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p53 responsive elements in human retrotransposons
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“p53 binds to the promoter region of the retrotransposon element LINE1 and prevents the expression of transposon sequences.81”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [81]
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Cites
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“On the basis of X-ray crystallography of the p53–DNA complex, the most critical bases in -’ are the 6-nt 50-RCWWGY-30, which come into close contact with the core DNA-binding domain of the p53 protein (Cho et al., 1994).”
BackgroundDefinition of a consensus binding site for p53
El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985
The p53 pathway: positive and negative feedback loops
Harris, S. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208615 · Cited by 1,967
Self-citationThe complexity of p53 stabilization and activation
Lavin, M. F., & Gueven, N. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401925 · Cited by 701
Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes
Han, J. S., Szak, S. T., & Boeke, J. D. (2004) · Nature · doi:10.1038/nature02536 · Cited by 484
Determination of L1 retrotransposition kinetics in cultured cells
Ostertag, E. M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.6.1418 · Cited by 291 · cited 1×
“The plasmid 99PUR-RPSeGFP was a gift from H Kazazian (University of Pennsylvania) and has been described previously (Ostertag et al., 2000).”
MethodAsymmetric methylation in the hypermethylated CpG promoter region of the human L1 retrotransposon
Woodcock, D. M., Lawler, C. B., Linsenmeyer, M. E., Doherty, J. P., & Warren, W. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7810 · Cited by 168
p53 Suppresses the Activation of the Bcl-2 Promoter by the Brn-3a POU Family Transcription Factor
Budhram-Mahadeo, V., Morris, P. J., Smith, M. D., Midgley, C. A., Boxer, L. M., & Latchman, D. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.15237 · Cited by 144
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Cited by
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
Roles for retrotransposon insertions in human disease
Hancks, D. C., & Kazazian, H. H. (2016) · Mobile DNA · doi:10.1186/s13100-016-0065-9 · Cited by 670
Restricting retrotransposons: a review
Goodier, J. L. (2016) · Mobile DNA · doi:10.1186/s13100-016-0070-z · Cited by 436
Modulation of LINE-1 and Alu/SVA Retrotransposition by Aicardi-Goutières Syndrome-Related SAMHD1
Zhao, K., Du, J., Han, X., Goodier, J. L., Li, P., Zhou, X., Wei, W., Evans, S. L., Li, L., Zhang, W., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.019 · Cited by 194
Zhou, X., Singh, M., Sanz Santos, G., Guerlavais, V., Carvajal, L. A., Aivado, M., Zhan, Y., Oliveira, M. M. S., Westerberg, L. S., Annis, D. A., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1741 · Cited by 169
Metadata
- Authors
- Harris, C. R., DeWan, A., Zupnick, A., Normart, R., Gabriel, A., Prives, C., Levine, A. J., & Hoh, J.
- Venue
- Oncogene
- Published
- 2009-08-31
- Volume
- 28
- Issue
- 44
- Pages
- 3857-3865
- ISSN
- 0950-9232
- 1476-5594
- Cited by
- 102
- References
- 11
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
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- Harris, C. R., DeWan, A., Zupnick, A., Normart, R., Gabriel, A., Prives, C., Levine, A. J., & Hoh, J. (2009). p53 responsive elements in human retrotransposons. Oncogene. https://doi.org/10.1038/onc.2009.246
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