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Cited by 45

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Quaternary structure of the specific p53–DNA complex reveals the mechanism of p53 mutant dominance

Aramayo, Ricardo, Sherman, Michael B., Brownless, Kathryne, Lurz, Rudi, Okorokov, Andrei L., Orlova, Elena V.·2011·Nucleic Acids Research
DOI 10.1093/nar/gkr386
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Research works printed but not linked: 54

  1. Vogelstein, 2000, Surfing the p53 network, Nature, 408, 307, 10.1038/35042675 · DOI · Paper page
  2. Oren, 2003, Decision making by p53: life, death and cancer, Cell Death Differ., 10, 431, 10.1038/sj.cdd.4401183 · DOI · Paper page
  3. Murray-ZmijewskI, 2008, A complex barcode underlies the heterogeneous response of p53 to stress, Nat. Rev. Mol. Cell Biol., 9, 702, 10.1038/nrm2451 · DOI · Paper page
  4. Vousden, 2009, Blinded by the Light: The Growing Complexity of p53, Cell, 137, 413, 10.1016/j.cell.2009.04.037 · DOI · Paper page
  5. Vousden, 2007, p53 in health and disease, Nat. Rev. Mol. Cell. Biol., 8, 275, 10.1038/nrm2147 · DOI · Paper page
  6. Parant, 2003, Disrupting TP53 in mouse models of human cancers, Hum. Mutat., 21, 321, 10.1002/humu.10186 · DOI
  7. Royds, 2006, p53 and disease: when the guardian angel fails, Cell Death Differ., 13, 1017, 10.1038/sj.cdd.4401913 · DOI
  8. Bakalkin, 1995, p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain, Nucleic Acids Res., 23, 362, 10.1093/nar/23.3.362 · DOI · Paper page
  9. Lee, 1995, p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches, Cell, 81, 1013, 10.1016/S0092-8674(05)80006-6 · DOI · Paper page
  10. Cain, 2000, The N terminus of p53 regulates its dissociation from DNA, J. Biol. Chem., 275, 39944, 10.1074/jbc.M002509200 · DOI
  11. Espinosa, 2001, Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment, Mol. Cell, 8, 57, 10.1016/S1097-2765(01)00283-0 · DOI · Paper page
  12. McKinney, 2002, Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein, Mol. Cell Biol., 22, 6797, 10.1128/MCB.22.19.6797-6808.2002 · DOI
  13. McKinney, 2004, p53 linear diffusion along DNA requires its C terminus, Mol. Cell, 16, 413, 10.1016/j.molcel.2004.09.032 · DOI · Paper page
  14. Joerger, 2007, Structural biology of the tumor suppressor p53 and cancer-associated mutants, Adv. Cancer Res., 97, 1, 10.1016/S0065-230X(06)97001-8 · DOI · Paper page
  15. Okorokov, 2009, Structural biology of the p53 tumour suppressor, Curr. Opin. Struct. Biol., 19, 197, 10.1016/j.sbi.2009.02.003 · DOI
  16. Kern, 1991, Identification of p53 as a sequence-specific DNA-binding protein, Science, 252, 1708, 10.1126/science.2047879 · DOI · Paper page
  17. Tokino, 1994, p53 tagged sites from human genomic DNA, Hum. Mol. Genet., 3, 1537, 10.1093/hmg/3.9.1537 · DOI · Paper page
  18. Harris, 2009, p53 responsive elements in human retrotransposons, Oncogene, 28, 3857, 10.1038/onc.2009.246 · DOI · Paper page
  19. Kim, 2006, The versatile interactions of p53 with DNA: when flexibility serves specificity, Cell Death Differ., 13, 885, 10.1038/sj.cdd.4401909 · DOI
  20. Wang, 1995, Interaction of p53 with its consensus DNA-binding site, Mol. Cell Biol., 15, 2157, 10.1128/MCB.15.4.2157 · DOI
  21. Nicholls, 2002, Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect, J. Biol. Chem., 277, 12937, 10.1074/jbc.M108815200 · DOI
  22. Zhao, 2001, Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolution, J. Biol. Chem., 276, 12120, 10.1074/jbc.M011644200 · DOI
  23. Kitayner, 2006, Structural basis of DNA recognition by p53 tetramers, Mol. Cell, 22, 741, 10.1016/j.molcel.2006.05.015 · DOI · Paper page
  24. Varley, 1997, A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene, Oncogene, 14, 865, 10.1038/sj.onc.1201041 · DOI
  25. Okorokov, 2006, The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity, EMBO J., 25, 5191, 10.1038/sj.emboj.7601382 · DOI · Paper page
  26. Tidow, 2007, Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex, Proc. Natl Acad. Sci. USA, 104, 12324, 10.1073/pnas.0705069104 · DOI · Paper page
  27. Melero, 2011, Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA, Proc. Natl Acad. Sci. USA, 108, 557, 10.1073/pnas.1015520107 · DOI · Paper page
  28. Hyatt, 2000, Principles and techniques of electron microscopy: biological applications, 543
  29. Ludtke, 1999, EMAN: semiautomated software for high-resolution single-particle reconstructions, J. Struct. Biol., 128, 82, 10.1006/jsbi.1999.4174 · DOI · Paper page
  30. Mindell, 2003, Accurate determination of local defocus and specimen tilt in electron microscopy, J. Struct. Biol., 142, 334, 10.1016/S1047-8477(03)00069-8 · DOI · Paper page
