Somatic mutations and aging: a re-evaluation

A genetic model for colorectal tumorigenesis

Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132 · see citing works

The Metabolic and Molecular Bases of Inherited Disease

Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101 · see citing works

The serial cultivation of human diploid cell strains

Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works

Oxidants, antioxidants, and the degenerative diseases of aging.

Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958 · see citing works

Instability and decay of the primary structure of DNA

Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679 · see citing works

Viable offspring derived from fetal and adult mammalian cells

Wilmut, I., Schnieke, A., McWhir, J., Kind, A., & Campbell, K. (1997) · Nature · doi:10.1038/385810a0 · Cited by 4,976 · see citing works

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975 · see citing works

Pleiotropy, natural selection, and the evolution of senescence.

Williams, G. C. (1957) · Evolution · doi:10.1111/j.1558-5646.1957.tb02911.x · Cited by 4,279 · see citing works

Genetic instabilities in human cancers

Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168 · see citing works

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

Greenblatt, M. S., Bennett, W. P., Hollstein, M., & Harris, C. C. (1994) · PubMed · Cited by 3,463 · see citing works

The relation of recombination to mutational advance

Muller, H. J. (1964) · Mutation Research · doi:10.1016/0027-5107(64)90047-8 · Cited by 2,512 · see citing works

Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei

Wakayama, T., Perry, A. C. F., Zuccotti, M., Johnson, K. R., & Yanagimachi, R. (1998) · Nature · doi:10.1038/28615 · Cited by 2,250 · see citing works

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108 · see citing works

Pleiotropy, natural selection, and the evolution of senescence

Williams, G. C. (1957) · Evolution · doi:10.2307/2406060 · Cited by 1,912 · see citing works

Untitled work

Olovnikov (1973) · doi:10.1016/0022-5193(73)90198-7 · Cited by 1,847 · see citing works

AN UNSOLVED PROBLEM OF BIOLOGY

(1953) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1953.tb84985.x · Cited by 1,805 · see citing works

Evolution in age-structured populations

(1995) · Choice Reviews Online · doi:10.5860/choice.32-3873 · Cited by 1,756 · see citing works

Positional Cloning of the Werner's Syndrome Gene

Yu, C., Oshima, J., Fu, Y., Wijsman, E. M., Hisama, F. M., Alisch, R. S., Matthews, S., Nakura, J., Miki, T., Ouais, S. G., et al. (1996) · Science · doi:10.1126/science.272.5259.258 · Cited by 1,705 · see citing works

Distinctive gene expression patterns in human mammary epithelial cells and breast cancers

Perou, C. M., Jeffrey, S. S., van de Rijn, M., Rees, C. A., Eisen, M. B., Ross, D. T., Pergamenschikov, A., Williams, C. F., Zhu, S., Lee, J. C. F., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9212 · Cited by 1,402 · see citing works

Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting

Gu, H., Marth, J. D., Orban, P. C., Mossmann, H., & Rajewsky, K. (1994) · Science · doi:10.1126/science.8016642 · Cited by 1,397 · see citing works

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349 · see citing works

Untitled work

(1991) · PubMed · Cited by 1,305 · see citing works

Essential role of mouse telomerase in highly proliferative organs

Lee, H.-W., Blasco, M. A., Gottlieb, G. J., Horner, J. W., Greider, C. W., & DePinho, R. A. (1998) · Nature · doi:10.1038/33345 · Cited by 1,270 · see citing works

Principles of Geriatric Medicine and Gerontology.

(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-817_6 · Cited by 1,056 · see citing works

Evolution in Age-Structured Populations

Gilbert, N., & Charlesworth, B. (1981) · Journal of Animal Ecology · doi:10.2307/4092 · Cited by 954 · see citing works

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

Xu, X., Wagner, K., Larson, D. M., Ohler, Z. W., Li, C., Ried, T., Hennighausen, L. G., Wynshaw-Boris, A. J., & Deng, C. (1999) · Nature Genetics · doi:10.1038/8743 · Cited by 758 · see citing works

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

Hart, R. W., & Setlow, R. B. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.6.2169 · Cited by 739 · see citing works

On the nature of the aging process

Szilard, L. (1959) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.45.1.30 · Cited by 651 · see citing works

Genetic analysis of ageing: role of oxidative damage and environmental stresses

Martin, G. M., Austad, S. N., & Johnson, T. E. (1996) · Nature Genetics · doi:10.1038/ng0596-25 · Cited by 641 · see citing works

Telomere length and replicative aging in human vascular tissues.

Chang, E., & Harley, C. B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11190 · Cited by 635 · see citing works

Untitled work

(1995) · PubMed · Cited by 496 · see citing works

Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo.

Gossen, J. A., de Leeuw, W. J., Tan, C. H., Zwarthoff, E. C., Berends, F., Lohman, P. H. M., Knook, D. L., & Vijg, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.7971 · Cited by 494 · see citing works

Reactive oxygen species in tumorigenesis.

Feig, D. I., Reid, T. M., & Loeb, L. A. (1994) · PubMed · Cited by 472 · see citing works

The mutation rate and cancer

Tomlinson, I. P. M., Novelli, M. R., & Bodmer, W. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14800 · Cited by 457 · see citing works

The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease

Huang, S., Li, B., Gray, M. D., Oshima, J., Mian, S. I., & Campisi, J. (1998) · Nature Genetics · doi:10.1038/2410 · Cited by 453 · see citing works

Repeat unit sequence variation in minisatellites: A novel source of DNA polymorphism for studying variation and mutation by single molecule analysis

Jeffreys, A. J., Neumann, R., & Wilson, V. (1990) · Cell · doi:10.1016/0092-8674(90)90598-9 · Cited by 448 · see citing works

Replicative Senescence: An Old Lives' Tale?

Campisi, J. (1996) · Cell · doi:10.1016/s0092-8674(00)81023-5 · Cited by 434 · see citing works

Mutator phenotype of Werner syndrome is characterized by extensive deletions.

