The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Health disorders of shift workers
Abstract
The effects of shift work on physiological function through disruption of circadian rhythms are well described. However, shift work can also be associated with specific pathological disorders. This article reviews the evidence for a relationship between specific medical disorders and working at night or on shift systems. The strongest evidence exists for an association with peptic ulcer disease, coronary heart disease and compromised pregnancy outcome.
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“Disrupted rhythmicity in the gut microbiome may be involved in an immediate and frequently reported, yet hitherto poorly understood, effect of shift work, namely, gastrointestinal discomfort [42,43].”
From Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being (2017) · cites this paper as [42]
In the citing paper
“Multiple studies, opinions, and guidelines have suggested melatonin as primary therapy for improved health and sleep of shift workers [69,70,71].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [69]
In the citing paper
“this is important because circadian disruption (CD; eg, shift work and jet lag) and sleep deprivation are not uncommon in the modern world and constitute an increasing health concern.19,20”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [20]
In the citing paper
“For example, shift work 201 and short-turn around time for air crews on trans-meridianal flights 202 have health and cognitive effects that could be ameliorated by work policies.”
From Socio‐economic differentials in peripheral biology: Cumulative allostatic load (2010) · cites this paper as [201]
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Citations
Cites
Impact of sleep debt on metabolic and endocrine function
Spiegel, K., Leproult, R., & Van Cauter, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01376-8 · Cited by 3,668
Shift work and disturbed sleep/wakefulness
Akerstedt, T. (2003) · Occupational Medicine · doi:10.1093/occmed/kqg046 · Cited by 1,101
Shift work, safety and productivity
Folkard, S. (2003) · Occupational Medicine · doi:10.1093/occmed/kqg047 · Cited by 774
Shift work, risk factors and cardiovascular disease
Bøggild, H., & Knutsson, A. (1999) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.410 · Cited by 683
Self-citationProspective study of shift work and risk of coronary heart disease in women
Kawachi, I., Colditz, G. A., Stampfer, M. J., Willett, W. C., Manson, J. E., Speizer, F. E., & Hennekens, C. H. (1995) · Circulation · doi:10.1161/01.cir.92.11.3178 · Cited by 524
Increased breast cancer risk among women who work predominantly at night
Hansen, J. (2001) · Epidemiology · doi:10.1097/00001648-200101000-00013 · Cited by 503
Increased risk of ischaemic heart disease in shift workers
Knutsson, A., Jonsson, B., Akerstedt, T., & Orth-Gomer, K. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91619-3 · Cited by 459
Self-citationPREMATURITY AND OCCUPATIONAL ACTIVITY DURING PREGNANCY
MAMELLE, N., Laumon, B., & Lazar, P. (1984) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113750 · Cited by 318
Alfredsson, L. S., Karasek, R. A., & Theorell, T. (1982) · Social Science & Medicine · doi:10.1016/0277-9536(82)90054-5 · Cited by 296
Shift work, occupation and coronary heart disease over
Tenkanen, L., Sjöblom, T., Kalimo, R., Alikoski, T., & Härmä, M. (1997) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.218 · Cited by 194
Research works printed but not linked: 1
- Scott AJ, LaDou J. Health and safety in shift workers. In: Zenz C, Dickerson OB, Horvath EP, eds. Occupational Medicine. St Louis, MO: Mosby, 1994; 960-986.
Cited by
Sorted by citations
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,223
The Circadian Clock and Human Health
Roenneberg, T., & Merrow, M. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.011 · Cited by 1,004
Buxton, O. M., Cain, S. W., O’Connor, S. P., Porter, J. H., Duffy, J. F., Wang, W., Czeisler, C. A., & Shea, S. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003200 · Cited by 932
Depression as a disease of modernity: explanations for increasing prevalence
Hidaka, B. H. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.12.036 · Cited by 769
Metadata
- Authors
- Knutsson, A.
- Affiliations
- Mid Sweden University (SE)
- Corresponding author
- Knutsson, A.
- Venue
- Occupational Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-03-01
- Volume
- 53
- Issue
- 2
- Pages
- 103-108
- ISSN
- 0962-7480 (ISSN-L)
- 1471-8405
- OpenAlex
- W2135303822
- Cited by
- 1,218
- References
- 40
- Citations by year
- 2026: 20 · 2025: 26 · 2024: 29 · 2023: 46 · 2022: 38 · 2021: 51 · 2020: 55 · 2019: 70 · 2018: 57 · 2017: 63 · 2016: 72 · 2015: 70 · 2014: 77 · 2013: 71 · 2012: 68
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Occupational Medicine (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Workplace Health and Well-being
- Keywords
- shift work, circadian rhythm disruption, health disorders, peptic ulcer, coronary artery disease, pregnancy outcomes, night work, occupational health
- MeSH terms
- Cardiovascular Diseases, Circadian Rhythm, Diabetes Mellitus, Female, Gastrointestinal Diseases, Humans, Longevity, Metabolic Diseases, Neoplasms, Occupational Diseases, Pregnancy, Pregnancy Complications, Work Schedule Tolerance
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