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Adherence to the Mediterranean diet and risk of depression: a systematic review and updated meta-analysis of observational studies
Abstract
CONTEXT: More than 300 million people worldwide have been diagnosed with depression, which is a leading cause of disability and disease burden. Elucidating dietary patterns that may reduce the risk of depression could help reduce the incidence of other diseases. DATA SOURCES: PubMed/MEDLINE, ISI Web of Science, Scopus, Embase, and Google Scholar databases were searched to identify relevant publications up to May 2018. STUDY SELECTION: All observational studies that considered the Mediterranean diet as the exposure variable and depression as the main outcome or as one of the outcome variables were included in this systematic review and meta-analysis. Two authors independently screened 3229 publications. A total of 14 observational studies were included in the meta-analysis. DATA EXTRACTION: Two authors independently extracted the data and assessed the risk of bias. RESULTS: The studies in the meta-analysis included a total of 56 043 participants. When 5 effect sizes from 4 cohort studies were combined, no significant association was observed between adherence to the Mediterranean diet and risk of depression (overall hazard ratio = 0.95; 95%CI, 0.79-1.16). When 3 effect sizes from 3 cohort studies that reported β coefficients were combined, again no significant association was found (β = -0.00; 95%CI, -0.12, 0.12). However, when 9 effect sizes from 9 cross-sectional studies were combined, an inverse significant association was found between adherence to the Mediterranean diet and risk of depression (overall odds ratio = 0.72; 95%CI, 0.60-0.87). CONCLUSIONS: The analysis of cohort studies revealed no significant association was found between adherence to the Mediterranean diet and risk of depression. However, an inverse significant association between adherence to the Mediterranean diet and odds of depression in cross-sectional studies.
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“Of note, one seemingly eligible study 28 was excluded for invalid findings due to inconsistent coding of effect directionality.”
From A meta-review of "lifestyle psychiatry": the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders (2020) · cites this paper as [28]
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Cites
Murray, C. J. L., & López, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07492-2 · Cited by 7,007
So depression is an inflammatory disease, but where does the inflammation come from?
Berk, M., Williams, L. J., Jacka, F. N., O’Neil, A., Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., Byrne, M. L., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-200 · Cited by 1,423
Mediterranean diet, stroke, cognitive impairment, and depression: A meta‐analysis
Psaltopoulou, T., Sergentanis, T. N., Panagiotakos, D. B., Sergentanis, I. N., Kosti, R., & Scarmeas, N. (2013) · Annals of Neurology · doi:10.1002/ana.23944 · Cited by 793
Adherence to a Mediterranean Diet, Cognitive Decline, and Risk of Dementia
Féart, C. (2009) · JAMA · doi:10.1001/jama.2009.1146 · Cited by 757
Association of the Mediterranean Dietary Pattern With the Incidence of Depression
Sánchez‐Villegas, A., Delgado‐Rodríguez, M., Alonso, Á., Schlatter, J., Lahortiga‐Ramos, F., Serra‐Majem, L., & Martínez‐González, M. Á. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.129 · Cited by 604
Dietary pattern and depressive symptoms in middle age
Akbaraly, T. N., Brunner, E. J., Ferrie, J. E., Marmot, M. G., Kivimaki, M., & Singh-Manoux, A. (2009) · British Journal of Psychiatry · doi:10.1192/bjp.bp.108.058925 · Cited by 602
Dietary patterns and depression risk: a meta-analysis
Li, Y., Lv, M.-R., Wei, Y.-J., Sun, L., Zhang, J.-X., Zhang, H.-G., & Li, B. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.04.020 · Cited by 599
Molendijk, M., Molero, P., Ortuño Sánchez-Pedreño, F., Van der Does, W., & Angel Martínez-González, M. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.09.022 · Cited by 550
Mental health survey of the adult population in Iran
