Lactate dehydrogenase A silencing in IDH mutant gliomas

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857 · see citing works

<i>IDH1</i> and <i>IDH2</i> Mutations in Gliomas

Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808710 · Cited by 5,847 · see citing works

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154 · see citing works

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S.-H., Ito, S., Yang, C., Wang, P., Xiao, M.-T., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.12.014 · Cited by 2,875 · see citing works

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

He, Y., Li, B.-Z., Li, Z., Liu, P., Wang, Y., Tang, Q., Ding, J., Jia, Y., Chen, Z., Li, L., et al. (2011) · Science · doi:10.1126/science.1210944 · Cited by 2,776 · see citing works

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

Figueroa, M. E., Abdel-Wahab, O., Lu, C., Ward, P. S., Patel, J., Shih, A., Li, Y., Bhagwat, N., Vasanthakumar, A., Fernandez, H. F., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.11.015 · Cited by 2,766 · see citing works

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

Turcan, S., Rohle, D., Goenka, A., Walsh, L. A., Fang, F., Yilmaz, E., Campos, C., Fabius, A. W. M., Lu, C., Ward, P. S., et al. (2012) · Nature · doi:10.1038/nature10866 · Cited by 1,974 · see citing works

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

Semenza, G., Roth, P. H., Fang, H. M., & Wang, G. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31580-6 · Cited by 1,892 · see citing works

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

Fantin, V. R., St-Pierre, J., & Leder, P. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.04.023 · Cited by 1,635 · see citing works

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

Le, A., Cooper, C. R., Gouw, A. M., Dinavahi, R., Maitra, A., Deck, L. M., Royer, R. E., Jagt, D. L. V., Semenza, G. L., & Dang, C. V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914433107 · Cited by 1,528 · see citing works

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells

Rohle, D., Popovici-Muller, J., Palaskas, N., Turcan, S., Grommes, C., Campos, C., Tsoi, J., Clark, O., Oldrini, B., Komisopoulou, E., et al. (2013) · Science · doi:10.1126/science.1236062 · Cited by 1,153 · see citing works

Glioma-Derived Mutations in <i>IDH1</i> Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α

Zhao, S., Lin, Y., Xu, W., Jiang, W., Zha, Z., Wang, P., Yu, W., Li, Z., Gong, L., Peng, Y., et al. (2009) · Science · doi:10.1126/science.1170944 · Cited by 1,119 · see citing works

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

Chowdhury, R., Yeoh, K. K., Tian, Y., Hillringhaus, L., Bagg, E. A., Rose, N. R., Leung, I. K. H., Li, X. S., Woon, E. C. Y., Yang, M., et al. (2011) · The EMBO Reports · doi:10.1038/embor.2011.43 · Cited by 1,035 · see citing works

IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas

Watanabe, T., Nobusawa, S., Kleihues, P., & Ohgaki, H. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080958 · Cited by 1,027 · see citing works

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

Koivunen, P., Lee, S., Duncan, C. G., Lopez, G., Lu, G., Ramkissoon, S., Losman, J. A., Joensuu, P., Bergmann, U., Gross, S., et al. (2012) · Nature · doi:10.1038/nature10898 · Cited by 727 · see citing works

Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer

King, A., Selak, M. A., & Gottlieb, E. (2006) · Oncogene · doi:10.1038/sj.onc.1209594 · Cited by 672 · see citing works

Hypoxic Regulation of Lactate Dehydrogenase A

Firth, J. D., Ebert, B. L., & Ratcliffe, P. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.36.21021 · Cited by 576 · see citing works

IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas

Houillier, C., Wang, X., Kaloshi, G., Mokhtari, K., Guillevin, R., Laffaire, J., Paris, S., Boisselier, B., Idbaïh, A., Laigle–Donadey, F., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f96282 · Cited by 532 · see citing works

Roles of p53, MYC and HIF-1 in regulating glycolysis–the seventh hallmark of cancer

Yeung, S. J., Pan, J., & Lee, M.-H. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8224-x · Cited by 514 · see citing works

Lactate: mirror and motor of tumor malignancy

Walenta, S., & Mueller‐Klieser, W. (2004) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2004.04.004 · Cited by 432 · see citing works

LACTIC DEHYDROGENASE IN HUMAN NEOPLASTIC TISSUES.

Goldman, R. D., Kaplan, N. O., & Hall, T. C. (1964) · PubMed · Cited by 355 · see citing works

DNA methylation and gene silencing in cancer: which is the guilty party?

Clark, S. J., & Melki, J. R. (2002) · Oncogene · doi:10.1038/sj.onc.1205598 · Cited by 288 · see citing works

Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma.