Fukuchi, K.-I., Martin, G. M., & Monnat, R. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.15.5893 · Cited by 422 · see citing works

Test of synergistic interactions among deleterious mutations in bacteria

Elena, S. F., & Lenski, R. E. (1997) · Nature · doi:10.1038/37108 · Cited by 416 · see citing works

Increased Susceptibility to Ultraviolet-B and Carcinogens of Mice Lacking the DNA Excision Repair Gene XPA

Vries, A. D., van Oostrom, C. T. M., Hofhuis, F. M. A., Dortant, P. M., Berg, R. J. W., Gruijl, F. R. D., Wester, P. W., van Kreijl, C. F., Capel, P. J. A., Steeg, H. V., et al. (1995) · Nature · doi:10.1038/377169a0 · Cited by 406 · see citing works

Estimate of the genomic mutation rate deleterious to overall fitness in E. coll

Kibota, T. T., & Lynch, M. F. (1996) · Nature · doi:10.1038/381694a0 · Cited by 358 · see citing works

Defective Transcription-Coupled Repair in Cockayne Syndrome B Mice Is Associated with Skin Cancer Predisposition

van der Horst, G. T. J., STEEG, H. V., Berg, R. J. W., van Gool, A. J., de Wit, J., Weeda, G., Morreau, H., Beems, R. B., van Kreijl, C. F., de Gruijl, F. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80223-8 · Cited by 334 · see citing works

Oxidative DNA damage, antioxidants, and cancer

Collins, A. R. (1999) · BioEssays · doi:10.1002/(sici)1521-1878(199903)21:3 · Cited by 312 · see citing works

Mismatch Repair Deficiency in Phenotypically Normal Human Cells

Parsons, R. E., Li, G., Longley, M. J., Modrich, P. L., Liu, B., Berk, T., Hamilton, S. R., Kinzler, K. W., & Vogelstein, B. (1995) · Science · doi:10.1126/science.7632227 · Cited by 305 · see citing works

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

Lebel, M., & Leder, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13097 · Cited by 304 · see citing works

The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting

Ramsey, M. J., Moore, D. H., Briner, J. F., Lee, D. A., Olsen, L. A., Senft, J. R., & Tucker, J. D. (1995) · Mutation Research/DNAging · doi:10.1016/0921-8734(95)00015-x · Cited by 278 · see citing works

Werner Syndrome Protein

Shen, J.-C., Gray, M. D., Oshima, J., Kamath‐Loeb, A. S., Fry, M., & Loeb, L. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34139 · Cited by 266 · see citing works

1994 William Allan Award Address. Mitochondrial DNA variation in human evolution, degenerative disease, and aging.

Wallace, D. C. (1995) · PubMed Central · Cited by 264 · see citing works

Role of Free Radicals in Aging and Disease

Harman, D. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb27444.x · Cited by 262 · see citing works

Rapid accumulation of genome rearrangements in liver but not in brain of old mice

Dollé, M. E. T., Giese, H., Hopkins, C. L., Martus, H., Hausdorff, J. M., & Vijg, J. (1997) · Nature Genetics · doi:10.1038/ng1297-431 · Cited by 248 · see citing works

Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation?

Mohrenweiser, H. W., & Jones, I. M. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(98)00059-1 · Cited by 227 · see citing works

Apoptosis and Its Role in Human Disease

Barr, P. J., & Tomei, L. (1994) · Nature Biotechnology · doi:10.1038/nbt0594-487 · Cited by 225 · see citing works

Caloric Restriction and Aging

Weindruch, R. H. (1996) · Scientific American · doi:10.1038/scientificamerican0196-46 · Cited by 216 · see citing works

THE AGING PROCESS AND CANCEROGENESIS

Failla, G. (1958) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1958.tb46828.x · Cited by 215 · see citing works

New prospects for human stem-cell therapy in the nervous system

Svendsen, C. N., & Smith, A. G. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01428-9 · Cited by 213 · see citing works

Somatic heterogeneity of the CTG repeat in myotonic dystrophy is age and size dependent.

Wong, L.-J., Ashizawa, T., Monckton, D. G., Caskey, C. T., & Richards, C. S. (1995) · Europe PMC (PubMed Central) · Cited by 204 · see citing works

Inducible Repair of Thymine Glycol Detected by an Ultrasensitive Assay for DNA Damage

Le, X. C., Xing, J. Z., Lee, J., Leadon, S. A., & Weinfeld, M. (1998) · Science · doi:10.1126/science.280.5366.1066 · Cited by 204 · see citing works

Siblings of centenarians live longer

Perls, T. T., Bubrick, E. J., Wager, C. G., Vijg, J., & Kruglyak, L. (1998) · The Lancet · doi:10.1016/s0140-6736(05)61126-9 · Cited by 194 · see citing works

Muller's ratchet decreases fitness of a DNA-based microbe.

Andersson, D. I., & Hughes, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.906 · Cited by 180 · see citing works

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions

Khrapko, K., Bodyak, N. D., Thilly, W. G., van Orsouw, N. J., Zhang, X., Coller, H. A., Perls, T. T., Upton, M. P., Vijg, J., & Wei, J. Y. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.11.2434 · Cited by 179 · see citing works

Microsatellite instability: The mutator that mutates the other mutator

Perucho, M. (1996) · Nature Medicine · doi:10.1038/nm0696-630 · Cited by 177 · see citing works

Mouse minisatellite mutations induced by ionizing radiation

Dubrova, Y. E., Jeffreys, A. J., & Малашенко, А. М. (1993) · Nature Genetics · doi:10.1038/ng0993-92 · Cited by 176 · see citing works

Full-Length Human L1 Insertions Retain the Capacity for High Frequency Retrotransposition in Cultured Cells

Kimberland, M. L., Divoký, V., Prchal, J. T., Schwahn, U., Berger, W., & Kazazian, H. H. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.8.1557 · Cited by 173 · see citing works

[1] Preparation of cDNA from single cells and subcellular regions

Kacharmina, J. E., Crino, P. B., & Eberwine, J. H. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)03003-7 · Cited by 166 · see citing works

Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice.

Reitmair, A. H., Redston, M. S., Cai, J. C., Chuang, T. C.-Y., Bjerknes, M., Cheng, H., Hay, K., Gallinger, S., Bapat, B. V., & Mak, T. W. (1996) · PubMed · Cited by 166 · see citing works

Mouse models for hereditary nonpolyposis colorectal cancer.

de Wind, N., Dekker, M., van Rossum, A. G. J., van der Valk, M., & Riele, H. T. (1998) · PubMed · Cited by 162 · see citing works

DNA, mutations and aging

Kirkwood, T. B. L. (1989) · Mutation Research/DNAging · doi:10.1016/0921-8734(89)90035-0 · Cited by 156 · see citing works

The origin of point mutations in human tumor cells.