Noorbala, A. A., Yazdi, S. A. B., Yasamy, M. T., & Mohammad, K. (2003) · The British Journal of Psychiatry · doi:10.1192/bjp.184.1.70 · Cited by 430
The association between diet quality, dietary patterns and depression in adults: a systematic review
Quirk, S. E., Williams, L. J., O'Neil, A. E., Pasco, J. A., Jacka, F. N., Housden, S., Berk, M., & Brennan-Olsen, S. L. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-175 · Cited by 419
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Items 101–148 of 148
Determinants of Adherence to The Mediterranean Diet and Depressive Symptoms in Turkish Young Adults
Ceylan, J. A., & Gümüş, A. B. (2025) · Journal of Basic and Clinical Health Sciences · doi:10.30621/jbachs.1530196 · Cited by 3
Mediterranean diet and mental well-being in the young
Muros, J. J., & Knox, E. C. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818649-7.00040-0 · Cited by 3
Vilugrón, F., Fernández, N., Letelier, J., Medina, A., & Torrejón, M. (2022) · Revista Española de Nutrición Humana y Dietética · doi:10.14306/renhyd.26.1.1438 · Cited by 6
Tutunchi, H., Saghafi‐Asl, M., Hosseinzadeh‐Attar, M. J., Jafarabadi, M. A., & Ostadrahimi, A. (2020) · doi:10.21203/rs.3.rs-15574/v1 · Cited by 3
Taherpour, A., Bahrami, A., Zarban, A., Khorasanchi, Z., Asadian, A. H., Ferns, G. A., & Karbasi, S. (2025) · BMC Pediatrics · doi:10.1186/s12887-024-05321-w · Cited by 3
Clinical Characterisation of the Co-Occurrence of Mental and Physical Disorders
Holt, R. I. G. (2025) · Springer eBooks · doi:10.1007/978-3-031-81802-8_6 · Cited by 2
Benisi-Kohansal, S., Kazeminejad, S., Lotfi, K., Monazzam, M. R., Imani, H., & Esmaillzadeh, A. (2025) · Journal of Health Population and Nutrition · doi:10.1186/s41043-025-01135-3 · Cited by 2
Self-citationHlaing, H. H., Dolja‐Gore, X., Tavener, M., & Hure, A. J. (2023) · British Journal Of Nutrition · doi:10.1017/s0007114523001605 · Cited by 2
Determinants of health-related quality of life among adolescents: The role of the Mediterranean diet
Mitri, R., Khalife, S., & Ziade, F. (2023) · Revue d Épidémiologie et de Santé Publique · doi:10.1016/j.respe.2023.102148 · Cited by 2
Diet and Depression during Peri- and Post-Menopause: A Scoping Review Protocol
Bodnaruc, A. M., Duquet, M., Prud’homme, D., & Giroux, I. (2023) · Methods and Protocols · doi:10.3390/mps6050091 · Cited by 2
Ivanišević, J., Tominac, A., Moro, E., Albala, K., Medina, F. X., & Babić, D. (2023) · Etnološka tribina · doi:10.15378/1848-9540.2023.46.01 · Cited by 2
AL-Basri, H., & Fallows, S. J. (2023) · GLOBAL PSYCHIATRY ARCHIVES · doi:10.52095/gpa.2023.5941.1065 · Cited by 2
van der Wurff, I. S. M., Golsteijn, R. H. J., Stamhuis, I., Oenema, A., & Lechner, L. (2025) · European Journal of Nutrition · doi:10.1007/s00394-025-03760-4 · Cited by 3
Feeding the mood: The role of macronutrients in depression prevention and treatment
Wang, C., Tang, J., & Cao, Y. (2025) · World Journal of Psychiatry · doi:10.5498/wjp.v15.i8.107435 · Cited by 2
Kunugi, H., & Tikhonova, M. A. (2022) · Progress in brain research · doi:10.1016/bs.pbr.2022.01.023 · Cited by 2
Kanukula, R., McKenzie, J. E., Bero, L. A., Dai, Z., McDonald, S., Kroeger, C. M., Korevaar, E., Forbes, A. B., & Page, M. J. (2024) · Research Synthesis Methods · doi:10.1002/jrsm.1706 · Cited by 2
Marx, W., Travica, N., O'Neil, A. E., & Jacka, F. N. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad018 · Cited by 1
Hatab, A. A., Sam, K. G., Beshir, S. A., Elnour, A. A., Mazrouei, N. A., Al-Kubaisi, K. A., Alkaabi, M., Amoodi, A. A., Menon, V. B., Mohammed, A., et al. (2024) · Nutritional Neuroscience · doi:10.1080/1028415x.2024.2304941 · Cited by 1
Kazeminejad, S., Abtahi, M., Askari, M., Marbini, M. H., Jalilpiran, Y., & Azadbakht, L. (2025) · BMC Research Notes · doi:10.1186/s13104-025-07155-w · Cited by 1
González-Cidad, A., García-Moncó, J. C., & Román, G. C. (2026) · Medicina · doi:10.3390/medicina62040696 · Cited by 1
Karimi, A. B., Alamdari, N. M., Hosseini, L., & Maghsoumi‐Norouzabad, L. (2026) · Trials · doi:10.1186/s13063-026-09860-8 · Cited by 1
Precision Nutrition in Aging and Brain Health
Chen, S. T., & Small, G. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15315-0.00017-1 · Cited by 1