Sonoda, Y., Ozawa, T., Hirose, Y., Aldape, K. D., McMahon, M., Berger, M. S., & Pieper, R. O. (2001) · PubMed · Cited by 278 · see citing works

Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma

Sheng, S. L., Liu, J., Dai, Y., Sun, X. G., Xiong, X. P., & Huang, G. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08748.x · Cited by 263 · see citing works

LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer

Xie, H., Valera, V., Merino, M. J., Amato, A. M., Signoretti, S., Linehan, W. M., Sukhatme, V. P., & Seth, P. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-1049 · Cited by 232 · see citing works

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression

Luo, W., Chang, R., Zhong, J., Pandey, A., & Semenza, G. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217394109 · Cited by 228 · see citing works

Gene silencing in mammalian cells and the spread of DNA methylation

Turker, M. S. (2002) · Oncogene · doi:10.1038/sj.onc.1205599 · Cited by 221 · see citing works

Proliferation of Human Glioblastoma Stem Cells Occurs Independently of Exogenous Mitogens

Kelly, J. J., Stechishin, O. D. M., Chojnacki, A. K., Lun, X. Q., Sun, B., Senger, D. L., Forsyth, P. A., Auer, R. N., Dunn, J. F., Cairncross, J. G., et al. (2009) · Stem Cells · doi:10.1002/stem.98 · Cited by 187 · see citing works

Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases

Kaelin, W. G. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010975 · Cited by 161 · see citing works

Mutant Metabolic Enzymes Are at the Origin of Gliomas

Yan, H., Bigner, D. D., Velculescu, V. E., & Parsons, D. W. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2650 · Cited by 153 · see citing works

LDHA is necessary for the tumorigenicity of esophageal squamous cell carcinoma

Yao, F., Zhao, T., Zhong, C., Zhu, J. J., & Zhao, H. (2012) · Tumor Biology · doi:10.1007/s13277-012-0506-0 · Cited by 131 · see citing works

L-Lactate Dehydrogenase A4- and A3B Isoforms Are Bona Fide Peroxisomal Enzymes in Rat Liver

Baumgart‐Vogt, E., Fahimi, H. D., Stich, A., & Völkl, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.7.3846 · Cited by 112 · see citing works

2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP+-Dependent Isocitrate Dehydrogenase Mutations

Jin, G., Reitman, Z. J., Spasojevic, I., Batinic-Haberle, I., Yang, J., Schmidt-Kittler, O., Bigner, D. D., & Yan, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016812 · Cited by 112 · see citing works

Oligodendroglioma cell lines containing t(1;19)(q10;p10)

Kelly, J. J., Blough, M. D., Stechishin, O. D. M., Chan, J. A.-W., Beauchamp, D. R., Perizzolo, M., Demetrick, D. J., Steele, L., Auer, R. N., Hader, W. J., et al. (2010) · Neuro-Oncology · doi:10.1093/neuonc/noq031 · Cited by 94 · see citing works

Isocitrate dehydrogenase mutations in gliomas

Guo, C., Pirozzi, C. J., Lopez, G. Y., & Yan, H. (2011) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32834cd415 · Cited by 89 · see citing works

pH i , Aerobic Glycolysis and Vascular Endothelial Growth Factor in Tumour Growth

Pouysségur, J., Franchi, A., & Pagès, G. (2001) · Novartis Foundation symposium · doi:10.1002/0470868716.ch13 · Cited by 63 · see citing works

Evolutionary Relationship of a Fish C Type Lactate Dehydrogenase to Other Vertebrate Lactate Dehydrogenase Isozymes

Rehse, P. H., & Davidson, W. S. (1986) · Canadian Journal of Fisheries and Aquatic Sciences · doi:10.1139/f86-130 · Cited by 31 · see citing works

17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2

Brandes, A., Ward, C. S., & Ronen, S. M. (2010) · Breast Cancer Research · doi:10.1186/bcr2729 · Cited by 31 · see citing works

DNA hypermethylation and 1p Loss silence NHE‐1 in oligodendroglioma

Blough, M. D., Al‐Najjar, M., Chesnelong, C., Binding, C., Rogers, A. D., Luchman, H. A., Kelly, J. J., Fliegel, L., Morozova, O., Yip, S. S. F., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23610 · Cited by 22 · see citing works

Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy

Feng, Y., Xiong, Y., Qiao, T., Li, X., Jia, L., & Han, Y. (2018) · Cancer Medicine · doi:10.1002/cam4.1820 · Cited by 712 · see citing works

IDH mutation in glioma: molecular mechanisms and potential therapeutic targets

Han, S., Liu, Y., Cai, S. J., Qian, M., Ding, J., Larion, M., Gilbert, M. R., & Yang, C. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-0814-x · Cited by 661 · see citing works

The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor

Valvona, C. J., Fillmore, H. L., Nunn, P. B., & Pilkington, G. J. (2015) · Brain Pathology · doi:10.1111/bpa.12299 · Cited by 570 · see citing works