Strauss, B. S. (1992) · PubMed · Cited by 154 · see citing works

Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene  <i>Pms2</i>

Narayanan, L., Fritzell, J. A., Baker, S. M., Liskay, R. M., & Glazer, P. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3122 · Cited by 152 · see citing works

Somatic Mutations Are Frequent and Increase with Age in Human Kidney Epithelial Cells

Martin, G. M., Ogburn, C. E., Colgin, L. M., Gown, A. M., Edland, S. D., & Monnat, R. J. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.2.215 · Cited by 150 · see citing works

In vivo human somatic mutation: frequency and spectrum with age

Grist, S. A., McCarron, M., Kutlaca, A., Turner, D. R., & Morley, A. A. (1992) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(92)90186-6 · Cited by 146 · see citing works

Oxidative DNA damage processing in nuclear and mitochondrial DNA

Bohr, V. A., & Dianov, G. L. (1999) · Biochimie · doi:10.1016/s0300-9084(99)80048-0 · Cited by 142 · see citing works

The DNA Helicase Activity of BLM Is Necessary for the Correction of the Genomic Instability of Bloom Syndrome Cells

Neff, N. F., Ellis, N. A., Ye, T.-Z., Noonan, J. P., Huang, K. J., Sanz, M. M., & Proytcheva, M. A. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.3.665 · Cited by 135 · see citing works

Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice

Shao, C., Deng, L., Henegariu, O., Liang, L., Raikwar, N. S., Sahota, A. S., Stambrook, P. J., & Tischfield, J. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9230 · Cited by 133 · see citing works

Rates of apoptosis and proliferation vary with caloric intake and may influence incidence of spontaneous hepatoma in C57BL/6 x C3H F1 mice.

James, S. J., & Muskhelishvili, L. (1994) · PubMed · Cited by 131 · see citing works

Unusual DNA structures, chromatin and transcription

Holde, K. V., & Zlatanova, J. S. (1994) · BioEssays · doi:10.1002/bies.950160110 · Cited by 130 · see citing works

Cell proliferation, cell death and aging

Franceschi, C. (1989) · Aging Clinical and Experimental Research · doi:10.1007/bf03323871 · Cited by 128 · see citing works

Comparison of Chromosome Telomere Integrity in Multiple Tissues from Subjects at Different Ages

Butler, M. G., Tilburt, J. C., DeVries, A., Muralidhar, B., Aue, G., Hedges, L. K., Atkinson, J. T., & Schwartz, H. S. (1998) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(98)00029-6 · Cited by 124 · see citing works

Untitled work

(1991) · PubMed · Cited by 123 · see citing works

Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?

Wright, W. E., & Shay, J. W. (1995) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)89044-3 · Cited by 121 · see citing works

Cockayne syndrome: defective repair of transcription?

van Gool, A. J., van der Horst, G. T. J., Citterio, E., & Hoeijmakers, J. H. J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.14.4155 · Cited by 115 · see citing works

Mutation and senescence: where genetics and demography meet

Promislow, D., & Tatar, M. (1998) · Genetica · doi:10.1023/a:1017047212008 · Cited by 113 · see citing works

Double strand break rejoining by mammalian mitochondrial extracts

Lakshmipathy, U. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.4.1198 · Cited by 106 · see citing works

Somatic microsatellite mutations as molecular tumor clocks

Shibata, D. K., Navidi, W. C., Salovaara, R., Li, Z., & Aaltonen, L. A. (1996) · Nature Medicine · doi:10.1038/nm0696-676 · Cited by 103 · see citing works

The Biologic Effects of Pile Radiations

Henshaw, P. S., Riley, E. F., & Stapleton, G. E. (1947) · Radiology · doi:10.1148/49.3.349 · Cited by 98 · see citing works

Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse

Ono, T., Ikehata, H., Nakamura, S., Saito, Y., Hosoi, Y., Takai, Y., Yamada, S., Onodera, J., & Yamamoto, K. (2000) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(99)00200-6 · Cited by 89 · see citing works

Effect of dietary restriction on in vivo somatic mutation in mice

Dempsey, J. L., Pfeiffer, M. L., & Morley, A. A. (1993) · Mutation Research/Environmental Mutagenesis and Related Subjects · doi:10.1016/0165-1161(93)90153-q · Cited by 87 · see citing works

Age-related changes in the intrinsic rate of apoptosis in livers of diet-restricted and ad libitum-fed B6C3F1 mice.

Muskhelishvili, L., Hart, R. W., Turturro, A., & James, S. J. (1995) · Europe PMC (PubMed Central) · Cited by 85 · see citing works

The Modification by X-Irradiation of the Life Span of Haploids and Diploids of the Wasp, Habrobracon SP

Clark, A. M., & Rubin, M. A. (1961) · Radiation Research · doi:10.2307/3571256 · Cited by 84 · see citing works

Spontaneous liver tumors and Benzo[a]pyrene-induced lymphomas in XPA-deficient mice

de Vries, A., van Oostrom, C. T. M., Dortant, P. M., Beems, R. B., van Kreijl, C. F., Capel, P. J., & STEEG, H. V. (1997) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199705)19:1 · Cited by 83 · see citing works

Reduced RNA polymerase II transcription in extracts of Cockayne syndrome and xeroderma pigmentosum/Cockayne syndrome cells

Dianov, G. L., Houle, J.-F., Iyer, N., Bohr, V. A., & Friedberg, E. C. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.18.3636 · Cited by 81 · see citing works

Cancer from the outside, aging from the inside: Mouse models to study the consequences of defective nucleotide excision repair

de Boer, J., & Hoeijmakers, J. H. J. (1999) · Biochimie · doi:10.1016/s0300-9084(99)80045-5 · Cited by 80 · see citing works

An age-associated correlation between cellular bioenergy decline and mtDNA rearrangements in human skeletal muscle

Kopsidas, G., Kovalenko, S. A., Kelso, J., & Linnane, A. W. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(98)00150-x · Cited by 79 · see citing works

From oocyte to embryo: a model, deduced from in vitro fertilization, for natural selection against chromosome abnormalities.

