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Expression Atlas update: from tissues to single cells

Papatheodorou, Irene, Moreno, Pablo, Manning, Jonathan, Fuentes, Alfonso Muñoz-Pomer, George, Nancy, Fexova, Silvie, Fonseca, Nuno A, Füllgrabe, Anja, Green, Matthew, Huang, Ni, Huerta, Laura, Iqbal, Haider, Jianu, Monica, Mohammed, Suhaib, Zhao, Lingyun, Jarnuczak, Andrew F, Jupp, Simon, Marioni, John, Meyer, Kerstin, Petryszak, Robert, Prada Medina, Cesar Augusto, Talavera-López, Carlos, Teichmann, Sarah, Vizcaino, Juan Antonio, Brazma, Alvis·2019·Nucleic Acids Research

Abstract

Expression Atlas is EMBL-EBI’s resource for gene and protein expression. It sources and compiles data on the abundance and localisation of RNA and proteins in various biological systems and contexts and provides open access to this data for the research community. With the increased availability of single cell RNA-Seq datasets in the public archives, we have now extended Expression Atlas with a new added-value service to display gene expression in single cells. Single Cell Expression Atlas was launched in 2018 and currently includes 123 single cell RNA-Seq studies from 12 species. The website can be searched by genes within or across species to reveal experiments, tissues and cell types where this gene is expressed or under which conditions it is a marker gene. Within each study, cells can be visualized using a pre-calculated t-SNE plot and can be coloured by different features or by cell clusters based on gene expression. Within each experiment, there are links to downloadable files, such as RNA quantification matrices, clustering results, reports on protocols and associated metadata, such as assigned cell types.

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Metadata

Authors
Papatheodorou, I., Moreno, P., Manning, J., Fuentes, A. M.-P., George, N., Fexova, S., Fonseca, N. A., Füllgrabe, A., Green, M., Huang, N., Huerta, L., Iqbal, H., Jianu, M., Mohammed, S., Zhao, L., Jarnuczak, A. F., Jupp, S., Marioni, J., Meyer, K., Petryszak, R., Prada Medina, C. A., Talavera-López, C., Teichmann, S., Vizcaino, J. A., & Brazma, A.
Affiliations
  • European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Hinxton, UK
  • Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK
Venue
Nucleic Acids Research
Published
2019-10-30
ISSN
  • 0305-1048
  • 1362-4962
Cited by
224
References
6
Language
en
Funders
  • European Molecular Biology Laboratory
  • Wellcome Trust (108437/Z/15/Z, 208391/Z/17/Z)
  • National Science Foundation (NSF IOS #1127112)
  • BBSRC (BB/P027849/1)

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