Control of the localization and function of a miRNA silencing component TNRC6A by Argonaute protein

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

Meister, G., Landthaler, M., Patkaniowska, A., Dorsett, Y., Teng, G., & Tuschl, T. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.07.007 · Cited by 1,718 · see citing works

P bodies and the control of mRNA translation and degradation

Parker, R., & Sheth, U. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.011 · Cited by 1,335 · see citing works

siRNAs can function as miRNAsPreprint

Doench, J. G., Petersen, C. P., & Sharp, P. A. (2003) · Genes & Development · doi:10.1101/gad.1064703 · Cited by 1,262 · see citing works

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencingPreprint

Kanellopoulou, C., Muljo, S. A., Kung, A. L., Ganesan, S., Drapkin, R., Jenuwein, T., Livingston, D. M., & Rajewsky, K. (2005) · Genes & Development · doi:10.1101/gad.1248505 · Cited by 1,256 · see citing works

Argonaute proteins: functional insights and emerging roles

Meister, G. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3462 · Cited by 1,008 · see citing works

Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity

Jackson, A. L., Burchard, J., Schelter, J. M., Chau, B. N., Cleary, M. A., Lim, L. P., & Linsley, P. S. (2006) · RNA · doi:10.1261/rna.25706 · Cited by 953 · see citing works

Purified Argonaute2 and an siRNA form recombinant human RISC

Rivas, F. V., Tolia, N. H., Song, J., Aragon, J. P., Liu, J., Hannon, G. J., & Joshua‐Tor, L. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb918 · Cited by 760 · see citing works

A role for the P-body component GW182 in microRNA function

Liu, J., Rivas, F. V., Wohlschlegel, J. A., Yates, J. R., Parker, R., & Hannon, G. J. (2005) · Nature Cell Biology · doi:10.1038/ncb1333 · Cited by 680 · see citing works

Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

Khan, A. A., Betel, D., Miller, M. L., Sander, C., Leslie, C. S., & Marks, D. S. (2009) · Nature Biotechnology · doi:10.1038/nbt.1543 · Cited by 534 · see citing works

Ribonuclease activity and RNA binding of recombinant human Dicer

Provost, P., Dishart, D., Doucet, J., Frendewey, D., Samuelsson, B., & Rådmark, O. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf578 · Cited by 452 · see citing works

Identification of eight members of the Argonaute family in the human genome☆

Sasaki, T., Shiohama, A., Minoshima, S., & Shimizu, N. (2003) · Genomics · doi:10.1016/s0888-7543(03)00129-0 · Cited by 409 · see citing works

The Control of mRNA Decapping and P-Body Formation

Franks, T. M., & Lykke‐Andersen, J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.11.001 · Cited by 399 · see citing works

Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation

Fabian, M. R., Mathonnet, G., Sundermeier, T. R., Mathys, H., Zipprich, J. T., Svitkin, Y. V., Rivas, F. V., Jínek, M., Wohlschlegel, J. A., Doudna, J. A., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.08.004 · Cited by 388 · see citing works

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

Braun, J. E., Huntzinger, E., Fauser, M., & Izaurralde, E. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.09.007 · Cited by 371 · see citing works

siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

Lin, X. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki762 · Cited by 368 · see citing works

RNAi Factors Are Present and Active in Human Cell Nuclei

Gagnon, K. T., Li, L., Chu, Y., Janowski, B. A., & Corey, D. R. (2014) · Cell Reports · doi:10.1016/j.celrep.2013.12.013 · Cited by 367 · see citing works

Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung

Thomas, M., Lu, J. J.-Q., Ge, Q., Zhang, C. C., Chen, J., & Klibanov, A. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502067102 · Cited by 366 · see citing works

A Phosphorylated Cytoplasmic Autoantigen, GW182, Associates with a Unique Population of Human mRNAs within Novel Cytoplasmic Speckles

Eystathioy, T., Chan, E. K. L., Tenenbaum, S. A., Keene, J. D., Griffith, K. J., & Fritzler, M. J. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-11-0544 · Cited by 363 · see citing works

ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing

Ota, H., Sakurai, M., Gupta, R., Valente, L., Wulff, B., Ariyoshi, K., Iizasa, H., Davuluri, R. V., & Nishikura, K. (2013) · Cell · doi:10.1016/j.cell.2013.03.024 · Cited by 357 · see citing works

miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs

Chekulaeva, M., Mathys, H., Zipprich, J. T., Attig, J., Čolić, M., Parker, R., & Filipowicz, W. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2166 · Cited by 353 · see citing works

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT

Fabian, M. R., Cieplak-Rotowska, M. K., Frank, F., Morita, M., Green, J., Srikumar, T., Nagar, B., Yamamoto, T. S., Raught, B., Duchaîne, T. F., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2149 · Cited by 329 · see citing works

Argonaute proteins couple chromatin silencing to alternative splicing

Ameyar‐Zazoua, M., Rachez, C., Souidi, M., Robin, P., Fritsch, L., Young, R. S., Morozova, N., Fenouil, R., Descostes, N., Andrau, J., et al. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2373 · Cited by 275 · see citing works

The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies: FIGURE 1.