Plachot, M., GROUCHY, J. D., Am, J., Mandelbaum, J., TURLEAU, C., Couillin, P., Cohen, J. J., & Salat‐Baroux, J. (1987) · PubMed · Cited by 78 · see citing works

Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans

Jones, I. M., Thomas, C. B., Tucker, B. D., Thompson, C. L., Pleshanov, P. G., Vorobtsova, I., & Moore, D. H. (1995) · Mutation Research/DNAging · doi:10.1016/0921-8734(95)00018-2 · Cited by 76 · see citing works

Study of the forces stabilizing complexes between chlorophylls and heterocyclic amine mutagens

Dashwood, R. H., Yamane, S., & Larsen, R. W. (1996) · Environmental and Molecular Mutagenesis · doi:10.1002/(sici)1098-2280(1996)27:3 · Cited by 76 · see citing works

Chromosome Aberrations in Liver Cells in Relation to the Somatic Mutation Theory of Aging

Curtis, H. J., & Crowley, C. (1963) · Radiation Research · doi:10.2307/3571455 · Cited by 74 · see citing works

Sex and Death in Protozoa

Partridge, L., & Bell, G. (1991) · Journal of Animal Ecology · doi:10.2307/5466 · Cited by 72 · see citing works

Accelerated accumulation of somatic mutations in the senescence-accelerated mouse

Odagiri, Y., Uchida, H., Hosokawa, M., Takemoto, K., Morley, A. A., & Takeda, T. (1998) · Nature Genetics · doi:10.1038/468 · Cited by 71 · see citing works

Frequency of spontaneous chromosome aberrations in mice: effects of age

Tucker, J. D., Spruill, M., Ramsey, M. J., Director, A. D., & Nath, J. (1999) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(99)00036-6 · Cited by 71 · see citing works

Comparative analysis of DNA mutations in lacI transgenic mice with age

Lee, A. T., DeSimone, C., Cerami, A., & Bucala, R. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.8.8181674 · Cited by 69 · see citing works

Minisatellites and Human Disease

Krontiris, T. G. (1995) · Science · doi:10.1126/science.7569893 · Cited by 65 · see citing works

Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice

Andrew, S. E., Reitmair, A. H., Fox, J. A., Hsiao, L., Francis, A., McKinnon, M. L., Mak, T. W., & Jirik, F. R. (1997) · Oncogene · doi:10.1038/sj.onc.1201180 · Cited by 65 · see citing works

A Unifying Hypothesis To Explain the Retardation of Aging and Tumorigenesis by Caloric Restriction

Warner, H. R., Fernandes, G., & Wang, E. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.3.b107 · Cited by 64 · see citing works

A novel signature mutation for oxidative damage resembles a mutational pattern found commonly in human cancers.

Turker, M. S., Gage, B. M., Rose, J., Elroy, D., Ponomareva, O. N., Stambrook, P. J., & Tischfield, J. A. (1999) · PubMed · Cited by 63 · see citing works

Understanding the Biology of Aging: The Key To Prevention and Therapy

Vijg, J., & Wei, J. Y. (1995) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1995.tb05819.x · Cited by 59 · see citing works

A Theory of Ageing

Smith, J. M. (1959) · Nature · doi:10.1038/184956a0 · Cited by 59 · see citing works

In vivo mutations in human blood cells: biomarkers for molecular epidemiology.

Albertini, R. J., Nicklas, J. A., Fuscoe, J. C., Skopek, T. R., Branda, R. F., & O’Neill, J. P. (1993) · Environmental Health Perspectives · doi:10.1289/ehp.9399135 · Cited by 59 · see citing works

High somatic mutation frequencies in a LacZ transgene integrated on the mouse X-chromosome

Gossen, J. A., de Leeuw, W. J. F., Verwest, A. M., Lohman, P. H. M., & Vijg, J. (1991) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(91)90198-w · Cited by 49 · see citing works

Mismatch repair, somatic mutations, and the origins of cancer.

MacPhee, D. G. (1995) · PubMed · Cited by 45 · see citing works

Shortening of the Life Span of Mice by Irradiation with X-Rays and Treatment with Radiomimetic Chemicals

Alexander, P. M., & Connell, D. I. (1960) · Radiation Research · doi:10.2307/3570821 · Cited by 39 · see citing works

Increased mutation frequency and altered spectrum in one of four thymic lymphomas derived from tumor prone p53/Big Blue double transgenic mice.

Buettner, V. L., Hill, K. A., Nishino, H., Schaid, D. J., Frisk, C. S., & Sommer, S. S. (1996) · PubMed · Cited by 36 · see citing works

Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability

Baross, Á., Andrew, S. E., Penney, J. E., & Jirik, F. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8739 · Cited by 35 · see citing works

Use of transgenic mouse models for studying somatic mutations in aging

Martus, H., Dollé, M. E. T., Gossen, J. A., Boerrigter, M. E. T. I., & Vijg, J. (1995) · Mutation Research/DNAging · doi:10.1016/0921-8734(95)00025-2 · Cited by 35 · see citing works

Genetic and Environmental Modulations of Chromosomal Stability: Their Roles in Aging and Oncogenesis

Martin, G. M. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb16995.x · Cited by 34 · see citing works

Accelerated accumulation of somatic mutations in mice deficient in the nucleotide excision repair gene XPA

Giese, H., Dollé, M. E. T., Hezel, A. F., STEEG, H. V., & Vijg, J. (1999) · Oncogene · doi:10.1038/sj.onc.1202404 · Cited by 34 · see citing works

Transgenic assays for mutations and cancer: current status and future perspectives.

Vijg, J., & van Steeg, H. (1998) · Mutation research · doi:10.1016/s0027-5107(98)00030-x · Cited by 32 · see citing works

Estimation of mutation frequencies in normal mammalian cells and the development of cancer

Turker, M. S. (1998) · Seminars in Cancer Biology · doi:10.1006/scbi.1998.0112 · Cited by 29 · see citing works

Accumulation of genetic alterations and their significance in each primary human cancer and cell line

Murakami, Y., & Sekiya, T. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(98)00031-1 · Cited by 27 · see citing works

Randomness, redundancy and repair: Roles and relevance to biological aging

Strehler, B. L., & Freeman, M. R. (1980) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(80)90103-7 · Cited by 26 · see citing works

Is ageing the result of dominant and co-dominant mutations?