Coupling Krebs cycle metabolites to signalling in immunity and cancer

Ryan, D. G., Murphy, M. P., Frezza, C., Prag, H. A., Chouchani, E. T., O’Neill, L. A., & Mills, E. L. (2018) · Nature Metabolism · doi:10.1038/s42255-018-0014-7 · Cited by 398 · see citing works

Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

Miroshnikova, Y. A., Mouw, J. K., Barnes, J. M., Pickup, M. W., Lakins, J. N., Kim, Y., Lobo, K. A., Persson, A. I., Reis, G. F., McKnight, T. R., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3429 · Cited by 380 · see citing works

IDH mutation status is associated with a distinct hypoxia/angiogenesis transcriptome signature which is non-invasively predictable with rCBV imaging in human glioma

Kickingereder, P., Sahm, F., Radbruch, A., Wick, W., Heiland, S., von Deimling, A., Bendszus, M., & Wiestler, B. (2015) · Scientific Reports · doi:10.1038/srep16238 · Cited by 314 · see citing works

Oncometabolite d -2HG alters T cell metabolism to impair CD8 + T cell function

Notarangelo, G., Spinelli, J. B., Perez, E. M., Baker, G. J., Kurmi, K., Elia, I., Stopka, S. A., Baquer, G., Lin, J., Golby, A. J., et al. (2022) · Science · doi:10.1126/science.abj5104 · Cited by 292 · see citing works

Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

Liao, M., Yao, D., Wu, L., Luo, C., Wang, Z., Zhang, J., & Liu, B. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.12.003 · Cited by 280 · see citing works

Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy

Ye, Y., Hu, Q., Chen, H., Liang, K., Yuan, Y., Xiang, Y., Ruan, H., Zhang, Z., Song, A., Zhang, H., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0045-8 · Cited by 251 · see citing works

Molecular Heterogeneity in Glioblastoma: Potential Clinical Implications

Parker, N., Khong, P., Parkinson, J., Howell, V. M., & Wheeler, H. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00055 · Cited by 248 · see citing works

Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates

Ye, D., Guan, K.-L., & Xiong, Y. (2018) · Trends in Cancer · doi:10.1016/j.trecan.2017.12.005 · Cited by 242 · see citing works

Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer

Clark, O., Yen, K. E., & Mellinghoff, I. K. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1333 · Cited by 205 · see citing works

Isocitrate Dehydrogenase Mutation and ( <i>R</i> )-2-Hydroxyglutarate: From Basic Discovery to Therapeutics Development

Dang, L., & Su, S.-S. M. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-044732 · Cited by 204 · see citing works

Crosstalk between metabolic reprogramming and epigenetics in cancer: updates on mechanisms and therapeutic opportunities

Ge, T., Gu, X., Jia, R., Ge, S., Chai, P., Zhuang, A., & Fan, X. (2022) · 癌症：英文版 · doi:10.1002/cac2.12374 · Cited by 206 · see citing works

The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation

Molenaar, R. J., Radivoyevitch, T., Maciejewski, J. P., Noorden, C. J. F. V., & Bleeker, F. E. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.05.004 · Cited by 181 · see citing works

HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells

Lee, S.-H., Golinska, M., & Griffiths, J. R. (2021) · Cells · doi:10.3390/cells10092371 · Cited by 169 · see citing works

Metabolic consequences of oncogenic IDH mutations

Parker, S. J., & Metallo, C. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.05.003 · Cited by 158 · see citing works

The Roles of 2-Hydroxyglutarate

Du, X., & Hu, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.651317 · Cited by 152 · see citing works

Treatment Response Assessment in IDH-Mutant Glioma Patients by Noninvasive 3D Functional Spectroscopic Mapping of 2-Hydroxyglutarate

Andronesi, O. C., Loebel, F., Bogner, W., Marjańska, M., Heiden, M. G. V., Iafrate, A. J., Dietrich, J., Batchelor, T. T., Gerstner, E. R., Kaelin, W. G., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0656 · Cited by 153 · see citing works

Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance

Zhou, W., & Wahl, D. R. (2019) · Cancers · doi:10.3390/cancers11091231 · Cited by 146 · see citing works

Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways

Fack, F., Tardito, S., Hochart, G., Oudin, A., Zheng, L., Fritah, S., Golebiewska, A., Nazarov, P. V., Bernard, A., Hau, A., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201707729 · Cited by 144 · see citing works

Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling

Gagné, L. M., Boulay, K., Topisirović, I., Huot, M., & Mallette, F. A. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.06.002 · Cited by 141 · see citing works

Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate

Andronesi, O. C., Arrillaga‐Romany, I., Ly, I., Bogner, W., Ratai, E., Reitz, K., Iafrate, A. J., Dietrich, J., Gerstner, E. R., Chi, A. S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03905-6 · Cited by 141 · see citing works

Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1

Mazor, T., Chesnelong, C., Pankov, A., Jalbert, L. E., Hong, C., Hayes, J. L., Smirnov, I. V., Marshall, R. E., de Souza, C. F., Shen, Y., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708914114 · Cited by 136 · see citing works

Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis

Chinopoulos, C., & Seyfried, T. N. (2018) · ASN NEURO · doi:10.1177/1759091418818261 · Cited by 128 · see citing works

<i>IDH1</i> Mutation Induces Reprogramming of Pyruvate Metabolism

Izquierdo-Garcia, J. L., Viswanath, P., Eriksson, P., Cai, L., Radoul, M., Chaumeil, M. M., Blough, M., Luchman, H. A., Weiss, S., Cairncross, J. G., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0840 · Cited by 123 · see citing works

Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation

Ohka, F., Ito, M., Ranjit, M., Senga, T., Motomura, A., Motomura, K., Saito, K., Kato, K., Kato, Y., Wakabayashi, T., et al. (2014) · Tumor Biology · doi:10.1007/s13277-014-1784-5 · Cited by 121 · see citing works

Epigenetic modulation of metabolism in glioblastoma

Dong, Z., & Cui, H. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.09.002 · Cited by 121 · see citing works

An Epigenetic Role of Mitochondria in Cancer

Liu, Y., Chen, C., Wang, X., Sun, Y., Zhang, J., Chen, J., & Shi, Y. (2022) · Cells · doi:10.3390/cells11162518 · Cited by 125 · see citing works

Revisiting the Warburg Effect with Focus on Lactate

Kocianova, E., Piatrikova, V., & Golias, T. (2022) · Cancers · doi:10.3390/cancers14246028 · Cited by 116 · see citing works

LOX Expression and Functional Analysis in Astrocytomas and Impact of IDH1 Mutation

da Silva, R., Uno, M., Marie, S. K. N., & Oba‐Shinjo, S. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119781 · Cited by 110 · see citing works

The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1 -Mutant Cancers and Potentiates NAD+ Depletion–Mediated Cytotoxicity

Tateishi, K., Higuchi, F., Miller, J. J., Koerner, M. V. A., Lelic, N., Shankar, G. M., Tanaka, S., Fisher, D. E., Batchelor, T. T., Iafrate, A. J., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2263 · Cited by 98 · see citing works

The pro-tumorigenic effects of metabolic alterations in glioblastoma including brain tumor initiating cells

Libby, C. J., Tran, A. N., Scott, S. E., Griguer, C. E., & Hjelmeland, A. B. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.01.004 · Cited by 91 · see citing works

Cancer-associated Isocitrate Dehydrogenase 1 (IDH1) R132H Mutation and d-2-Hydroxyglutarate Stimulate Glutamine Metabolism under Hypoxia

Reitman, Z. J., Duncan, C. G., Poteet, E. C., Winters, A., Yan, L., Gooden, D. M., Spasojević, I., Boros, L. G., Yang, S.-H., & Yan, H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.575183 · Cited by 90 · see citing works

Hyperpolarized [1-13C] Glutamate: A Metabolic Imaging Biomarker of IDH1 Mutational Status in Glioma

Chaumeil, M. M., Larson, P. E. Z., Woods, S. M., Cai, L., Eriksson, P., Robinson, A. E., Lupo, J., Vigneron, D. B., Nelson, S. J., Pieper, R. O., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0680 · Cited by 87 · see citing works

Extracellular Vesicles from Neurosurgical Aspirates Identifies Chaperonin Containing TCP1 Subunit 6A as a Potential Glioblastoma Biomarker with Prognostic Significance

Hallal, S. M., Russell, B. P., Wei, H., Lee, M. Y. T., Toon, C. W., Sy, J. S., Shivalingam, B., Buckland, M. E., & Alexander, K. L. (2018) · PROTEOMICS · doi:10.1002/pmic.201800157 · Cited by 87 · see citing works

Friend or foe—IDH1 mutations in glioma 10 years on

Huang, L. E. (2019) · Carcinogenesis · doi:10.1093/carcin/bgz134 · Cited by 82 · see citing works

IDH Mutations in Glioma: Double-Edged Sword in Clinical Applications?

