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MicroScope: an integrated platform for the annotation and exploration of microbial gene functions through genomic, pangenomic and metabolic comparative analysis

Open access
Vallenet, David, Calteau, Alexandra, Dubois, Mathieu, Amours, Paul, Bazin, Adelme, Beuvin, Mylène, Burlot, Laura, Bussell, Xavier, Fouteau, Stéphanie, Gautreau, Guillaume, Lajus, Aurélie, Langlois, Jordan, Planel, Rémi, Roche, David, Rollin, Johan, Rouy, Zoe, Sabatet, Valentin, Médigue, Claudine·2019·Nucleic Acids Research

Abstract

Large-scale genome sequencing and the increasingly massive use of high-throughput approaches produce a vast amount of new information that completely transforms our understanding of thousands of microbial species. However, despite the development of powerful bioinformatics approaches, full interpretation of the content of these genomes remains a difficult task. Launched in 2005, the MicroScope platform (https://www.genoscope.cns.fr/agc/microscope) has been under continuous development and provides analysis for prokaryotic genome projects together with metabolic network reconstruction and post-genomic experiments allowing users to improve the understanding of gene functions. Here we present new improvements of the MicroScope user interface for genome selection, navigation and expert gene annotation. Automatic functional annotation procedures of the platform have also been updated and we added several new tools for the functional annotation of genes and genomic regions. We finally focus on new tools and pipeline developed to perform comparative analyses on hundreds of genomes based on pangenome graphs. To date, MicroScope contains data for >11 800 microbial genomes, part of which are manually curated and maintained by microbiologists (>4500 personal accounts in September 2019). The platform enables collaborative work in a rich comparative genomic context and improves community-based curation efforts.

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Metadata

Authors
Vallenet, D., Calteau, A., Dubois, M., Amours, P., Bazin, A., Beuvin, M., Burlot, L., Bussell, X., Fouteau, S., Gautreau, G., Lajus, A., Langlois, J., Planel, R., Roche, D., Rollin, J., Rouy, Z., Sabatet, V., & Médigue, C.
Venue
Nucleic Acids Research
Published
2019-10-24
Volume
48
Issue
D1
Pages
D579-D589
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2981519702
Cited by
346
References
33
FWCI
12.17
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: MicroScope: an integrated platform for the annotation and exploration of microbial gene functions through genomic, pangenomic and metabolic comparative analysis. https://app.cochat.ai/papers/10.1093/nar/gkz926
The paper
Vallenet, D., Calteau, A., Dubois, M., Amours, P., Bazin, A., Beuvin, M., Burlot, L., Bussell, X., Fouteau, S., Gautreau, G., Lajus, A., Langlois, J., Planel, R., Roche, D., Rollin, J., Rouy, Z., Sabatet, V., & Médigue, C. (2019). MicroScope: an integrated platform for the annotation and exploration of microbial gene functions through genomic, pangenomic and metabolic comparative analysis. Nucleic Acids Research. https://doi.org/10.1093/nar/gkz926

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.