Morley, A. A. (1982) · Journal of Theoretical Biology · doi:10.1016/0022-5193(82)90131-x · Cited by 25 · see citing works

Somatic mutations and cellular aging

Vijg, J., & Gossen, J. A. (1993) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(93)90264-6 · Cited by 25 · see citing works

Genotypic selection of mitochondrial and oncogenic mutations in human tissue suggests mechanisms of age-related pathophysiology

Cortopassi, G. A., & Liu, Y. (1995) · Mutation Research/DNAging · doi:10.1016/0921-8734(95)00020-7 · Cited by 24 · see citing works

Chromosomally Abnormal Gametes as a Cause of Developmental and Congenital Anomalies in Humans*

Kamiguchi, Y., Tateno, H., & MIKAMO, K. (1994) · Congenital Anomalies · doi:10.1111/j.1741-4520.1994.tb00266.x · Cited by 22 · see citing works

Excess risk of colon cancer associated with a polymorphism of the APC gene?

White, R. L. (1998) · PubMed · Cited by 21 · see citing works

The estimation of in vivo mutation rate and frequency from samples of human lymphocytes

Morley, A. A. (1996) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(96)00096-6 · Cited by 20 · see citing works

Mutation and mutagenesis in inherited and acquired human disease. The first EEMS Frits Sobels Prize Lecture, Noordwijkerhout, The Netherlands, June 1995.

Evans, H. (1996) · Mutation research · doi:10.1016/0027-5107(95)00201-4 · Cited by 17 · see citing works

Somatic cell mutation frequency at the HPRT, T-cell antigen receptor and glycophorin A loci in Cockayne syndrome

Lin, Y.-W., Kubota, M., Hirota, H., Furusho, K., Tomiwa, K., Ochi, J., Kasahara, Y., Sasaki, H., & Ohta, S. (1995) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(95)00014-b · Cited by 11 · see citing works

Parsing age, mutations and time

Warner, H. R., & Johnson, T. E. (1997) · Nature Genetics · doi:10.1038/ng1297-368 · Cited by 7 · see citing works

What good is it to get old?

Nusbaum, N. J. (1996) · Medical Hypotheses · doi:10.1016/s0306-9877(96)90441-7 · Cited by 6 · see citing works

Untitled work

Andersson (1999) · doi:10.1002/(sici)1096-8628(19990219)82:5 · Cited by 1 · see citing works

Cellular senescence in cancer and aging.

Collado, M., Blasco, M. A., & Serrano, M. (2007) · Cell · doi:10.1016/j.cell.2007.07.003 · Cited by 1,708 · see citing works

Trends in oxidative aging theories

Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053 · see citing works

DNA Repair, Genome Stability, and Aging

Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M., & Alt, F. W. (2005) · Cell · doi:10.1016/j.cell.2005.01.028 · Cited by 944 · see citing works

Sir2 links chromatin silencing, metabolism, and agingPreprint

Guarente, L. (2000) · Genes & Development · doi:10.1101/gad.14.9.1021 · Cited by 718 · see citing works

Premature Aging in Mice Deficient in DNA Repair and Transcription

de Boer, J., Andressoo, J. O., de Wit, J., Huijmans, J., Beems, R. B., van Steeg, H., Weeda, G., van der Horst, G. T. J., van Leeuwen, W., Themmen, A. P. N., et al. (2002) · Science · doi:10.1126/science.1070174 · Cited by 545 · see citing works

Leaf senescence: progression, regulation, and application

Guo, Y., Ren, G., Zhang, K., Li, Z., Miao, Y., & Guo, H. (2021) · Molecular Horticulture · doi:10.1186/s43897-021-00006-9 · Cited by 437 · see citing works

Differences between germline and somatic mutation rates in humans and mice

Milholland, B., Dong, X., Zhang, L., Hao, X., Suh, Y., & Vijg, J. (2017) · Nature Communications · doi:10.1038/ncomms15183 · Cited by 423 · see citing works

Changes in DNA repair during aging

Gorbunova, V., Seluanov, A., Mao, Z., & Hine, C. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm756 · Cited by 405 · see citing works

Mechanisms and consequences of somatic mosaicism in humans

Youssoufian, H., & Pyeritz, R. E. (2002) · Nature Reviews Genetics · doi:10.1038/nrg906 · Cited by 391 · see citing works

The role of DNA damage and repair in aging through the prism of Koch-like criteria

Moskalev, A. A., Shaposhnikov, M. V., Plyusnina, E. N., Zhavoronkov, A., Budovsky, A., Yanai, H., & Fraifeld, V. E. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.02.001 · Cited by 387 · see citing works

Changes in aqueous humor dynamics with age and glaucoma

Gabelt, B. T., & Kaufman, P. L. (2005) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.10.003 · Cited by 380 · see citing works

DNA damage and ageing: new-age ideas for an age-old problem

Garinis, G. A., van der Horst, G. T. J., Vijg, J., & H.J. Hoeijmakers, J. (2008) · Nature Cell Biology · doi:10.1038/ncb1108-1241 · Cited by 366 · see citing works

Melatonin as antioxidant, geroprotector and anticarcinogen

Anisimov, V. N., Popovich, I. G., Zabezhinski, M. A., Anisimov, S. V., Vesnushkin, G. M., & Vinogradova, I. A. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.03.012 · Cited by 263 · see citing works

Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases

Reddy, P. H., & Reddy, T. P. (2011) · Current Alzheimer Research · doi:10.2174/156720511795745401 · Cited by 227 · see citing works

The aging hippocampus: A multi-level analysis in the rat

Driscoll, I. F., Howard, S. R., Stone, J. C., Monfils, M., Tomanek, B., Brooks, W. M., & Sutherland, R. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.040 · Cited by 223 · see citing works

Somatic mutations in aging, cancer and neurodegeneration

Kennedy, S. R., Loeb, L. A., & Herr, A. J. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.10.009 · Cited by 216 · see citing works

Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture

Busuttil, R. A., Rubio, M. Á., Dollé, M. E. T., Campisi, J., & Vijg, J. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00066.x · Cited by 209 · see citing works

Evolutionary Theories of Aging and Longevity

Gavrilov, L. A., & Gavrilova, N. S. (2002) · The Scientific World JOURNAL · doi:10.1100/tsw.2002.96 · Cited by 201 · see citing works

Time‐course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging

Mańczak, M., Jung, Y., Park, B. S., Partovi, D., & Reddy, P. H. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02884.x · Cited by 192 · see citing works

Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing

Greaves, L. C., Nooteboom, M., Elson, J. L., Tuppen, H. A. L., Taylor, G. A., Commane, D. M., Arasaradnam, R. P., Khrapko, K., Taylor, R. W., Kirkwood, T. B. L., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004620 · Cited by 172 · see citing works

Does p53 affect organismal aging?