Amiri, S., Alajlouni, O., Al-Rawi, S. O., Samra, A., Jamil, G., Kieu, A., & Khan, M. A. (2024) · International Journal of Occupational Safety and Ergonomics · doi:10.1080/10803548.2024.2424098 · Cited by 1
Holmes, E. J., Aryal, S., & Walters, S. T. (2021) · Journal of Public Health · doi:10.1007/s10389-021-01555-5
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(2019) · Nutrition, science en évolution · doi:10.7202/1062459ar
Beesdo‐Baum, K. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738680951.793580928
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Kose, J., Duquenne, P., Srour, B., Debras, C., Léger, D., Péneau, S., Galan, P., Herçberg, S., Touvier, M., & Andreeva, V. A. (2022) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2022.09.005 · Cited by 1
Allcock, L., Mantzioris, E., & Villani, A. M. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4513783
Bodnaruc, A. M., Vincent, C., Soto, C., Duquet, M., Prud’homme, D., & Giroux, I. (2023) · Methods and Protocols · doi:10.3390/mps6050078
Wang, Y., Liu, L., & Yang, D. (2024) · Actas Españolas de Psiquiatría · doi:10.62641/aep.v52i3.1637
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F. H. Ouriaghli, & Elhaty, I. A. (2025) · The Ukrainian Biochemical Journal · doi:10.15407/ubj97.02.013 · Cited by 1
Kahl, K., Ceolin, G., d’Orsi, E., & Moreira, J. D. (2025) · Aging & Mental Health · doi:10.1080/13607863.2025.2519620
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Крупка, Н. О., & Chemerys, N. M. (2025) · Hygiene of populated places · doi:10.32402/hygiene2025.75.139
Liu, X., Jing, Z.-X., Li, Y., Bu, Z., Yin, B., Xu, C., Wang, S., Chen, X., & Shi, H. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120849
García, G. R., Martínez-Sancho, J., Bagué, A. B., Mateu‐Figueras, G., Buxó, M., Martí‐Lluch, R., Zacarías‐Pons, L., Puig, J., Ramos, R., Fernández‐Real, J. M., et al. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1727223 · Cited by 1
Parastouei, K., Rostami, H., & Chambari, M. (2024) · Figshare · doi:10.6084/m9.figshare.26578415
Roponen, J., Ruusunen, A. A., Absetz, P., Partonen, T., Kuvaja-Köllner, V., Hujo, M., & Nuutinen, O. (2021) · Figshare · doi:10.6084/m9.figshare.14608894
Fan, M., Jin, G., Gao, Y., Jia, Y., Zeng, J., Chen, B., You, Q., Tian, Q., & Xu, S. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121645
Zhu, S., Yu, Q., Jiang, Y., Zu, Q., & Pang, W. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1725745
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Biłyk, K., Marzec, W., Maruchniak, H., Biedroń, P., Skrzypek, A., Hutkowski, M., Zbrożek, M., Chwostek, Z., Kosiarski, B., & Markowicz, P. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.2(50).2026.5307
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Sasidharan, S., & Dhillon, H. S. (2026) · Annals of the National Academy of Medical Sciences (India) · doi:10.25259/anams_194_2025
Yavas, F., Rad, N. H., & Almasi, N. (2026) · Nutrition & Food Science · doi:10.1108/nfs-01-2026-0004
Alonso‐Domínguez, R., González‐Sánchez, J., Vaquero, C., Garcia-Yu, I. A., Sánchez‐Aguadero, N., Sedano, A. C., & Recio-Rodriguez, J. I. (2026) · Nutrients · doi:10.3390/nu18203305
Shin, S., & Park, C. Y. (2026) · Nutrients · doi:10.3390/nu18213479
Metadata
- Authors
- Shafiei, F., Salari-Moghaddam, A., Larijani, B., & Esmaillzadeh, A.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Endocrinology and Metabolism Clinical Sciences Institute (IR)
- Isfahan University of Medical Sciences (IR)
- Corresponding author
- Esmaillzadeh, Ahmad
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-02-06
- Volume
- 77
- Issue
- 4
- Pages
- 230-239
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2911660708
- Cited by
- 147
- References
- 54
- Citations by year
- 2026: 11 · 2025: 24 · 2024: 24 · 2023: 30 · 2022: 23 · 2021: 14 · 2020: 14 · 2019: 7
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Nutrition Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tehran University of Medical Sciences
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- Mediterranean diet, dietary adherence, depression, depression risk, dietary habits, cross-sectional study, cohort studies, risk of bias
- MeSH terms
- Depressive Disorder, Humans, Diet, Mediterranean, Observational Studies as Topic
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