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Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations

Open access
Gonzalez-Galarza, F. F., Christmas, S., Middleton, D., Jones, A. R.·2011·Nucleic Acids Research

Abstract

The allele frequency net database (http://www.allelefrequencies.net) is an online repository that contains information on the frequencies of immune genes and their corresponding alleles in different populations. The extensive variability observed in genes and alleles related to the immune system response and its significance in transplantation, disease association studies and diversity in populations led to the development of this electronic resource. At present, the system contains data from 1133 populations in 608,813 individuals on the frequency of genes from different polymorphic regions such as human leukocyte antigens, killer-cell immunoglobulin-like receptors, major histocompatibility complex Class I chain-related genes and a number of cytokine gene polymorphisms. The project was designed to create a central source for the storage of frequency data and provide individuals with a set of bioinformatics tools to analyze the occurrence of these variants in worldwide populations. The resource has been used in a wide variety of contexts, including clinical applications (histocompatibility, immunology, epidemiology and pharmacogenetics) and population genetics. Demographic information, frequency data and searching tools can be freely accessed through the website.

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Metadata

Authors
Gonzalez-Galarza, F. F., Christmas, S., Middleton, D., & Jones, A. R.
Venue
Nucleic Acids Research
Published
2010-11-09
Volume
39
Issue
Database
Pages
D913-D919
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2158804326
Cited by
724
References
1
FWCI
40.07
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations. https://app.cochat.ai/papers/10.1093/nar/gkq1128
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Gonzalez-Galarza, F. F., Christmas, S., Middleton, D., & Jones, A. R. (2011). Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations. Nucleic Acids Research. https://doi.org/10.1093/nar/gkq1128

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