Donehower, L. A. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10104 · Cited by 155 · see citing works

The Role of Oxidative Stress in the Aging Process

de Oliveira, B. F., Nogueira‐Machado, J. A., & Chaves, M. M. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.94 · Cited by 148 · see citing works

SIRT6 in DNA repair, metabolism and ageing

Lombard, D. B., Schwer, B., Alt, F. W., & Mostoslavsky, R. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01902.x · Cited by 146 · see citing works

Large genome rearrangements as a primary cause of aging

Vijg, J., & Dollé, M. E. T. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00028-3 · Cited by 146 · see citing works

Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retina

Wang, N., Luo, Z., Jin, M., Sheng, W., Wang, H.-T., Long, X., Wu, Y., Hu, P., Xu, H. A., & Zhang, X. (2019) · Aging · doi:10.18632/aging.101966 · Cited by 148 · see citing works

High-resolution respirometry–a modern tool in aging research

Hütter, E., Unterluggauer, H., Garedew, A., Jansen‐Dürr, P., & Gnaiger, E. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.09.011 · Cited by 121 · see citing works

Origin of carcinoma associated fibroblasts

Haviv, I., Polyák, K., Qiu, W., Hu, M., & Campbell, I. (2009) · Cell Cycle · doi:10.4161/cc.8.4.7669 · Cited by 113 · see citing works

Aging alters the apoptotic response to genotoxic stress

Suh, Y., Lee, K.-A., Kim, W. H., Han, B. G., Vijg, J., & Park, S. C. (2002) · Nature Medicine · doi:10.1038/nm0102-3 · Cited by 114 · see citing works

Somatic mosaicism and variable expressivity

Gottlieb, B., Beitel, L. K., & Trifiro, M. A. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(00)02178-8 · Cited by 112 · see citing works

Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice

Dollé, M. E. T., Busuttil, R. A., Garcia, A. M., Wijnhoven, S., van Drunen, E., Niedernhofer, L. J., van der Horst, G. T. J., Hoeijmakers, J. H. J., STEEG, H. V., & Vijg, J. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.11.008 · Cited by 109 · see citing works

The Biology of Aging and Cancer

Zhang, X., Meng, X., Chen, Y., Leng, S. X., & Zhang, H. (2017) · The Cancer Journal · doi:10.1097/ppo.0000000000000270 · Cited by 105 · see citing works

Intercellular competition and the inevitability of multicellular aging

Nelson, P., & Masel, J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618854114 · Cited by 100 · see citing works

Loss of Nfkb1 leads to early onset aging

Bernal, G. M., Wahlstrom, J. S., Crawley, C. D., Cahill, K. E., Pytel, P., Liang, H., Kang, S., Weichselbaum, R. R., & Yamini, B. (2014) · Aging · doi:10.18632/aging.100702 · Cited by 97 · see citing works

The relationship between aging and carcinogenesis: a critical appraisal

Anisimov, V. N. (2003) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(02)00121-x · Cited by 94 · see citing works

Partial uncoupling of oxidative phosphorylation induces premature senescence in human fibroblasts and yeast mother cells

Stöckl, P., Zankl, C., Hütter, E., Unterluggauer, H., Laun, P., Heeren, G., Bogengruber, E., Herndler‐Brandstetter, D., Breitenbach, M., & Jansen‐Dürr, P. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.06.005 · Cited by 93 · see citing works

Repair of telomeric DNA prior to replicative senescence

Lansdorp, P. M. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00151-2 · Cited by 87 · see citing works

DNA double strand break repair, aging and the chromatin connection

Gorbunova, V., & Seluanov, A. (2016) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2016.02.004 · Cited by 87 · see citing works

Mutational fingerprints of aging

Dolle, M. E. T. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.2.545 · Cited by 87 · see citing works

Differential proteomic profiling of mitochondria from Podospora anserina, rat and human reveals distinct patterns of age-related oxidative changes

Groebe, K., Krause, F., Kunstmann, B., Unterluggauer, H., Reifschneider, N. H., Scheckhuber, C. Q., Sastri, C., Stegmann, W., Woźny, W., Schwall, G., et al. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.07.001 · Cited by 86 · see citing works

DNA damage, vascular senescence and atherosclerosis

Andreassi, M. G. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0358-7 · Cited by 86 · see citing works

The Biology of Aging and Cancer: Frailty, Inflammation, and Immunity

Zhang, X., Meng, X., Chen, Y., Leng, S. X., & Zhang, H. (2017) · The Cancer Journal · doi:10.1097/00130404-201707000-00002 · Cited by 78 · see citing works

Photoaging of Skin

Krutmann, J., & Gilchrest, B. A. (2006) · Springer eBooks · doi:10.1007/3-540-32953-6_4 · Cited by 75 · see citing works

Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity

Hasty, P., & Vijg, J. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00082.x · Cited by 77 · see citing works

The large-scale distribution of somatic mutations in cancer genomes

Hodgkinson, A., Chen, Y., & Eyre‐Walker, A. (2011) · Human Mutation · doi:10.1002/humu.21616 · Cited by 76 · see citing works

Effects of Exogenous Melatonin - A Review

Anisimov, V. N. (2003) · Toxicologic Pathology · doi:10.1080/01926230390257885 · Cited by 76 · see citing works

One thousand somatic SNVs per skin fibroblast cell set baseline of mosaic mutational load with patterns that suggest proliferative originPreprint

Abyzov, A. S., Tomasini, L., Zhou, B., Vasmatzis, N., Coppola, G., Amenduni, M., Pattni, R., Wilson, M., Gerstein, M., Weissman, S. M., et al. (2017) · Genome Research · doi:10.1101/gr.215517.116 · Cited by 73 · see citing works