  31. van Heel, 1996, A new generation of the IMAGIC image processing system, J. Struct. Biol., 116, 17, 10.1006/jsbi.1996.0004 · DOI · Paper page
  32. van Heel, 2000, Single-particle electron cryo-microscopy: towards atomic resolution, Q. Rev. Biophys., 33, 307, 10.1017/S0033583500003644 · DOI · Paper page
  33. Scheres, 2009, Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization, Structure, 17, 1563, 10.1016/j.str.2009.10.009 · DOI
  34. Pettersen, 2004, UCSF Chimera - A visualization system for exploratory research and analysis, J. Comput. Chem., 25, 1605, 10.1002/jcc.20084 · DOI · Paper page
  35. Siebert, 2009, UROX 2.0: an interactive tool for fitting atomic models into electron-microscopy reconstructions, Acta Crystallogr. D Biol. Crystallogr., 65, 651, 10.1107/S0907444909008671 · doi:10.1107/s0907444909008671
  36. Jeffrey, 1995, Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms, Science, 267, 1498, 10.1126/science.7878469 · DOI · Paper page
  37. Collaborative Computational Project, Number 4, 1994, The CCP4 suite: programs for protein crystallography, Acta Crystallogr. D Biol. Crystallogr., 50, 760, 10.1107/S0907444994003112 · DOI · Paper page
  38. Milner, 1991, Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation, Cell, 65, 765, 10.1016/0092-8674(91)90384-B · DOI · Paper page
  39. Hupp, 1994, Allosteric activation of latent p53 tetramers, Curr. Biol., 4, 865, 10.1016/S0960-9822(00)00195-0 · DOI · Paper page
  40. Kellenberger, 1982, The wrapping phenomenon in air-dried and negatively stained preparations, Ultramicroscopy, 9, 139, 10.1016/0304-3991(82)90236-4 · DOI
  41. Malecka, 2009, Crystal structure of a p53 core tetramer bound to DNA, Oncogene, 28, 325, 10.1038/onc.2008.400 · DOI
  42. Jiao, 2001, Dynamic interactions of p53 with DNA in solution by time-lapse atomic force microscopy, J. Mol. Biol., 314, 233, 10.1006/jmbi.2001.5129 · DOI
  43. Popovych, 2009, Structural basis for cAMP-mediated allosteric control of the catabolite activator protein, Proc. Natl Acad. Sci. USA, 106, 6927, 10.1073/pnas.0900595106 · DOI · Paper page
  44. Levy, 2008, Molecular basis of halorespiration control by CprK, a CRP-FNR type transcriptional regulator, Mol. Microbiol., 70, 151, 10.1111/j.1365-2958.2008.06399.x · DOI
  45. Berg, 1981, Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory, Biochemistry, 20, 6929, 10.1021/bi00527a028 · DOI · Paper page
  46. Waterman, 1995, The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding, EMBO J., 14, 512, 10.1002/j.1460-2075.1995.tb07027.x · DOI
  47. Stenger, 1994, p53 oligomerization and DNA looping are linked with transcriptional activation, EMBO J., 13, 6011, 10.1002/j.1460-2075.1994.tb06947.x · DOI · Paper page
  48. Jackson, 1998, Synergistic transcriptional activation of the MCK promoter by p53: tetramers link separated DNA response elements by DNA looping, Oncogene, 16, 283, 10.1038/sj.onc.1201491 · DOI
  49. Harvey, 1995, A mutant p53 transgene accelerates tumour development in hetero zygous but not nulli zygous p53-deficient mice, Nat. Genet., 9, 305, 10.1038/ng0395-305 · DOI
  50. Liu, 2000, High metastatic potential in mice inheriting a targeted p53 missense mutation, Proc. Natl Acad. Sci. USA, 97, 4174, 10.1073/pnas.97.8.4174 · DOI · Paper page
  51. de Vries, 2002, Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function, Proc. Natl Acad. Sci. USA, 99, 2948, 10.1073/pnas.052713099 · DOI
  52. Chène, 2001, The role of tetramerization in p53 function, Oncogene, 20, 2611, 10.1038/sj.onc.1204373 · DOI · Paper page
  53. Willis, 2004, Mutant p53 exerts a dominant negative effect by pre venting wild-type p53 from binding to the promoter of its target genes, Oncogene, 23, 2330, 10.1038/sj.onc.1207396 · DOI · Paper page
  54. Kern, 1992, Oncogenic forms of p53 inhibit p53-regulated gene expression, Science, 256, 827, 10.1126/science.1589764 · DOI · Paper page

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Metadata

Authors
Aramayo, R., Sherman, M. B., Brownless, K., Lurz, R., Okorokov, A. L., & Orlova, E. V.
Venue
Nucleic Acids Research
Publisher
Oxford University Press (OUP)
Published
2011-07-15
Volume
39
Issue
20
Pages
8960-8971
ISSN
  • 1362-4962
  • 0305-1048
DOI
10.1093/nar/gkr386
Cited by
45
References
4
Language
en
Licence
creativecommons.org/licenses/by-nc/3.0 (vor, 1942 d)

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Aramayo, R., Sherman, M. B., Brownless, K., Lurz, R., Okorokov, A. L., & Orlova, E. V. (2011). Quaternary structure of the specific p53–DNA complex reveals the mechanism of p53 mutant dominance. Nucleic Acids Research. https://doi.org/10.1093/nar/gkr386

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