Kayabölen, A., Yilmaz, E., & Onder, T. B. (2021) · Biomedicines · doi:10.3390/biomedicines9070799 · Cited by 83 · see citing works

Cancer stem cell molecular reprogramming of the Warburg effect in glioblastomas: a new target gleaned from an old concept

Yuen, C., Asuthkar, S., Guda, M. R., Tsung, A. J., & Velpula, K. K. (2016) · CNS Oncology · doi:10.2217/cns-2015-0006 · Cited by 82 · see citing works

Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis

Guyon, J., Fernández‐Moncada, I., Larrieu, C. M., Bouchez, C. L., Zottola, A. C. P., Galvis, J., Chouleur, T., Burban, A., Joseph, K., Ravi, V. M., et al. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202115343 · Cited by 84 · see citing works

Mutant IDH1-Driven Cellular Transformation Increases RAD51-Mediated Homologous Recombination and Temozolomide Resistance

Ohba, S., Mukherjee, J., See, W. L., & Pieper, R. O. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0924 · Cited by 81 · see citing works

Metabolic Reprogramming in Mutant IDH1 Glioma Cells

Izquierdo-García, J. L., Viswanath, P., Eriksson, P., Chaumeil, M. M., Pieper, R. O., Phillips, J. J., & Ronen, S. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118781 · Cited by 84 · see citing works

Glioma Cells with the IDH1 Mutation Modulate Metabolic Fractional Flux through Pyruvate Carboxylase

Izquierdo-García, J. L., Cai, L. M., Chaumeil, M. M., Eriksson, P., Robinson, A. E., Pieper, R. O., Phillips, J. J., & Ronen, S. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108289 · Cited by 73 · see citing works

Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation

Zhou, L., Wang, Z., Hu, C., Zhang, C., Kovatcheva‐Datchary, P., Yu, D., Liu, S., Ren, F., Wang, X., Li, Y., et al. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00663 · Cited by 73 · see citing works

Warburg effect, lactate dehydrogenase, and radio/chemo-therapy efficacy

Koukourakis, M. I., & Giatromanolaki, A. N. (2018) · International Journal of Radiation Biology · doi:10.1080/09553002.2018.1490041 · Cited by 73 · see citing works

The Tricarboxylic Acid Cycle at the Crossroad Between Cancer and Immunity

Scagliola, A., Mainini, F., & Cardaci, S. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7974 · Cited by 73 · see citing works

Biology of IDH mutant cholangiocarcinoma

Wu, M., Shi, L., Merritt, J., Zhu, A. X., & Bardeesy, N. M. (2022) · Hepatology · doi:10.1002/hep.32424 · Cited by 71 · see citing works

New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein

Sakane, F., Hoshino, F., & Murakami, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186794 · Cited by 69 · see citing works

Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma

Li, J., Zhu, S., Tong, J., Hao, H., Yang, J., Liu, Z., & Wang, Y. (2015) · Neuroreport · doi:10.1097/wnr.0000000000000506 · Cited by 68 · see citing works

In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma

Khurshed, M., Molenaar, R. J., Lenting, K., Leenders, W. P. J., & Noorden, C. J. F. V. (2017) · Oncotarget · doi:10.18632/oncotarget.17106 · Cited by 68 · see citing works

GPR65 sensing tumor-derived lactate induces HMGB1 release from TAM via the cAMP/PKA/CREB pathway to promote glioma progression

Yan, C., Yang, Z., Chen, P., Yeh, Y., Sun, C., Xie, T., Huang, W., & Zhang, X. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03025-8 · Cited by 67 · see citing works

Hyperpolarized 13C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring

Chaumeil, M. M., Radoul, M., Najac, C., Eriksson, P., Viswanath, P., Blough, M. D., Chesnelong, C., Luchman, H. A., Cairncross, J. G., & Ronen, S. M. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.06.018 · Cited by 67 · see citing works

Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma

Duraj, T., Kalamian, M., Zuccoli, G., Maroon, J. C., D’Agostino, D. P., Scheck, A. C., Poff, A. M., Winter, S. F., Hu, J. L., Klement, R. J., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03775-4 · Cited by 64 · see citing works

PI3K/mTOR inhibition of IDH1 mutant glioma leads to reduced 2HG production that is associated with increased survival

Batsios, G., Viswanath, P., Subramani, E., Najac, C., Gillespie, A. M., Santos, R. D., Molloy, A. R., Pieper, R. O., & Ronen, S. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-47021-x · Cited by 60 · see citing works

The Acidic Brain—Glycolytic Switch in the Microenvironment of Malignant Glioma

Reuss, A. M., Groos, D., Buchfelder, M., & Savaskan, N. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115518 · Cited by 57 · see citing works

Metabolic reprogramming associated with aggressiveness occurs in the G-CIMP-high molecular subtypes of IDH1mut lower grade gliomas

Ruiz‐Rodado, V., Malta, T. M., Seki, T., Lita, A., Dowdy, T., Celiku, O., Saldana, A. C., Li, A., Liu, Y., Han, S., et al. (2019) · Neuro-Oncology · doi:10.1093/neuonc/noz207 · Cited by 58 · see citing works

Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations

Hvinden, I. C., Cadoux-Hudson, T. A. D., Schofield, C. J., & McCullagh, J. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100469 · Cited by 59 · see citing works