Making ends meet in old age: DSB repair and aging

Gorbunova, V. A., & Seluanov, A. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.02.008 · Cited by 73 · see citing works

Biologia do envelhecimento: teorias, mecanismos e perspectivas

Teixeira, I. N. D. O., & Guariento, M. E. (2010) · Ciência & Saúde Coletiva · doi:10.1590/s1413-81232010000600022 · Cited by 73 · see citing works

Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues

Garcia, A. M., Busuttil, R. A., Calder, R. B., Dollé, M. E. T., Diaz, V., McMahan, C. A., Bartke, A., Nelson, J. F., Reddick, R. L., & Vijg, J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.04.013 · Cited by 70 · see citing works

Haploinsufficiency in DNA Polymerase β Increases Cancer Risk with Age and Alters Mortality Rate

Cabelof, D. C., Ikeno, Y., Nyska, A., Busuttil, R. A., Anyangwe, N., Vijg, J., Matherly, L. H., Tucker, J. D., Wilson, S. H., Richardson, A., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1177 · Cited by 70 · see citing works

The mechanism of ageing: primary role of transposable elements in genome disintegration

Sturm, Á., Ivics, Z., & Vellai, T. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1896-0 · Cited by 69 · see citing works

Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations

Marusyk, A., & DeGregori, J. V. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2007.09.001 · Cited by 67 · see citing works

Genome Dynamics in Aging Mice

Dollé, M. E. T., & Vijg, J. (2002) · Genome Research · doi:10.1101/gr.125502 · Cited by 66 · see citing works

From the Rarest to the Most Common: Insights from Progeroid Syndromes into Skin Cancer and Aging

Capell, B. C., Tlougan, B. E., & Orlow, S. J. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.103 · Cited by 64 · see citing works

Genetics of aging, progeria and lamin disorders

Ghosh, S., & Zhou, Z. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.05.003 · Cited by 66 · see citing works

Spontaneous mutation in Big Blue® mice from fetus to old age: Tissue‐specific time courses of mutation frequency but similar mutation types

Hill, K. A., Buettner, V. L., Halangoda, A., Kunishige, M., Moore, S. R., Longmate, J., Scaringe, W. A., & Sommer, S. S. (2004) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20004 · Cited by 65 · see citing works

Carcinogenesis and aging 20 years after: Escaping horizon

Anisimov, V. N. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.02.004 · Cited by 63 · see citing works

Cancer in the oldest old

Andersen, S. L., Terry, D. F., Wilcox, M., Babineau, T. J., Malek, K. S., & Perls, T. T. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.019 · Cited by 63 · see citing works

The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old

Soerensen, M., Christensen, K., Stevnsner, T., & Christiansen, L. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.01.005 · Cited by 63 · see citing works

Variable expressivity and mutation databases: The androgen receptor gene mutations database

Gottlieb, B., Beitel, L. K., & Trifiro, M. A. (2001) · Human Mutation · doi:10.1002/humu.1113 · Cited by 61 · see citing works

Influence of age and sex on the spontaneous DNA damage detected by Micronucleus test and Comet assay in mice peripheral blood cells

Heuser, V. D., de Andrade, V. M., Peres, A., Braga, L., & Chies, J. A. B. (2008) · Cell Biology International · doi:10.1016/j.cellbi.2008.07.005 · Cited by 60 · see citing works

Accumulation of mutations and somatic selection in aging neural stem/progenitor cells

Bailey, K. J., Maslov, A. Y., & Pruitt, S. C. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00128.x · Cited by 60 · see citing works

The current research status of normal tension glaucoma

Mi, X.-S., Yuan, T., & So, K. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s67263 · Cited by 57 · see citing works

Which is the most significant cause of aging?

Liochev, S. (2015) · Antioxidants · doi:10.3390/antiox4040793 · Cited by 56 · see citing works

Open-minded scepticism: inferring the causal mechanisms of human ageing from genetic perturbations

de Magalhães, J. P. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2004.05.003 · Cited by 54 · see citing works

A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians

Nebel, A., Flachsbart, F., Till, A., Caliebe, A., Blanché, H., Arlt, A., Häsler, R., Jacobs, G., Kleindorp, R., & Franke, A. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.08.004 · Cited by 53 · see citing works

Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice

Anisimov, V. N. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00240-1 · Cited by 53 · see citing works

Comparative Studies of Oxidative Stress and Mitochondrial Function in Aging

Shi, Y., Buffenstein, R., Pulliam, D. A., & Remmen, H. V. (2010) · Integrative and Comparative Biology · doi:10.1093/icb/icq079 · Cited by 52 · see citing works

Nutrition for Healthy Skin

Krutmann, J., & Humbert, P. G. (2010) · Springer eBooks · doi:10.1007/978-3-642-12264-4 · Cited by 81 · see citing works

Nuclear and Chromatin Reorganization during Cell Senescence and Aging – A Mini-Review

Shin, D., Kucia, M., & Ratajczak, M. Z. (2010) · Gerontology · doi:10.1159/000281882 · Cited by 49 · see citing works

Identification of a Novel Mitochondrial Mutation in Dupuytren’s Disease Using Multiplex DHPLC

Bayat, A., Walter, J., Lambe, H., Watson, J. S., Stanley, J. K., Marino, M. A., Ferguson, M. W. J., & Ollier, W. (2005) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000146039.21330.ce · Cited by 50 · see citing works

Understanding and Modulating Ageing

Rattan, S. I. S., & Clark, B. F. C. (2005) · IUBMB Life · doi:10.1080/15216540500092195 · Cited by 61 · see citing works

Aging Research in Yeast

Breitenbach, M., Laun, P., & Jazwinski, S. M. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-2561-4 · Cited by 50 · see citing works

Assessment of age-associated cognitive deficits in rats: a tricky business

van der Staay, F. J. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00062-3 · Cited by 49 · see citing works

Mismatch Repair System and Aging: Microsatellite Instability in Peripheral Blood Cells From Differently Aged Participants

Neri, S., Gardini, A., Facchini, A., Olivieri, F., Franceschi, C., Ravaglia, G., & Mariani, E. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.3.285 · Cited by 47 · see citing works

Microsatellite instability (MSI) increases with age in normal somatic cells

Coolbaugh-Murphy, M. I., Xu, J., Ramagli, L. S., Brown, B. W., & Siciliano, M. J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.06.005 · Cited by 47 · see citing works

Cell signaling in aging and apoptosis

Suh, Y. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00025-8 · Cited by 47 · see citing works

Genome instability: a conserved mechanism of ageing?

