Issue
- 11
- Pages
- 2434-2441
- ISSN
- 0305-1048
- 1362-4962
- Cited by
- 149
- References
- 2
- Language
- en
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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