Mutant IDH in Gliomas: Role in Cancer and Treatment Options

Solomou, G., Finch, A., Asghar, A., & Bardella, C. (2023) · Cancers · doi:10.3390/cancers15112883 · Cited by 57 · see citing works

2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas

Viswanath, P., Radoul, M., Izquierdo-García, J. L., Ong, W. Q., Luchman, H. A., Cairncross, J. G., Huang, B., Pieper, R. O., Phillips, J. J., & Ronen, S. M. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2926 · Cited by 54 · see citing works

Blocking LDHA glycolytic pathway sensitizes glioblastoma cells to radiation and temozolomide

Koukourakis, M. I., Tsolou, A., Pouliliou, S., Lamprou, I., Papadopoulou, M., Ilemosoglou, M., Kostoglou, G., Ananiadou, D., Sivridis, E., & Giatromanolaki, A. N. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.07.138 · Cited by 54 · see citing works

Extracellular citrate and metabolic adaptations of cancer cells

Parkinson, E. K., Adamski, J., Zahn, G., Gaumann, A. K. A., Flores‐Borja, F., Ziegler, C. M., & Mycielska, M. E. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10007-1 · Cited by 49 · see citing works

Hypoxia-inducible factor–1 and associated upstream and downstream proteins in the pathophysiology and management of glioblastoma

Womeldorff, M. R., Gillespie, D. L., & Jensen, R. L. (2014) · Neurosurgical FOCUS · doi:10.3171/2014.9.focus14496 · Cited by 50 · see citing works

Studies of Metabolism Using 13C MRS of Hyperpolarized Probes

Chaumeil, M. M., Najac, C., & Ronen, S. M. (2015) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2015.04.001 · Cited by 50 · see citing works

Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI

Yao, J., Chakhoyan, A., Nathanson, D. A., Yong, W. H., Salamon, N., Raymond, C., Mareninov, S., Lai, A., Nghiemphu, P. L., Prins, R. M., et al. (2019) · Neuro-Oncology · doi:10.1093/neuonc/noz078 · Cited by 51 · see citing works

Can the Mitochondrial Metabolic Theory Explain Better the Origin and Management of Cancer than Can the Somatic Mutation Theory?

Seyfried, T. N., & Chinopoulos, C. (2021) · Metabolites · doi:10.3390/metabo11090572 · Cited by 52 · see citing works

Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic Strategies

Madala, H. R., Punganuru, S. R., Arutla, V., Misra, S., Thomas, T., & Srivenugopal, K. S. (2018) · Cancers · doi:10.3390/cancers10020049 · Cited by 46 · see citing works

Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner

Viswanath, P., Radoul, M., Izquierdo-García, J. L., Luchman, H. A., Cairncross, J. G., Pieper, R. O., Phillips, J. J., & Ronen, S. M. (2018) · Cancer & Metabolism · doi:10.1186/s40170-018-0178-3 · Cited by 46 · see citing works

Magnetic Resonance (MR) Metabolic Imaging in Glioma

Chaumeil, M. M., Lupo, J., & Ronen, S. M. (2015) · Brain Pathology · doi:10.1111/bpa.12310 · Cited by 44 · see citing works

Human IDH mutant 1p/19q co-deleted gliomas have low tumor acidity as evidenced by molecular MRI and PET: a retrospective study

Yao, J., Hagiwara, A., Raymond, C., Shabani, S., Pope, W. B., Salamon, N., Lai, A., Ji, M., Nghiemphu, P. L., Liau, L. M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-68733-5 · Cited by 43 · see citing works

The Warburg hypothesis and the emergence of the mitochondrial metabolic theory of cancer

Seyfried, T. N., Lee, D. C., Duraj, T., Ta, N. L., Mukherjee, P., Kiebish, M. A., Arismendi-Morillo, G., & Chinopoulos, C. (2025) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-025-10059-w · Cited by 45 · see citing works

Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2– β -Catenin–BRG1 Transcriptional Network-Driven CD47 Expression

Gowda, P., Patrick, S., Singh, A., Sheikh, T., & Sen, E. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00001-18 · Cited by 43 · see citing works

Glycolysis-associated lncRNAs identify a subgroup of cancer patients with poor prognoses and a high-infiltration immune microenvironment

Ho, K., Huang, T.-W., Shih, C.-M., Lee, Y.-T., Liu, A.-J., Chen, P., & Chen, K. (2021) · BMC Medicine · doi:10.1186/s12916-021-01925-6 · Cited by 42 · see citing works

IDH Mutations in Glioma: Molecular, Cellular, Diagnostic, and Clinical Implications

Choate, K. A., Pratt, E. P. S., Jennings, M. J., Winn, R. J., & Mann, P. B. (2024) · Biology · doi:10.3390/biology13110885 · Cited by 43 · see citing works