Vijg, J., Dong, X., Milholland, B., & Zhang, L. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160082 · Cited by 45 · see citing works

Tumors of the testis and midgut in aging flies

Salomon, R., & Jackson, F. R. (2008) · Fly · doi:10.4161/fly.7396 · Cited by 45 · see citing works

Age-specific changes in expression, activity, and activation of the c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinases by methyl methanesulfonate in rats

Suh, Y. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00301-3 · Cited by 44 · see citing works

Sealing the gap between nuclear DNA damage and longevity

Schumacher, B., Hoeijmakers, J. H. J., & Garinis, G. A. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.031 · Cited by 43 · see citing works

Cancer Immunotherapy: Whence and Whither

Stambrook, P. J., Maher, J. F., & Farzaneh, F. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0427 · Cited by 43 · see citing works

Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis

Debrabant, B., Soerensen, M., Flachsbart, F., Dato, S., Mengel‐From, J., Stevnsner, T., Bohr, V. A., Kruse, T. A., Schreiber, S., Nebel, A., et al. (2014) · European Journal of Human Genetics · doi:10.1038/ejhg.2013.299 · Cited by 41 · see citing works

Mutant and genetically modified mice as models for studying the relationship between aging and carcinogenesis

Anisimov, V. N. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00262-7 · Cited by 41 · see citing works

Loss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscle

Didier, N., Hourdé, C., Amthor, H., Marazzi, G., & Sassoon, D. A. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201101075 · Cited by 40 · see citing works

Proceedings of a workshop on DNA adducts: Biological significance and applications to risk assessment Washington, DC, April 13–14, 2004

Sander, M., Cadet, J., Casciano, D. A., Galloway, S. M., Marnett, L. J., NOVAK, R. F., Pettit, S. D., Preston, R. J., Skare, J. A., Williams, G. M., et al. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.12.012 · Cited by 40 · see citing works

Yeast mother cell-specific ageing, genetic (in)stability, and the somatic mutation theory of ageing

Laun, P., Bruschi, C. V., Dickinson, J. R., Rinnerthaler, M., Heeren, G., Schwimbersky, R., Rid, R., & Breitenbach, M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm919 · Cited by 40 · see citing works

Aging is a deprivation syndrome driven by a germ–soma conflict

Heininger, K. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00015-6 · Cited by 38 · see citing works

ATM suppresses leaf senescence triggered by DNA double‐strand break through epigenetic control of senescence‐associated genes in Arabidopsis

Li, Z., Kim, J. H., Kim, J., Lyu, J. I., Zhang, Y., Guo, H., Nam, H. G., & Woo, H. R. (2020) · New Phytologist · doi:10.1111/nph.16535 · Cited by 37 · see citing works

Mutation theory of aging, assessed in transgenic mice and knockout mice

Ono, T., Uehara, Y., Saito, Y., & Ikehata, H. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00090-8 · Cited by 37 · see citing works

Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM

Daimon, M., Oizumi, T., Toriyama, S., Karasawa, S., Jimbu, Y., Wada, K., Kameda, W., Susa, S., Muramatsu, M., Kubota, I., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.05.119 · Cited by 36 · see citing works

The blood brain barrier: Insights from development and ageing

Delaney, C. P., & Campbell, M. (2017) · Tissue Barriers · doi:10.1080/21688370.2017.1373897 · Cited by 35 · see citing works

The role of DNA damage and repair in aging: New approaches to an old problem

Vijg, J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.02.009 · Cited by 35 · see citing works

Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes

Tyrberg, B., Anachkov, K. A., Dib, S. A., Wang‐Rodriguez, J., Yoon, K., & Levine, F. (2002) · BMC Endocrine Disorders · doi:10.1186/1472-6823-2-2 · Cited by 35 · see citing works

Resistance to Genotoxic Stresses in Arctica islandica, the Longest Living Noncolonial Animal: Is Extreme Longevity Associated With a Multistress Resistance Phenotype?

Ungvari, Z. I., Sosnowska, D., Mason, J. B., Gruber, H., Lee, S. W., Schwartz, T. S., Brown, M. K., Storm, N. J., Fortney, K., Sowa, J. N., et al. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls193 · Cited by 34 · see citing works

Aging: Somatic Mutations, Epigenetic Drift and Gene Dosage Imbalance.

Veitia, R., Govindaraju, D., Bottani, S., & Birchler, J. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.11.006 · Cited by 37 · see citing works

On evolutionary origin of cancer.

Lichtenstein, A. V. (2005) · Cancer Cell International · doi:10.1186/1475-2867-5-5 · Cited by 32 · see citing works

Somatic mutations and ageing in silico

Kirkwood, T. B. L., & Proctor, C. J. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00177-x · Cited by 33 · see citing works

Mice and mitochondria

Martin, G. M., & Loeb, L. A. (2004) · Nature · doi:10.1038/429357a · Cited by 30 · see citing works

Behavior of Metastatic and Nonmetastatic Breast Tumors in Old Mice

Gravekamp, C., Sypniewska, R. K., Gauntt, S., Tarango, M., Price, P., & Reddick, R. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422900711 · Cited by 30 · see citing works

Somatic mutations and cellular aging

Vijg, J., & Gossen, J. A. (1993) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(93)90264-6 · Cited by 25 · see citing works

Somatic mutations in aging and disease

Ren, P., Zhang, J., & Vijg, J. (2024) · GeroScience · doi:10.1007/s11357-024-01113-3 · Cited by 29 · see citing works

Aging and Genome Maintenance

Vijg, J., Busuttil, R. A., Bahar, R., & Dollé, M. E. T. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1323.007 · Cited by 68 · see citing works

Current approaches to somatic mutation testing in aging research

Macauley, J. B. (1996) · AGE · doi:10.1007/bf02434072

Challenges of proving a causal role of somatic mutations in the aging process

Franco, I., Revêchon, G., & Eriksson, M. (2022) · Aging Cell · doi:10.1111/acel.13613 · Cited by 18 · see citing works