Eystathioy, T., Jakymiw, A., Chan, E. K. L., Séraphin, B., Cougot, N., & Fritzler, M. J. (2003) · RNA · doi:10.1261/rna.5810203 · Cited by 267 · see citing works

A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain

Till, S., Lejeune, E., Thermann, R., Bortfeld‐Miller, M., Hothorn, M., Enderle, D., Heinrich, C., Hentze, M. W., & Ladurner, A. G. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1302 · Cited by 242 · see citing works

Short-Interfering-RNA-Mediated Gene Silencing in Mammalian Cells Requires Dicer and eIF2C Translation Initiation Factors

Doi, N., Zenno, S., Ueda, R., Ohki‐Hamazaki, H., Ui‐Tei, K., & Saigo, K. (2003) · Current Biology · doi:10.1016/s0960-9822(02)01394-5 · Cited by 220 · see citing works

Argonaute proteins at a glance

Ender, C., & Meister, G. (2010) · Journal of Cell Science · doi:10.1242/jcs.055210 · Cited by 220 · see citing works

Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer

Tahbaz, N., Kolb, F. A., Zhang, H., Jaronczyk, K., Filipowicz, W., & Hobman, T. C. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400070 · Cited by 220 · see citing works

Promoter RNA links transcriptional regulation of inflammatory pathway genes

Matsui, M., Chu, Y., Zhang, H., Gagnon, K. T., Shaikh, S., Kuchimanchi, S., Manoharan, M., Corey, D. R., & Janowski, B. A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt777 · Cited by 219 · see citing works

Thermodynamic stability and Watson–Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect

Ui‐Tei, K., Naito, Y., Nishi, K., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn902 · Cited by 207 · see citing works

The GW182 protein family in animal cells: New insights into domains required for miRNA-mediated gene silencing

Eulálio, A., Tritschler, F., & Izaurralde, E. (2009) · RNA · doi:10.1261/rna.1703809 · Cited by 207 · see citing works

Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus

Nishi, K., Nishi, A., Nagasawa, T., & Ui-Tei, K. (2013) · RNA · doi:10.1261/rna.034769.112 · Cited by 188 · see citing works

The Silencing Domain of GW182 Interacts with PABPC1 To Promote Translational Repression and Degradation of MicroRNA Targets and Is Required for Target Release

Zekri, L., Huntzinger, E., Heimstädt, S., & Izaurralde, E. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01081-09 · Cited by 186 · see citing works

Phosphorylation of human Argonaute proteins affects small RNA binding

Rüdel, S., Wang, Y., Lenobel, R., Körner, R., Hsiao, H.-H., Urlaub, H., Patel, D., & Meister, G. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1032 · Cited by 168 · see citing works

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins

Lazzaretti, D., Tournier, I., & Izaurralde, E. (2009) · RNA · doi:10.1261/rna.1606309 · Cited by 153 · see citing works

Argonaute-2 Expression Is Regulated by Epidermal Growth Factor Receptor and Mitogen-Activated Protein Kinase Signaling and Correlates with a Transformed Phenotype in Breast Cancer Cells

Adams, B. D., Claffey, K. P., & White, B. A. (2008) · Endocrinology · doi:10.1210/en.2008-0984 · Cited by 152 · see citing works

The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing

Lian, S. L., Li, S., Abadal, G. X., Pauley, B. A., Fritzler, M. J., & Chan, E. K. L. (2009) · RNA · doi:10.1261/rna.1229409 · Cited by 150 · see citing works

Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression

Takimoto, K., Wakiyama, M., & Yokoyama, S. (2009) · RNA · doi:10.1261/rna.1363109 · Cited by 130 · see citing works

A C-terminal silencing domain in GW182 is essential for miRNA function

Eulálio, A., Helms, S., Fritzsch, C., Fauser, M., & Izaurralde, E. (2009) · RNA · doi:10.1261/rna.1605509 · Cited by 130 · see citing works

Argonaute proteins: potential biomarkers for human colon cancer

Li, L., Yu, C., Gao, H., et al. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-38 · Cited by 124 · see citing works

Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA‐induced silencing complex (RISC) components argonaute‐1, argonaute‐2, PACT, TARBP1, and TARBP2 in epithelial skin cancer

Sand, M. S., Skrygan, M., Georgas, D., et al. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20861 · Cited by 115 · see citing works

Somatic mutations and losses of expression of microRNA regulation‐related genes AGO2 and TNRC6A in gastric and colorectal cancers