How DNA methylation affects the Warburg effect

Zhu, X., Xuan, Z., Chen, J., Li, Z., Zheng, S., & Song, P. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.45420 · Cited by 40 · see citing works

Metabolic Roles of HIF1, c-Myc, and p53 in Glioma Cells

Trejo‐Solís, C., Castillo‐Rodríguez, R. A., Serrano-García, N., Silva‐Adaya, D., Vargas-Cruz, S., Chávez-Cortéz, E. G., Gallardo‐Pérez, J. C., Zavala-Vega, S., Cruz-Salgado, A., & Magaña-Maldonado, R. (2024) · Metabolites · doi:10.3390/metabo14050249 · Cited by 40 · see citing works

Magnetic resonance spectroscopy for the study of cns malignancies

Ruiz‐Rodado, V., Brender, J., Cherukuri, M. K., Gilbert, M. R., & Larion, M. (2020) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2020.11.001 · Cited by 37 · see citing works

Ketogenic Metabolic Therapy, Without Chemo or Radiation, for the Long-Term Management of IDH1-Mutant Glioblastoma: An 80-Month Follow-Up Case Report

Seyfried, T. N., Shivane, A. G., Kalamian, M., Maroon, J. C., Mukherjee, P., & Zuccoli, G. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.682243 · Cited by 36 · see citing works

Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells

Viswanath, P., Chaumeil, M. M., & Ronen, S. M. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00060 · Cited by 38 · see citing works

IGFBP2 expression predicts IDH-mutant glioma patient survival

Huang, L. E., Cohen, A. L., Colman, H., Jensen, R. L., Fults, D. W., & Couldwell, W. T. (2016) · Oncotarget · doi:10.18632/oncotarget.13329 · Cited by 37 · see citing works

Metabolic targeting of EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma

Velpula, K. K., Guda, M. R., Sahu, K., Tuszyński, J. A., Asuthkar, S., Bach, S. E., Lathia, J. D., & Tsung, A. J. (2017) · Oncotarget · doi:10.18632/oncotarget.16767 · Cited by 37 · see citing works

Identification of a Prognostic Hypoxia-Associated Gene Set in IDH-Mutant Glioma

Trong, P. D., Roesch, S., Mairbäurl, H., Pusch, S., Unterberg, A. W., Herold‐Mende, C. C., & Warta, R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102903 · Cited by 37 · see citing works

Cyclin G2 Inhibits the Warburg Effect and Tumour Progression by Suppressing LDHA Phosphorylation in Glioma

Li, S., Gao, J., Zhuang, X., Zhao, C., Hou, X., Xing, X., Chen, C., Liu, Q., Liu, S., & Luo, Y. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.30297 · Cited by 37 · see citing works

Emerging Roles and Therapeutic Interventions of Aerobic Glycolysis in Glioma

Han, W., Shi, J. Y., Cao, J., Dong, B., & Guan, W. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s260376 · Cited by 37 · see citing works

Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters

Viswanath, P., Najac, C., Izquierdo-García, J. L., Pankov, A., Hong, C., Eriksson, P., Costello, J., Pieper, R. O., & Ronen, S. M. (2016) · Oncotarget · doi:10.18632/oncotarget.9006 · Cited by 35 · see citing works

Evolving Treatment Strategies for Elderly Leukemia Patients with IDH Mutations

Buege, M. J., DiPippo, A. J., & Dinardo, C. D. (2018) · Cancers · doi:10.3390/cancers10060187 · Cited by 35 · see citing works

Classification of glioma based on prognostic alternative splicing

Li, Y., Ren, Z., Peng, Y.-P., Li, K., Wang, X., Huang, G., Qi, S., & Liu, Y. (2019) · BMC Medical Genomics · doi:10.1186/s12920-019-0603-7 · Cited by 35 · see citing works

MicroRNA Regulation of Glycolytic Metabolism in Glioblastoma

Alfardus, H., McIntyre, A., & Smith, S. J. (2017) · BioMed Research International · doi:10.1155/2017/9157370 · Cited by 33 · see citing works

Patient-derived cells from recurrent tumors that model the evolution of IDH-mutant glioma

Jones, L. E., Hilz, S., Grimmer, M., Mazor, T., Najac, C., Mukherjee, J., McKinney, A., Chow, T. T., Pieper, R. O., Ronen, S. M., et al. (2020) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdaa088 · Cited by 31 · see citing works

Non-invasive assessment of telomere maintenance mechanisms in brain tumors

Viswanath, P., Batsios, G., Mukherjee, J., Gillespie, A. M., Larson, P. E. Z., Luchman, H. A., Phillips, J. J., Costello, J., Pieper, R. O., & Ronen, S. M. (2021) · Nature Communications · doi:10.1038/s41467-020-20312-y · Cited by 34 · see citing works