Kim, M. S., Oh, J. E., Kim, Y. R., Park, S. W., Kang, M. R., Kim, S. S., An, C. H., Yoo, N. J., & Lee, S. H. (2010) · The Journal of Pathology · doi:10.1002/path.2683 · Cited by 114 · see citing works

Two PABPC1‐binding sites in GW182 proteins promote miRNA‐mediated gene silencing

Huntzinger, E., Braun, J. E., Heimstädt, S., Zekri, L., & Izaurralde, E. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.274 · Cited by 112 · see citing works

Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

Jínek, M., Fabian, M. R., Coyle, S. M., Sonenberg, N., & Doudna, J. A. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1768 · Cited by 106 · see citing works

Coexpression of Argonaute-2 enhances RNA interference toward perfect match binding sites

Diederichs, S., Jung, S., Rothenberg, S. M., Smolen, G. A., Mlody, B., & Haber, D. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800803105 · Cited by 100 · see citing works

TRIM65 regulates microRNA activity by ubiquitination of TNRC6

Li, S., Wang, L., Fu, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322545111 · Cited by 76 · see citing works

Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effects

Petri, S., Dueck, A., Lehmann, G. J., Putz, N., Rüdel, S., Kremmer, E., & Meister, G. (2011) · RNA · doi:10.1261/rna.2348111 · Cited by 72 · see citing works

A role for transportin in deposition of TTP to cytoplasmic RNA granules and mRNA decay

Chang, W.-L., & Tarn, W. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp717 · Cited by 63 · see citing works

A Molecular Link between miRISCs and Deadenylases Provides New Insight into the Mechanism of Gene Silencing by MicroRNAs

Braun, J. E., Huntzinger, E., & Izaurralde, E. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012328 · Cited by 61 · see citing works

Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines

Börner, K., Niopek, D., Cotugno, G., Kaldenbach, M., Pankert, T., Willemsen, J., Zhang, X., Schürmann, N., Mockenhaupt, S., Serva, A., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt836 · Cited by 61 · see citing works

Cellular Internalization of Green Fluorescent Protein Fused with Herpes Simplex Virus Protein VP22 via a Lipid Raft-mediated Endocytic Pathway Independent of Caveolae and Rho Family GTPases but Dependent on Dynamin and Arf6

Nishi, K., & Saigo, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703810200 · Cited by 59 · see citing works

Importin-β facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels

Schraivogel, D., Schindler, S., Danner, J., Kremmer, E., Pfaff, J., Hannus, S., Depping, R., & Meister, G. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv705 · Cited by 56 · see citing works

Immunohistochemical analysis of RNA‐induced silencing complex‐related proteins AGO2 and TNRC6A in prostate and esophageal cancers

Yoo, N. J., Hur, S. Y., Kim, M. S., et al. (2010) · Apmis · doi:10.1111/j.1600-0463.2010.02588.x · Cited by 38 · see citing works

Argonaute 2 is up-regulated in tissues of urothelial carcinoma of bladder.

Yang, F., Huang, J., Liu, M., et al. (2014) · PubMed · Cited by 25 · see citing works

EIF2C Is Overexpressed and Amplified in Head and Neck Squamous Cell Carcinoma

Chang, S. S., Smith, I., Glazer, C. A., et al. (2010) · ORL · doi:10.1159/000320597 · Cited by 21 · see citing works

MicroRNA-binding is required for recruitment of human Argonaute 2 to stress granules and P-bodies

Pare, J. M., López-Orozco, J., & Hobman, T. C. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.09.068 · Cited by 19 · see citing works

Evaluation of Argonaute protein as a predictive marker for human clear cell renal cell carcinoma.

Li, W., Liu, M., Feng, Y., et al. (2013) · PubMed · Cited by 11 · see citing works

Fluctuation of Global Gene Expression by Endogenous miRNA Response to the Introduction of an Exogenous miRNA

Nagata, Y., Shimizu, E., Hibio, N., et al. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140611171 · Cited by 10 · see citing works

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287 · see citing works

Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline

Das, P. P. (2008) · doi:10.53846/goediss-1343 · Cited by 15 · see citing works

A germline-specific class of small RNAs binds mammalian Piwi proteins

Girard, A., Sachidanandam, R., Hannon, G. J., & Carmell, M. A. (2006) · Nature · doi:10.1038/nature04917 · Cited by 1,762 · see citing works

Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains

Tian, Y., Simanshu, D. K., Ma, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017762108 · Cited by 104 · see citing works

The Argonaute protein family

Höck, J., & Meister, G. (2008) · Genome biology · doi:10.1186/gb-2008-9-2-210 · Cited by 564 · see citing works

Overlapping Functions of Argonaute Proteins in Patterning and Morphogenesis of Drosophila Embryos

Meyer, W., Schreiber, S., Guo, Y., Volkmann, T. E., Welte, M. A., & Müller, H. ‐. J. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020134 · Cited by 62 · see citing works