Altered Metabolism in Glioblastoma: Myeloid-Derived Suppressor Cell (MDSC) Fitness and Tumor-Infiltrating Lymphocyte (TIL) Dysfunction

Ianni, N. D., Musio, S., & Pellegatta, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094460 · Cited by 34 · see citing works

Deuterium metabolic imaging for 3D mapping of glucose metabolism in humans with central nervous system lesions at 3T

Adamson, P. M., Datta, K., Watkins, R., Recht, L. D., Hurd, R. E., & Spielman, D. M. (2023) · Magnetic Resonance in Medicine · doi:10.1002/mrm.29830 · Cited by 33 · see citing works

Metabolic management of microenvironment acidity in glioblastoma

Seyfried, T. N., Arismendi-Morillo, G., Zuccoli, G., Lee, D. C., Duraj, T., Elsakka, A. M., Maroon, J. C., Mukherjee, P., Ta, N. L., Shelton, L. M., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.968351 · Cited by 32 · see citing works

LDHA: The Obstacle to T cell responses against tumor

Tang, Y., Gu, S., Zhu, L., Wu, Y., Zhang, W., & Zhao, C. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1036477 · Cited by 31 · see citing works

Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation

Fujiwara, H., Tateishi, K., Misumi, K., Hayashi, A., Igarashi, K., Kato, H., Nakatsuka, T., Suzuki, N., Yamamoto, K., Kudo, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-55211-w · Cited by 31 · see citing works

MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma

Molloy, A. R., Najac, C., Viswanath, P., Lakhani, A., Subramani, E., Batsios, G., Radoul, M., Gillespie, A. M., Pieper, R. O., & Ronen, S. M. (2020) · Theranostics · doi:10.7150/thno.47317 · Cited by 31 · see citing works

IDH1 Targeting as a New Potential Option for Intrahepatic Cholangiocarcinoma Treatment—Current State and Future Perspectives

Crispo, F., Pietrafesa, M., Condelli, V., Maddalena, F., Bruno, G., Piscazzi, A., Sgambato, A., Esposito, F., & Landriscina, M. (2020) · Molecules · doi:10.3390/molecules25163754 · Cited by 32 · see citing works

Deuterium magnetic resonance spectroscopy enables noninvasive metabolic imaging of tumor burden and response to therapy in low-grade gliomas

Taglang, C., Batsios, G., Mukherjee, J., Tran, M., Gillespie, A. M., Hong, D., Ronen, S. M., Luchman, H. A., Pieper, R. O., & Viswanath, P. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noac022 · Cited by 29 · see citing works

Development of a Bioinformatics Framework for Identification and Validation of Genomic Biomarkers and Key Immunopathology Processes and Controllers in Infectious and Non-infectious Severe Inflammatory Response Syndrome

Tong, D. L., Kempsell, K. E., Szakmány, T., & Ball, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00380 · Cited by 29 · see citing works

Sirtuin activation targets IDH-mutant tumors

Miller, J. J., Fink, A. L., Banagis, J. A., Nagashima, H., Subramanian, M. P., Lee, C. K., Melamed, L., Tummala, S. S., Tateishi, K., Wakimoto, H., et al. (2020) · Neuro-Oncology · doi:10.1093/neuonc/noaa180 · Cited by 28 · see citing works

The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability

Ravn-Boess, N., Roy, N., Hattori, T., Bready, D., Donaldson, H., Lawson, C., Lapierre, C., Korman, A., Rodrick, T. C., Liu, E., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113374 · Cited by 28 · see citing works

LDHA deregulation in glioma

LaFlamme, B. A. (2014) · Nature Genetics · doi:10.1038/ng.3024 · Cited by 1 · see citing works

In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma

Khurshed, M., Molenaar, R. J., Lenting, K., Leenders, W. P. J., & Noorden, C. J. F. V. (2017) · Oncotarget · doi:10.18632/oncotarget.17106 · Cited by 68 · see citing works

Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma

Li, J., Zhu, S., Tong, J., Hao, H., Yang, J., Liu, Z., & Wang, Y. (2015) · Neuroreport · doi:10.1097/wnr.0000000000000506 · Cited by 68 · see citing works

Letter: A Role for Wild-Type Isocitrate Dehydrogenase 1 in Gliomagenesis

Nissiri, F., & Das, S. (2017) · Neurosurgery · doi:10.1093/neuros/nyx395

Abstract 431: IDH1-mutated gliomas rely on anaplerosis of glutamate and lactate whereas IDH1 wild-type gliomas rely on glycolysis and acetate anaplerosis

Khurshed, M., Lenting, K., Molenaar, R. J., Leenders, W. P. J., & Noorden, C. J. F. V. (2017) · Cancer Research · doi:10.1158/1538-7445.am2017-431 · Cited by 1 · see citing works